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Protein

Leucine-rich repeat-containing protein 73

Gene

LRRC73

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 73
Gene namesi
Name:LRRC73
Synonyms:C6orf154
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21375. LRRC73.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973511.

Polymorphism and mutation databases

DMDMi74742140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Leucine-rich repeat-containing protein 73PRO_0000252159Add
BLAST

Proteomic databases

PaxDbiQ5JTD7.
PRIDEiQ5JTD7.

PTM databases

iPTMnetiQ5JTD7.
PhosphoSiteiQ5JTD7.

Expressioni

Gene expression databases

BgeeiQ5JTD7.
CleanExiHS_C6orf154.
GenevisibleiQ5JTD7. HS.

Organism-specific databases

HPAiHPA046698.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361518.

Structurei

3D structure databases

ProteinModelPortaliQ5JTD7.
SMRiQ5JTD7. Positions 5-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati57 – 7822LRR 1Add
BLAST
Repeati86 – 10621LRR 2Add
BLAST
Repeati114 – 13724LRR 3Add
BLAST
Repeati145 – 16622LRR 4Add
BLAST
Repeati174 – 18714LRR 5Add
BLAST
Repeati202 – 22322LRR 6Add
BLAST
Repeati231 – 25020LRR 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi256 – 2627Poly-Glu

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IGKN. Eukaryota.
ENOG4111F6R. LUCA.
GeneTreeiENSGT00390000003256.
HOGENOMiHOG000007995.
HOVERGENiHBG079697.
InParanoidiQ5JTD7.
OMAiDFGHVCR.
OrthoDBiEOG7G7KPP.
PhylomeDBiQ5JTD7.
TreeFamiTF328343.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JTD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSSIQISG EPLSGAEVRD ICRGLRDNAV RLLSLRGCRL CDRDFGRICR
60 70 80 90 100
ALAGATSLAQ LNLNLGVVSS PSRIKQLAEA LRTNRSIQSL FLHGSPLTDA
110 120 130 140 150
GLALLNPALA LHPALVALDL GDCMLGDEAI NLICGLLPPD GAKSGLKELT
160 170 180 190 200
LSANPGITPK GWSRLAIAVA HSSQVRVLNL DYNPLGDHVA GMLAVAVASS
210 220 230 240 250
RTLEVLDLEG TGLTNQSAQT LLDMVENYPT ALRSLVLAEN SISPELQQQI
260 270 280 290 300
CDLLSEGEEE EEVAGGAGDT QEWERGREPA AHQRGSSSWM CPSDPSSQMV
310
LMTSGLGDSL LAETEM
Length:316
Mass (Da):33,409
Last modified:February 15, 2005 - v1
Checksum:i014D6BD27350EDD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355802 Genomic DNA. Translation: CAI42621.1.
BC108661 mRNA. Translation: AAI08662.1.
CCDSiCCDS34456.1.
RefSeqiNP_001012992.1. NM_001012974.2.
NP_001258811.1. NM_001271882.1.
UniGeneiHs.445552.

Genome annotation databases

EnsembliENST00000372441; ENSP00000361518; ENSG00000204052.
GeneIDi221424.
KEGGihsa:221424.
UCSCiuc003ovk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355802 Genomic DNA. Translation: CAI42621.1.
BC108661 mRNA. Translation: AAI08662.1.
CCDSiCCDS34456.1.
RefSeqiNP_001012992.1. NM_001012974.2.
NP_001258811.1. NM_001271882.1.
UniGeneiHs.445552.

3D structure databases

ProteinModelPortaliQ5JTD7.
SMRiQ5JTD7. Positions 5-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361518.

PTM databases

iPTMnetiQ5JTD7.
PhosphoSiteiQ5JTD7.

Polymorphism and mutation databases

DMDMi74742140.

Proteomic databases

PaxDbiQ5JTD7.
PRIDEiQ5JTD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372441; ENSP00000361518; ENSG00000204052.
GeneIDi221424.
KEGGihsa:221424.
UCSCiuc003ovk.3. human.

Organism-specific databases

CTDi221424.
GeneCardsiLRRC73.
HGNCiHGNC:21375. LRRC73.
HPAiHPA046698.
neXtProtiNX_Q5JTD7.
PharmGKBiPA134973511.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGKN. Eukaryota.
ENOG4111F6R. LUCA.
GeneTreeiENSGT00390000003256.
HOGENOMiHOG000007995.
HOVERGENiHBG079697.
InParanoidiQ5JTD7.
OMAiDFGHVCR.
OrthoDBiEOG7G7KPP.
PhylomeDBiQ5JTD7.
TreeFamiTF328343.

Miscellaneous databases

GenomeRNAii221424.
PROiQ5JTD7.

Gene expression databases

BgeeiQ5JTD7.
CleanExiHS_C6orf154.
GenevisibleiQ5JTD7. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiLRC73_HUMAN
AccessioniPrimary (citable) accession number: Q5JTD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.