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Protein

Leucine-rich repeat-containing protein 73

Gene

LRRC73

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 73
Gene namesi
Name:LRRC73
Synonyms:C6orf154
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204052.4.
HGNCiHGNC:21375. LRRC73.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204052.
PharmGKBiPA134973511.

Polymorphism and mutation databases

DMDMi74742140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002521591 – 316Leucine-rich repeat-containing protein 73Add BLAST316

Proteomic databases

EPDiQ5JTD7.
PaxDbiQ5JTD7.
PeptideAtlasiQ5JTD7.
PRIDEiQ5JTD7.

PTM databases

iPTMnetiQ5JTD7.
PhosphoSitePlusiQ5JTD7.

Expressioni

Gene expression databases

BgeeiENSG00000204052.
CleanExiHS_C6orf154.
GenevisibleiQ5JTD7. HS.

Organism-specific databases

HPAiHPA046698.

Interactioni

Protein-protein interaction databases

BioGridi128724. 11 interactors.
IntActiQ5JTD7. 8 interactors.
STRINGi9606.ENSP00000361518.

Structurei

3D structure databases

ProteinModelPortaliQ5JTD7.
SMRiQ5JTD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 78LRR 1Add BLAST22
Repeati86 – 106LRR 2Add BLAST21
Repeati114 – 137LRR 3Add BLAST24
Repeati145 – 166LRR 4Add BLAST22
Repeati174 – 187LRR 5Add BLAST14
Repeati202 – 223LRR 6Add BLAST22
Repeati231 – 250LRR 7Add BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi256 – 262Poly-Glu7

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IGKN. Eukaryota.
ENOG4111F6R. LUCA.
GeneTreeiENSGT00390000003256.
HOGENOMiHOG000007995.
HOVERGENiHBG079697.
InParanoidiQ5JTD7.
OMAiDFGHVCR.
OrthoDBiEOG091G0DW0.
PhylomeDBiQ5JTD7.
TreeFamiTF328343.

Sequencei

Sequence statusi: Complete.

Q5JTD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSSIQISG EPLSGAEVRD ICRGLRDNAV RLLSLRGCRL CDRDFGRICR
60 70 80 90 100
ALAGATSLAQ LNLNLGVVSS PSRIKQLAEA LRTNRSIQSL FLHGSPLTDA
110 120 130 140 150
GLALLNPALA LHPALVALDL GDCMLGDEAI NLICGLLPPD GAKSGLKELT
160 170 180 190 200
LSANPGITPK GWSRLAIAVA HSSQVRVLNL DYNPLGDHVA GMLAVAVASS
210 220 230 240 250
RTLEVLDLEG TGLTNQSAQT LLDMVENYPT ALRSLVLAEN SISPELQQQI
260 270 280 290 300
CDLLSEGEEE EEVAGGAGDT QEWERGREPA AHQRGSSSWM CPSDPSSQMV
310
LMTSGLGDSL LAETEM
Length:316
Mass (Da):33,409
Last modified:February 15, 2005 - v1
Checksum:i014D6BD27350EDD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355802 Genomic DNA. No translation available.
BC108661 mRNA. Translation: AAI08662.1.
CCDSiCCDS34456.1.
RefSeqiNP_001012992.1. NM_001012974.2.
NP_001258811.1. NM_001271882.1.
UniGeneiHs.445552.

Genome annotation databases

EnsembliENST00000372441; ENSP00000361518; ENSG00000204052.
GeneIDi221424.
KEGGihsa:221424.
UCSCiuc003ovk.3. human.

Similar proteinsi

Entry informationi

Entry nameiLRC73_HUMAN
AccessioniPrimary (citable) accession number: Q5JTD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 15, 2005
Last modified: September 27, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM