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Protein

Tight junction-associated protein 1

Gene

TJAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tight junction-associated protein 1
Alternative name(s):
Protein incorporated later into tight junctions
Tight junction protein 4
Gene namesi
Name:TJAP1
Synonyms:PILT, TJP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17949. TJAP1.

Subcellular locationi

  • Golgi apparatus By similarity
  • Cell junctiontight junction By similarity

  • Note: Recruited to tight junctions (TJ) during late stages of maturation of the TJ complexes. Excluded from adherens junctions and desmosomes (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Golgi apparatus, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi93643.
OpenTargetsiENSG00000137221.
PharmGKBiPA38268.

Polymorphism and mutation databases

BioMutaiTJAP1.
DMDMi74742134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000725502 – 557Tight junction-associated protein 1Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei422PhosphothreonineCombined sources1
Modified residuei491PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5JTD0.
MaxQBiQ5JTD0.
PaxDbiQ5JTD0.
PeptideAtlasiQ5JTD0.
PRIDEiQ5JTD0.

PTM databases

iPTMnetiQ5JTD0.
PhosphoSitePlusiQ5JTD0.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000137221.
CleanExiHS_TJAP1.
ExpressionAtlasiQ5JTD0. baseline and differential.
GenevisibleiQ5JTD0. HS.

Organism-specific databases

HPAiHPA030164.
HPA030165.
HPA030166.

Interactioni

Subunit structurei

Interacts with DLG1.1 Publication

Protein-protein interaction databases

BioGridi125043. 19 interactors.
IntActiQ5JTD0. 18 interactors.
STRINGi9606.ENSP00000361522.

Structurei

3D structure databases

ProteinModelPortaliQ5JTD0.
SMRiQ5JTD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili36 – 175Sequence analysisAdd BLAST140

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi271 – 327Pro-richAdd BLAST57

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJKM. Eukaryota.
ENOG410Z76C. LUCA.
GeneTreeiENSGT00530000063778.
HOVERGENiHBG056279.
InParanoidiQ5JTD0.
KOiK06105.
OMAiMSEGVPG.
OrthoDBiEOG091G03KA.
PhylomeDBiQ5JTD0.
TreeFamiTF331612.

Family and domain databases

InterProiIPR028179. Tjap1.
[Graphical view]
PANTHERiPTHR28664:SF3. PTHR28664:SF3. 1 hit.
PfamiPF15453. Pilt. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JTD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSAAPAKKP YRKAPPEHRE LRLEIPGSRL EQEEPLTDAE RMKLLQEENE
60 70 80 90 100
ELRRRLASAT RRTEALEREL EIGQDCLELE LGQSREELDK FKDKFRRLQN
110 120 130 140 150
SYTASQRTNQ ELEDKLHTLA SLSHSWIFAI KKAEMDRKTL DWEIVELTNK
160 170 180 190 200
LLDAKNTINK LEELNERYRL DCNLAVQLLK CNKSHFRNHK FADLPCELQD
210 220 230 240 250
MVRKHLHSGQ EAASPGPAPS LAPGAVVPTS VIARVLEKPE SLLLNSAQSG
260 270 280 290 300
SAGRPLAEDV FVHVDMSEGV PGDPASPPAP GSPTPQPNGE CHSLGTARGS
310 320 330 340 350
PEEELPLPAF EKLNPYPTPS PPHPLYPGRR VIEFSEDKVR IPRNSPLPNC
360 370 380 390 400
TYATRQAISL SLVEEGSERA RPSPVPSTPA SAQASPHHQP SPAPLTLSAP
410 420 430 440 450
ASSASSEEDL LVSWQRAFVD RTPPPAAVAQ RTAFGRDALP ELQRHFAHSP
460 470 480 490 500
ADRDEVVQAP SARPEESELL LPTEPDSGFP REEEELNLPI SPEEERQSLL
510 520 530 540 550
PINRGTEEGP GTSHTEGRAW PLPSSSRPQR SPKRMGVHHL HRKDSLTQAQ

EQGNLLN
Note: No experimental confirmation available.
Length:557
Mass (Da):61,821
Last modified:February 15, 2005 - v1
Checksum:i07D41B72E1CB0E20
GO
Isoform 2 (identifier: Q5JTD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-129: Missing.

Show »
Length:547
Mass (Da):60,721
Checksum:i25EEC24A2CAE1789
GO
Isoform 3 (identifier: Q5JTD0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-557: Missing.

Note: No experimental confirmation available.
Show »
Length:43
Mass (Da):4,959
Checksum:iC9195BEA9B859982
GO
Isoform 4 (identifier: Q5JTD0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.
     66-66: L → M
     120-129: Missing.

Note: No experimental confirmation available.
Show »
Length:482
Mass (Da):53,174
Checksum:i7A8B2B9A850B9DBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174L → P in BAB14867 (PubMed:14702039).Curated1
Sequence conflicti185 – 186HF → QV in CAI46221 (PubMed:17974005).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0159991 – 65Missing in isoform 4. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_01600044 – 557Missing in isoform 3. 1 PublicationAdd BLAST514
Alternative sequenceiVSP_01600166L → M in isoform 4. 1 Publication1
Alternative sequenceiVSP_016002120 – 129Missing in isoform 2 and isoform 4. 3 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024269 mRNA. Translation: BAB14867.1.
CR749480 mRNA. Translation: CAH18308.1.
AL117398 Transcribed RNA. Translation: CAI46221.1.
AL355802 Genomic DNA. Translation: CAI42617.1.
AL355802 Genomic DNA. Translation: CAI42618.1.
AL355802 Genomic DNA. Translation: CAI42619.1.
BC046239 mRNA. Translation: AAH46239.1.
BC064401 mRNA. Translation: AAH64401.1.
CCDSiCCDS4898.1. [Q5JTD0-2]
CCDS55004.1. [Q5JTD0-1]
RefSeqiNP_001139488.1. NM_001146016.1. [Q5JTD0-1]
NP_001139489.1. NM_001146017.1. [Q5JTD0-1]
NP_001139490.1. NM_001146018.1. [Q5JTD0-2]
NP_001139491.1. NM_001146019.1. [Q5JTD0-2]
NP_001139492.1. NM_001146020.1. [Q5JTD0-2]
NP_542171.2. NM_080604.2. [Q5JTD0-2]
XP_006715312.1. XM_006715249.1. [Q5JTD0-1]
XP_006715313.1. XM_006715250.3. [Q5JTD0-1]
XP_006715314.1. XM_006715251.2. [Q5JTD0-1]
XP_006715315.1. XM_006715252.2. [Q5JTD0-1]
XP_006715317.1. XM_006715254.3. [Q5JTD0-1]
XP_006715319.1. XM_006715256.1. [Q5JTD0-1]
XP_006715320.1. XM_006715257.2. [Q5JTD0-1]
XP_006715322.1. XM_006715259.3. [Q5JTD0-1]
XP_006715323.1. XM_006715260.1. [Q5JTD0-1]
XP_006715324.1. XM_006715261.1. [Q5JTD0-1]
XP_006715325.1. XM_006715262.2. [Q5JTD0-1]
XP_006715326.1. XM_006715263.2. [Q5JTD0-1]
XP_006715328.1. XM_006715265.1. [Q5JTD0-2]
XP_006715329.1. XM_006715266.1. [Q5JTD0-2]
XP_011513297.1. XM_011514995.1. [Q5JTD0-1]
XP_016866977.1. XM_017011488.1. [Q5JTD0-1]
XP_016866978.1. XM_017011489.1. [Q5JTD0-1]
XP_016866979.1. XM_017011490.1. [Q5JTD0-2]
XP_016866980.1. XM_017011491.1. [Q5JTD0-2]
XP_016866981.1. XM_017011492.1. [Q5JTD0-2]
XP_016866982.1. XM_017011493.1. [Q5JTD0-2]
UniGeneiHs.520145.

Genome annotation databases

EnsembliENST00000259751; ENSP00000259751; ENSG00000137221. [Q5JTD0-2]
ENST00000372444; ENSP00000361521; ENSG00000137221. [Q5JTD0-2]
ENST00000372445; ENSP00000361522; ENSG00000137221. [Q5JTD0-1]
ENST00000372449; ENSP00000361527; ENSG00000137221. [Q5JTD0-1]
ENST00000372452; ENSP00000361530; ENSG00000137221. [Q5JTD0-2]
ENST00000436109; ENSP00000407080; ENSG00000137221. [Q5JTD0-2]
ENST00000438588; ENSP00000408769; ENSG00000137221. [Q5JTD0-1]
ENST00000612912; ENSP00000484142; ENSG00000137221. [Q5JTD0-3]
GeneIDi93643.
KEGGihsa:93643.
UCSCiuc003ovc.3. human. [Q5JTD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024269 mRNA. Translation: BAB14867.1.
CR749480 mRNA. Translation: CAH18308.1.
AL117398 Transcribed RNA. Translation: CAI46221.1.
AL355802 Genomic DNA. Translation: CAI42617.1.
AL355802 Genomic DNA. Translation: CAI42618.1.
AL355802 Genomic DNA. Translation: CAI42619.1.
BC046239 mRNA. Translation: AAH46239.1.
BC064401 mRNA. Translation: AAH64401.1.
CCDSiCCDS4898.1. [Q5JTD0-2]
CCDS55004.1. [Q5JTD0-1]
RefSeqiNP_001139488.1. NM_001146016.1. [Q5JTD0-1]
NP_001139489.1. NM_001146017.1. [Q5JTD0-1]
NP_001139490.1. NM_001146018.1. [Q5JTD0-2]
NP_001139491.1. NM_001146019.1. [Q5JTD0-2]
NP_001139492.1. NM_001146020.1. [Q5JTD0-2]
NP_542171.2. NM_080604.2. [Q5JTD0-2]
XP_006715312.1. XM_006715249.1. [Q5JTD0-1]
XP_006715313.1. XM_006715250.3. [Q5JTD0-1]
XP_006715314.1. XM_006715251.2. [Q5JTD0-1]
XP_006715315.1. XM_006715252.2. [Q5JTD0-1]
XP_006715317.1. XM_006715254.3. [Q5JTD0-1]
XP_006715319.1. XM_006715256.1. [Q5JTD0-1]
XP_006715320.1. XM_006715257.2. [Q5JTD0-1]
XP_006715322.1. XM_006715259.3. [Q5JTD0-1]
XP_006715323.1. XM_006715260.1. [Q5JTD0-1]
XP_006715324.1. XM_006715261.1. [Q5JTD0-1]
XP_006715325.1. XM_006715262.2. [Q5JTD0-1]
XP_006715326.1. XM_006715263.2. [Q5JTD0-1]
XP_006715328.1. XM_006715265.1. [Q5JTD0-2]
XP_006715329.1. XM_006715266.1. [Q5JTD0-2]
XP_011513297.1. XM_011514995.1. [Q5JTD0-1]
XP_016866977.1. XM_017011488.1. [Q5JTD0-1]
XP_016866978.1. XM_017011489.1. [Q5JTD0-1]
XP_016866979.1. XM_017011490.1. [Q5JTD0-2]
XP_016866980.1. XM_017011491.1. [Q5JTD0-2]
XP_016866981.1. XM_017011492.1. [Q5JTD0-2]
XP_016866982.1. XM_017011493.1. [Q5JTD0-2]
UniGeneiHs.520145.

3D structure databases

ProteinModelPortaliQ5JTD0.
SMRiQ5JTD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125043. 19 interactors.
IntActiQ5JTD0. 18 interactors.
STRINGi9606.ENSP00000361522.

PTM databases

iPTMnetiQ5JTD0.
PhosphoSitePlusiQ5JTD0.

Polymorphism and mutation databases

BioMutaiTJAP1.
DMDMi74742134.

Proteomic databases

EPDiQ5JTD0.
MaxQBiQ5JTD0.
PaxDbiQ5JTD0.
PeptideAtlasiQ5JTD0.
PRIDEiQ5JTD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259751; ENSP00000259751; ENSG00000137221. [Q5JTD0-2]
ENST00000372444; ENSP00000361521; ENSG00000137221. [Q5JTD0-2]
ENST00000372445; ENSP00000361522; ENSG00000137221. [Q5JTD0-1]
ENST00000372449; ENSP00000361527; ENSG00000137221. [Q5JTD0-1]
ENST00000372452; ENSP00000361530; ENSG00000137221. [Q5JTD0-2]
ENST00000436109; ENSP00000407080; ENSG00000137221. [Q5JTD0-2]
ENST00000438588; ENSP00000408769; ENSG00000137221. [Q5JTD0-1]
ENST00000612912; ENSP00000484142; ENSG00000137221. [Q5JTD0-3]
GeneIDi93643.
KEGGihsa:93643.
UCSCiuc003ovc.3. human. [Q5JTD0-1]

Organism-specific databases

CTDi93643.
DisGeNETi93643.
GeneCardsiTJAP1.
H-InvDBHIX0165025.
HGNCiHGNC:17949. TJAP1.
HPAiHPA030164.
HPA030165.
HPA030166.
MIMi612658. gene.
neXtProtiNX_Q5JTD0.
OpenTargetsiENSG00000137221.
PharmGKBiPA38268.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJKM. Eukaryota.
ENOG410Z76C. LUCA.
GeneTreeiENSGT00530000063778.
HOVERGENiHBG056279.
InParanoidiQ5JTD0.
KOiK06105.
OMAiMSEGVPG.
OrthoDBiEOG091G03KA.
PhylomeDBiQ5JTD0.
TreeFamiTF331612.

Miscellaneous databases

ChiTaRSiTJAP1. human.
GeneWikiiTJAP1.
GenomeRNAii93643.
PROiQ5JTD0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137221.
CleanExiHS_TJAP1.
ExpressionAtlasiQ5JTD0. baseline and differential.
GenevisibleiQ5JTD0. HS.

Family and domain databases

InterProiIPR028179. Tjap1.
[Graphical view]
PANTHERiPTHR28664:SF3. PTHR28664:SF3. 1 hit.
PfamiPF15453. Pilt. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTJAP1_HUMAN
AccessioniPrimary (citable) accession number: Q5JTD0
Secondary accession number(s): Q05BH9
, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.