ID   KLF17_HUMAN             Reviewed;         389 AA.
AC   Q5JT82; Q86VQ7; Q8N805;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 151.
DE   RecName: Full=Krueppel-like factor 17;
DE   AltName: Full=Zinc finger protein 393;
GN   Name=KLF17; Synonyms=ZNF393;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASN-35 AND THR-57.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS THR-57 AND SER-156.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, AND DNA-BINDING.
RX   PubMed=16460907; DOI=10.1016/j.ygeno.2005.12.011;
RA   van Vliet J., Crofts L.A., Quinlan K.G.R., Czolij R., Perkins A.C.,
RA   Crossley M.;
RT   "Human KLF17 is a new member of the Sp/KLF family of transcription
RT   factors.";
RL   Genomics 87:474-482(2006).
CC   -!- FUNCTION: Transcription repressor that binds to the promoter of target
CC       genes and prevents their expression. Acts as a negative regulator of
CC       epithelial-mesenchymal transition and metastasis in breast cancer.
CC       Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a
CC       key metastasis regulator in breast cancer, and repress its expression.
CC       May be a germ cell-specific transcription factor that plays important
CC       roles in spermatid differentiation and oocyte development (By
CC       similarity). {ECO:0000250, ECO:0000269|PubMed:16460907}.
CC   -!- INTERACTION:
CC       Q5JT82; Q96Q77: CIB3; NbExp=6; IntAct=EBI-10292791, EBI-10292696;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; AK097479; BAC05070.1; -; mRNA.
DR   EMBL; AL356653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC049844; AAH49844.1; -; mRNA.
DR   CCDS; CCDS508.1; -.
DR   RefSeq; NP_775755.3; NM_173484.3.
DR   AlphaFoldDB; Q5JT82; -.
DR   SMR; Q5JT82; -.
DR   BioGRID; 126099; 2.
DR   IntAct; Q5JT82; 2.
DR   STRING; 9606.ENSP00000361373; -.
DR   iPTMnet; Q5JT82; -.
DR   PhosphoSitePlus; Q5JT82; -.
DR   BioMuta; KLF17; -.
DR   DMDM; 74762198; -.
DR   MassIVE; Q5JT82; -.
DR   PaxDb; 9606-ENSP00000361373; -.
DR   PeptideAtlas; Q5JT82; -.
DR   Antibodypedia; 18431; 228 antibodies from 30 providers.
DR   DNASU; 128209; -.
DR   Ensembl; ENST00000372299.4; ENSP00000361373.3; ENSG00000171872.5.
DR   GeneID; 128209; -.
DR   KEGG; hsa:128209; -.
DR   MANE-Select; ENST00000372299.4; ENSP00000361373.3; NM_173484.4; NP_775755.3.
DR   UCSC; uc001clp.4; human.
DR   AGR; HGNC:18830; -.
DR   CTD; 128209; -.
DR   DisGeNET; 128209; -.
DR   GeneCards; KLF17; -.
DR   HGNC; HGNC:18830; KLF17.
DR   HPA; ENSG00000171872; Tissue enriched (testis).
DR   MIM; 609602; gene.
DR   neXtProt; NX_Q5JT82; -.
DR   OpenTargets; ENSG00000171872; -.
DR   PharmGKB; PA134877071; -.
DR   VEuPathDB; HostDB:ENSG00000171872; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000162020; -.
DR   HOGENOM; CLU_827795_0_0_1; -.
DR   InParanoid; Q5JT82; -.
DR   OMA; MMPLGEP; -.
DR   OrthoDB; 4892855at2759; -.
DR   PhylomeDB; Q5JT82; -.
DR   TreeFam; TF315506; -.
DR   PathwayCommons; Q5JT82; -.
DR   SignaLink; Q5JT82; -.
DR   BioGRID-ORCS; 128209; 23 hits in 1165 CRISPR screens.
DR   ChiTaRS; KLF17; human.
DR   GeneWiki; KLF17; -.
DR   GenomeRNAi; 128209; -.
DR   Pharos; Q5JT82; Tbio.
DR   PRO; PR:Q5JT82; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5JT82; Protein.
DR   Bgee; ENSG00000171872; Expressed in left testis and 63 other cell types or tissues.
DR   ExpressionAtlas; Q5JT82; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd21574; KLF17_N; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23235:SF154; KRUEPPEL-LIKE FACTOR 17; 1.
DR   PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
DR   Genevisible; Q5JT82; HS.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..389
FT                   /note="Krueppel-like factor 17"
FT                   /id="PRO_0000047555"
FT   ZN_FING         283..307
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         313..337
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         343..365
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..383
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         35
FT                   /note="I -> N (in dbSNP:rs11210969)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_052719"
FT   VARIANT         57
FT                   /note="S -> T (in dbSNP:rs2429051)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_052720"
FT   VARIANT         80
FT                   /note="Q -> H (in dbSNP:rs6656945)"
FT                   /id="VAR_052721"
FT   VARIANT         156
FT                   /note="N -> S (in dbSNP:rs2485652)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_026198"
SQ   SEQUENCE   389 AA;  42577 MW;  0AA451DB23C2580A CRC64;
     MYGRPQAEME QEAGELSRWQ AAHQAAQDNE NSAPILNMSS SSGSSGVHTS WNQGLPSIQH
     FPHSAEMLGS PLVSVEAPGQ NVNEGGPQFS MPLPERGMSY CPQATLTPSR MIYCQRMSPP
     QQEMTIFSGP QLMPVGEPNI PRVARPFGGN LRMPPNGLPV SASTGIPIMS HTGNPPVPYP
     GLSTVPSDET LLGPTVPSTE AQAVLPSMAQ MLPPQDAHDL GMPPAESQSL LVLGSQDSLV
     SQPDSQEGPF LPEQPGPAPQ TVEKNSRPQE GTGRRGSSEA RPYCCNYENC GKAYTKRSHL
     VSHQRKHTGE RPYSCNWESC SWSFFRSDEL RRHMRVHTRY RPYKCDQCSR EFMRSDHLKQ
     HQKTHRPGPS DPQANNNNGE QDSPPAAGP
//