Q5JT82 (KLF17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Krueppel-like factor 17

Alternative name(s):
Zinc finger protein 393

Gene names

Name:	KLF17
Synonyms:	ZNF393

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development By similarity. Ref.4
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gamete generation Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB transcription regulatory region DNA binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Krueppel-like factor 17		PRO_0000047555
Regions
	Zinc finger	283 – 307	25	C2H2-type 1
	Zinc finger	313 – 337	25	C2H2-type 2
	Zinc finger	343 – 365	23	C2H2-type 3
Natural variations
	Natural variant	35	1	I → N. Ref.1 Corresponds to variant rs11210969 [ dbSNP | Ensembl ].		VAR_052719
	Natural variant	57	1	S → T. Ref.1 Ref.3 Corresponds to variant rs2429051 [ dbSNP | Ensembl ].		VAR_052720
	Natural variant	80	1	Q → H. Corresponds to variant rs6656945 [ dbSNP | Ensembl ].		VAR_052721
	Natural variant	156	1	N → S. Ref.3 Corresponds to variant rs2485652 [ dbSNP | Ensembl ].		VAR_026198

Sequences

	Sequence		Length	Mass (Da)
	Q5JT82 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 0AA451DB23C2580A	FASTA	389	42,577
	10 20 30 40 50 60 MYGRPQAEME QEAGELSRWQ AAHQAAQDNE NSAPILNMSS SSGSSGVHTS WNQGLPSIQH 70 80 90 100 110 120 FPHSAEMLGS PLVSVEAPGQ NVNEGGPQFS MPLPERGMSY CPQATLTPSR MIYCQRMSPP 130 140 150 160 170 180 QQEMTIFSGP QLMPVGEPNI PRVARPFGGN LRMPPNGLPV SASTGIPIMS HTGNPPVPYP 190 200 210 220 230 240 GLSTVPSDET LLGPTVPSTE AQAVLPSMAQ MLPPQDAHDL GMPPAESQSL LVLGSQDSLV 250 260 270 280 290 300 SQPDSQEGPF LPEQPGPAPQ TVEKNSRPQE GTGRRGSSEA RPYCCNYENC GKAYTKRSHL 310 320 330 340 350 360 VSHQRKHTGE RPYSCNWESC SWSFFRSDEL RRHMRVHTRY RPYKCDQCSR EFMRSDHLKQ 370 380 HQKTHRPGPS DPQANNNNGE QDSPPAAGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-35 AND THR-57. Tissue: Testis.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-57 AND SER-156. Tissue: Brain.
[4]	"Human KLF17 is a new member of the Sp/KLF family of transcription factors." van Vliet J., Crofts L.A., Quinlan K.G.R., Czolij R., Perkins A.C., Crossley M. Genomics 87:474-482(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DNA-BINDING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK097479 mRNA. Translation: BAC05070.1. AL356653 Genomic DNA. Translation: CAI15911.1. BC049844 mRNA. Translation: AAH49844.1.
IPI	IPI00328949.
RefSeq	NP_775755.3. NM_173484.3.
UniGene	Hs.567674.
3D structure databases
ProteinModelPortal	Q5JT82.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000361373.
Polymorphism databases
DMDM	74762198.
Proteomic databases
PaxDb	Q5JT82.
PRIDE	Q5JT82.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372299; ENSP00000361373; ENSG00000171872.
GeneID	128209.
KEGG	hsa:128209.
UCSC	uc001clp.3. human.
Organism-specific databases
CTD	128209.
GeneCards	GC01P044584.
HGNC	HGNC:18830. KLF17.
HPA	HPA024629.
MIM	609602. gene.
neXtProt	NX_Q5JT82.
PharmGKB	PA134877071.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000049152.
HOVERGEN	HBG080136.
InParanoid	Q5JT82.
KO	K09211.
OMA	WSFFRSD.
OrthoDB	EOG4PG610.
PhylomeDB	Q5JT82.
Gene expression databases
Bgee	Q5JT82.
CleanEx	HS_KLF17.
Genevestigator	Q5JT82.
GermOnline	ENSG00000171872. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 3 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	128209.
NextBio	82242.
SOURCE	Search...

Entry information

Entry name

KLF17_HUMAN

Accession

Primary (citable) accession number: Q5JT82
Secondary accession number(s): Q86VQ7, Q8N805

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.