Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Krueppel-like factor 17

Gene

KLF17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri283 – 30725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 17
Alternative name(s):
Zinc finger protein 393
Gene namesi
Name:KLF17
Synonyms:ZNF393
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18830. KLF17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134877071.

Polymorphism and mutation databases

BioMutaiKLF17.
DMDMi74762198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Krueppel-like factor 17PRO_0000047555Add
BLAST

Proteomic databases

PaxDbiQ5JT82.
PRIDEiQ5JT82.

Expressioni

Gene expression databases

BgeeiQ5JT82.
CleanExiHS_KLF17.
GenevisibleiQ5JT82. HS.

Organism-specific databases

HPAiHPA024629.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CIB3Q96Q773EBI-10292791,EBI-10292696

Protein-protein interaction databases

BioGridi126099. 1 interaction.
IntActiQ5JT82. 1 interaction.
STRINGi9606.ENSP00000361373.

Structurei

3D structure databases

ProteinModelPortaliQ5JT82.
SMRiQ5JT82. Positions 283-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri283 – 30725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000049152.
HOVERGENiHBG080136.
InParanoidiQ5JT82.
KOiK09211.
OMAiWSFFRSD.
OrthoDBiEOG7FJH1D.
PhylomeDBiQ5JT82.
TreeFamiTF315506.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JT82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGRPQAEME QEAGELSRWQ AAHQAAQDNE NSAPILNMSS SSGSSGVHTS
60 70 80 90 100
WNQGLPSIQH FPHSAEMLGS PLVSVEAPGQ NVNEGGPQFS MPLPERGMSY
110 120 130 140 150
CPQATLTPSR MIYCQRMSPP QQEMTIFSGP QLMPVGEPNI PRVARPFGGN
160 170 180 190 200
LRMPPNGLPV SASTGIPIMS HTGNPPVPYP GLSTVPSDET LLGPTVPSTE
210 220 230 240 250
AQAVLPSMAQ MLPPQDAHDL GMPPAESQSL LVLGSQDSLV SQPDSQEGPF
260 270 280 290 300
LPEQPGPAPQ TVEKNSRPQE GTGRRGSSEA RPYCCNYENC GKAYTKRSHL
310 320 330 340 350
VSHQRKHTGE RPYSCNWESC SWSFFRSDEL RRHMRVHTRY RPYKCDQCSR
360 370 380
EFMRSDHLKQ HQKTHRPGPS DPQANNNNGE QDSPPAAGP
Length:389
Mass (Da):42,577
Last modified:February 15, 2005 - v1
Checksum:i0AA451DB23C2580A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351I → N.1 Publication
Corresponds to variant rs11210969 [ dbSNP | Ensembl ].
VAR_052719
Natural varianti57 – 571S → T.2 Publications
Corresponds to variant rs2429051 [ dbSNP | Ensembl ].
VAR_052720
Natural varianti80 – 801Q → H.
Corresponds to variant rs6656945 [ dbSNP | Ensembl ].
VAR_052721
Natural varianti156 – 1561N → S.1 Publication
Corresponds to variant rs2485652 [ dbSNP | Ensembl ].
VAR_026198

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097479 mRNA. Translation: BAC05070.1.
AL356653 Genomic DNA. Translation: CAI15911.1.
BC049844 mRNA. Translation: AAH49844.1.
CCDSiCCDS508.1.
RefSeqiNP_775755.3. NM_173484.3.
UniGeneiHs.567674.

Genome annotation databases

EnsembliENST00000372299; ENSP00000361373; ENSG00000171872.
GeneIDi128209.
KEGGihsa:128209.
UCSCiuc001clp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097479 mRNA. Translation: BAC05070.1.
AL356653 Genomic DNA. Translation: CAI15911.1.
BC049844 mRNA. Translation: AAH49844.1.
CCDSiCCDS508.1.
RefSeqiNP_775755.3. NM_173484.3.
UniGeneiHs.567674.

3D structure databases

ProteinModelPortaliQ5JT82.
SMRiQ5JT82. Positions 283-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126099. 1 interaction.
IntActiQ5JT82. 1 interaction.
STRINGi9606.ENSP00000361373.

Polymorphism and mutation databases

BioMutaiKLF17.
DMDMi74762198.

Proteomic databases

PaxDbiQ5JT82.
PRIDEiQ5JT82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372299; ENSP00000361373; ENSG00000171872.
GeneIDi128209.
KEGGihsa:128209.
UCSCiuc001clp.3. human.

Organism-specific databases

CTDi128209.
GeneCardsiGC01P044584.
HGNCiHGNC:18830. KLF17.
HPAiHPA024629.
MIMi609602. gene.
neXtProtiNX_Q5JT82.
PharmGKBiPA134877071.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000049152.
HOVERGENiHBG080136.
InParanoidiQ5JT82.
KOiK09211.
OMAiWSFFRSD.
OrthoDBiEOG7FJH1D.
PhylomeDBiQ5JT82.
TreeFamiTF315506.

Miscellaneous databases

GeneWikiiKLF17.
GenomeRNAii128209.
NextBioi82242.
PROiQ5JT82.
SOURCEiSearch...

Gene expression databases

BgeeiQ5JT82.
CleanExiHS_KLF17.
GenevisibleiQ5JT82. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-35 AND THR-57.
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-57 AND SER-156.
    Tissue: Brain.
  4. "Human KLF17 is a new member of the Sp/KLF family of transcription factors."
    van Vliet J., Crofts L.A., Quinlan K.G.R., Czolij R., Perkins A.C., Crossley M.
    Genomics 87:474-482(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING.

Entry informationi

Entry nameiKLF17_HUMAN
AccessioniPrimary (citable) accession number: Q5JT82
Secondary accession number(s): Q86VQ7, Q8N805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: February 15, 2005
Last modified: July 22, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.