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Protein

Ras-related protein Rab-41

Gene

RAB41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458GTPBy similarity
Nucleotide bindingi86 – 905GTPBy similarity
Nucleotide bindingi144 – 1474GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-41
Gene namesi
Name:RAB41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18293. RAB41.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: punctate localization concentrated in ruffled regions at the cell periphery.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34140.

Polymorphism and mutation databases

BioMutaiRAB41.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Ras-related protein Rab-41PRO_0000244618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi222 – 2221S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiQ5JT25.
PaxDbiQ5JT25.
PeptideAtlasiQ5JT25.
PRIDEiQ5JT25.

PTM databases

iPTMnetiQ5JT25.
PhosphoSiteiQ5JT25.

Expressioni

Tissue specificityi

Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.1 Publication

Gene expression databases

BgeeiENSG00000147127.
CleanExiHS_RAB41.
ExpressionAtlasiQ5JT25. baseline and differential.

Organism-specific databases

HPAiHPA001510.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10244509,EBI-307352
TCF4P158843EBI-10244509,EBI-533224

Protein-protein interaction databases

BioGridi131446. 6 interactions.
IntActiQ5JT25. 2 interactions.
STRINGi9606.ENSP00000276066.

Structurei

3D structure databases

ProteinModelPortaliQ5JT25.
SMRiQ5JT25. Positions 33-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi60 – 689Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5JT25.
KOiK07896.
OMAiFKETDKW.
OrthoDBiEOG091G0ORZ.
PhylomeDBiQ5JT25.
TreeFamiTF300803.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JT25-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAFGHDEAW MEAGGFGLEA AERTEYQSLC KSKLLFLGEQ SVGKTSIISR
60 70 80 90 100
FMYNSFGCAC QATVGIDFLS KTMYLEDQIV QLQLWDTAGQ ERFHSLIPSY
110 120 130 140 150
IRDSTIAVVV YDITNINSFK ETDKWVEHVR AERGDDVVIM LLGNKIDLDN
160 170 180 190 200
KRQVTAEQGE EKSRNLNVMF IETSAKTGYN VKKLFRRVAS ALLSTRTSPP
210 220
PKEGTVEIEL ESFEESGNRS YC
Length:222
Mass (Da):25,038
Last modified:May 5, 2009 - v2
Checksum:i91F90E1749A7C39E
GO
Isoform 2 (identifier: Q5JT25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-42: Missing.

Show »
Length:221
Mass (Da):24,939
Checksum:i4D569A9FAD1586ED
GO

Sequence cautioni

The sequence CAI41489 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei42 – 421Missing in isoform 2. 1 PublicationVSP_037051

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL357752 Genomic DNA. Translation: CAI41489.1. Different initiation.
BC117239 mRNA. Translation: AAI17240.1.
CCDSiCCDS35322.2. [Q5JT25-2]
RefSeqiNP_001027898.2. NM_001032726.2. [Q5JT25-2]
UniGeneiHs.276327.

Genome annotation databases

EnsembliENST00000276066; ENSP00000276066; ENSG00000147127. [Q5JT25-2]
ENST00000374473; ENSP00000363597; ENSG00000147127. [Q5JT25-1]
GeneIDi347517.
KEGGihsa:347517.
UCSCiuc010nkv.3. human. [Q5JT25-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL357752 Genomic DNA. Translation: CAI41489.1. Different initiation.
BC117239 mRNA. Translation: AAI17240.1.
CCDSiCCDS35322.2. [Q5JT25-2]
RefSeqiNP_001027898.2. NM_001032726.2. [Q5JT25-2]
UniGeneiHs.276327.

3D structure databases

ProteinModelPortaliQ5JT25.
SMRiQ5JT25. Positions 33-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131446. 6 interactions.
IntActiQ5JT25. 2 interactions.
STRINGi9606.ENSP00000276066.

PTM databases

iPTMnetiQ5JT25.
PhosphoSiteiQ5JT25.

Polymorphism and mutation databases

BioMutaiRAB41.

Proteomic databases

MaxQBiQ5JT25.
PaxDbiQ5JT25.
PeptideAtlasiQ5JT25.
PRIDEiQ5JT25.

Protocols and materials databases

DNASUi347517.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276066; ENSP00000276066; ENSG00000147127. [Q5JT25-2]
ENST00000374473; ENSP00000363597; ENSG00000147127. [Q5JT25-1]
GeneIDi347517.
KEGGihsa:347517.
UCSCiuc010nkv.3. human. [Q5JT25-1]

Organism-specific databases

CTDi347517.
GeneCardsiRAB41.
HGNCiHGNC:18293. RAB41.
HPAiHPA001510.
neXtProtiNX_Q5JT25.
PharmGKBiPA34140.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5JT25.
KOiK07896.
OMAiFKETDKW.
OrthoDBiEOG091G0ORZ.
PhylomeDBiQ5JT25.
TreeFamiTF300803.

Enzyme and pathway databases

ReactomeiR-HSA-6811438. Intra-Golgi traffic.

Miscellaneous databases

GenomeRNAii347517.
PROiQ5JT25.

Gene expression databases

BgeeiENSG00000147127.
CleanExiHS_RAB41.
ExpressionAtlasiQ5JT25. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB41_HUMAN
AccessioniPrimary (citable) accession number: Q5JT25
Secondary accession number(s): Q17RQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 5, 2009
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.