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Protein

Meiosis expressed gene 1 protein homolog

Gene

MEIG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential for spermiogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis expressed gene 1 protein homolog
Gene namesi
Name:MEIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23429. MEIG1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134895701.

Polymorphism and mutation databases

BioMutaiMEIG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888Meiosis expressed gene 1 protein homologPRO_0000313025Add
BLAST

Proteomic databases

PaxDbiQ5JSS6.
PRIDEiQ5JSS6.

PTM databases

iPTMnetiQ5JSS6.
PhosphoSiteiQ5JSS6.

Expressioni

Gene expression databases

BgeeiENSG00000197889.
CleanExiHS_MEIG1.
GenevisibleiQ5JSS6. HS.

Organism-specific databases

HPAiHPA044594.

Interactioni

Subunit structurei

Interacts with PACRG.By similarity

Protein-protein interaction databases

BioGridi569980. 1 interaction.
STRINGi9606.ENSP00000367486.

Structurei

3D structure databases

ProteinModelPortaliQ5JSS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MEIG1 family.Curated

Phylogenomic databases

eggNOGiENOG410IZAK. Eukaryota.
ENOG4111XG3. LUCA.
GeneTreeiENSGT00390000013550.
HOGENOMiHOG000231567.
HOVERGENiHBG052452.
InParanoidiQ5JSS6.
OMAiTFYYYNR.
OrthoDBiEOG091G15MX.
PhylomeDBiQ5JSS6.
TreeFamiTF329080.

Family and domain databases

InterProiIPR020186. Meiosis-expressed_gene_1.
[Graphical view]
PfamiPF15163. Meiosis_expr. 1 hit.
[Graphical view]
ProDomiPD062760. Meiosis-expressed_gene_1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q5JSS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSDVKPKS VSHAKKWSEE IENLYRFQQA GYRDETEYRQ VKQVSMVDRW
60 70 80
PETGYVKKLQ RRDNTFYYYN KQRECDDKEV HKVKIYAY
Length:88
Mass (Da):10,795
Last modified:February 15, 2005 - v1
Checksum:iB560DAFFB60DC274
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91K → T.
Corresponds to variant rs4750568 [ dbSNP | Ensembl ].
VAR_053979

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360083 Genomic DNA. Translation: CAI40026.1.
CCDSiCCDS31151.1.
RefSeqiNP_001074305.1. NM_001080836.2.
UniGeneiHs.257249.

Genome annotation databases

EnsembliENST00000378240; ENSP00000367486; ENSG00000197889.
ENST00000407572; ENSP00000384334; ENSG00000197889.
GeneIDi644890.
KEGGihsa:644890.
UCSCiuc009xjk.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360083 Genomic DNA. Translation: CAI40026.1.
CCDSiCCDS31151.1.
RefSeqiNP_001074305.1. NM_001080836.2.
UniGeneiHs.257249.

3D structure databases

ProteinModelPortaliQ5JSS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi569980. 1 interaction.
STRINGi9606.ENSP00000367486.

PTM databases

iPTMnetiQ5JSS6.
PhosphoSiteiQ5JSS6.

Polymorphism and mutation databases

BioMutaiMEIG1.

Proteomic databases

PaxDbiQ5JSS6.
PRIDEiQ5JSS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378240; ENSP00000367486; ENSG00000197889.
ENST00000407572; ENSP00000384334; ENSG00000197889.
GeneIDi644890.
KEGGihsa:644890.
UCSCiuc009xjk.1. human.

Organism-specific databases

CTDi644890.
GeneCardsiMEIG1.
HGNCiHGNC:23429. MEIG1.
HPAiHPA044594.
MIMi614174. gene.
neXtProtiNX_Q5JSS6.
PharmGKBiPA134895701.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZAK. Eukaryota.
ENOG4111XG3. LUCA.
GeneTreeiENSGT00390000013550.
HOGENOMiHOG000231567.
HOVERGENiHBG052452.
InParanoidiQ5JSS6.
OMAiTFYYYNR.
OrthoDBiEOG091G15MX.
PhylomeDBiQ5JSS6.
TreeFamiTF329080.

Miscellaneous databases

GenomeRNAii644890.
PROiQ5JSS6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197889.
CleanExiHS_MEIG1.
GenevisibleiQ5JSS6. HS.

Family and domain databases

InterProiIPR020186. Meiosis-expressed_gene_1.
[Graphical view]
PfamiPF15163. Meiosis_expr. 1 hit.
[Graphical view]
ProDomiPD062760. Meiosis-expressed_gene_1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiMEIG1_HUMAN
AccessioniPrimary (citable) accession number: Q5JSS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.