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Q5JSL3

- DOC11_HUMAN

UniProt

Q5JSL3 - DOC11_HUMAN

Protein

Dedicator of cytokinesis protein 11

Gene

DOCK11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.By similarity

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: Ensembl

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dedicator of cytokinesis protein 11
    Alternative name(s):
    Activated Cdc42-associated guanine nucleotide exchange factor
    Short name:
    ACG
    Zizimin-2
    Gene namesi
    Name:DOCK11
    Synonyms:ZIZ2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:23483. DOCK11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394757.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20732073Dedicator of cytokinesis protein 11PRO_0000299558Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei161 – 1611Phosphoserine1 Publication
    Modified residuei248 – 2481Phosphotyrosine1 Publication
    Modified residuei251 – 2511Phosphotyrosine1 Publication
    Modified residuei266 – 2661Phosphothreonine1 Publication
    Modified residuei440 – 4401Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5JSL3.
    PaxDbiQ5JSL3.
    PRIDEiQ5JSL3.

    PTM databases

    PhosphoSiteiQ5JSL3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5JSL3.
    BgeeiQ5JSL3.
    CleanExiHS_DOCK11.
    GenevestigatoriQ5JSL3.

    Organism-specific databases

    HPAiHPA059695.

    Interactioni

    Subunit structurei

    Interacts with CDC42.By similarity

    Protein-protein interaction databases

    BioGridi126589. 3 interactions.
    IntActiQ5JSL3. 4 interactions.
    STRINGi9606.ENSP00000276202.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JSL3.
    SMRiQ5JSL3. Positions 162-294, 1613-2035.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini165 – 272108PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini640 – 818179DHR-1Add
    BLAST
    Domaini1609 – 2036428DHR-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni66 – 12661Interaction with activated CDC42By similarityAdd
    BLAST

    Domaini

    The DHR-2 domain is necessary for the GEF activity.By similarity

    Sequence similaritiesi

    Belongs to the DOCK family.Curated
    Contains 1 DHR-1 domain.Curated
    Contains 1 DHR-2 domain.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG242127.
    HOGENOMiHOG000231373.
    HOVERGENiHBG107819.
    PhylomeDBiQ5JSL3.
    TreeFamiTF313629.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR021816. DOCK_C/D_N.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR23317. PTHR23317. 1 hit.
    PfamiPF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF11878. DUF3398. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 4 hits.
    PROSITEiPS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5JSL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEVRKFTKR LSKPGTAAEL RQSVSEAVRG SVVLEKAKVV EPLDYENVIA     50
    QRKTQIYSDP LRDLLMFPME DISISVIGRQ RRTVQSTVPE DAEKRAQSLF 100
    VKECIKTYST DWHVVNYKYE DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC 150
    EKDEDSSSLC SQKGGVIKQG WLHKANVNST ITVTMKVFKR RYFYLTQLPD 200
    GSYILNSYKD EKNSKESKGC IYLDACIDVV QCPKMRRHAF ELKMLDKYSH 250
    YLAAETEQEM EEWLITLKKI IQINTDSLVQ EKKETVETAQ DDETSSQGKA 300
    ENIMASLERS MHPELMKYGR ETEQLNKLSR GDGRQNLFSF DSEVQRLDFS 350
    GIEPDIKPFE EKCNKRFLVN CHDLTFNILG QIGDNAKGPP TNVEPFFINL 400
    ALFDVKNNCK ISADFHVDLN PPSVREMLWG SSTQLASDGS PKGSSPESYI 450
    HGIAESQLRY IQQGIFSVTN PHPEIFLVAR IEKVLQGNIT HCAEPYIKNS 500
    DPVKTAQKVH RTAKQVCSRL GQYRMPFAWA ARPIFKDTQG SLDLDGRFSP 550
    LYKQDSSKLS SEDILKLLSE YKKPEKTKLQ IIPGQLNITV ECVPVDLSNC 600
    ITSSYVPLKP FEKNCQNITV EVEEFVPEMT KYCYPFTIYK NHLYVYPLQL 650
    KYDSQKTFAK ARNIAVCVEF RDSDESDASA LKCIYGKPAG SVFTTNAYAV 700
    VSHHNQNPEF YDEIKIELPI HLHQKHHLLF TFYHVSCEIN TKGTTKKQDT 750
    VETPVGFAWV PLLKDGRIIT FEQQLPVSAN LPPGYLNLND AESRRQCNVD 800
    IKWVDGAKPL LKIKSHLEST IYTQDLHVHK FFHHCQLIQS GSKEVPGELI 850
    KYLKCLHAME IQVMIQFLPV ILMQLFRVLT NMTHEDDVPI NCTMVLLHIV 900
    SKCHEEGLDS YLRSFIKYSF RPEKPSAPQA QLIHETLATT MIAILKQSAD 950
    FLSINKLLKY SWFFFEIIAK SMATYLLEEN KIKLPRGQRF PETYHHVLHS 1000
    LLLAIIPHVT IRYAEIPDES RNVNYSLASF LKRCLTLMDR GFIFNLINDY 1050
    ISGFSPKDPK VLAEYKFEFL QTICNHEHYI PLNLPMAFAK PKLQRVQDSN 1100
    LEYSLSDEYC KHHFLVGLLL RETSIALQDN YEIRYTAISV IKNLLIKHAF 1150
    DTRYQHKNQQ AKIAQLYLPF VGLLLENIQR LAGRDTLYSC AAMPNSASRD 1200
    EFPCGFTSPA NRGSLSTDKD TAYGSFQNGH GIKREDSRGS LIPEGATGFP 1250
    DQGNTGENTR QSSTRSSVSQ YNRLDQYEIR SLLMCYLYIV KMISEDTLLT 1300
    YWNKVSPQEL INILILLEVC LFHFRYMGKR NIARVHDAWL SKHFGIDRKS 1350
    QTMPALRNRS GVMQARLQHL SSLESSFTLN HSSTTTEADI FHQALLEGNT 1400
    ATEVSLTVLD TISFFTQCFK TQLLNNDGHN PLMKKVFDIH LAFLKNGQSE 1450
    VSLKHVFASL RAFISKFPSA FFKGRVNMCA AFCYEVLKCC TSKISSTRNE 1500
    ASALLYLLMR NNFEYTKRKT FLRTHLQIII AVSQLIADVA LSGGSRFQES 1550
    LFIINNFANS DRPMKATAFP AEVKDLTKRI RTVLMATAQM KEHEKDPEML 1600
    IDLQYSLAKS YASTPELRKT WLDSMAKIHV KNGDFSEAAM CYVHVAALVA 1650
    EFLHRKKLFP NGCSAFKKIT PNIDEEGAMK EDAGMMDVHY SEEVLLELLE 1700
    QCVDGLWKAE RYEIISEISK LIVPIYEKRR EFEKLTQVYR TLHGAYTKIL 1750
    EVMHTKKRLL GTFFRVAFYG QSFFEEEDGK EYIYKEPKLT GLSEISLRLV 1800
    KLYGEKFGTE NVKIIQDSDK VNAKELDPKY AHIQVTYVKP YFDDKELTER 1850
    KTEFERNHNI SRFVFEAPYT LSGKKQGCIE EQCKRRTILT TSNSFPYVKK 1900
    RIPINCEQQI NLKPIDVATD EIKDKTAELQ KLCSSTDVDM IQLQLKLQGC 1950
    VSVQVNAGPL AYARAFLNDS QASKYPPKKV SELKDMFRKF IQACSIALEL 2000
    NERLIKEDQV EYHEGLKSNF RDMVKELSDI IHEQILQEDT MHSPWMSNTL 2050
    HVFCAISGTS SDRGYGSPRY AEV 2073
    Length:2,073
    Mass (Da):237,671
    Last modified:September 11, 2007 - v2
    Checksum:i558FC01EE5D23B6E
    GO

    Sequence cautioni

    The sequence BAB71253.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC86230.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI41407.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI41411.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti376 – 3761F → L in AAU04438. (PubMed:16968698)Curated
    Sequence conflicti740 – 7401N → K in AAU04438. (PubMed:16968698)Curated
    Sequence conflicti1984 – 19841K → E in AAU04438. (PubMed:16968698)Curated
    Sequence conflicti1984 – 19841K → E in BAB71253. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti813 – 8131I → F.
    Corresponds to variant rs16995229 [ dbSNP | Ensembl ].
    VAR_034854

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY692226 mRNA. Translation: AAU04438.1.
    AL391237, AC007021, AL391280 Genomic DNA. Translation: CAI41407.1. Sequence problems.
    AL391280, AC007021, AL391237 Genomic DNA. Translation: CAI41411.1. Sequence problems.
    CH471161 Genomic DNA. Translation: EAW89895.1.
    AK056684 mRNA. Translation: BAB71253.1. Different initiation.
    AK125641 mRNA. Translation: BAC86230.1. Different initiation.
    BC047713 mRNA. Translation: AAH47713.1.
    CCDSiCCDS35373.1.
    RefSeqiNP_653259.3. NM_144658.3.
    UniGeneiHs.368203.

    Genome annotation databases

    EnsembliENST00000276202; ENSP00000276202; ENSG00000147251.
    GeneIDi139818.
    KEGGihsa:139818.
    UCSCiuc004eqp.2. human.

    Polymorphism databases

    DMDMi158563857.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY692226 mRNA. Translation: AAU04438.1 .
    AL391237 , AC007021 , AL391280 Genomic DNA. Translation: CAI41407.1 . Sequence problems.
    AL391280 , AC007021 , AL391237 Genomic DNA. Translation: CAI41411.1 . Sequence problems.
    CH471161 Genomic DNA. Translation: EAW89895.1 .
    AK056684 mRNA. Translation: BAB71253.1 . Different initiation.
    AK125641 mRNA. Translation: BAC86230.1 . Different initiation.
    BC047713 mRNA. Translation: AAH47713.1 .
    CCDSi CCDS35373.1.
    RefSeqi NP_653259.3. NM_144658.3.
    UniGenei Hs.368203.

    3D structure databases

    ProteinModelPortali Q5JSL3.
    SMRi Q5JSL3. Positions 162-294, 1613-2035.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126589. 3 interactions.
    IntActi Q5JSL3. 4 interactions.
    STRINGi 9606.ENSP00000276202.

    PTM databases

    PhosphoSitei Q5JSL3.

    Polymorphism databases

    DMDMi 158563857.

    Proteomic databases

    MaxQBi Q5JSL3.
    PaxDbi Q5JSL3.
    PRIDEi Q5JSL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276202 ; ENSP00000276202 ; ENSG00000147251 .
    GeneIDi 139818.
    KEGGi hsa:139818.
    UCSCi uc004eqp.2. human.

    Organism-specific databases

    CTDi 139818.
    GeneCardsi GC0XP117629.
    H-InvDB HIX0017007.
    HGNCi HGNC:23483. DOCK11.
    HPAi HPA059695.
    MIMi 300681. gene.
    neXtProti NX_Q5JSL3.
    PharmGKBi PA128394757.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242127.
    HOGENOMi HOG000231373.
    HOVERGENi HBG107819.
    PhylomeDBi Q5JSL3.
    TreeFami TF313629.

    Enzyme and pathway databases

    Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    ChiTaRSi DOCK11. human.
    GeneWikii Dock11.
    GenomeRNAii 139818.
    NextBioi 84048.
    PROi Q5JSL3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5JSL3.
    Bgeei Q5JSL3.
    CleanExi HS_DOCK11.
    Genevestigatori Q5JSL3.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR021816. DOCK_C/D_N.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR23317. PTHR23317. 1 hit.
    Pfami PF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF11878. DUF3398. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 4 hits.
    PROSITEi PS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42."
      Lin Q., Yang W., Baird D., Feng Q., Cerione R.A.
      J. Biol. Chem. 281:35253-35262(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 811-2073.
      Tissue: Synovium.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1283-2073.
      Tissue: Testis.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-248; TYR-251; THR-266 AND SER-440, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDOC11_HUMAN
    AccessioniPrimary (citable) accession number: Q5JSL3
    Secondary accession number(s): A6NMF0
    , Q66M66, Q6ZUJ5, Q86VU8, Q96MN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    'Zizim' means 'spike' in Hebrew.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3