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Q5JSL3

- DOC11_HUMAN

UniProt

Q5JSL3 - DOC11_HUMAN

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Protein

Dedicator of cytokinesis protein 11

Gene

DOCK11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.By similarity

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: Ensembl

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 11
Alternative name(s):
Activated Cdc42-associated guanine nucleotide exchange factor
Short name:
ACG
Zizimin-2
Gene namesi
Name:DOCK11
Synonyms:ZIZ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:23483. DOCK11.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394757.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20732073Dedicator of cytokinesis protein 11PRO_0000299558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei161 – 1611Phosphoserine1 Publication
Modified residuei248 – 2481Phosphotyrosine1 Publication
Modified residuei251 – 2511Phosphotyrosine1 Publication
Modified residuei266 – 2661Phosphothreonine1 Publication
Modified residuei440 – 4401Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5JSL3.
PaxDbiQ5JSL3.
PRIDEiQ5JSL3.

PTM databases

PhosphoSiteiQ5JSL3.

Expressioni

Gene expression databases

BgeeiQ5JSL3.
CleanExiHS_DOCK11.
ExpressionAtlasiQ5JSL3. baseline and differential.
GenevestigatoriQ5JSL3.

Organism-specific databases

HPAiHPA059695.

Interactioni

Subunit structurei

Interacts with CDC42.By similarity

Protein-protein interaction databases

BioGridi126589. 3 interactions.
IntActiQ5JSL3. 4 interactions.
STRINGi9606.ENSP00000276202.

Structurei

3D structure databases

ProteinModelPortaliQ5JSL3.
SMRiQ5JSL3. Positions 162-294, 1613-2035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 272108PHPROSITE-ProRule annotationAdd
BLAST
Domaini640 – 818179DHR-1Add
BLAST
Domaini1609 – 2036428DHR-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 12661Interaction with activated CDC42By similarityAdd
BLAST

Domaini

The DHR-2 domain is necessary for the GEF activity.By similarity

Sequence similaritiesi

Belongs to the DOCK family.Curated
Contains 1 DHR-1 domain.Curated
Contains 1 DHR-2 domain.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG242127.
GeneTreeiENSGT00760000119234.
HOGENOMiHOG000231373.
HOVERGENiHBG107819.
InParanoidiQ5JSL3.
PhylomeDBiQ5JSL3.
TreeFamiTF313629.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PfamiPF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JSL3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEVRKFTKR LSKPGTAAEL RQSVSEAVRG SVVLEKAKVV EPLDYENVIA
60 70 80 90 100
QRKTQIYSDP LRDLLMFPME DISISVIGRQ RRTVQSTVPE DAEKRAQSLF
110 120 130 140 150
VKECIKTYST DWHVVNYKYE DFSGDFRMLP CKSLRPEKIP NHVFEIDEDC
160 170 180 190 200
EKDEDSSSLC SQKGGVIKQG WLHKANVNST ITVTMKVFKR RYFYLTQLPD
210 220 230 240 250
GSYILNSYKD EKNSKESKGC IYLDACIDVV QCPKMRRHAF ELKMLDKYSH
260 270 280 290 300
YLAAETEQEM EEWLITLKKI IQINTDSLVQ EKKETVETAQ DDETSSQGKA
310 320 330 340 350
ENIMASLERS MHPELMKYGR ETEQLNKLSR GDGRQNLFSF DSEVQRLDFS
360 370 380 390 400
GIEPDIKPFE EKCNKRFLVN CHDLTFNILG QIGDNAKGPP TNVEPFFINL
410 420 430 440 450
ALFDVKNNCK ISADFHVDLN PPSVREMLWG SSTQLASDGS PKGSSPESYI
460 470 480 490 500
HGIAESQLRY IQQGIFSVTN PHPEIFLVAR IEKVLQGNIT HCAEPYIKNS
510 520 530 540 550
DPVKTAQKVH RTAKQVCSRL GQYRMPFAWA ARPIFKDTQG SLDLDGRFSP
560 570 580 590 600
LYKQDSSKLS SEDILKLLSE YKKPEKTKLQ IIPGQLNITV ECVPVDLSNC
610 620 630 640 650
ITSSYVPLKP FEKNCQNITV EVEEFVPEMT KYCYPFTIYK NHLYVYPLQL
660 670 680 690 700
KYDSQKTFAK ARNIAVCVEF RDSDESDASA LKCIYGKPAG SVFTTNAYAV
710 720 730 740 750
VSHHNQNPEF YDEIKIELPI HLHQKHHLLF TFYHVSCEIN TKGTTKKQDT
760 770 780 790 800
VETPVGFAWV PLLKDGRIIT FEQQLPVSAN LPPGYLNLND AESRRQCNVD
810 820 830 840 850
IKWVDGAKPL LKIKSHLEST IYTQDLHVHK FFHHCQLIQS GSKEVPGELI
860 870 880 890 900
KYLKCLHAME IQVMIQFLPV ILMQLFRVLT NMTHEDDVPI NCTMVLLHIV
910 920 930 940 950
SKCHEEGLDS YLRSFIKYSF RPEKPSAPQA QLIHETLATT MIAILKQSAD
960 970 980 990 1000
FLSINKLLKY SWFFFEIIAK SMATYLLEEN KIKLPRGQRF PETYHHVLHS
1010 1020 1030 1040 1050
LLLAIIPHVT IRYAEIPDES RNVNYSLASF LKRCLTLMDR GFIFNLINDY
1060 1070 1080 1090 1100
ISGFSPKDPK VLAEYKFEFL QTICNHEHYI PLNLPMAFAK PKLQRVQDSN
1110 1120 1130 1140 1150
LEYSLSDEYC KHHFLVGLLL RETSIALQDN YEIRYTAISV IKNLLIKHAF
1160 1170 1180 1190 1200
DTRYQHKNQQ AKIAQLYLPF VGLLLENIQR LAGRDTLYSC AAMPNSASRD
1210 1220 1230 1240 1250
EFPCGFTSPA NRGSLSTDKD TAYGSFQNGH GIKREDSRGS LIPEGATGFP
1260 1270 1280 1290 1300
DQGNTGENTR QSSTRSSVSQ YNRLDQYEIR SLLMCYLYIV KMISEDTLLT
1310 1320 1330 1340 1350
YWNKVSPQEL INILILLEVC LFHFRYMGKR NIARVHDAWL SKHFGIDRKS
1360 1370 1380 1390 1400
QTMPALRNRS GVMQARLQHL SSLESSFTLN HSSTTTEADI FHQALLEGNT
1410 1420 1430 1440 1450
ATEVSLTVLD TISFFTQCFK TQLLNNDGHN PLMKKVFDIH LAFLKNGQSE
1460 1470 1480 1490 1500
VSLKHVFASL RAFISKFPSA FFKGRVNMCA AFCYEVLKCC TSKISSTRNE
1510 1520 1530 1540 1550
ASALLYLLMR NNFEYTKRKT FLRTHLQIII AVSQLIADVA LSGGSRFQES
1560 1570 1580 1590 1600
LFIINNFANS DRPMKATAFP AEVKDLTKRI RTVLMATAQM KEHEKDPEML
1610 1620 1630 1640 1650
IDLQYSLAKS YASTPELRKT WLDSMAKIHV KNGDFSEAAM CYVHVAALVA
1660 1670 1680 1690 1700
EFLHRKKLFP NGCSAFKKIT PNIDEEGAMK EDAGMMDVHY SEEVLLELLE
1710 1720 1730 1740 1750
QCVDGLWKAE RYEIISEISK LIVPIYEKRR EFEKLTQVYR TLHGAYTKIL
1760 1770 1780 1790 1800
EVMHTKKRLL GTFFRVAFYG QSFFEEEDGK EYIYKEPKLT GLSEISLRLV
1810 1820 1830 1840 1850
KLYGEKFGTE NVKIIQDSDK VNAKELDPKY AHIQVTYVKP YFDDKELTER
1860 1870 1880 1890 1900
KTEFERNHNI SRFVFEAPYT LSGKKQGCIE EQCKRRTILT TSNSFPYVKK
1910 1920 1930 1940 1950
RIPINCEQQI NLKPIDVATD EIKDKTAELQ KLCSSTDVDM IQLQLKLQGC
1960 1970 1980 1990 2000
VSVQVNAGPL AYARAFLNDS QASKYPPKKV SELKDMFRKF IQACSIALEL
2010 2020 2030 2040 2050
NERLIKEDQV EYHEGLKSNF RDMVKELSDI IHEQILQEDT MHSPWMSNTL
2060 2070
HVFCAISGTS SDRGYGSPRY AEV
Length:2,073
Mass (Da):237,671
Last modified:September 11, 2007 - v2
Checksum:i558FC01EE5D23B6E
GO

Sequence cautioni

The sequence BAB71253.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC86230.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI41407.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI41411.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti376 – 3761F → L in AAU04438. (PubMed:16968698)Curated
Sequence conflicti740 – 7401N → K in AAU04438. (PubMed:16968698)Curated
Sequence conflicti1984 – 19841K → E in AAU04438. (PubMed:16968698)Curated
Sequence conflicti1984 – 19841K → E in BAB71253. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti813 – 8131I → F.
Corresponds to variant rs16995229 [ dbSNP | Ensembl ].
VAR_034854

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY692226 mRNA. Translation: AAU04438.1.
AL391237, AC007021, AL391280 Genomic DNA. Translation: CAI41407.1. Sequence problems.
AL391280, AC007021, AL391237 Genomic DNA. Translation: CAI41411.1. Sequence problems.
CH471161 Genomic DNA. Translation: EAW89895.1.
AK056684 mRNA. Translation: BAB71253.1. Different initiation.
AK125641 mRNA. Translation: BAC86230.1. Different initiation.
BC047713 mRNA. Translation: AAH47713.1.
CCDSiCCDS35373.1.
RefSeqiNP_653259.3. NM_144658.3.
UniGeneiHs.368203.

Genome annotation databases

EnsembliENST00000276202; ENSP00000276202; ENSG00000147251.
GeneIDi139818.
KEGGihsa:139818.
UCSCiuc004eqp.2. human.

Polymorphism databases

DMDMi158563857.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY692226 mRNA. Translation: AAU04438.1 .
AL391237 , AC007021 , AL391280 Genomic DNA. Translation: CAI41407.1 . Sequence problems.
AL391280 , AC007021 , AL391237 Genomic DNA. Translation: CAI41411.1 . Sequence problems.
CH471161 Genomic DNA. Translation: EAW89895.1 .
AK056684 mRNA. Translation: BAB71253.1 . Different initiation.
AK125641 mRNA. Translation: BAC86230.1 . Different initiation.
BC047713 mRNA. Translation: AAH47713.1 .
CCDSi CCDS35373.1.
RefSeqi NP_653259.3. NM_144658.3.
UniGenei Hs.368203.

3D structure databases

ProteinModelPortali Q5JSL3.
SMRi Q5JSL3. Positions 162-294, 1613-2035.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126589. 3 interactions.
IntActi Q5JSL3. 4 interactions.
STRINGi 9606.ENSP00000276202.

PTM databases

PhosphoSitei Q5JSL3.

Polymorphism databases

DMDMi 158563857.

Proteomic databases

MaxQBi Q5JSL3.
PaxDbi Q5JSL3.
PRIDEi Q5JSL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276202 ; ENSP00000276202 ; ENSG00000147251 .
GeneIDi 139818.
KEGGi hsa:139818.
UCSCi uc004eqp.2. human.

Organism-specific databases

CTDi 139818.
GeneCardsi GC0XP117629.
H-InvDB HIX0017007.
HGNCi HGNC:23483. DOCK11.
HPAi HPA059695.
MIMi 300681. gene.
neXtProti NX_Q5JSL3.
PharmGKBi PA128394757.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242127.
GeneTreei ENSGT00760000119234.
HOGENOMi HOG000231373.
HOVERGENi HBG107819.
InParanoidi Q5JSL3.
PhylomeDBi Q5JSL3.
TreeFami TF313629.

Enzyme and pathway databases

Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

ChiTaRSi DOCK11. human.
GeneWikii Dock11.
GenomeRNAii 139818.
NextBioi 84048.
PROi Q5JSL3.
SOURCEi Search...

Gene expression databases

Bgeei Q5JSL3.
CleanExi HS_DOCK11.
ExpressionAtlasi Q5JSL3. baseline and differential.
Genevestigatori Q5JSL3.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR021816. DOCK_C/D_N.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR23317. PTHR23317. 1 hit.
Pfami PF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF11878. DUF3398. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
PROSITEi PS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42."
    Lin Q., Yang W., Baird D., Feng Q., Cerione R.A.
    J. Biol. Chem. 281:35253-35262(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 811-2073.
    Tissue: Synovium.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1283-2073.
    Tissue: Testis.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-248; TYR-251; THR-266 AND SER-440, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDOC11_HUMAN
AccessioniPrimary (citable) accession number: Q5JSL3
Secondary accession number(s): A6NMF0
, Q66M66, Q6ZUJ5, Q86VU8, Q96MN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Zizim' means 'spike' in Hebrew.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3