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Protein

Integrator complex subunit 6-like

Gene

INTS6L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 6-like
Alternative name(s):
Protein DDX26B
Gene namesi
Name:INTS6L
Synonyms:DDX26B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:27334. INTS6L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921149.

Polymorphism and mutation databases

BioMutaiDDX26B.
DMDMi74742010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861Integrator complex subunit 6-likePRO_0000076215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei617 – 6171PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5JSJ4.
MaxQBiQ5JSJ4.
PaxDbiQ5JSJ4.
PeptideAtlasiQ5JSJ4.
PRIDEiQ5JSJ4.

PTM databases

iPTMnetiQ5JSJ4.
PhosphoSiteiQ5JSJ4.

Expressioni

Gene expression databases

BgeeiENSG00000165359.
CleanExiHS_DDX26B.
GenevisibleiQ5JSJ4. HS.

Organism-specific databases

HPAiHPA013200.
HPA013335.
HPA030747.

Interactioni

Protein-protein interaction databases

BioGridi128475. 7 interactions.
IntActiQ5JSJ4. 2 interactions.
STRINGi9606.ENSP00000359788.

Structurei

3D structure databases

ProteinModelPortaliQ5JSJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 227225VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 VWFA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3768. Eukaryota.
ENOG410XRER. LUCA.
GeneTreeiENSGT00390000016655.
HOGENOMiHOG000015308.
HOVERGENiHBG081468.
InParanoidiQ5JSJ4.
KOiK13180.
OMAiIGRSYCV.
OrthoDBiEOG091G03YA.
PhylomeDBiQ5JSJ4.
TreeFamiTF323386.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR029307. INT_SG_DDX_CT_C.
IPR002035. VWF_A.
[Graphical view]
PfamiPF15300. INT_SG_DDX_CT_C. 1 hit.
PF13519. VWA_2. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JSJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPILLFLIDT SASMNQRTDL GTSYLDIAKG AVELFLKLRA RDPASRGDRY
60 70 80 90 100
MLVTYDEPPY CIKAGWKENH ATFMSELKNL QASGLTTLGQ ALRSSFDLLN
110 120 130 140 150
LNRLISGIDN YGQGRNPFFL EPSILITITD GNKLTSTAGV QEELHLPLNS
160 170 180 190 200
PLPGSELTKE PFRWDQRLFA LVLRLPGVAS TEPEQLGSVP TDESAITQMC
210 220 230 240 250
EVTGGRSYCV RTQRMLNQCL ESLVQKVQSG VVINFEKTGP DPLPIGEDGL
260 270 280 290 300
MDSSRPSNSF AAQPWHSCHK LIYVRPNSKT GVPVGHWPIP ESFWPDQNLP
310 320 330 340 350
SLPPRTSHPV VRFSCVDCEP MVIDKLPFDK YELEPSPLTQ YILERKSPHT
360 370 380 390 400
CWQVFVTSSG KYNELGYPFG YLKASTTLTC VNLFVMPYNY PVLLPLLDDL
410 420 430 440 450
FKVHKLKPNL KWRQAFDSYL KTLPPYYLLT KLESERILAS VGKKPPQEIG
460 470 480 490 500
IKVKNHSGGG MSLTHNKNFR KLLKEITGET ALRLTELNTK EFAGFQIGLL
510 520 530 540 550
NKDLKPQTYR NAYDIPRRGL LDQLTRMRSN LLKTHKFIVG QDEDSLHSVP
560 570 580 590 600
VAQMGNYQEY LKTLASPLRE IDPDQPKRLH TFGNPFKQDK KGMMIDEADE
610 620 630 640 650
FVAGPQNKVK RPGEPNSPMS SKRRRSMSLL LRKPQTPPTV TNHVGGKGPP
660 670 680 690 700
SASWFPSYPN LIKPTLVHTD ATIIHDGHEE KMENGQITPD GFLSKSAPSE
710 720 730 740 750
LINMTGDLMP PNQVDSLSDD FTSLSKDGLI QKPGSNAFVG GAKNCSLSVD
760 770 780 790 800
DQKDPVASTL GAMPNTLQIT PAMAQGINAD IKHQLMKEVR KFGRKYERIF
810 820 830 840 850
ILLEEVQGPL EMKKQFVEFT IKEAARFKRR VLIQYLEKVL EKINSHHLHN
860
NISHINSRSS C
Length:861
Mass (Da):96,673
Last modified:February 15, 2005 - v1
Checksum:i46CE8A7FB8A377C5
GO
Isoform 3 (identifier: Q5JSJ4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-553: Missing.

Note: No experimental confirmation available.
Show »
Length:308
Mass (Da):34,423
Checksum:i9C8EDD0393821E4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521L → P in CAI56763 (PubMed:17974005).Curated
Sequence conflicti428 – 4281Missing in CAI56763 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti769 – 7691I → V.1 Publication
VAR_069425

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 553553Missing in isoform 3. 1 PublicationVSP_016867Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123209 mRNA. Translation: BAC85559.1.
CR936620 Transcribed RNA. Translation: CAI56763.1.
AL391380, AL357834 Genomic DNA. Translation: CAI40723.1.
AL357834, AL391380 Genomic DNA. Translation: CAI40867.1.
CCDSiCCDS35401.1. [Q5JSJ4-1]
RefSeqiNP_872346.3. NM_182540.4. [Q5JSJ4-1]
UniGeneiHs.496829.

Genome annotation databases

EnsembliENST00000370752; ENSP00000359788; ENSG00000165359. [Q5JSJ4-1]
GeneIDi203522.
KEGGihsa:203522.
UCSCiuc004eyw.5. human. [Q5JSJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123209 mRNA. Translation: BAC85559.1.
CR936620 Transcribed RNA. Translation: CAI56763.1.
AL391380, AL357834 Genomic DNA. Translation: CAI40723.1.
AL357834, AL391380 Genomic DNA. Translation: CAI40867.1.
CCDSiCCDS35401.1. [Q5JSJ4-1]
RefSeqiNP_872346.3. NM_182540.4. [Q5JSJ4-1]
UniGeneiHs.496829.

3D structure databases

ProteinModelPortaliQ5JSJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128475. 7 interactions.
IntActiQ5JSJ4. 2 interactions.
STRINGi9606.ENSP00000359788.

PTM databases

iPTMnetiQ5JSJ4.
PhosphoSiteiQ5JSJ4.

Polymorphism and mutation databases

BioMutaiDDX26B.
DMDMi74742010.

Proteomic databases

EPDiQ5JSJ4.
MaxQBiQ5JSJ4.
PaxDbiQ5JSJ4.
PeptideAtlasiQ5JSJ4.
PRIDEiQ5JSJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370752; ENSP00000359788; ENSG00000165359. [Q5JSJ4-1]
GeneIDi203522.
KEGGihsa:203522.
UCSCiuc004eyw.5. human. [Q5JSJ4-1]

Organism-specific databases

CTDi203522.
GeneCardsiDDX26B.
H-InvDBHIX0017075.
HGNCiHGNC:27334. INTS6L.
HPAiHPA013200.
HPA013335.
HPA030747.
neXtProtiNX_Q5JSJ4.
PharmGKBiPA134921149.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3768. Eukaryota.
ENOG410XRER. LUCA.
GeneTreeiENSGT00390000016655.
HOGENOMiHOG000015308.
HOVERGENiHBG081468.
InParanoidiQ5JSJ4.
KOiK13180.
OMAiIGRSYCV.
OrthoDBiEOG091G03YA.
PhylomeDBiQ5JSJ4.
TreeFamiTF323386.

Miscellaneous databases

ChiTaRSiDDX26B. human.
GenomeRNAii203522.
PROiQ5JSJ4.

Gene expression databases

BgeeiENSG00000165359.
CleanExiHS_DDX26B.
GenevisibleiQ5JSJ4. HS.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR029307. INT_SG_DDX_CT_C.
IPR002035. VWF_A.
[Graphical view]
PfamiPF15300. INT_SG_DDX_CT_C. 1 hit.
PF13519. VWA_2. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINT6L_HUMAN
AccessioniPrimary (citable) accession number: Q5JSJ4
Secondary accession number(s): Q5CZA2
, Q6IPS3, Q6ZTU5, Q6ZWE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.