Q5JSH3 (WDR44_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 44

Alternative name(s):
Rabphilin-11

Gene names

Name:

WDR44

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	913 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Downstream effector for RAB11. May be involved in vesicle recycling By similarity.
Subunit structure	Interacts with the GTP-bound form of RAB11 when membrane-associated. Does not bind to other Rab and Rho small G proteins By similarity.
Subcellular location	Cytoplasm › cytosol. Cytoplasm › perinuclear region. Endosome membrane. Golgi apparatus › trans-Golgi network. Note: Colocalized with RAB11 along microtubules oriented toward lamellipodia By similarity.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13
Sequence similarities	Contains 7 WD repeats.
Sequence caution	The sequence BAA92015.1 differs from that shown. Reason: Frameshift at position 792. The sequence BAC03799.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Endosome Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat WD repeat
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5JSH3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5JSH3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     796-803: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5JSH3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-473: Missing.
     474-477: DEGM → MVNV
     884-913: IMKTDNTEVLLSADFTGAIKVFVNKRKNVS → AVAHACNPSTLGGRGRRIT

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 913	912	WD repeat-containing protein 44		PRO_0000262769
Regions
	Repeat	509 – 548	40	WD 1
	Repeat	605 – 643	39	WD 2
	Repeat	645 – 685	41	WD 3
	Repeat	690 – 729	40	WD 4
	Repeat	740 – 779	40	WD 5
	Repeat	784 – 823	40	WD 6
	Repeat	876 – 913	38	WD 7
	Region	2 – 170	169	Binding activity
	Coiled coil	119 – 184	66	Potential
	Compositional bias	211 – 257	47	Pro-rich
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.12
	Modified residue	5	1	Phosphoserine Ref.5 Ref.12
	Modified residue	27	1	Phosphoserine Ref.5
	Modified residue	50	1	Phosphoserine Ref.6 Ref.7 Ref.11 Ref.12 Ref.13
	Modified residue	90	1	Phosphoserine Ref.12
	Modified residue	96	1	Phosphoserine Ref.6 Ref.9 Ref.11 Ref.12 Ref.13
	Modified residue	158	1	Phosphothreonine Ref.12
	Modified residue	161	1	Phosphoserine Ref.12
	Modified residue	162	1	Phosphoserine Ref.12
	Modified residue	163	1	Phosphothreonine Ref.12
	Modified residue	219	1	Phosphothreonine Ref.11
	Modified residue	262	1	Phosphoserine Ref.5 Ref.7 Ref.11
	Modified residue	271	1	Phosphothreonine Ref.7
	Modified residue	344	1	Phosphoserine By similarity
	Modified residue	349	1	Phosphothreonine By similarity
	Modified residue	403	1	Phosphoserine Ref.5 Ref.11 Ref.12 Ref.13
	Modified residue	470	1	Phosphoserine Ref.10 Ref.11
	Modified residue	471	1	Phosphoserine Ref.10 Ref.11
	Modified residue	472	1	Phosphoserine Ref.10 Ref.11
	Modified residue	561	1	Phosphoserine Ref.8 Ref.10 Ref.12
	Modified residue	563	1	Phosphoserine Ref.12
	Modified residue	565	1	Phosphoserine Ref.8 Ref.12
	Modified residue	568	1	Phosphoserine Ref.8
	Modified residue	783	1	Phosphotyrosine Ref.7
	Modified residue	799	1	Phosphothreonine Ref.7
	Modified residue	800	1	Phosphotyrosine Ref.7
Natural variations
	Alternative sequence	1 – 473	473	Missing in isoform 3.		VSP_021807
	Alternative sequence	474 – 477	4	DEGM → MVNV in isoform 3.		VSP_021808
	Alternative sequence	796 – 803	8	Missing in isoform 2.		VSP_021809
	Alternative sequence	884 – 913	30	IMKTD…RKNVS → AVAHACNPSTLGGRGRRIT in isoform 3.		VSP_021810
	Natural variant	289	1	A → T. Ref.2 Corresponds to variant rs17271416 [ dbSNP | Ensembl ].		VAR_029538
	Natural variant	296	1	T → A. Ref.4 Corresponds to variant rs17855531 [ dbSNP | Ensembl ].		VAR_029539
Experimental info
	Sequence conflict	89	1	L → P in CAD97788. Ref.2
	Sequence conflict	96	1	S → G in CAL38210. Ref.2
	Sequence conflict	194	1	S → P in AAH28697. Ref.4
	Sequence conflict	206	1	V → A in CAL38662. Ref.2
	Sequence conflict	250	1	P → L in CAL38662. Ref.2
	Sequence conflict	331	1	A → P in CAD98010. Ref.2
	Sequence conflict	380	1	G → D in CAL38210. Ref.2
	Sequence conflict	473	1	D → N in CAL38662. Ref.2
	Sequence conflict	534	1	V → A in CAD97788. Ref.2
	Sequence conflict	539	1	A → L in CAD97788. Ref.2
	Sequence conflict	586	1	E → G in CAD97788. Ref.2
	Sequence conflict	613	1	L → P in CAL38662. Ref.2
	Sequence conflict	649 – 650	2	Missing in BAA92015. Ref.1
	Sequence conflict	740	1	K → R in CAL38210. Ref.2
	Sequence conflict	740	1	K → R in CAL38662. Ref.2
	Sequence conflict	858	1	L → S in CAL38662. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 8E43761C542DD6B9	FASTA	913	101,366
	10 20 30 40 50 60 MASESDTEEF YDAPEDVHLG GGYPVGSPGK VGLSTFKETE NTAYKVGNES PVQELKQDVS 70 80 90 100 110 120 KKIIESIIEE SQKVLQLEDD SLDSKGKELS DQATASPIVA RTDLSNIPGL LAIDQVLPEE 130 140 150 160 170 180 SQKAESQNTF EETELELKKC FPSDETCEKP VDETTKLTQT SSTEQLNVLE TETEVLNKEA 190 200 210 220 230 240 VEVKGGGDVL EPVSSDSLST KDFAAVEEVA PAKPPRHLTP EPDIVASTKK PVPARPPPPT 250 260 270 280 290 300 NFPPPRPPPP SRPAPPPRKR KSELEFETLK TPDIDVPKEN ITSDSLLTAS MASESTVKDS 310 320 330 340 350 360 QPSLDLASAT SGDKIVTAQE NGKAPDGQTV AGEVMGPQRP RSNSGRELTD EEILASVMIK 370 380 390 400 410 420 NLDTGEEIPL SLAEEKLPTG INPLTLHIMR RTKEYVSNDA AQSDDEEKLQ SQPTDTDGGR 430 440 450 460 470 480 LKQKTTQLKK FLGKSVKRAK HLAEEYGERA INKVKSVRDE VFHTDQDDPS SSDDEGMPYT 490 500 510 520 530 540 RPVKFKAAHG FKGPYDFDQI KVVQDLSGEH MGAVWTMKFS HCGRLLASAG QDNVVRIWAL 550 560 570 580 590 600 KNAFDYFNNM RMKYNTEGRV SPSPSQESLS SSKSDTDTGV CSGTDEDPDD KNAPFRQRPF 610 620 630 640 650 660 CKYKGHTADL LDLSWSKNYF LLSSSMDKTV RLWHISRREC LCCFQHIDFV TAIAFHPRDD 670 680 690 700 710 720 RYFLSGSLDG KLRLWNIPDK KVALWNEVDG QTKLITAANF CQNGKYAVIG TYDGRCIFYD 730 740 750 760 770 780 TEHLKYHTQI HVRSTRGRNK VGRKITGIEP LPGENKILVT SNDSRIRLYD LRDLSLSMKY 790 800 810 820 830 840 KGYVNSSSQI KASFSHDFTY LVSGSEDKYV YIWSTYHDLS KFTSVRRDRN DFWEGIKAHN 850 860 870 880 890 900 AVVTSAIFAP NPSLMLSLDV QSEKSEGNEK SEDAEVLDAT PSGIMKTDNT EVLLSADFTG 910 AIKVFVNKRK NVS
	Isoform 2 [UniParc]. Checksum: 81A8AAA300D4FE9F	FASTA	905	100,403
	10 20 30 40 50 60 MASESDTEEF YDAPEDVHLG GGYPVGSPGK VGLSTFKETE NTAYKVGNES PVQELKQDVS 70 80 90 100 110 120 KKIIESIIEE SQKVLQLEDD SLDSKGKELS DQATASPIVA RTDLSNIPGL LAIDQVLPEE 130 140 150 160 170 180 SQKAESQNTF EETELELKKC FPSDETCEKP VDETTKLTQT SSTEQLNVLE TETEVLNKEA 190 200 210 220 230 240 VEVKGGGDVL EPVSSDSLST KDFAAVEEVA PAKPPRHLTP EPDIVASTKK PVPARPPPPT 250 260 270 280 290 300 NFPPPRPPPP SRPAPPPRKR KSELEFETLK TPDIDVPKEN ITSDSLLTAS MASESTVKDS 310 320 330 340 350 360 QPSLDLASAT SGDKIVTAQE NGKAPDGQTV AGEVMGPQRP RSNSGRELTD EEILASVMIK 370 380 390 400 410 420 NLDTGEEIPL SLAEEKLPTG INPLTLHIMR RTKEYVSNDA AQSDDEEKLQ SQPTDTDGGR 430 440 450 460 470 480 LKQKTTQLKK FLGKSVKRAK HLAEEYGERA INKVKSVRDE VFHTDQDDPS SSDDEGMPYT 490 500 510 520 530 540 RPVKFKAAHG FKGPYDFDQI KVVQDLSGEH MGAVWTMKFS HCGRLLASAG QDNVVRIWAL 550 560 570 580 590 600 KNAFDYFNNM RMKYNTEGRV SPSPSQESLS SSKSDTDTGV CSGTDEDPDD KNAPFRQRPF 610 620 630 640 650 660 CKYKGHTADL LDLSWSKNYF LLSSSMDKTV RLWHISRREC LCCFQHIDFV TAIAFHPRDD 670 680 690 700 710 720 RYFLSGSLDG KLRLWNIPDK KVALWNEVDG QTKLITAANF CQNGKYAVIG TYDGRCIFYD 730 740 750 760 770 780 TEHLKYHTQI HVRSTRGRNK VGRKITGIEP LPGENKILVT SNDSRIRLYD LRDLSLSMKY 790 800 810 820 830 840 KGYVNSSSQI KASFSGSEDK YVYIWSTYHD LSKFTSVRRD RNDFWEGIKA HNAVVTSAIF 850 860 870 880 890 900 APNPSLMLSL DVQSEKSEGN EKSEDAEVLD ATPSGIMKTD NTEVLLSADF TGAIKVFVNK RKNVS
	Isoform 3 [UniParc]. Checksum: B6AA91342F478464	FASTA	429	48,565
	10 20 30 40 50 60 MVNVPYTRPV KFKAAHGFKG PYDFDQIKVV QDLSGEHMGA VWTMKFSHCG RLLASAGQDN 70 80 90 100 110 120 VVRIWALKNA FDYFNNMRMK YNTEGRVSPS PSQESLSSSK SDTDTGVCSG TDEDPDDKNA 130 140 150 160 170 180 PFRQRPFCKY KGHTADLLDL SWSKNYFLLS SSMDKTVRLW HISRRECLCC FQHIDFVTAI 190 200 210 220 230 240 AFHPRDDRYF LSGSLDGKLR LWNIPDKKVA LWNEVDGQTK LITAANFCQN GKYAVIGTYD 250 260 270 280 290 300 GRCIFYDTEH LKYHTQIHVR STRGRNKVGR KITGIEPLPG ENKILVTSND SRIRLYDLRD 310 320 330 340 350 360 LSLSMKYKGY VNSSSQIKAS FSHDFTYLVS GSEDKYVYIW STYHDLSKFT SVRRDRNDFW 370 380 390 400 410 420 EGIKAHNAVV TSAIFAPNPS LMLSLDVQSE KSEGNEKSED AEVLDATPSG AVAHACNPST LGGRGRRIT

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 190-913 (ISOFORM 1). Tissue: Teratocarcinoma and Tongue.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-289. Tissue: Colon endothelium and Endometrial tumor.
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-296. Tissue: Testis.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-27; SER-262 AND SER-403, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50 AND SER-96, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-262; THR-271; TYR-783; THR-799 AND TYR-800, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561; SER-565 AND SER-568, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[9]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-470; SER-471; SER-472 AND SER-561, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-96; THR-219; SER-262; SER-403; SER-470; SER-471 AND SER-472, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-50; SER-90; SER-96; THR-158; SER-161; SER-162; THR-163; SER-403; SER-561; SER-563 AND SER-565, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-96 AND SER-403, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001978 mRNA. Translation: BAA92015.1. Sequence problems. AK092077 mRNA. Translation: BAC03799.1. Different initiation. AK127556 mRNA. Translation: BAC87033.1. AM393332 mRNA. Translation: CAL38210.1. AM393787 mRNA. Translation: CAL38662.1. BX537578 mRNA. Translation: CAD97788.1. BX538087 mRNA. Translation: CAD98010.1. AL391474, AL391803, AL391830 Genomic DNA. Translation: CAI41402.1. AL391474, AL391803, AL391830 Genomic DNA. Translation: CAI41403.1. AL391803, AL391474, AL391830 Genomic DNA. Translation: CAI41482.1. AL391803, AL391474, AL391830 Genomic DNA. Translation: CAI41483.1. AL391830, AL391474, AL391803 Genomic DNA. Translation: CAI41512.1. AL391830, AL391474, AL391803 Genomic DNA. Translation: CAI41513.1. BC028697 mRNA. Translation: AAH28697.3.
IPI	IPI00444371. IPI00807730. IPI00872729.
RefSeq	NP_001171894.1. NM_001184965.1. NP_001171895.1. NM_001184966.1. NP_061918.3. NM_019045.4.
UniGene	Hs.98510.
3D structure databases
HSSP	HSSP built from PDB template 1R5M based on UniProtKB P38262.
ProteinModelPortal	Q5JSH3.
SMR	Q5JSH3. Positions 494-814.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5JSH3. 1 interaction.
STRING	Q5JSH3.
PTM databases
PhosphoSite	Q5JSH3.
Polymorphism databases
DMDM	74762196.
Proteomic databases
PRIDE	Q5JSH3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254029; ENSP00000254029; ENSG00000131725.
GeneID	54521.
KEGG	hsa:54521.
NMPDR	fig|9606.3.peg.33281.
UCSC	uc004eqn.1. human. uc004eqo.1. human.
Organism-specific databases
CTD	54521.
GeneCards	GC0XP117480.
H-InvDB	HIX0017006.
HGNC	HGNC:30512. WDR44.
HPA	HPA038084.
neXtProt	NX_Q5JSH3.
PharmGKB	PA128394668.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17842.
GeneTree	ENSGT00530000063479.
HOVERGEN	HBG080376.
InParanoid	Q5JSH3.
OMA	DHTEVLL.
OrthoDB	EOG4K6G3H.
PhylomeDB	Q5JSH3.
Gene expression databases
ArrayExpress	Q5JSH3.
Bgee	Q5JSH3.
CleanEx	HS_WDR44.
Genevestigator	Q5JSH3.
GermOnline	ENSG00000131725. Homo sapiens.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 3 hits.
Pfam	PF00400. WD40. 4 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	56920.

Entry information

Entry name

WDR44_HUMAN

Accession

Primary (citable) accession number: Q5JSH3
Secondary accession number(s): Q0JS52 , Q0JTF3, Q5JSH2, Q6ZSC1, Q7Z365, Q7Z3P6, Q8NAU8, Q8NHU5, Q9NUV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.