TFDP1

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
transcription coactivator activity Source: InterPro
transcription factor activity, sequence-specific DNA binding Source: InterPro
transcription factor binding Source: InterPro

GO - Biological processⁱ

mitotic cell cycle Source: InterPro
transcription, DNA-templated Source: UniProtKB-KW

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotation
Biological process	Transcription, Transcription regulationUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Transcription factor Dp-1Imported
Gene namesⁱ	Name:TFDP1Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

HGNCⁱ

HGNC:11749. TFDP1.

Subcellular locationⁱ

Nucleus
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU003796

GO - Cellular componentⁱ

nucleoplasm Source: HPA
transcription factor complex Source: InterPro

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusUniRule annotation

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000198176.

OpenTargetsⁱ

ENSG00000198176.

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q5JSB5.
PeptideAtlas More...PeptideAtlasⁱ	Q5JSB5.
PRIDEⁱ	Q5JSB5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198176.
ExpressionAtlasⁱ	Q5JSB5. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

transcription factor binding Source: InterPro

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000364519.

STRINGⁱ

9606.ENSP00000364519.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	111 – 193	E2F_TDPInterPro annotationAdd BLAST		83

Sequence similaritiesⁱ

Belongs to the E2F/DP family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG2829. Eukaryota. ENOG410Y9QP. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018222.
HOGENOMⁱ	HOG000030696.
HOVERGENⁱ	HBG009894.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR028313. DP-1. IPR003316. E2F_WHTH_DNA-bd_dom. IPR014889. Transc_factor_DP_C. IPR015648. Transcrpt_fac_DP. IPR011991. WHTH_DNA-bd_dom.
PANTHERⁱ	PTHR12548. PTHR12548. 1 hit. PTHR12548:SF19. PTHR12548:SF19. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08781. DP. 1 hit. PF02319. E2F_TDP. 1 hit.
PIRSFⁱ	PIRSF009404. Transcription_factor_DP. 1 hit.
SMARTⁱ	View protein in SMART SM01372. E2F_TDP. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q5JSB5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAKDAGLIEA NGELKVFIDQ NLSPGKGVVS LVAVHPSTVN PLGKQLLPKT 
        60         70         80         90        100
FGQSNVNIAQ QVVIGTPQRP AASNTLVVGS PHTPSTHFAS QNQPSDSSPW 
       110        120        130        140        150
SAGKRNRKGE KNGKGLRHFS MKVCEKVQRK GTTSYNEVAD ELVAEFSAAD 
       160        170        180        190        200
NHILPNESAY DQKNIRRRVY DALNVLMAMN IISKEKKEIK WIGLPTNSAQ 
       210        220        230 
ECQNLEVERQ RRLERIKQKQ SQLQELILQQ IAFKN

Length:235

Mass (Da):26,062

Last modified:October 5, 2016 - v8

Checksum:ⁱ738BAD9D389A9881

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	235	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL442125 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL442125 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000408980; ENSP00000386145; ENSG00000198176.
UCSC genome browser More...UCSCⁱ	uc058yob.1. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL442125 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL442125 Genomic DNA. No translation available.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000364519.

STRINGⁱ

9606.ENSP00000364519.

Proteomic databases

PaxDbⁱ	Q5JSB5.
PeptideAtlas More...PeptideAtlasⁱ	Q5JSB5.
PRIDEⁱ	Q5JSB5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000408980; ENSP00000386145; ENSG00000198176.
UCSC genome browser More...UCSCⁱ	uc058yob.1. human.

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11749. TFDP1.
Open Targets More...OpenTargetsⁱ	ENSG00000198176.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2829. Eukaryota. ENOG410Y9QP. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018222.
HOGENOMⁱ	HOG000030696.
HOVERGENⁱ	HBG009894.

Miscellaneous databases

ChiTaRSⁱ	TFDP1. human.

ChiTaRSⁱ

TFDP1. human.

Gene expression databases

Bgeeⁱ	ENSG00000198176.
ExpressionAtlasⁱ	Q5JSB5. baseline and differential.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR028313. DP-1. IPR003316. E2F_WHTH_DNA-bd_dom. IPR014889. Transc_factor_DP_C. IPR015648. Transcrpt_fac_DP. IPR011991. WHTH_DNA-bd_dom.
PANTHERⁱ	PTHR12548. PTHR12548. 1 hit. PTHR12548:SF19. PTHR12548:SF19. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08781. DP. 1 hit. PF02319. E2F_TDP. 1 hit.
PIRSFⁱ	PIRSF009404. Transcription_factor_DP. 1 hit.
SMARTⁱ	View protein in SMART SM01372. E2F_TDP. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5JSB5_HUMAN
Accessionⁱ	Q5JSB5Primary (citable) accession number: Q5JSB5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 15, 2005
	Last sequence update:	October 5, 2016
	Last modified:	June 7, 2017
	This is version 107 of the entry and version 8 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5JSB5 (Q5JSB5_HUMAN)

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Transcription factor Dp-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ