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Protein
Submitted name:

Peripheral plasma membrane protein CASK

Gene

CASK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Peripheral plasma membrane protein CASKImported
Gene namesi
Name:CASKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:1497. CASK.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ5JS72.
PRIDEiQ5JS72.

Expressioni

Gene expression databases

BgeeiENSG00000147044.
ExpressionAtlasiQ5JS72. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5JS72.
SMRiQ5JS72. Positions 18-71, 102-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 1313L27InterPro annotationAdd
BLAST
Domaini17 – 7054L27InterPro annotationAdd
BLAST
Domaini105 – 18682PDZ (DHR)InterPro annotationAdd
BLAST
Domaini204 – 27471SH3InterPro annotationAdd
BLAST
Domaini331 – 503173Guanylate kinase-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation
Contains SH3 domain.SAAS annotation

Keywords - Domaini

SH3 domainSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 1 hit.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 1 hit.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JS72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LYDKINTKSS PQIRNPPSDA VQRAKEVLEE ISCYPENNDA KELKRILTQP
60 70 80 90 100
HFMALLQTHD VVAHEVYSDE ALRVTPPPTS PYLNGDSPES ANGDMDMENV
110 120 130 140 150
TRVRLVQFQK NTDEPMGITL KMNELNHCIV ARIMHGGMIH RQGTLHVGDE
160 170 180 190 200
IREINGISVA NQTVEQLQKM LREMRGSITF KIVPSYRTQS SSCEDLPSTT
210 220 230 240 250
QPKGRQIYVR AQFEYDPAKD DLIPCKEAGI RFRVGDIIQI ISKDDHNWWQ
260 270 280 290 300
GKLENSKNGT AGLIPSPELQ EWRVACIAME KTKQEQQASC TWFGKKKKQY
310 320 330 340 350
KDKYLAKHNA VFDQLDLVTY EEVVKLPAFK RKTLVLLGAH GVGRRHIKNT
360 370 380 390 400
LITKHPDRFA YPIPHTTRPP KKDEENGKNY YFVSHDQMMQ DISNNEYLEY
410 420 430 440 450
GSHEDAMYGT KLETIRKIHE QGLIAILDVE PQALKVLRTA EFAPFVVFIA
460 470 480 490 500
APTITPGLNE DESLQRLQKE SDILQRTYAH YFDLTIINNE IDETIRHLEE
510
AVELVCTAPQ WVPVSWVY
Length:518
Mass (Da):59,365
Last modified:February 5, 2008 - v1
Checksum:i705EE0A1FC929BBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158144 Genomic DNA. No translation available.
AL353691 Genomic DNA. No translation available.
AL445239 Genomic DNA. No translation available.
AL603754 Genomic DNA. No translation available.
AL627402 Genomic DNA. No translation available.
KF459071 Genomic DNA. No translation available.
KF459072 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000378179; ENSP00000367421; ENSG00000147044.
UCSCiuc064yqq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158144 Genomic DNA. No translation available.
AL353691 Genomic DNA. No translation available.
AL445239 Genomic DNA. No translation available.
AL603754 Genomic DNA. No translation available.
AL627402 Genomic DNA. No translation available.
KF459071 Genomic DNA. No translation available.
KF459072 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5JS72.
SMRiQ5JS72. Positions 18-71, 102-517.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ5JS72.
PRIDEiQ5JS72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378179; ENSP00000367421; ENSG00000147044.
UCSCiuc064yqq.1. human.

Organism-specific databases

HGNCiHGNC:1497. CASK.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.

Miscellaneous databases

ChiTaRSiCASK. human.

Gene expression databases

BgeeiENSG00000147044.
ExpressionAtlasiQ5JS72. baseline and differential.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 1 hit.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 1 hit.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5JS72_HUMAN
AccessioniPrimary (citable) accession number: Q5JS72
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.