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Protein

NHL repeat-containing protein 3

Gene

NHLRC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
NHL repeat-containing protein 3
Gene namesi
Name:NHLRC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000188811.12
HGNCiHGNC:33751 NHLRC3
neXtProtiNX_Q5JS37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188811
PharmGKBiPA162397544

Polymorphism and mutation databases

DMDMi74741946

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000031719426 – 347NHL repeat-containing protein 3Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ5JS37
MaxQBiQ5JS37
PaxDbiQ5JS37
PeptideAtlasiQ5JS37
PRIDEiQ5JS37

PTM databases

iPTMnetiQ5JS37
PhosphoSitePlusiQ5JS37

Expressioni

Gene expression databases

BgeeiENSG00000188811
CleanExiHS_NHLRC3
ExpressionAtlasiQ5JS37 baseline and differential
GenevisibleiQ5JS37 HS

Organism-specific databases

HPAiHPA013738

Interactioni

Protein-protein interaction databases

BioGridi132506, 34 interactors
STRINGi9606.ENSP00000368920

Structurei

3D structure databases

ProteinModelPortaliQ5JS37
SMRiQ5JS37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 93NHL 1Add BLAST47
Repeati150 – 196NHL 2Add BLAST47
Repeati200 – 243NHL 3Add BLAST44
Repeati294 – 338NHL 4Add BLAST45

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410ITFF Eukaryota
ENOG410ZCFR LUCA
GeneTreeiENSGT00390000008657
HOGENOMiHOG000070097
HOVERGENiHBG104921
InParanoidiQ5JS37
OMAiYFTGATF
OrthoDBiEOG091G099V
PhylomeDBiQ5JS37
TreeFamiTF331018

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
PfamiView protein in Pfam
PF01436 NHL, 1 hit
PROSITEiView protein in PROSITE
PS51125 NHL, 4 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JS37-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARFWVCVAG AGFFLAFLVL HSRFCGSPVL RNFTFAVSWR TEKILYRLDV
60 70 80 90 100
GWPKHPEYFT GTTFCVAVDS LNGLVYIGQR GDNIPKILVF TEDGYFLRAW
110 120 130 140 150
NYTVDTPHGI FAASTLYEQS VWITDVGSGF FGHTVKKYSS FGDLVQVLGT
160 170 180 190 200
PGKKGTSLNP LQFDNPAELY VEDTGDIYIV DGDGGLNNRL IKLSQDFMIL
210 220 230 240 250
WLHGENGTGP AKFNIPHSVT LDSAGRVWVA DRGNKRIQVF DKDTGEWLGA
260 270 280 290 300
WNNCFTEEGP SSVRFTPDGK YLIVAQLNLS RLSVVAAPPV GSIGECSVIS
310 320 330 340
TIQLADQVLP HLLEVDRKTG AVYVAEIGAK QVQKYVPLNS YVPSFGS
Length:347
Mass (Da):38,283
Last modified:February 15, 2005 - v1
Checksum:i7CF110AF0FC10489
GO
Isoform 2 (identifier: Q5JS37-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-195: Missing.

Note: No experimental confirmation available.
Show »
Length:280
Mass (Da):31,054
Checksum:i199284AA4110371C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051233221L → R. Corresponds to variant dbSNP:rs9603498Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042858129 – 195Missing in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300260 mRNA Translation: BAG62022.1
AL445590 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08613.1
CH471075 Genomic DNA Translation: EAX08615.1
BC140877 mRNA Translation: AAI40878.1
BC140878 mRNA Translation: AAI40879.1
AL833329 mRNA Translation: CAH10395.1
CCDSiCCDS31961.1 [Q5JS37-1]
CCDS31962.1 [Q5JS37-2]
RefSeqiNP_001012772.1, NM_001012754.3 [Q5JS37-1]
NP_001017370.1, NM_001017370.2 [Q5JS37-2]
UniGeneiHs.507783

Genome annotation databases

EnsembliENST00000379599; ENSP00000368919; ENSG00000188811 [Q5JS37-2]
ENST00000379600; ENSP00000368920; ENSG00000188811 [Q5JS37-1]
GeneIDi387921
KEGGihsa:387921
UCSCiuc001uxc.5 human [Q5JS37-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNHLC3_HUMAN
AccessioniPrimary (citable) accession number: Q5JS37
Secondary accession number(s): B2RTZ2, B4DTL0, Q69YI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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