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Protein

NHL repeat-containing protein 3

Gene

NHLRC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NHL repeat-containing protein 3
Gene namesi
Name:NHLRC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:33751. NHLRC3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162397544.

Polymorphism and mutation databases

DMDMi74741946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 347322NHL repeat-containing protein 3PRO_0000317194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ5JS37.
MaxQBiQ5JS37.
PaxDbiQ5JS37.
PRIDEiQ5JS37.

PTM databases

iPTMnetiQ5JS37.
PhosphoSiteiQ5JS37.

Expressioni

Gene expression databases

BgeeiQ5JS37.
CleanExiHS_NHLRC3.
ExpressionAtlasiQ5JS37. baseline and differential.
GenevisibleiQ5JS37. HS.

Organism-specific databases

HPAiHPA013738.

Interactioni

Protein-protein interaction databases

BioGridi132506. 11 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5JS37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati47 – 9347NHL 1Add
BLAST
Repeati150 – 19647NHL 2Add
BLAST
Repeati200 – 24344NHL 3Add
BLAST
Repeati294 – 33845NHL 4Add
BLAST

Sequence similaritiesi

Contains 4 NHL repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410ITFF. Eukaryota.
ENOG410ZCFR. LUCA.
GeneTreeiENSGT00390000008657.
HOGENOMiHOG000070097.
HOVERGENiHBG104921.
InParanoidiQ5JS37.
OMAiGYFLRSW.
PhylomeDBiQ5JS37.
TreeFamiTF331018.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR001258. NHL_repeat.
IPR013017. NHL_repeat_subgr.
[Graphical view]
PfamiPF01436. NHL. 1 hit.
[Graphical view]
PROSITEiPS51125. NHL. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JS37-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARFWVCVAG AGFFLAFLVL HSRFCGSPVL RNFTFAVSWR TEKILYRLDV
60 70 80 90 100
GWPKHPEYFT GTTFCVAVDS LNGLVYIGQR GDNIPKILVF TEDGYFLRAW
110 120 130 140 150
NYTVDTPHGI FAASTLYEQS VWITDVGSGF FGHTVKKYSS FGDLVQVLGT
160 170 180 190 200
PGKKGTSLNP LQFDNPAELY VEDTGDIYIV DGDGGLNNRL IKLSQDFMIL
210 220 230 240 250
WLHGENGTGP AKFNIPHSVT LDSAGRVWVA DRGNKRIQVF DKDTGEWLGA
260 270 280 290 300
WNNCFTEEGP SSVRFTPDGK YLIVAQLNLS RLSVVAAPPV GSIGECSVIS
310 320 330 340
TIQLADQVLP HLLEVDRKTG AVYVAEIGAK QVQKYVPLNS YVPSFGS
Length:347
Mass (Da):38,283
Last modified:February 15, 2005 - v1
Checksum:i7CF110AF0FC10489
GO
Isoform 2 (identifier: Q5JS37-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-195: Missing.

Note: No experimental confirmation available.
Show »
Length:280
Mass (Da):31,054
Checksum:i199284AA4110371C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti221 – 2211L → R.
Corresponds to variant rs9603498 [ dbSNP | Ensembl ].
VAR_051233

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei129 – 19567Missing in isoform 2. 1 PublicationVSP_042858Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300260 mRNA. Translation: BAG62022.1.
AL445590 Genomic DNA. Translation: CAI40978.1.
CH471075 Genomic DNA. Translation: EAX08613.1.
CH471075 Genomic DNA. Translation: EAX08615.1.
BC140877 mRNA. Translation: AAI40878.1.
BC140878 mRNA. Translation: AAI40879.1.
AL833329 mRNA. Translation: CAH10395.1.
CCDSiCCDS31961.1. [Q5JS37-1]
CCDS31962.1. [Q5JS37-2]
RefSeqiNP_001012772.1. NM_001012754.3. [Q5JS37-1]
NP_001017370.1. NM_001017370.2. [Q5JS37-2]
UniGeneiHs.507783.

Genome annotation databases

EnsembliENST00000379599; ENSP00000368919; ENSG00000188811. [Q5JS37-2]
ENST00000379600; ENSP00000368920; ENSG00000188811. [Q5JS37-1]
GeneIDi387921.
KEGGihsa:387921.
UCSCiuc001uxc.5. human. [Q5JS37-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300260 mRNA. Translation: BAG62022.1.
AL445590 Genomic DNA. Translation: CAI40978.1.
CH471075 Genomic DNA. Translation: EAX08613.1.
CH471075 Genomic DNA. Translation: EAX08615.1.
BC140877 mRNA. Translation: AAI40878.1.
BC140878 mRNA. Translation: AAI40879.1.
AL833329 mRNA. Translation: CAH10395.1.
CCDSiCCDS31961.1. [Q5JS37-1]
CCDS31962.1. [Q5JS37-2]
RefSeqiNP_001012772.1. NM_001012754.3. [Q5JS37-1]
NP_001017370.1. NM_001017370.2. [Q5JS37-2]
UniGeneiHs.507783.

3D structure databases

ProteinModelPortaliQ5JS37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132506. 11 interactions.

PTM databases

iPTMnetiQ5JS37.
PhosphoSiteiQ5JS37.

Polymorphism and mutation databases

DMDMi74741946.

Proteomic databases

EPDiQ5JS37.
MaxQBiQ5JS37.
PaxDbiQ5JS37.
PRIDEiQ5JS37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379599; ENSP00000368919; ENSG00000188811. [Q5JS37-2]
ENST00000379600; ENSP00000368920; ENSG00000188811. [Q5JS37-1]
GeneIDi387921.
KEGGihsa:387921.
UCSCiuc001uxc.5. human. [Q5JS37-1]

Organism-specific databases

CTDi387921.
GeneCardsiNHLRC3.
H-InvDBHIX0022671.
HGNCiHGNC:33751. NHLRC3.
HPAiHPA013738.
neXtProtiNX_Q5JS37.
PharmGKBiPA162397544.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITFF. Eukaryota.
ENOG410ZCFR. LUCA.
GeneTreeiENSGT00390000008657.
HOGENOMiHOG000070097.
HOVERGENiHBG104921.
InParanoidiQ5JS37.
OMAiGYFLRSW.
PhylomeDBiQ5JS37.
TreeFamiTF331018.

Miscellaneous databases

ChiTaRSiNHLRC3. human.
GenomeRNAii387921.
PROiQ5JS37.

Gene expression databases

BgeeiQ5JS37.
CleanExiHS_NHLRC3.
ExpressionAtlasiQ5JS37. baseline and differential.
GenevisibleiQ5JS37. HS.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR001258. NHL_repeat.
IPR013017. NHL_repeat_subgr.
[Graphical view]
PfamiPF01436. NHL. 1 hit.
[Graphical view]
PROSITEiPS51125. NHL. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-129 (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiNHLC3_HUMAN
AccessioniPrimary (citable) accession number: Q5JS37
Secondary accession number(s): B2RTZ2, B4DTL0, Q69YI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.