Q5JS13B4DR86E9PBQ5O15059Q5JT60Q5JT65Q5JUG5Q8N4S6Q8N5H4Q8WUV7Q9NZ16RGPS1_HUMANRas-specific guanine nucleotide-releasing factor RalGPS1Ral GEF with PH domain and SH3-binding motif 1Ral guanine nucleotide exchange factor 2RalGEF 2RalA exchange factor RalGPS1RALGPS1KIAA0351RALGEF2Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoIdentification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)FUNCTIONINTERACTION WITH GRB2; NCK1; PLCG1; RALA AND SRCTISSUE SPECIFICITYPrediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)DNA sequence and analysis of human chromosome 9.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 6)RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.FUNCTIONSUBCELLULAR LOCATIONTISSUE SPECIFICITYMUTAGENESIS OF LEU-148Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a.X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 23-289Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for.Interacts with the SH3 domains of GRB2, NCK1, PLCG1 and SRC.Q5JS13-3Q8TAP6false3CytoplasmCell membraneAssociates with membranes through the PH domain.Q5JS13-11RALGPS1BQ5JS13-22RALGPS1AQ5JS13-33Q5JS13-44Q5JS13-55Q5JS13-66Q5JS13-77Widely expressed (at protein level). Isoform 2 is expressed in brain, colon, kidney, pancreas, prostate, skeletal muscle, small intestine, testis, thymus and uterus. Isoform 1 is expressed at high levels in heart and testis and at lower levels in brain, pancreas, skeletal muscle, small intestine and thymus.The PH domain mediates binding to membranes. It is required for efficient GEF activity.Extended N-terminus.Extended N-terminus.3D-structureAlternative splicingCell membraneCytoplasmGuanine-nucleotide releasing factorMembraneReference proteomeELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREKGWPARMEDSLQKSTVSSRPHDTLQFRKTLPVGPGTIYLLDLIYIRSLNWLIFFGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLVSHLSSLSHQGQAEEARLKPTSGQHPAWMWPSSSRVPAAPPASAAPRSPWPRNLRNDQGQPGAVALTCNPSTLGSRSRRITGPAMMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMSSGLERGRLYATLGPNWRVPVRNSPRTRSCVYVPANLMSFEEAGAAPGPTGTDSHEVDHLEGGAGKEAGPCASNLASTEGHRMYKRNGLMASVLVTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License