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Q5JS13

- RGPS1_HUMAN

UniProt

Q5JS13 - RGPS1_HUMAN

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Protein

Ras-specific guanine nucleotide-releasing factor RalGPS1

Gene
RALGPS1, KIAA0351, RALGEF2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization By similarity. Guanine nucleotide exchange factor for.2 Publications

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: UniProtKB
  2. Ral guanyl-nucleotide exchange factor activity Source: FlyBase

GO - Biological processi

  1. intracellular signal transduction Source: UniProtKB
  2. regulation of GTPase activity Source: GOC
  3. regulation of Ral GTPase activity Source: GOC
  4. regulation of Ral protein signal transduction Source: FlyBase
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-specific guanine nucleotide-releasing factor RalGPS1
Alternative name(s):
Ral GEF with PH domain and SH3-binding motif 1
Ral guanine nucleotide exchange factor 2
Short name:
RalGEF 2
RalA exchange factor RalGPS1
Gene namesi
Name:RALGPS1
Synonyms:KIAA0351, RALGEF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:16851. RALGPS1.

Subcellular locationi

Cytoplasm. Cell membrane
Note: Associates with membranes through the PH domain.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi148 – 1481L → A: Loss of activity. 1 Publication

Organism-specific databases

PharmGKBiPA134907502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Ras-specific guanine nucleotide-releasing factor RalGPS1PRO_0000333192Add
BLAST

Proteomic databases

MaxQBiQ5JS13.
PaxDbiQ5JS13.
PRIDEiQ5JS13.

PTM databases

PhosphoSiteiQ5JS13.

Expressioni

Tissue specificityi

Widely expressed (at protein level). Isoform 2 is expressed in brain, colon, kidney, pancreas, prostate, skeletal muscle, small intestine, testis, thymus and uterus. Isoform 1 is expressed at high levels in heart and testis and at lower levels in brain, pancreas, skeletal muscle, small intestine and thymus.2 Publications

Gene expression databases

ArrayExpressiQ5JS13.
BgeeiQ5JS13.
CleanExiHS_RALGPS1.
GenevestigatoriQ5JS13.

Interactioni

Subunit structurei

Interacts with the SH3 domains of GRB2, NCK1, PLCG1 and SRC.1 Publication

Protein-protein interaction databases

BioGridi115007. 6 interactions.
IntActiQ5JS13. 2 interactions.
MINTiMINT-7968995.

Structurei

Secondary structure

1
557
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi46 – 483
Helixi51 – 6717
Helixi71 – 766
Helixi84 – 874
Helixi89 – 11022
Helixi115 – 13420
Helixi138 – 14811
Helixi151 – 1544
Helixi157 – 1615
Helixi165 – 17713
Helixi181 – 19212
Turni193 – 1964
Helixi203 – 21614
Beta strandi219 – 2213
Helixi223 – 24523
Helixi256 – 2638
Helixi269 – 2713
Helixi272 – 28615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QXLX-ray2.24A/B23-289[»]
ProteinModelPortaliQ5JS13.
SMRiQ5JS13. Positions 44-288, 432-547.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 289240Ras-GEFAdd
BLAST
Domaini431 – 543113PHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni433 – 557125Required for stimulation of nucleotide exchange by RALAAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi330 – 3334PXXP

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 266Poly-Ser

Domaini

The PH domain mediates binding to membranes. It is required for efficient GEF activity.

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 Ras-GEF domain.

Phylogenomic databases

eggNOGiNOG275669.
HOVERGENiHBG059258.
InParanoidiQ5JS13.
OMAiAPNIVAF.
OrthoDBiEOG70KGP7.
PhylomeDBiQ5JS13.
TreeFamiTF352150.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5JS13-1) [UniParc]FASTAAdd to Basket

Also known as: RALGPS1B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYKRNGLMAS VLVTSATPQG SSSSDSLEGQ SCDYASKSYD AVVFDVLKVT    50
PEEFASQITL MDIPVFKAIQ PEELASCGWS KKEKHSLAPN VVAFTRRFNQ 100
VSFWVVREIL TAQTLKIRAE ILSHFVKIAK KLLELNNLHS LMSVVSALQS 150
APIFRLTKTW ALLNRKDKTT FEKLDYLMSK EDNYKRTREY IRSLKMVPSI 200
PYLGIYLLDL IYIDSAYPAS GSIMENEQRS NQMNNILRII ADLQVSCSYD 250
HLTTLPHVQK YLKSVRYIEE LQKFVEDDNY KLSLRIEPGS SSPRLVSSKE 300
DLAGPSAGSG SARFSRRPTC PDTSVAGSLP TPPVPRHRKS HSLGNNMMCQ 350
LSVVESKSAT FPSEKARHLL DDSVLESRSP RRGLALTSSS AVTNGLSLGS 400
SESSEFSEEM SSGLESPTGP CICSLGNSAA VPTMEGPLRR KTLLKEGRKP 450
ALSSWTRYWV ILSGSTLLYY GAKSLRGTDR KHYKSTPGKK VSIVGWMVQL 500
PDDPEHPDIF QLNNPDKGNV YKFQTGSRFH AILWHKHLDD ACKSNRPQVP 550
ANLMSFE 557
Length:557
Mass (Da):62,133
Last modified:February 5, 2008 - v1
Checksum:i0C93A55468ED95ED
GO
Isoform 2 (identifier: Q5JS13-2) [UniParc]FASTAAdd to Basket

Also known as: RALGPS1A

The sequence of this isoform differs from the canonical sequence as follows:
     347-415: MMCQLSVVES...FSEEMSSGLE → RGRLYATLGPNWRVPVRNSPRTRSCVY
     483-490: Missing.
     549-557: VPANLMSFE → EAGAAPGPTGTDSHEVDHLEGGAGKEAGPCA

Note: No experimental confirmation available.

Show »
Length:529
Mass (Da):58,975
Checksum:i49CFB803DABF6BAA
GO
Isoform 3 (identifier: Q5JS13-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-384: GPSAGSGSAR...LESRSPRRGL → VSHLSSLSHQ...TLGSRSRRIT
     385-557: Missing.

Note: No experimental confirmation available.

Show »
Length:384
Mass (Da):43,154
Checksum:i2B0F6988D850036E
GO
Isoform 4 (identifier: Q5JS13-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-305: GP → AM
     306-557: Missing.

Note: No experimental confirmation available.

Show »
Length:305
Mass (Da):34,728
Checksum:iA23253E8A5E97706
GO
Isoform 5 (identifier: Q5JS13-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-213: IYLLDLIYI → RSLNWLIFF
     214-557: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.

Show »
Length:213
Mass (Da):24,325
Checksum:i6BE4541C45159E89
GO
Isoform 6 (identifier: Q5JS13-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-108: ELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVRE → KGWPARMEDSLQKSTVSSRPHDTLQFRKTLPVGPGT
     109-557: Missing.

Note: No experimental confirmation available.

Show »
Length:108
Mass (Da):11,772
Checksum:i96CA60064D585BB5
GO
Isoform 7 (identifier: Q5JS13-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-415: MMCQLSVVES...FSEEMSSGLE → RGRLYATLGPNWRVPVRNSPRTRSCVY
     549-557: VPANLMSFE → EAGAAPGPTGTDSHEVDHLEGGAGKEAGPCA

Note: No experimental confirmation available.

Show »
Length:537
Mass (Da):59,865
Checksum:i3CCD9778267F43FA
GO

Sequence cautioni

The sequence AAH19329.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAA20808.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti290 – 2901S → N.
Corresponds to variant rs55918931 [ dbSNP | Ensembl ].
VAR_061785

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei73 – 10836ELASC…WVVRE → KGWPARMEDSLQKSTVSSRP HDTLQFRKTLPVGPGT in isoform 6. VSP_033471Add
BLAST
Alternative sequencei109 – 557449Missing in isoform 6. VSP_033472Add
BLAST
Alternative sequencei205 – 2139IYLLDLIYI → RSLNWLIFF in isoform 5. VSP_033473
Alternative sequencei214 – 557344Missing in isoform 5. VSP_033474Add
BLAST
Alternative sequencei304 – 38481GPSAG…PRRGL → VSHLSSLSHQGQAEEARLKP TSGQHPAWMWPSSSRVPAAP PASAAPRSPWPRNLRNDQGQ PGAVALTCNPSTLGSRSRRI T in isoform 3. VSP_033475Add
BLAST
Alternative sequencei304 – 3052GP → AM in isoform 4. VSP_033476
Alternative sequencei306 – 557252Missing in isoform 4. VSP_033477Add
BLAST
Alternative sequencei347 – 41569MMCQL…SSGLE → RGRLYATLGPNWRVPVRNSP RTRSCVY in isoform 2 and isoform 7. VSP_033478Add
BLAST
Alternative sequencei385 – 557173Missing in isoform 3. VSP_033479Add
BLAST
Alternative sequencei483 – 4908Missing in isoform 2. VSP_033480
Alternative sequencei549 – 5579VPANLMSFE → EAGAAPGPTGTDSHEVDHLE GGAGKEAGPCA in isoform 2 and isoform 7. VSP_033481

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861S → T in AAH32372. 1 Publication
Sequence conflicti189 – 1891E → G in BAG61198. 1 Publication
Sequence conflicti251 – 2511H → R in BAG61198. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF221098 mRNA. Translation: AAF65253.1.
AB002349 mRNA. Translation: BAA20808.2. Different initiation.
AK299149 mRNA. Translation: BAG61198.1.
AL357623, AL160169, AL356862 Genomic DNA. Translation: CAH72699.1.
AL357623
, AL160169, AL356862, AL450263 Genomic DNA. Translation: CAH72700.1.
AL357623
, AL160169, AL356862, AL450263 Genomic DNA. Translation: CAH72701.1.
AL357623, AL160169, AL356862 Genomic DNA. Translation: CAH72702.1.
AL356862, AL160169, AL357623 Genomic DNA. Translation: CAI39718.1.
AL356862
, AL160169, AL357623, AL450263 Genomic DNA. Translation: CAI39719.1.
AL356862
, AL160169, AL357623, AL450263 Genomic DNA. Translation: CAI39720.1.
AL356862, AL160169, AL357623 Genomic DNA. Translation: CAI39721.1.
AL356862, AL160169 Genomic DNA. Translation: CAI39723.1.
AL160169, AL356862, AL357623 Genomic DNA. Translation: CAI40638.1.
AL160169
, AL356862, AL357623, AL450263 Genomic DNA. Translation: CAI40639.1.
AL160169
, AL356862, AL357623, AL450263 Genomic DNA. Translation: CAI40640.1.
AL160169, AL356862, AL357623 Genomic DNA. Translation: CAI40641.1.
AL160169, AL356862 Genomic DNA. Translation: CAI40643.1.
AL160169 Genomic DNA. Translation: CAI40644.1.
AL450263
, AL160169, AL356862, AL357623 Genomic DNA. Translation: CAI41460.1.
AL450263
, AL160169, AL356862, AL357623 Genomic DNA. Translation: CAI41461.1.
CH471090 Genomic DNA. Translation: EAW87645.1.
CH471090 Genomic DNA. Translation: EAW87646.1.
CH471090 Genomic DNA. Translation: EAW87648.1.
BC019329 mRNA. Translation: AAH19329.1. Different initiation.
BC032372 mRNA. Translation: AAH32372.1.
BC033708 mRNA. Translation: AAH33708.1.
CCDSiCCDS35143.1. [Q5JS13-1]
CCDS55344.1. [Q5JS13-4]
CCDS55345.1. [Q5JS13-7]
CCDS55346.1. [Q5JS13-2]
RefSeqiNP_001177657.1. NM_001190728.1. [Q5JS13-2]
NP_001177658.1. NM_001190729.1. [Q5JS13-7]
NP_001177659.1. NM_001190730.1. [Q5JS13-4]
NP_055451.1. NM_014636.2. [Q5JS13-1]
UniGeneiHs.432842.
Hs.606576.
Hs.721343.

Genome annotation databases

EnsembliENST00000259351; ENSP00000259351; ENSG00000136828. [Q5JS13-1]
ENST00000373434; ENSP00000362533; ENSG00000136828. [Q5JS13-2]
ENST00000373436; ENSP00000362535; ENSG00000136828. [Q5JS13-4]
ENST00000394011; ENSP00000377579; ENSG00000136828. [Q5JS13-6]
ENST00000394022; ENSP00000377590; ENSG00000136828. [Q5JS13-3]
ENST00000424082; ENSP00000415630; ENSG00000136828. [Q5JS13-7]
GeneIDi9649.
KEGGihsa:9649.
UCSCiuc004bqo.2. human. [Q5JS13-1]
uc004bqq.4. human. [Q5JS13-2]
uc011mab.2. human. [Q5JS13-3]
uc011mac.2. human. [Q5JS13-7]
uc022bno.1. human. [Q5JS13-4]

Polymorphism databases

DMDMi189040074.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF221098 mRNA. Translation: AAF65253.1 .
AB002349 mRNA. Translation: BAA20808.2 . Different initiation.
AK299149 mRNA. Translation: BAG61198.1 .
AL357623 , AL160169 , AL356862 Genomic DNA. Translation: CAH72699.1 .
AL357623
, AL160169 , AL356862 , AL450263 Genomic DNA. Translation: CAH72700.1 .
AL357623
, AL160169 , AL356862 , AL450263 Genomic DNA. Translation: CAH72701.1 .
AL357623 , AL160169 , AL356862 Genomic DNA. Translation: CAH72702.1 .
AL356862 , AL160169 , AL357623 Genomic DNA. Translation: CAI39718.1 .
AL356862
, AL160169 , AL357623 , AL450263 Genomic DNA. Translation: CAI39719.1 .
AL356862
, AL160169 , AL357623 , AL450263 Genomic DNA. Translation: CAI39720.1 .
AL356862 , AL160169 , AL357623 Genomic DNA. Translation: CAI39721.1 .
AL356862 , AL160169 Genomic DNA. Translation: CAI39723.1 .
AL160169 , AL356862 , AL357623 Genomic DNA. Translation: CAI40638.1 .
AL160169
, AL356862 , AL357623 , AL450263 Genomic DNA. Translation: CAI40639.1 .
AL160169
, AL356862 , AL357623 , AL450263 Genomic DNA. Translation: CAI40640.1 .
AL160169 , AL356862 , AL357623 Genomic DNA. Translation: CAI40641.1 .
AL160169 , AL356862 Genomic DNA. Translation: CAI40643.1 .
AL160169 Genomic DNA. Translation: CAI40644.1 .
AL450263
, AL160169 , AL356862 , AL357623 Genomic DNA. Translation: CAI41460.1 .
AL450263
, AL160169 , AL356862 , AL357623 Genomic DNA. Translation: CAI41461.1 .
CH471090 Genomic DNA. Translation: EAW87645.1 .
CH471090 Genomic DNA. Translation: EAW87646.1 .
CH471090 Genomic DNA. Translation: EAW87648.1 .
BC019329 mRNA. Translation: AAH19329.1 . Different initiation.
BC032372 mRNA. Translation: AAH32372.1 .
BC033708 mRNA. Translation: AAH33708.1 .
CCDSi CCDS35143.1. [Q5JS13-1 ]
CCDS55344.1. [Q5JS13-4 ]
CCDS55345.1. [Q5JS13-7 ]
CCDS55346.1. [Q5JS13-2 ]
RefSeqi NP_001177657.1. NM_001190728.1. [Q5JS13-2 ]
NP_001177658.1. NM_001190729.1. [Q5JS13-7 ]
NP_001177659.1. NM_001190730.1. [Q5JS13-4 ]
NP_055451.1. NM_014636.2. [Q5JS13-1 ]
UniGenei Hs.432842.
Hs.606576.
Hs.721343.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3QXL X-ray 2.24 A/B 23-289 [» ]
ProteinModelPortali Q5JS13.
SMRi Q5JS13. Positions 44-288, 432-547.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115007. 6 interactions.
IntActi Q5JS13. 2 interactions.
MINTi MINT-7968995.

PTM databases

PhosphoSitei Q5JS13.

Polymorphism databases

DMDMi 189040074.

Proteomic databases

MaxQBi Q5JS13.
PaxDbi Q5JS13.
PRIDEi Q5JS13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259351 ; ENSP00000259351 ; ENSG00000136828 . [Q5JS13-1 ]
ENST00000373434 ; ENSP00000362533 ; ENSG00000136828 . [Q5JS13-2 ]
ENST00000373436 ; ENSP00000362535 ; ENSG00000136828 . [Q5JS13-4 ]
ENST00000394011 ; ENSP00000377579 ; ENSG00000136828 . [Q5JS13-6 ]
ENST00000394022 ; ENSP00000377590 ; ENSG00000136828 . [Q5JS13-3 ]
ENST00000424082 ; ENSP00000415630 ; ENSG00000136828 . [Q5JS13-7 ]
GeneIDi 9649.
KEGGi hsa:9649.
UCSCi uc004bqo.2. human. [Q5JS13-1 ]
uc004bqq.4. human. [Q5JS13-2 ]
uc011mab.2. human. [Q5JS13-3 ]
uc011mac.2. human. [Q5JS13-7 ]
uc022bno.1. human. [Q5JS13-4 ]

Organism-specific databases

CTDi 9649.
GeneCardsi GC09P129679.
HGNCi HGNC:16851. RALGPS1.
MIMi 614444. gene.
neXtProti NX_Q5JS13.
PharmGKBi PA134907502.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG275669.
HOVERGENi HBG059258.
InParanoidi Q5JS13.
OMAi APNIVAF.
OrthoDBi EOG70KGP7.
PhylomeDBi Q5JS13.
TreeFami TF352150.

Miscellaneous databases

GenomeRNAii 9649.
NextBioi 36221.
PROi Q5JS13.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5JS13.
Bgeei Q5JS13.
CleanExi HS_RALGPS1.
Genevestigatori Q5JS13.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral."
    Rebhun J.F., Chen H., Quilliam L.A.
    J. Biol. Chem. 275:13406-13410(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH GRB2; NCK1; PLCG1; RALA AND SRC, TISSUE SPECIFICITY.
    Tissue: Small intestine.
  2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 6).
    Tissue: Brain and Pancreas.
  7. "RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral."
    de Bruyn K.M., de Rooij J., Wolthuis R.M., Rehmann H., Wesenbeek J., Cool R.H., Wittinghofer A.H., Bos J.L.
    J. Biol. Chem. 275:29761-29766(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF LEU-148.
  8. "Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a."
    Peng W., Xu J., Guan X., Sun Y., Zhang X.C., Li X., Rao Z.
    Protein Cell 2:308-319(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 23-289.

Entry informationi

Entry nameiRGPS1_HUMAN
AccessioniPrimary (citable) accession number: Q5JS13
Secondary accession number(s): B4DR86
, E9PBQ5, O15059, Q5JT60, Q5JT65, Q5JUG5, Q8N4S6, Q8N5H4, Q8WUV7, Q9NZ16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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