ID   O10J3_HUMAN             Reviewed;         329 AA.
AC   Q5JRS4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 145.
DE   RecName: Full=Olfactory receptor 10J3;
GN   Name=OR10J3; Synonyms=OR10J3P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10J3";
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DR   EMBL; AL513323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001004467.1; NM_001004467.1.
DR   AlphaFoldDB; Q5JRS4; -.
DR   SMR; Q5JRS4; -.
DR   GlyCosmos; Q5JRS4; 1 site, No reported glycans.
DR   GlyGen; Q5JRS4; 1 site.
DR   iPTMnet; Q5JRS4; -.
DR   PhosphoSitePlus; Q5JRS4; -.
DR   BioMuta; OR10J3; -.
DR   DMDM; 74762193; -.
DR   PaxDb; 9606-ENSP00000331789; -.
DR   PeptideAtlas; Q5JRS4; -.
DR   Antibodypedia; 49616; 149 antibodies from 23 providers.
DR   DNASU; 441911; -.
DR   Ensembl; ENST00000709165.1; ENSP00000517530.1; ENSG00000291901.1.
DR   UCSC; uc010piu.2; human.
DR   AGR; HGNC:14992; -.
DR   DisGeNET; 441911; -.
DR   GeneCards; OR10J3; -.
DR   HGNC; HGNC:14992; OR10J3.
DR   neXtProt; NX_Q5JRS4; -.
DR   PharmGKB; PA31984; -.
DR   VEuPathDB; HostDB:ENSG00000196266; -.
DR   eggNOG; ENOG502T9MC; Eukaryota.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q5JRS4; -.
DR   OMA; FFEFINM; -.
DR   PhylomeDB; Q5JRS4; -.
DR   TreeFam; TF337624; -.
DR   PathwayCommons; Q5JRS4; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q5JRS4; -.
DR   BioGRID-ORCS; 441911; 15 hits in 749 CRISPR screens.
DR   ChiTaRS; OR10J3; human.
DR   GeneWiki; OR10J3; -.
DR   GenomeRNAi; 441911; -.
DR   Pharos; Q5JRS4; Tdark.
DR   PRO; PR:Q5JRS4; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5JRS4; Protein.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF726; OLFACTORY RECEPTOR 418; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..329
FT                   /note="Olfactory receptor 10J3"
FT                   /id="PRO_0000150708"
FT   TOPO_DOM        1..26
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..329
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         235
FT                   /note="Q -> R (in dbSNP:rs11265165)"
FT                   /id="VAR_053282"
SQ   SEQUENCE   329 AA;  36549 MW;  793EF6620BB3E1AA CRC64;
     MPKLNSTFVT EFLFEGFSSF RRQHKLVFFV VFLTLYLLTL SGNVIIMTII RLDHHLHTPM
     YFFLCMLSIS ETCYTVAIIP HMLSGLLNPH QPIATQSCAT QLFFYLTFGI NNCFLLTVMG
     YDRYVAICNP LRYSVIMGKR ACIQLASGSL GIGLGMAIVQ VTSVFGLPFC DAFVISHFFC
     DVRHLLKLAC TDTTVNEIIN FVVSVCVLVL PMGLVFISYV LIISTILKIA SAEGQKKAFA
     TCASHLTVVI IHYGCASIIY LKPKSQSSLG QDRLISVTYT HHSPTEPCCV QPEEQGGQRC
     SAQSRGAKNS VSLMKRGCEG FSFAFINMY
//