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Q5JRS4

- O10J3_HUMAN

UniProt

Q5JRS4 - O10J3_HUMAN

Protein

Olfactory receptor 10J3

Gene

OR10J3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10J3
    Gene namesi
    Name:OR10J3
    Synonyms:OR10J3P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14992. OR10J3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31984.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329Olfactory receptor 10J3PRO_0000150708Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ5JRS4.
    PRIDEiQ5JRS4.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10J3.
    GenevestigatoriQ5JRS4.

    Organism-specific databases

    HPAiHPA042963.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000331789.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JRS4.
    SMRiQ5JRS4. Positions 25-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 32936CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148711.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ5JRS4.
    KOiK04257.
    OMAiMERIPEC.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ5JRS4.
    TreeFamiTF337624.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5JRS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKLNSTFVT EFLFEGFSSF RRQHKLVFFV VFLTLYLLTL SGNVIIMTII    50
    RLDHHLHTPM YFFLCMLSIS ETCYTVAIIP HMLSGLLNPH QPIATQSCAT 100
    QLFFYLTFGI NNCFLLTVMG YDRYVAICNP LRYSVIMGKR ACIQLASGSL 150
    GIGLGMAIVQ VTSVFGLPFC DAFVISHFFC DVRHLLKLAC TDTTVNEIIN 200
    FVVSVCVLVL PMGLVFISYV LIISTILKIA SAEGQKKAFA TCASHLTVVI 250
    IHYGCASIIY LKPKSQSSLG QDRLISVTYT HHSPTEPCCV QPEEQGGQRC 300
    SAQSRGAKNS VSLMKRGCEG FSFAFINMY 329
    Length:329
    Mass (Da):36,549
    Last modified:February 15, 2005 - v1
    Checksum:i793EF6620BB3E1AA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti235 – 2351Q → R.
    Corresponds to variant rs11265165 [ dbSNP | Ensembl ].
    VAR_053282

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513323 Genomic DNA. Translation: CAI15595.1.
    CCDSiCCDS30909.1.
    RefSeqiNP_001004467.1. NM_001004467.1.
    UniGeneiHs.553833.

    Genome annotation databases

    EnsembliENST00000332217; ENSP00000331789; ENSG00000196266.
    GeneIDi441911.
    KEGGihsa:441911.
    UCSCiuc010piu.2. human.

    Polymorphism databases

    DMDMi74762193.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513323 Genomic DNA. Translation: CAI15595.1 .
    CCDSi CCDS30909.1.
    RefSeqi NP_001004467.1. NM_001004467.1.
    UniGenei Hs.553833.

    3D structure databases

    ProteinModelPortali Q5JRS4.
    SMRi Q5JRS4. Positions 25-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000331789.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 74762193.

    Proteomic databases

    PaxDbi Q5JRS4.
    PRIDEi Q5JRS4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332217 ; ENSP00000331789 ; ENSG00000196266 .
    GeneIDi 441911.
    KEGGi hsa:441911.
    UCSCi uc010piu.2. human.

    Organism-specific databases

    CTDi 441911.
    GeneCardsi GC01M159249.
    HGNCi HGNC:14992. OR10J3.
    HPAi HPA042963.
    neXtProti NX_Q5JRS4.
    PharmGKBi PA31984.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148711.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q5JRS4.
    KOi K04257.
    OMAi MERIPEC.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q5JRS4.
    TreeFami TF337624.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10J3.
    GenomeRNAii 441911.
    NextBioi 110572.
    PROi Q5JRS4.

    Gene expression databases

    CleanExi HS_OR10J3.
    Genevestigatori Q5JRS4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiO10J3_HUMAN
    AccessioniPrimary (citable) accession number: Q5JRS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3