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Q5JRS4

- O10J3_HUMAN

UniProt

Q5JRS4 - O10J3_HUMAN

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Protein

Olfactory receptor 10J3

Gene

OR10J3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10J3
Gene namesi
Name:OR10J3
Synonyms:OR10J3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14992. OR10J3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31984.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Olfactory receptor 10J3PRO_0000150708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5JRS4.
PRIDEiQ5JRS4.

Expressioni

Gene expression databases

CleanExiHS_OR10J3.
GenevestigatoriQ5JRS4.

Organism-specific databases

HPAiHPA042963.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331789.

Structurei

3D structure databases

ProteinModelPortaliQ5JRS4.
SMRiQ5JRS4. Positions 25-168.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Topological domaini294 – 32936CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148711.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ5JRS4.
KOiK04257.
OMAiMERIPEC.
OrthoDBiEOG71K63J.
PhylomeDBiQ5JRS4.
TreeFamiTF337624.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JRS4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKLNSTFVT EFLFEGFSSF RRQHKLVFFV VFLTLYLLTL SGNVIIMTII
60 70 80 90 100
RLDHHLHTPM YFFLCMLSIS ETCYTVAIIP HMLSGLLNPH QPIATQSCAT
110 120 130 140 150
QLFFYLTFGI NNCFLLTVMG YDRYVAICNP LRYSVIMGKR ACIQLASGSL
160 170 180 190 200
GIGLGMAIVQ VTSVFGLPFC DAFVISHFFC DVRHLLKLAC TDTTVNEIIN
210 220 230 240 250
FVVSVCVLVL PMGLVFISYV LIISTILKIA SAEGQKKAFA TCASHLTVVI
260 270 280 290 300
IHYGCASIIY LKPKSQSSLG QDRLISVTYT HHSPTEPCCV QPEEQGGQRC
310 320
SAQSRGAKNS VSLMKRGCEG FSFAFINMY
Length:329
Mass (Da):36,549
Last modified:February 15, 2005 - v1
Checksum:i793EF6620BB3E1AA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351Q → R.
Corresponds to variant rs11265165 [ dbSNP | Ensembl ].
VAR_053282

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513323 Genomic DNA. Translation: CAI15595.1.
CCDSiCCDS30909.1.
RefSeqiNP_001004467.1. NM_001004467.1.
UniGeneiHs.553833.

Genome annotation databases

EnsembliENST00000332217; ENSP00000331789; ENSG00000196266.
GeneIDi441911.
KEGGihsa:441911.
UCSCiuc010piu.2. human.

Polymorphism databases

DMDMi74762193.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513323 Genomic DNA. Translation: CAI15595.1 .
CCDSi CCDS30909.1.
RefSeqi NP_001004467.1. NM_001004467.1.
UniGenei Hs.553833.

3D structure databases

ProteinModelPortali Q5JRS4.
SMRi Q5JRS4. Positions 25-168.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000331789.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 74762193.

Proteomic databases

PaxDbi Q5JRS4.
PRIDEi Q5JRS4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332217 ; ENSP00000331789 ; ENSG00000196266 .
GeneIDi 441911.
KEGGi hsa:441911.
UCSCi uc010piu.2. human.

Organism-specific databases

CTDi 441911.
GeneCardsi GC01M159249.
HGNCi HGNC:14992. OR10J3.
HPAi HPA042963.
neXtProti NX_Q5JRS4.
PharmGKBi PA31984.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148711.
GeneTreei ENSGT00760000119043.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q5JRS4.
KOi K04257.
OMAi MERIPEC.
OrthoDBi EOG71K63J.
PhylomeDBi Q5JRS4.
TreeFami TF337624.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10J3.
GenomeRNAii 441911.
NextBioi 110572.
PROi Q5JRS4.

Gene expression databases

CleanExi HS_OR10J3.
Genevestigatori Q5JRS4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiO10J3_HUMAN
AccessioniPrimary (citable) accession number: Q5JRS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3