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Protein
Submitted name:

Ubiquitin-like modifier-activating enzyme 1

Gene

UBA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-like modifier-activating enzyme 1Imported
Gene namesi
Name:UBA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12469. UBA1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130985.

PTM / Processingi

Proteomic databases

MaxQBiQ5JRS0.
PaxDbiQ5JRS0.
PeptideAtlasiQ5JRS0.
PRIDEiQ5JRS0.

Expressioni

Gene expression databases

BgeeiENSG00000130985.
ExpressionAtlasiQ5JRS0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5JRS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 239ThiFInterPro annotationAdd BLAST171
Domaini241 – 284E1_FCCHInterPro annotationAdd BLAST44

Phylogenomic databases

eggNOGiKOG2012. Eukaryota.
COG0476. LUCA.
GeneTreeiENSGT00390000016689.
HOGENOMiHOG000202122.

Family and domain databases

InterProiView protein in InterPro
IPR032418. E1_FCCH.
IPR000594. ThiF_NAD_FAD-bd.
IPR000011. UBQ/SUMO-activ_enz_E1-like.
PfamiView protein in Pfam
PF16190. E1_FCCH. 1 hit.
PF00899. ThiF. 1 hit.
PRINTSiPR01849. UBIQUITINACT.
SUPFAMiSSF69572. SSF69572. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5JRS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCVIYHLDN PVGKMSSSPL SKKRRVSGPD PKPGSNCSPA QSVLSEVPSV
60 70 80 90 100
PTNGMAKNGS EADIDEGLYS RQLYVLGHEA MKRLQTSSVL VSGLRGLGVE
110 120 130 140 150
IAKNIILGGV KAVTLHDQGT AQWADLSSQF YLREEDIGKN RAEVSQPRLA
160 170 180 190 200
ELNSYVPVTA YTGPLVEDFL SGFQVVVLTN TPLEDQLRVG EFCHNRGIKL
210 220 230 240 250
VVADTRGLFG QLFCDFGEEM ILTDSNGEQP LSAMVSMVTK DNPGVVTCLD
260 270 280
EARHGFESGD FVSFSEVQGM VELNGNQPME IKVL
Length:284
Mass (Da):30,764
Last modified:February 15, 2005 - v1
Checksum:iD941D1D79E6E4AAF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei284Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513366 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000442035; ENSP00000389583; ENSG00000130985.
UCSCiuc064ytz.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ5JRS0_HUMAN
AccessioniPrimary (citable) accession number: Q5JRS0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: July 5, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported