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Protein
Submitted name:

Ubiquitin-like modifier-activating enzyme 1

Gene

UBA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-like modifier-activating enzyme 1Imported
Gene namesi
Name:UBA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000130985.16
HGNCiHGNC:12469 UBA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130985

PTM / Processingi

Proteomic databases

MaxQBiQ5JRR6
PeptideAtlasiQ5JRR6
PRIDEiQ5JRR6

Expressioni

Gene expression databases

BgeeiENSG00000130985
ExpressionAtlasiQ5JRR6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5JRR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini370 – 501UBA_e1_CInterPro annotationAdd BLAST132

Phylogenomic databases

eggNOGiKOG2012 Eukaryota
COG0476 LUCA
GeneTreeiENSGT00390000016689
HOVERGENiHBG056231

Family and domain databases

Gene3Di3.10.290.60, 1 hit
InterProiView protein in InterPro
IPR000594 ThiF_NAD_FAD-bd
IPR018965 Ub-activating_enz_E1_C
IPR038252 UBA_E1_C_sf
IPR019572 UBA_E1_Cys
IPR035985 Ubiquitin-activating_enz
PfamiView protein in Pfam
PF09358 E1_UFD, 1 hit
PF00899 ThiF, 1 hit
PF10585 UBA_e1_thiolCys, 1 hit
SMARTiView protein in SMART
SM00985 UBA_e1_C, 1 hit
SUPFAMiSSF69572 SSF69572, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JRR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFHHVGQAG LEPLTSGDPS ALASQSAGIT GVSYCAWPGF SIEVGEWGRL
60 70 80 90 100
EGFPTSRVAV RLVLALFTDG PSNNACGNPF CQLWPHVICL LCLQWARDEF
110 120 130 140 150
EGLFKQPAEN VNQYLTDPKF VERTLRLAGT QPLEVLEAVQ RSLVLQRPQT
160 170 180 190 200
WADCVTWACH HWHTQYSNNI RQLLHNFPPD QLTSSGAPFW SGPKRCPHPL
210 220 230 240 250
TFDVNNPLHL DYVMAAANLF AQTYGLTGSQ DRAAVATFLQ SVQVPEFTPK
260 270 280 290 300
SGVKIHVSDQ ELQSANASVD DSRLEELKAT LPSPDKLPGF KMYPIDFEKD
310 320 330 340 350
DDSNFHMDFI VAASNLRAEN YDIPSADRHK SKLIAGKIIP AIATTTAAVV
360 370 380 390 400
GLVCLELYKV VQGHRQLDSY KNGFLNLALP FFGFSEPLAA PRHQYYNQEW
410 420 430 440 450
TLWDRFEVQG LQPNGEEMTL KQFLDYFKTE HKLEITMLSQ GVSMLYSFFM
460 470 480 490 500
PAAKLKERLD QPMTEIVSRV SKRKLGRHVR ALVLELCCND ESGEDVEVPY

VRYTIR
Length:506
Mass (Da):56,852
Last modified:February 15, 2005 - v1
Checksum:i41BDBD28B48D92A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513366 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000377269; ENSP00000366481; ENSG00000130985
UCSCiuc004dhm.4 human

Similar proteinsi

Entry informationi

Entry nameiQ5JRR6_HUMAN
AccessioniPrimary (citable) accession number: Q5JRR6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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