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Protein
Submitted name:

Disintegrin and metalloproteinase domain-containing protein 12

Gene

ADAM12

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Disintegrin and metalloproteinase domain-containing protein 12Imported
Gene namesi
Name:ADAM12Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:190. ADAM12.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500425796929 – 278Sequence analysisAdd BLAST250

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ5JRP2.
PaxDbiQ5JRP2.
PeptideAtlasiQ5JRP2.
PRIDEiQ5JRP2.

Expressioni

Gene expression databases

BgeeiENSG00000148848.
ExpressionAtlasiQ5JRP2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357668.

Structurei

3D structure databases

ProteinModelPortaliQ5JRP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 278Peptidase M12BInterPro annotationAdd BLAST68

Sequence similaritiesi

Contains 1 peptidase M12B domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000230883.
HOVERGENiHBG104105.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5JRP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG
60 70 80 90 100
DLWIPVKSFD SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL
110 120 130 140 150
QDGTDVSLAR NYTGHCYYHG HVRGYSDSAV SLSTCSGLRG LIVFENESYV
160 170 180 190 200
LEPMKSATNR YKLFPAKKLK SVRGSCGSHH NTPNLAAKNV FPPPSQTWAR
210 220 230 240 250
RHKRETLKAT KYVELVIVAD NREFQRQGKD LEKVKQRLIE IANHVDKFYR
260 270
PLNIRIVLVG VEVWNDMDKC SVSQDPFT
Length:278
Mass (Da):31,112
Last modified:February 15, 2005 - v1
Checksum:i60713D728978D436
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei278Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022015 Genomic DNA. No translation available.
AC026226 Genomic DNA. No translation available.
AC063963 Genomic DNA. No translation available.
AL589787 Genomic DNA. No translation available.
AL691463 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000448723; ENSP00000391268; ENSG00000148848.
UCSCiuc057wtm.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022015 Genomic DNA. No translation available.
AC026226 Genomic DNA. No translation available.
AC063963 Genomic DNA. No translation available.
AL589787 Genomic DNA. No translation available.
AL691463 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5JRP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357668.

Proteomic databases

MaxQBiQ5JRP2.
PaxDbiQ5JRP2.
PeptideAtlasiQ5JRP2.
PRIDEiQ5JRP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000448723; ENSP00000391268; ENSG00000148848.
UCSCiuc057wtm.1. human.

Organism-specific databases

HGNCiHGNC:190. ADAM12.
OpenTargetsiENSG00000148848.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000230883.
HOVERGENiHBG104105.

Miscellaneous databases

ChiTaRSiADAM12. human.

Gene expression databases

BgeeiENSG00000148848.
ExpressionAtlasiQ5JRP2. baseline and differential.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5JRP2_HUMAN
AccessioniPrimary (citable) accession number: Q5JRP2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.