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Protein

Uncharacterized protein CXorf66

Gene

CXorf66

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31980-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein CXorf66
Gene namesi
Name:CXorf66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:33743. CXorf66.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 47ExtracellularSequence analysisAdd BLAST28
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 361CytoplasmicSequence analysisAdd BLAST293

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi347487.
OpenTargetsiENSG00000203933.
PharmGKBiPA164718516.

Polymorphism and mutation databases

BioMutaiCXorf66.
DMDMi74741872.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000034843420 – 361Uncharacterized protein CXorf66Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5JRM2.
PeptideAtlasiQ5JRM2.
PRIDEiQ5JRM2.

PTM databases

iPTMnetiQ5JRM2.
PhosphoSitePlusiQ5JRM2.

Expressioni

Gene expression databases

BgeeiENSG00000203933.

Organism-specific databases

HPAiHPA048517.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000359571.

Structurei

3D structure databases

ProteinModelPortaliQ5JRM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi91 – 177Ser-richAdd BLAST87

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J08X. Eukaryota.
ENOG41117EF. LUCA.
GeneTreeiENSGT00390000004226.
HOGENOMiHOG000112110.
InParanoidiQ5JRM2.
OMAiIAFVFTC.
OrthoDBiEOG091G0CJA.
PhylomeDBiQ5JRM2.
TreeFamiTF352168.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JRM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLVICVLLL SIWKNNCMTT NQTNGSSTTG DKPVESMQTK LNYLRRNLLI
60 70 80 90 100
LVGIIIMVFV FICFCYLHYN CLSDDASKAG MVKKKGIAAK SSKTSFSEAK
110 120 130 140 150
TASQCSPETQ PMLSTADKSS DSSSPERASA QSSTEKLIRP SSLQKPSIPN
160 170 180 190 200
SAGKLTRPSY PKRSSKSSCS KKLSKSSHLE KAHKKGSLEK LCKLDYACKL
210 220 230 240 250
ASSDKPVRPP QLFKPLYSSH PQNEISPSKP FGPQELAKPP KHFNPKRSVS
260 270 280 290 300
LGRAALLSNS ELAETCQPYK KKHLVAKTYR PLVNDISEAK EKNTQNLHVS
310 320 330 340 350
SKVKSSSRSF RKLDSRNNAY GDHVNDSDTM KYYSEVDSDK VIIITCDRGY
360
NQVTSEVTLN D
Length:361
Mass (Da):39,944
Last modified:February 15, 2005 - v1
Checksum:i3CC5814E66EA947C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046157233P → L.Corresponds to variant rs5955139dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590077 Genomic DNA. Translation: CAI40419.1.
BC137148 mRNA. Translation: AAI37149.1.
BC137149 mRNA. Translation: AAI37150.1.
CCDSiCCDS35411.1.
RefSeqiNP_001013421.1. NM_001013403.2.
UniGeneiHs.121384.

Genome annotation databases

EnsembliENST00000370540; ENSP00000359571; ENSG00000203933.
GeneIDi347487.
KEGGihsa:347487.
UCSCiuc004fbb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590077 Genomic DNA. Translation: CAI40419.1.
BC137148 mRNA. Translation: AAI37149.1.
BC137149 mRNA. Translation: AAI37150.1.
CCDSiCCDS35411.1.
RefSeqiNP_001013421.1. NM_001013403.2.
UniGeneiHs.121384.

3D structure databases

ProteinModelPortaliQ5JRM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000359571.

PTM databases

iPTMnetiQ5JRM2.
PhosphoSitePlusiQ5JRM2.

Polymorphism and mutation databases

BioMutaiCXorf66.
DMDMi74741872.

Proteomic databases

PaxDbiQ5JRM2.
PeptideAtlasiQ5JRM2.
PRIDEiQ5JRM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370540; ENSP00000359571; ENSG00000203933.
GeneIDi347487.
KEGGihsa:347487.
UCSCiuc004fbb.4. human.

Organism-specific databases

CTDi347487.
DisGeNETi347487.
GeneCardsiCXorf66.
HGNCiHGNC:33743. CXorf66.
HPAiHPA048517.
neXtProtiNX_Q5JRM2.
OpenTargetsiENSG00000203933.
PharmGKBiPA164718516.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J08X. Eukaryota.
ENOG41117EF. LUCA.
GeneTreeiENSGT00390000004226.
HOGENOMiHOG000112110.
InParanoidiQ5JRM2.
OMAiIAFVFTC.
OrthoDBiEOG091G0CJA.
PhylomeDBiQ5JRM2.
TreeFamiTF352168.

Enzyme and pathway databases

BioCyciZFISH:G66-31980-MONOMER.

Miscellaneous databases

GenomeRNAii347487.
PROiQ5JRM2.

Gene expression databases

BgeeiENSG00000203933.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCX066_HUMAN
AccessioniPrimary (citable) accession number: Q5JRM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.