Q5JRA6 (MIA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Melanoma inhibitory activity protein 3

Alternative name(s):
C219-reactive peptide
D320
Transport and Golgi organization protein 1
Short name=TANGO1

Gene names

Name:	MIA3
Synonyms:	KIAA0268, TANGO
ORF Names:	UNQ6077/PRO20088

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1907 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. Ref.11
Subunit structure	Interacts (via SH3 domain) with COL7A1. Associates with the COPII coat subunits Sec23/Sec24. Ref.11
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note: Localizes at endoplasmic reticulum exit sites. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membrane. Ref.11
Tissue specificity	Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue. Ref.4 Ref.8
Domain	The proline-rich region (PRD) mediates the interaction with COPII coat subunits Sec23/24. Ref.11 Although 2 transmembrane domains are predicted, Ref.11 showed that it only contains one transmembrane domain. The other predicted transmembrane region is probably a hairpin-type region embedded into the membrane, which does not cross the membrane. It is unclear which of the 2 predicted transmembrane regions is the transmembrane or the hairpin-type region. Ref.11
Sequence similarities	Belongs to the MIA/OTOR family. Tango1 subfamily. Contains 1 SH3 domain.
Sequence caution	The sequence BAC04810.1 differs from that shown. Reason: Erroneous initiation. The sequence BAF83024.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI40474.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	ER-Golgi transport Exocytosis Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil SH3 domain Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	exocytosis Inferred from mutant phenotype Ref.11. Source: UniProtKB negative regulation of cell adhesion Inferred from direct assay PubMed 17726152. Source: BHF-UCL negative regulation of cell migration Inferred from direct assay Ref.8. Source: BHF-UCL positive regulation of leukocyte migration Inferred from direct assay PubMed 17726152. Source: BHF-UCL protein transport Inferred from mutant phenotype Ref.11. Source: UniProtKB wound healing Inferred from direct assay Ref.8. Source: BHF-UCL
Cellular_component	endoplasmic reticulum membrane Inferred from direct assay Ref.11. Source: UniProtKB integral to membrane Inferred from direct assay Ref.11. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
COL7A1	Q02388	2	EBI-2291868,EBI-724237

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5JRA6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5JRA6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1304-1362: Missing.

Isoform 3 (identifier: Q5JRA6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     493-500: MTVHSSVH → FKTEPIKL
     501-1907: Missing.

Isoform 4 (identifier: Q5JRA6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1122: Missing.
     1123-1159: IDANKQPETAAEEPASVTPLENAILLIYSFMFYLTKS → MDSVPATVPSIAATPGDPELVGPLSVLYAAFIAKLLE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 1907	1885	Melanoma inhibitory activity protein 3		PRO_0000288998
Regions
	Topological domain	23 – 1144	1122	Extracellular Potential
	Intramembrane	1145 – 1165	21	Potential
	Topological domain	1166 – 1176	11	Extracellular Potential
	Transmembrane	1177 – 1197	21	Helical; Potential
	Topological domain	1198 – 1907	710	Cytoplasmic Potential
	Domain	45 – 107	63	SH3
	Coiled coil	471 – 531	61	Potential
	Coiled coil	1214 – 1396	183	Potential
	Coiled coil	1487 – 1639	153	Potential
	Compositional bias	1640 – 1890	251	Pro-rich
Amino acid modifications
	Modified residue	382	1	Phosphothreonine By similarity
	Modified residue	1727	1	Phosphoserine By similarity
	Modified residue	1739	1	Phosphoserine By similarity
	Modified residue	1740	1	Phosphoserine By similarity
	Modified residue	1745	1	Phosphoserine Ref.15
	Modified residue	1892	1	Phosphoserine By similarity
	Modified residue	1906	1	Phosphoserine Ref.9
	Glycosylation	246	1	N-linked (GlcNAc...) Potential
	Glycosylation	589	1	N-linked (GlcNAc...) Ref.12
Natural variations
	Alternative sequence	1 – 1122	1122	Missing in isoform 4.		VSP_025860
	Alternative sequence	493 – 500	8	MTVHSSVH → FKTEPIKL in isoform 3.		VSP_025861
	Alternative sequence	501 – 1907	1407	Missing in isoform 3.		VSP_025862
	Alternative sequence	1123 – 1159	37	IDANK…YLTKS → MDSVPATVPSIAATPGDPEL VGPLSVLYAAFIAKLLE in isoform 4.		VSP_025863
	Alternative sequence	1304 – 1362	59	Missing in isoform 2.		VSP_025864
	Natural variant	482	1	K → E. Ref.1 Corresponds to variant rs2936053 [ dbSNP | Ensembl ].		VAR_032546
	Natural variant	605	1	K → R. Corresponds to variant rs2936052 [ dbSNP | Ensembl ].		VAR_032547
	Natural variant	881	1	E → G. Ref.5 Corresponds to variant rs2936051 [ dbSNP | Ensembl ].		VAR_032548
	Natural variant	1659	1	G → C. Ref.7 Corresponds to variant rs17857325 [ dbSNP | Ensembl ].		VAR_032549
	Natural variant	1723	1	K → E. Ref.7 Corresponds to variant rs17854428 [ dbSNP | Ensembl ].		VAR_032550
Experimental info
	Sequence conflict	46	1	Missing in AAQ89449. Ref.1
	Sequence conflict	1032	1	H → R in BAC04810. Ref.2
	Sequence conflict	1443	1	R → Q in AAH47116. Ref.7
	Sequence conflict	1754	1	K → R in BAH12416. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: D19C9AF1656F4B1C	FASTA	1,907	213,702
	10 20 30 40 50 60 MAAAPGLLVW LLVLRLPWRV PGQLDPSTGR RFSEHKLCAD DECSMLMYRG EALEDFTGPD 70 80 90 100 110 120 CRFVNFKKGD PVYVYYKLAR GWPEVWAGSV GRTFGYFPKD LIQVVHEYTK EELQVPTDET 130 140 150 160 170 180 DFVCFDGGRD DFHNYNVEEL LGFLELYNSA ATDSEKAVEK TLQDMEKNPE LSKEREPEPE 190 200 210 220 230 240 PVEANSEESD SVFSENTEDL QEQFTTQKHH SHANSQANHA QGEQASFESF EEMLQDKLKV 250 260 270 280 290 300 PESENNKTSN SSQVSNEQDK IDAYKLLKKE MTLDLKTKFG STADALVSDD ETTRLVTSLE 310 320 330 340 350 360 DDFDEELDTE YYAVGKEDEE NQEDFDELPL LTFTDGEDMK TPAKSGVEKY PTDKEQNSNE 370 380 390 400 410 420 EDKVQLTVPP GIKNDDKNIL TTWGDTIFSI VTGGEETRDT MDLESSSSEE EKEDDDDALV 430 440 450 460 470 480 PDSKQGKPQS ATDYSDPDNV DDGLFIVDIP KTNNDKEVNA EHHIKGKGRG VQESKRGLVQ 490 500 510 520 530 540 DKTELEDENQ EGMTVHSSVH SNNLNSMPAA EKGKDTLKSA YDDTENDLKG AAIHISKGML 550 560 570 580 590 600 HEEKPGEQIL EGGSESESAQ KAAGNQMNDR KIQQESLGSA PLMGDDHPNA SRDSVEGDAL 610 620 630 640 650 660 VNGAKLHTLS VEHQREELKE ELVLKTQNQP RFSSPDEIDL PRELEDEVPI LGRNLPWQQE 670 680 690 700 710 720 RDVAATASKQ MSEKIRLSEG EAKEDSLDEE FFHHKAMQGT EVGQTDQTDS TGGPAFLSKV 730 740 750 760 770 780 EEDDYPSEEL LEDENAINAK RSKEKNPGNQ GRQFDVNLQV PDRAVLGTIH PDPEIEESKQ 790 800 810 820 830 840 ETSMILDSEK TSETAAKGVN TGGREPNTMV EKERPLADKK AQRPFERSDF SDSIKIQTPE 850 860 870 880 890 900 LGEVFQNKDS DYLKNDNPEE HLKTSGLAGE PEGELSKEDH ENTEKYMGTE SQGSAAAEPE 910 920 930 940 950 960 DDSFHWTPHT SVEPGHSDKR EDLLIISSFF KEQQSLQRFQ KYFNVHELEA LLQEMSSKLK 970 980 990 1000 1010 1020 SAQQESLPYN MEKVLDKVFR ASESQILSIA EKMLDTRVAE NRDLGMNENN IFEEAAVLDD 1030 1040 1050 1060 1070 1080 IQDLIYFVRY KHSTAEETAT LVMAPPLEEG LGGAMEEMQP LHEDNFSREK TAELNVQVPE 1090 1100 1110 1120 1130 1140 EPTHLDQRVI GDTHASEVSQ KPNTEKDLDP GPVTTEDTPM DAIDANKQPE TAAEEPASVT 1150 1160 1170 1180 1190 1200 PLENAILLIY SFMFYLTKSL VATLPDDVQP GPDFYGLPWK PVFITAFLGI ASFAIFLWRT 1210 1220 1230 1240 1250 1260 VLVVKDRVYQ VTEQQISEKL KTIMKENTEL VQKLSNYEQK IKESKKHVQE TRKQNMILSD 1270 1280 1290 1300 1310 1320 EAIKYKDKIK TLEKNQEILD DTAKNLRVML ESEREQNVKN QDLISENKKS IEKLKDVISM 1330 1340 1350 1360 1370 1380 NASEFSEVQI ALNEAKLSEE KVKSECHRVQ EENARLKKKK EQLQQEIEDW SKLHAELSEQ 1390 1400 1410 1420 1430 1440 IKSFEKSQKD LEVALTHKDD NINALTNCIT QLNLLECESE SEGQNKGGND SDELANGEVG 1450 1460 1470 1480 1490 1500 GDRNEKMKNQ IKQMMDVSRT QTAISVVEED LKLLQLKLRA SVSTKCNLED QVKKLEDDRN 1510 1520 1530 1540 1550 1560 SLQAAKAGLE DECKTLRQKV EILNELYQQK EMALQKKLSQ EEYERQEREH RLSAADEKAV 1570 1580 1590 1600 1610 1620 SAAEEVKTYK RRIEEMEDEL QKTERSFKNQ IATHEKKAHE NWLKARAAER AIAEEKREAA 1630 1640 1650 1660 1670 1680 NLRHKLLELT QKMAMLQEEP VIVKPMPGKP NTQNPPRRGP LSQNGSFGPS PVSGGECSPP 1690 1700 1710 1720 1730 1740 LTVEPPVRPL SATLNRRDMP RSEFGSVDGP LPHPRWSAEA SGKPSPSDPG SGTATMMNSS 1750 1760 1770 1780 1790 1800 SRGSSPTRVL DEGKVNMAPK GPPPFPGVPL MSTPMGGPVP PPIRYGPPPQ LCGPFGPRPL 1810 1820 1830 1840 1850 1860 PPPFGPGMRP PLGLREFAPG VPPGRRDLPL HPRGFLPGHA PFRPLGSLGP REYFIPGTRL 1870 1880 1890 1900 PPPTHGPQEY PPPPAVRDLL PSGSRDEPPP ASQSTSQDCS QALKQSP
	Isoform 2 [UniParc]. Checksum: B793E3992499E137	FASTA	1,848	206,890
	10 20 30 40 50 60 MAAAPGLLVW LLVLRLPWRV PGQLDPSTGR RFSEHKLCAD DECSMLMYRG EALEDFTGPD 70 80 90 100 110 120 CRFVNFKKGD PVYVYYKLAR GWPEVWAGSV GRTFGYFPKD LIQVVHEYTK EELQVPTDET 130 140 150 160 170 180 DFVCFDGGRD DFHNYNVEEL LGFLELYNSA ATDSEKAVEK TLQDMEKNPE LSKEREPEPE 190 200 210 220 230 240 PVEANSEESD SVFSENTEDL QEQFTTQKHH SHANSQANHA QGEQASFESF EEMLQDKLKV 250 260 270 280 290 300 PESENNKTSN SSQVSNEQDK IDAYKLLKKE MTLDLKTKFG STADALVSDD ETTRLVTSLE 310 320 330 340 350 360 DDFDEELDTE YYAVGKEDEE NQEDFDELPL LTFTDGEDMK TPAKSGVEKY PTDKEQNSNE 370 380 390 400 410 420 EDKVQLTVPP GIKNDDKNIL TTWGDTIFSI VTGGEETRDT MDLESSSSEE EKEDDDDALV 430 440 450 460 470 480 PDSKQGKPQS ATDYSDPDNV DDGLFIVDIP KTNNDKEVNA EHHIKGKGRG VQESKRGLVQ 490 500 510 520 530 540 DKTELEDENQ EGMTVHSSVH SNNLNSMPAA EKGKDTLKSA YDDTENDLKG AAIHISKGML 550 560 570 580 590 600 HEEKPGEQIL EGGSESESAQ KAAGNQMNDR KIQQESLGSA PLMGDDHPNA SRDSVEGDAL 610 620 630 640 650 660 VNGAKLHTLS VEHQREELKE ELVLKTQNQP RFSSPDEIDL PRELEDEVPI LGRNLPWQQE 670 680 690 700 710 720 RDVAATASKQ MSEKIRLSEG EAKEDSLDEE FFHHKAMQGT EVGQTDQTDS TGGPAFLSKV 730 740 750 760 770 780 EEDDYPSEEL LEDENAINAK RSKEKNPGNQ GRQFDVNLQV PDRAVLGTIH PDPEIEESKQ 790 800 810 820 830 840 ETSMILDSEK TSETAAKGVN TGGREPNTMV EKERPLADKK AQRPFERSDF SDSIKIQTPE 850 860 870 880 890 900 LGEVFQNKDS DYLKNDNPEE HLKTSGLAGE PEGELSKEDH ENTEKYMGTE SQGSAAAEPE 910 920 930 940 950 960 DDSFHWTPHT SVEPGHSDKR EDLLIISSFF KEQQSLQRFQ KYFNVHELEA LLQEMSSKLK 970 980 990 1000 1010 1020 SAQQESLPYN MEKVLDKVFR ASESQILSIA EKMLDTRVAE NRDLGMNENN IFEEAAVLDD 1030 1040 1050 1060 1070 1080 IQDLIYFVRY KHSTAEETAT LVMAPPLEEG LGGAMEEMQP LHEDNFSREK TAELNVQVPE 1090 1100 1110 1120 1130 1140 EPTHLDQRVI GDTHASEVSQ KPNTEKDLDP GPVTTEDTPM DAIDANKQPE TAAEEPASVT 1150 1160 1170 1180 1190 1200 PLENAILLIY SFMFYLTKSL VATLPDDVQP GPDFYGLPWK PVFITAFLGI ASFAIFLWRT 1210 1220 1230 1240 1250 1260 VLVVKDRVYQ VTEQQISEKL KTIMKENTEL VQKLSNYEQK IKESKKHVQE TRKQNMILSD 1270 1280 1290 1300 1310 1320 EAIKYKDKIK TLEKNQEILD DTAKNLRVML ESEREQNVKN QDLLQQEIED WSKLHAELSE 1330 1340 1350 1360 1370 1380 QIKSFEKSQK DLEVALTHKD DNINALTNCI TQLNLLECES ESEGQNKGGN DSDELANGEV 1390 1400 1410 1420 1430 1440 GGDRNEKMKN QIKQMMDVSR TQTAISVVEE DLKLLQLKLR ASVSTKCNLE DQVKKLEDDR 1450 1460 1470 1480 1490 1500 NSLQAAKAGL EDECKTLRQK VEILNELYQQ KEMALQKKLS QEEYERQERE HRLSAADEKA 1510 1520 1530 1540 1550 1560 VSAAEEVKTY KRRIEEMEDE LQKTERSFKN QIATHEKKAH ENWLKARAAE RAIAEEKREA 1570 1580 1590 1600 1610 1620 ANLRHKLLEL TQKMAMLQEE PVIVKPMPGK PNTQNPPRRG PLSQNGSFGP SPVSGGECSP 1630 1640 1650 1660 1670 1680 PLTVEPPVRP LSATLNRRDM PRSEFGSVDG PLPHPRWSAE ASGKPSPSDP GSGTATMMNS 1690 1700 1710 1720 1730 1740 SSRGSSPTRV LDEGKVNMAP KGPPPFPGVP LMSTPMGGPV PPPIRYGPPP QLCGPFGPRP 1750 1760 1770 1780 1790 1800 LPPPFGPGMR PPLGLREFAP GVPPGRRDLP LHPRGFLPGH APFRPLGSLG PREYFIPGTR 1810 1820 1830 1840 LPPPTHGPQE YPPPPAVRDL LPSGSRDEPP PASQSTSQDC SQALKQSP
	Isoform 3 [UniParc]. Checksum: F785E148171092E6	FASTA	500	56,584
	10 20 30 40 50 60 MAAAPGLLVW LLVLRLPWRV PGQLDPSTGR RFSEHKLCAD DECSMLMYRG EALEDFTGPD 70 80 90 100 110 120 CRFVNFKKGD PVYVYYKLAR GWPEVWAGSV GRTFGYFPKD LIQVVHEYTK EELQVPTDET 130 140 150 160 170 180 DFVCFDGGRD DFHNYNVEEL LGFLELYNSA ATDSEKAVEK TLQDMEKNPE LSKEREPEPE 190 200 210 220 230 240 PVEANSEESD SVFSENTEDL QEQFTTQKHH SHANSQANHA QGEQASFESF EEMLQDKLKV 250 260 270 280 290 300 PESENNKTSN SSQVSNEQDK IDAYKLLKKE MTLDLKTKFG STADALVSDD ETTRLVTSLE 310 320 330 340 350 360 DDFDEELDTE YYAVGKEDEE NQEDFDELPL LTFTDGEDMK TPAKSGVEKY PTDKEQNSNE 370 380 390 400 410 420 EDKVQLTVPP GIKNDDKNIL TTWGDTIFSI VTGGEETRDT MDLESSSSEE EKEDDDDALV 430 440 450 460 470 480 PDSKQGKPQS ATDYSDPDNV DDGLFIVDIP KTNNDKEVNA EHHIKGKGRG VQESKRGLVQ 490 500 DKTELEDENQ EGFKTEPIKL
	Isoform 4 [UniParc]. Checksum: 0A3890131D1BA2D5	FASTA	785	87,438
	10 20 30 40 50 60 MDSVPATVPS IAATPGDPEL VGPLSVLYAA FIAKLLELVA TLPDDVQPGP DFYGLPWKPV 70 80 90 100 110 120 FITAFLGIAS FAIFLWRTVL VVKDRVYQVT EQQISEKLKT IMKENTELVQ KLSNYEQKIK 130 140 150 160 170 180 ESKKHVQETR KQNMILSDEA IKYKDKIKTL EKNQEILDDT AKNLRVMLES EREQNVKNQD 190 200 210 220 230 240 LISENKKSIE KLKDVISMNA SEFSEVQIAL NEAKLSEEKV KSECHRVQEE NARLKKKKEQ 250 260 270 280 290 300 LQQEIEDWSK LHAELSEQIK SFEKSQKDLE VALTHKDDNI NALTNCITQL NLLECESESE 310 320 330 340 350 360 GQNKGGNDSD ELANGEVGGD RNEKMKNQIK QMMDVSRTQT AISVVEEDLK LLQLKLRASV 370 380 390 400 410 420 STKCNLEDQV KKLEDDRNSL QAAKAGLEDE CKTLRQKVEI LNELYQQKEM ALQKKLSQEE 430 440 450 460 470 480 YERQEREHRL SAADEKAVSA AEEVKTYKRR IEEMEDELQK TERSFKNQIA THEKKAHENW 490 500 510 520 530 540 LKARAAERAI AEEKREAANL RHKLLELTQK MAMLQEEPVI VKPMPGKPNT QNPPRRGPLS 550 560 570 580 590 600 QNGSFGPSPV SGGECSPPLT VEPPVRPLSA TLNRRDMPRS EFGSVDGPLP HPRWSAEASG 610 620 630 640 650 660 KPSPSDPGSG TATMMNSSSR GSSPTRVLDE GKVNMAPKGP PPFPGVPLMS TPMGGPVPPP 670 680 690 700 710 720 IRYGPPPQLC GPFGPRPLPP PFGPGMRPPL GLREFAPGVP PGRRDLPLHP RGFLPGHAPF 730 740 750 760 770 780 RPLGSLGPRE YFIPGTRLPP PTHGPQEYPP PPAVRDLLPS GSRDEPPPAS QSTSQDCSQA LKQSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLU-482.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 419-1492 (ISOFORM 2). Tissue: Brain and Tongue.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Characterization and expression pattern of the novel MIA homolog TANGO." Bosserhoff A.K., Moser M., Buettner R. Gene Expr. Patterns 4:473-479(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-125, TISSUE SPECIFICITY.
[5]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 715-1907 (ISOFORM 1), VARIANT GLY-881. Tissue: Bone marrow.
[6]	"Analysis of a novel cDNA encoding a C219-reactive peptide isolated from methotrexate-selected multidrug-resistant human leukemic cells." Norris M.D., Gilbert J., Madafiglio J., Haber M. Gene 156:313-314(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1306-1441. Tissue: Leukemia.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1441-1907 (ISOFORM 1), VARIANTS CYS-1659 AND GLU-1723. Tissue: Brain.
[8]	"TANGO is a tumor suppressor of malignant melanoma." Arndt S., Bosserhoff A.K. Int. J. Cancer 119:2812-2820(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1906, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Liver.
[11]	"TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites." Saito K., Chen M., Bard F., Chen S., Zhou H., Woodley D., Polischuk R., Schekman R., Malhotra V. Cell 136:891-902(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH COL7A1, TOPOLOGY, DOMAIN.
[12]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-589, MASS SPECTROMETRY. Tissue: Liver.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1745, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY359091 mRNA. Translation: AAQ89449.1. AK096526 mRNA. Translation: BAC04810.1. Different initiation. AK290335 mRNA. Translation: BAF83024.1. Different initiation. AK296712 mRNA. Translation: BAH12416.1. AL592148 Genomic DNA. Translation: CAI40469.1. AL592148 Genomic DNA. Translation: CAI40470.1. AL592148 Genomic DNA. Translation: CAI40471.1. AL592148 Genomic DNA. Translation: CAI40473.1. AL592148 Genomic DNA. Translation: CAI40474.1. Sequence problems. D87742 mRNA. Translation: BAA13448.1. L34688 mRNA. Translation: AAB00324.1. DQ166034 mRNA. Translation: AAZ95512.1. BC047116 mRNA. Translation: AAH47116.2.
IPI	IPI00455473. IPI00655578. IPI00739902. IPI00741107.
RefSeq	NP_940953.2. NM_198551.2.
UniGene	Hs.118474.
3D structure databases
HSSP	HSSP built from PDB template 1HJD based on UniProtKB Q16674.
ProteinModelPortal	Q5JRA6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5JRA6. 3 interactions.
PTM databases
PhosphoSite	Q5JRA6.
Polymorphism databases
DMDM	74741823.
Proteomic databases
PaxDb	Q5JRA6.
PRIDE	Q5JRA6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340535; ENSP00000345866; ENSG00000154305. ENST00000344507; ENSP00000341348; ENSG00000154305. ENST00000344922; ENSP00000340900; ENSG00000154305.
GeneID	375056.
KEGG	hsa:375056.
UCSC	uc001hnl.3. human. uc001hnm.3. human. uc009xea.1. human.
Organism-specific databases
CTD	375056.
GeneCards	GC01P222791.
H-InvDB	HIX0001613.
HGNC	HGNC:24008. MIA3.
MIM	613455. gene.
neXtProt	NX_Q5JRA6.
PharmGKB	PA143485536.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG133684.
HOVERGEN	HBG108133.
InParanoid	Q5JRA6.
OMA	VALTHKD.
OrthoDB	EOG4JM7PQ.
Gene expression databases
ArrayExpress	Q5JRA6.
Bgee	Q5JRA6.
CleanEx	HS_MIA3.
Genevestigator	Q5JRA6.
Family and domain databases
InterPro	IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50002. SH3. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MIA3. human.
GenomeRNAi	375056.
NextBio	100389.
PMAP-CutDB	Q5JRA6.
SOURCE	Search...

Entry information

Entry name

MIA3_HUMAN

Accession

Primary (citable) accession number: Q5JRA6
Secondary accession number(s): A8K2S0 , A8MT05, A8MT13, B7Z430, Q14083, Q3S4X3, Q5JRA5, Q5JRB0, Q5JRB1, Q5JRB2, Q6UVY8, Q86Y60, Q8N8M5, Q92580

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.