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Q5JR98

- TC1D4_HUMAN

UniProt

Q5JR98 - TC1D4_HUMAN

Protein

Tctex1 domain-containing protein 4

Gene

TCTEX1D4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein phosphatase 1 binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tctex1 domain-containing protein 4
    Alternative name(s):
    Protein N22.1
    Tctex-2-beta
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:32315. TCTEX1D4.

    Subcellular locationi

    GO - Cellular componenti

    1. sperm flagellum Source: MGI

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162405436.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Tctex1 domain-containing protein 4PRO_0000316872Add
    BLAST

    Proteomic databases

    PaxDbiQ5JR98.
    PRIDEiQ5JR98.

    PTM databases

    PhosphoSiteiQ5JR98.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    BgeeiQ5JR98.
    CleanExiHS_TCTEX1D4.
    GenevestigatoriQ5JR98.

    Organism-specific databases

    HPAiHPA062652.

    Interactioni

    Subunit structurei

    Interacts with ENG/endoglin, TGFBR2 and TGFBR3.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPP1CCP36873-12EBI-4311709,EBI-356289
    PPP1CCP36873-23EBI-4311709,EBI-3964623

    Protein-protein interaction databases

    BioGridi131262. 2 interactions.
    IntActiQ5JR98. 2 interactions.
    STRINGi9606.ENSP00000341803.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JR98.
    SMRiQ5JR98. Positions 127-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG277811.
    HOGENOMiHOG000154519.
    HOVERGENiHBG096850.
    InParanoidiQ5JR98.
    OMAiSYRTEPA.
    OrthoDBiEOG7FR7HR.
    PhylomeDBiQ5JR98.
    TreeFamiTF313904.

    Family and domain databases

    InterProiIPR005334. Tctex.
    [Graphical view]
    PANTHERiPTHR21255. PTHR21255. 1 hit.
    PfamiPF03645. Tctex-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5JR98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRPLPPGR QEEENAKDSG RKPSPVRPRG CLPSIDEARP AGPGPAPASR    50
    RGSMLGLAAS FSRRNSLVGP GAGPGGQRPS LGPVPPLGSR VSFSGLPLAP 100
    ARWVAPSYRT EPVPGERWEA ARAQRALEAA LAAGLHDACY SSDEAARLVR 150
    ELCEQVHVRL RELSPPRYKL VCSVVLGPRA GQGVHVVSRA LWDVARDGLA 200
    SVSYTNTSLF AVATVHGLYC E 221
    Length:221
    Mass (Da):23,353
    Last modified:February 15, 2005 - v1
    Checksum:i77A6BB803CC83373
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ132441 mRNA. Translation: ABA06522.1.
    AL592166 Genomic DNA. Translation: CAI13007.1.
    BC092499 mRNA. Translation: AAH92499.1.
    CCDSiCCDS30699.1.
    RefSeqiNP_001013654.1. NM_001013632.2.
    XP_005270876.1. XM_005270819.2.
    UniGeneiHs.585137.

    Genome annotation databases

    EnsembliENST00000339355; ENSP00000341803; ENSG00000188396.
    GeneIDi343521.
    KEGGihsa:343521.
    UCSCiuc001cmp.3. human.

    Polymorphism databases

    DMDMi74741821.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ132441 mRNA. Translation: ABA06522.1 .
    AL592166 Genomic DNA. Translation: CAI13007.1 .
    BC092499 mRNA. Translation: AAH92499.1 .
    CCDSi CCDS30699.1.
    RefSeqi NP_001013654.1. NM_001013632.2.
    XP_005270876.1. XM_005270819.2.
    UniGenei Hs.585137.

    3D structure databases

    ProteinModelPortali Q5JR98.
    SMRi Q5JR98. Positions 127-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131262. 2 interactions.
    IntActi Q5JR98. 2 interactions.
    STRINGi 9606.ENSP00000341803.

    PTM databases

    PhosphoSitei Q5JR98.

    Polymorphism databases

    DMDMi 74741821.

    Proteomic databases

    PaxDbi Q5JR98.
    PRIDEi Q5JR98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339355 ; ENSP00000341803 ; ENSG00000188396 .
    GeneIDi 343521.
    KEGGi hsa:343521.
    UCSCi uc001cmp.3. human.

    Organism-specific databases

    CTDi 343521.
    GeneCardsi GC01M045271.
    HGNCi HGNC:32315. TCTEX1D4.
    HPAi HPA062652.
    MIMi 611713. gene.
    neXtProti NX_Q5JR98.
    PharmGKBi PA162405436.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277811.
    HOGENOMi HOG000154519.
    HOVERGENi HBG096850.
    InParanoidi Q5JR98.
    OMAi SYRTEPA.
    OrthoDBi EOG7FR7HR.
    PhylomeDBi Q5JR98.
    TreeFami TF313904.

    Miscellaneous databases

    GenomeRNAii 343521.
    NextBioi 98567.
    PROi Q5JR98.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5JR98.
    CleanExi HS_TCTEX1D4.
    Genevestigatori Q5JR98.

    Family and domain databases

    InterProi IPR005334. Tctex.
    [Graphical view ]
    PANTHERi PTHR21255. PTHR21255. 1 hit.
    Pfami PF03645. Tctex-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors."
      Meng Q.-J., Lux A., Holloschi A., Li J., Hughes J.M.X., Foerg T., McCarthy J.E.G., Heagerty A.M., Kioschis P., Hafner M., Garland J.M.
      J. Biol. Chem. 281:37069-37080(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ENG; TGFBR2 AND TGFBR3, TISSUE SPECIFICITY.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiTC1D4_HUMAN
    AccessioniPrimary (citable) accession number: Q5JR98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3