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Q5JR98

- TC1D4_HUMAN

UniProt

Q5JR98 - TC1D4_HUMAN

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Protein
Tctex1 domain-containing protein 4
Gene
TCTEX1D4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein phosphatase 1 binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tctex1 domain-containing protein 4
Alternative name(s):
Protein N22.1
Tctex-2-beta
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:32315. TCTEX1D4.

Subcellular locationi

GO - Cellular componenti

  1. sperm flagellum Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Tctex1 domain-containing protein 4
PRO_0000316872Add
BLAST

Proteomic databases

PaxDbiQ5JR98.
PRIDEiQ5JR98.

PTM databases

PhosphoSiteiQ5JR98.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ5JR98.
CleanExiHS_TCTEX1D4.
GenevestigatoriQ5JR98.

Organism-specific databases

HPAiHPA062652.

Interactioni

Subunit structurei

Interacts with ENG/endoglin, TGFBR2 and TGFBR3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CCP36873-12EBI-4311709,EBI-356289
PPP1CCP36873-23EBI-4311709,EBI-3964623

Protein-protein interaction databases

BioGridi131262. 2 interactions.
IntActiQ5JR98. 2 interactions.
STRINGi9606.ENSP00000341803.

Structurei

3D structure databases

ProteinModelPortaliQ5JR98.
SMRiQ5JR98. Positions 127-218.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG277811.
HOGENOMiHOG000154519.
HOVERGENiHBG096850.
InParanoidiQ5JR98.
OMAiSYRTEPA.
OrthoDBiEOG7FR7HR.
PhylomeDBiQ5JR98.
TreeFamiTF313904.

Family and domain databases

InterProiIPR005334. Tctex.
[Graphical view]
PANTHERiPTHR21255. PTHR21255. 1 hit.
PfamiPF03645. Tctex-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JR98-1 [UniParc]FASTAAdd to Basket

« Hide

MASRPLPPGR QEEENAKDSG RKPSPVRPRG CLPSIDEARP AGPGPAPASR    50
RGSMLGLAAS FSRRNSLVGP GAGPGGQRPS LGPVPPLGSR VSFSGLPLAP 100
ARWVAPSYRT EPVPGERWEA ARAQRALEAA LAAGLHDACY SSDEAARLVR 150
ELCEQVHVRL RELSPPRYKL VCSVVLGPRA GQGVHVVSRA LWDVARDGLA 200
SVSYTNTSLF AVATVHGLYC E 221
Length:221
Mass (Da):23,353
Last modified:February 15, 2005 - v1
Checksum:i77A6BB803CC83373
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ132441 mRNA. Translation: ABA06522.1.
AL592166 Genomic DNA. Translation: CAI13007.1.
BC092499 mRNA. Translation: AAH92499.1.
CCDSiCCDS30699.1.
RefSeqiNP_001013654.1. NM_001013632.2.
XP_005270876.1. XM_005270819.2.
UniGeneiHs.585137.

Genome annotation databases

EnsembliENST00000339355; ENSP00000341803; ENSG00000188396.
ENST00000372200; ENSP00000361274; ENSG00000188396.
GeneIDi343521.
KEGGihsa:343521.
UCSCiuc001cmp.3. human.

Polymorphism databases

DMDMi74741821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ132441 mRNA. Translation: ABA06522.1 .
AL592166 Genomic DNA. Translation: CAI13007.1 .
BC092499 mRNA. Translation: AAH92499.1 .
CCDSi CCDS30699.1.
RefSeqi NP_001013654.1. NM_001013632.2.
XP_005270876.1. XM_005270819.2.
UniGenei Hs.585137.

3D structure databases

ProteinModelPortali Q5JR98.
SMRi Q5JR98. Positions 127-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131262. 2 interactions.
IntActi Q5JR98. 2 interactions.
STRINGi 9606.ENSP00000341803.

PTM databases

PhosphoSitei Q5JR98.

Polymorphism databases

DMDMi 74741821.

Proteomic databases

PaxDbi Q5JR98.
PRIDEi Q5JR98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339355 ; ENSP00000341803 ; ENSG00000188396 .
ENST00000372200 ; ENSP00000361274 ; ENSG00000188396 .
GeneIDi 343521.
KEGGi hsa:343521.
UCSCi uc001cmp.3. human.

Organism-specific databases

CTDi 343521.
GeneCardsi GC01M045271.
HGNCi HGNC:32315. TCTEX1D4.
HPAi HPA062652.
MIMi 611713. gene.
neXtProti NX_Q5JR98.
PharmGKBi PA162405436.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277811.
HOGENOMi HOG000154519.
HOVERGENi HBG096850.
InParanoidi Q5JR98.
OMAi SYRTEPA.
OrthoDBi EOG7FR7HR.
PhylomeDBi Q5JR98.
TreeFami TF313904.

Miscellaneous databases

GenomeRNAii 343521.
NextBioi 98567.
PROi Q5JR98.
SOURCEi Search...

Gene expression databases

Bgeei Q5JR98.
CleanExi HS_TCTEX1D4.
Genevestigatori Q5JR98.

Family and domain databases

InterProi IPR005334. Tctex.
[Graphical view ]
PANTHERi PTHR21255. PTHR21255. 1 hit.
Pfami PF03645. Tctex-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors."
    Meng Q.-J., Lux A., Holloschi A., Li J., Hughes J.M.X., Foerg T., McCarthy J.E.G., Heagerty A.M., Kioschis P., Hafner M., Garland J.M.
    J. Biol. Chem. 281:37069-37080(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ENG; TGFBR2 AND TGFBR3, TISSUE SPECIFICITY.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiTC1D4_HUMAN
AccessioniPrimary (citable) accession number: Q5JR98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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