Q5JR98 (TC1D4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tctex1 domain-containing protein 4

Alternative name(s):
Protein N22.1
Tctex-2-beta

Gene names

Name:

TCTEX1D4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with ENG/endoglin, TGFBR2 and TGFBR3. Ref.1
Tissue specificity	Ubiquitously expressed. Ref.1
Sequence similarities	Belongs to the dynein light chain Tctex-type family.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PPP1CC	P36873-1	2	EBI-4311709,EBI-356289
PPP1CC	P36873-2	3	EBI-4311709,EBI-3964623

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Tctex1 domain-containing protein 4		PRO_0000316872

Sequences

	Sequence		Length	Mass (Da)
	Q5JR98 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 77A6BB803CC83373	FASTA	221	23,353
	10 20 30 40 50 60 MASRPLPPGR QEEENAKDSG RKPSPVRPRG CLPSIDEARP AGPGPAPASR RGSMLGLAAS 70 80 90 100 110 120 FSRRNSLVGP GAGPGGQRPS LGPVPPLGSR VSFSGLPLAP ARWVAPSYRT EPVPGERWEA 130 140 150 160 170 180 ARAQRALEAA LAAGLHDACY SSDEAARLVR ELCEQVHVRL RELSPPRYKL VCSVVLGPRA 190 200 210 220 GQGVHVVSRA LWDVARDGLA SVSYTNTSLF AVATVHGLYC E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors." Meng Q.-J., Lux A., Holloschi A., Li J., Hughes J.M.X., Foerg T., McCarthy J.E.G., Heagerty A.M., Kioschis P., Hafner M., Garland J.M. J. Biol. Chem. 281:37069-37080(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ENG; TGFBR2 AND TGFBR3, TISSUE SPECIFICITY.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ132441 mRNA. Translation: ABA06522.1. AL592166 Genomic DNA. Translation: CAI13007.1. BC092499 mRNA. Translation: AAH92499.1.
IPI	IPI00259372.
RefSeq	NP_001013654.1. NM_001013632.2.
UniGene	Hs.585137.
3D structure databases
ProteinModelPortal	Q5JR98.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5JR98. 2 interactions.
STRING	9606.ENSP00000341803.
PTM databases
PhosphoSite	Q5JR98.
Polymorphism databases
DMDM	74741821.
Proteomic databases
PaxDb	Q5JR98.
PRIDE	Q5JR98.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339355; ENSP00000341803; ENSG00000188396. ENST00000372200; ENSP00000361274; ENSG00000188396.
GeneID	343521.
KEGG	hsa:343521.
UCSC	uc001cmp.3. human.
Organism-specific databases
CTD	343521.
GeneCards	GC01M045271.
HGNC	HGNC:32315. TCTEX1D4.
MIM	611713. gene.
neXtProt	NX_Q5JR98.
PharmGKB	PA162405436.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG277811.
HOGENOM	HOG000154519.
HOVERGEN	HBG096850.
InParanoid	Q5JR98.
OMA	VVSRALW.
OrthoDB	EOG4XH017.
PhylomeDB	Q5JR98.
Gene expression databases
Bgee	Q5JR98.
CleanEx	HS_TCTEX1D4.
Genevestigator	Q5JR98.
Family and domain databases
InterPro	IPR005334. Tctex. [Graphical view]
PANTHER	PTHR21255. PTHR21255. 1 hit.
Pfam	PF03645. Tctex-1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	343521.
NextBio	98567.
SOURCE	Search...

Entry information

Entry name

TC1D4_HUMAN

Accession

Primary (citable) accession number: Q5JR98

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.