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Q5JR98 (TC1D4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tctex1 domain-containing protein 4
Alternative name(s):
Protein N22.1
Tctex-2-beta
Gene names
Name:TCTEX1D4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with ENG/endoglin, TGFBR2 and TGFBR3. Ref.1

Tissue specificity

Ubiquitously expressed. Ref.1

Sequence similarities

Belongs to the dynein light chain Tctex-type family.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221Tctex1 domain-containing protein 4
PRO_0000316872

Sequences

Sequence LengthMass (Da)Tools
Q5JR98 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 77A6BB803CC83373

FASTA22123,353
        10         20         30         40         50         60 
MASRPLPPGR QEEENAKDSG RKPSPVRPRG CLPSIDEARP AGPGPAPASR RGSMLGLAAS 

        70         80         90        100        110        120 
FSRRNSLVGP GAGPGGQRPS LGPVPPLGSR VSFSGLPLAP ARWVAPSYRT EPVPGERWEA 

       130        140        150        160        170        180 
ARAQRALEAA LAAGLHDACY SSDEAARLVR ELCEQVHVRL RELSPPRYKL VCSVVLGPRA 

       190        200        210        220 
GQGVHVVSRA LWDVARDGLA SVSYTNTSLF AVATVHGLYC E 

« Hide

References

« Hide 'large scale' references
[1]"Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors."
Meng Q.-J., Lux A., Holloschi A., Li J., Hughes J.M.X., Foerg T., McCarthy J.E.G., Heagerty A.M., Kioschis P., Hafner M., Garland J.M.
J. Biol. Chem. 281:37069-37080(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ENG; TGFBR2 AND TGFBR3, TISSUE SPECIFICITY.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ132441 mRNA. Translation: ABA06522.1.
AL592166 Genomic DNA. Translation: CAI13007.1.
BC092499 mRNA. Translation: AAH92499.1.
RefSeqNP_001013654.1. NM_001013632.2.
XP_005270876.1. XM_005270819.2.
UniGeneHs.585137.

3D structure databases

ProteinModelPortalQ5JR98.
SMRQ5JR98. Positions 127-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131262. 2 interactions.
IntActQ5JR98. 2 interactions.
STRING9606.ENSP00000341803.

PTM databases

PhosphoSiteQ5JR98.

Polymorphism databases

DMDM74741821.

Proteomic databases

PaxDbQ5JR98.
PRIDEQ5JR98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339355; ENSP00000341803; ENSG00000188396.
ENST00000372200; ENSP00000361274; ENSG00000188396.
GeneID343521.
KEGGhsa:343521.
UCSCuc001cmp.3. human.

Organism-specific databases

CTD343521.
GeneCardsGC01M045271.
HGNCHGNC:32315. TCTEX1D4.
HPAHPA062652.
MIM611713. gene.
neXtProtNX_Q5JR98.
PharmGKBPA162405436.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277811.
HOGENOMHOG000154519.
HOVERGENHBG096850.
InParanoidQ5JR98.
OMAVVSRALW.
OrthoDBEOG7FR7HR.
PhylomeDBQ5JR98.
TreeFamTF313904.

Gene expression databases

BgeeQ5JR98.
CleanExHS_TCTEX1D4.
GenevestigatorQ5JR98.

Family and domain databases

InterProIPR005334. Tctex.
[Graphical view]
PANTHERPTHR21255. PTHR21255. 1 hit.
PfamPF03645. Tctex-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi343521.
NextBio98567.
PROQ5JR98.
SOURCESearch...

Entry information

Entry nameTC1D4_HUMAN
AccessionPrimary (citable) accession number: Q5JR98
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM