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Protein

Tctex1 domain-containing protein 4

Gene

TCTEX1D4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tctex1 domain-containing protein 4
Alternative name(s):
Protein N22.1
Tctex-2-beta
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32315. TCTEX1D4.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. axoneme Source: Ensembl
  3. microtubule organizing center Source: Ensembl
  4. nucleus Source: Ensembl
  5. sperm flagellum Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405436.

Polymorphism and mutation databases

BioMutaiTCTEX1D4.
DMDMi74741821.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Tctex1 domain-containing protein 4PRO_0000316872Add
BLAST

Proteomic databases

PaxDbiQ5JR98.
PRIDEiQ5JR98.

PTM databases

PhosphoSiteiQ5JR98.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ5JR98.
CleanExiHS_TCTEX1D4.
GenevestigatoriQ5JR98.

Organism-specific databases

HPAiHPA062652.

Interactioni

Subunit structurei

Interacts with ENG/endoglin, TGFBR2 and TGFBR3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CCP36873-12EBI-4311709,EBI-356289
PPP1CCP36873-23EBI-4311709,EBI-3964623

Protein-protein interaction databases

BioGridi131262. 2 interactions.
IntActiQ5JR98. 2 interactions.
STRINGi9606.ENSP00000341803.

Structurei

3D structure databases

ProteinModelPortaliQ5JR98.
SMRiQ5JR98. Positions 127-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG277811.
GeneTreeiENSGT00530000063097.
HOGENOMiHOG000154519.
HOVERGENiHBG096850.
InParanoidiQ5JR98.
OMAiVVSRALW.
OrthoDBiEOG7FR7HR.
PhylomeDBiQ5JR98.
TreeFamiTF313904.

Family and domain databases

InterProiIPR005334. Tctex.
[Graphical view]
PANTHERiPTHR21255. PTHR21255. 1 hit.
PfamiPF03645. Tctex-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JR98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRPLPPGR QEEENAKDSG RKPSPVRPRG CLPSIDEARP AGPGPAPASR
60 70 80 90 100
RGSMLGLAAS FSRRNSLVGP GAGPGGQRPS LGPVPPLGSR VSFSGLPLAP
110 120 130 140 150
ARWVAPSYRT EPVPGERWEA ARAQRALEAA LAAGLHDACY SSDEAARLVR
160 170 180 190 200
ELCEQVHVRL RELSPPRYKL VCSVVLGPRA GQGVHVVSRA LWDVARDGLA
210 220
SVSYTNTSLF AVATVHGLYC E
Length:221
Mass (Da):23,353
Last modified:February 15, 2005 - v1
Checksum:i77A6BB803CC83373
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ132441 mRNA. Translation: ABA06522.1.
AL592166 Genomic DNA. Translation: CAI13007.1.
BC092499 mRNA. Translation: AAH92499.1.
CCDSiCCDS30699.1.
RefSeqiNP_001013654.1. NM_001013632.3.
XP_005270876.1. XM_005270819.3.
UniGeneiHs.585137.

Genome annotation databases

EnsembliENST00000339355; ENSP00000341803; ENSG00000188396.
GeneIDi343521.
KEGGihsa:343521.
UCSCiuc001cmp.3. human.

Polymorphism and mutation databases

BioMutaiTCTEX1D4.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ132441 mRNA. Translation: ABA06522.1.
AL592166 Genomic DNA. Translation: CAI13007.1.
BC092499 mRNA. Translation: AAH92499.1.
CCDSiCCDS30699.1.
RefSeqiNP_001013654.1. NM_001013632.3.
XP_005270876.1. XM_005270819.3.
UniGeneiHs.585137.

3D structure databases

ProteinModelPortaliQ5JR98.
SMRiQ5JR98. Positions 127-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131262. 2 interactions.
IntActiQ5JR98. 2 interactions.
STRINGi9606.ENSP00000341803.

PTM databases

PhosphoSiteiQ5JR98.

Polymorphism and mutation databases

BioMutaiTCTEX1D4.
DMDMi74741821.

Proteomic databases

PaxDbiQ5JR98.
PRIDEiQ5JR98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339355; ENSP00000341803; ENSG00000188396.
GeneIDi343521.
KEGGihsa:343521.
UCSCiuc001cmp.3. human.

Organism-specific databases

CTDi343521.
GeneCardsiGC01M045271.
HGNCiHGNC:32315. TCTEX1D4.
HPAiHPA062652.
MIMi611713. gene.
neXtProtiNX_Q5JR98.
PharmGKBiPA162405436.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG277811.
GeneTreeiENSGT00530000063097.
HOGENOMiHOG000154519.
HOVERGENiHBG096850.
InParanoidiQ5JR98.
OMAiVVSRALW.
OrthoDBiEOG7FR7HR.
PhylomeDBiQ5JR98.
TreeFamiTF313904.

Miscellaneous databases

GenomeRNAii343521.
NextBioi98567.
PROiQ5JR98.
SOURCEiSearch...

Gene expression databases

BgeeiQ5JR98.
CleanExiHS_TCTEX1D4.
GenevestigatoriQ5JR98.

Family and domain databases

InterProiIPR005334. Tctex.
[Graphical view]
PANTHERiPTHR21255. PTHR21255. 1 hit.
PfamiPF03645. Tctex-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors."
    Meng Q.-J., Lux A., Holloschi A., Li J., Hughes J.M.X., Foerg T., McCarthy J.E.G., Heagerty A.M., Kioschis P., Hafner M., Garland J.M.
    J. Biol. Chem. 281:37069-37080(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ENG; TGFBR2 AND TGFBR3, TISSUE SPECIFICITY.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiTC1D4_HUMAN
AccessioniPrimary (citable) accession number: Q5JR98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: April 29, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.