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Q5JR59

- MTUS2_HUMAN

UniProt

Q5JR59 - MTUS2_HUMAN

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Protein

Microtubule-associated tumor suppressor candidate 2

Gene
MTUS2, CAZIP, KIAA0774, TIP150
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.1 Publication

GO - Molecular functioni

  1. microtubule binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. protein homodimerization activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated tumor suppressor candidate 2
Alternative name(s):
Cardiac zipper protein
Microtubule plus-end tracking protein TIP150
Short name:
Tracking protein of 150 kDa
Gene namesi
Name:MTUS2
Synonyms:CAZIP, KIAA0774, TIP150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:20595. MTUS2.

Subcellular locationi

Cytoplasmcytoskeleton
Note: Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165505194.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13691369Microtubule-associated tumor suppressor candidate 2PRO_0000280111Add
BLAST

Proteomic databases

MaxQBiQ5JR59.
PaxDbiQ5JR59.
PRIDEiQ5JR59.

PTM databases

PhosphoSiteiQ5JR59.

Expressioni

Tissue specificityi

Detected in embryonic stem cells differentiating to cardiomyocytes.1 Publication

Gene expression databases

ArrayExpressiQ5JR59.
BgeeiQ5JR59.
CleanExiHS_KIAA0774.
GenevestigatoriQ5JR59.

Organism-specific databases

HPAiHPA031474.
HPA031475.

Interactioni

Subunit structurei

Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KIF2CQ996614EBI-742948,EBI-1642317
MAPRE1Q156917EBI-742948,EBI-1004115
PSMA1P257863EBI-742948,EBI-359352

Protein-protein interaction databases

BioGridi116880. 8 interactions.
IntActiQ5JR59. 20 interactions.
MINTiMINT-1457050.
STRINGi9606.ENSP00000255289.

Structurei

3D structure databases

ProteinModelPortaliQ5JR59.
SMRiQ5JR59. Positions 1300-1334.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni641 – 980340Mediates interaction with MAPRE1Add
BLAST
Regioni801 – 1150350Localization to the growing distal tip of microtubulesAdd
BLAST
Regioni801 – 89090Sufficient for interaction with KIF2CAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili991 – 1335345 Reviewed predictionAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the MTUS1 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG119660.
InParanoidiQ5JR59.
PhylomeDBiQ5JR59.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5JR59-2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSVPVAPKKS CYTQLRDNRN AARNNNESIL SLGDTNANQI MLEVSSSHDE     50
SKTCDLGDEI GNTNSSEPEN RTHFHKEFHQ LQGFGKGSQA GSASLKDFRL 100
SSTIQRELNE EHTVERGTDS LQTTRSIQGP SLSSWRNVMS EASLDVLAKR 150
DAEIPRHVPK DKLAKTLDNE ELRRHSLERA SSSVAAVGSL TPQHPQPLSL 200
DSREARGQIP GGGEGPQKTL PDHAVPAAFP ATDSTSEGKS VRHPKPSTSE 250
SKQSTPSETQ TVGAHVLQVC SEHTSHSAHP EPALNLTLAS KEIPSKLEAQ 300
LGQGKGEAKL DLKYVPPRRV EQEGKAAQEG YLGCHKEENL SALEGRDPCG 350
EAHPEATDAL GHLLNSDLHH LGVGRGNCEE KRGVNPGEQD SLHTTPKQGS 400
ASLGGADNQP TGKISPCAGE KLGERTSSSF SPGDSHVAFI PNNLTDSKPL 450
DVIEEERRLG SGNKDSVMVL VFNPSVGENK TEVPEPLDPQ SGRSEARESK 500
EVTTSVAENR NLLENADKIE STSARADSVL NIPAPLHPET TVNMTYQPTT 550
PSSSFQDVSV FGMDAGSPLV VPPPTDSARL LNTSPKVPDK NTCPSGIPKP 600
VFTHSKDTPS SQEGMENYQV EKTEERTETK PIIMPKPKHV RPKIITYIRR 650
NPQALGQVDA SLVPVGLPYA PPTCTMPLPH EEKAAGGDLK PSANLYEKFK 700
PDLQKPRVFS SGLMVSGIKP PGHPFSQMSE KFLQEVTDHP GKEEFCSPPY 750
AHYEVPPTFY RSAMLLKPQL GLGAMSRLPS AKSRILIASQ RSSASAIHPP 800
GPITTATSLY SSDPSADLKK ASSSNAAKSN LPKSGLRPPG YSRLPAAKLA 850
AFGFVRSSSV SSVSSTQSGD SAQPEQGRPA TRSTFGNEEQ PVLKASLPSK 900
DTPKGAGRVA PPASSSVTAP RRSLLPAPKS TSTPAGTKKD AQKDQDTNKP 950
AVSSPKRVAA STTKLHSPGY PKQRTAAARN GFPPKPDPQA REAERQLVLR 1000
LKERCEQQTR QLGVAQGELK RAICGFDALA VATQHFFRKN ESALVKEKEL 1050
SIELANIRDE VAFHTAKCEK LQKEKEELER RFEDEVKRLG WQQQAELQEL 1100
EERLQLQFEA EMARLQEEHG DQLLSIRCQH QEQVEDLTAS HDAALLEMEN 1150
NHTVAITILQ DDHDHKVQEL MSTHELEKKE LEENFEKLRL SLQDQVDTLT 1200
FQSQSLRDRA RRFEEALRKN TEEQLEIALA PYQHLEEDMK SLKQVLEMKN 1250
QQIHEQEKKI LELEKLAEKN IILEEKIQVL QQQNEDLKAR IDQNTVVTRQ 1300
LSEENANLQE YVEKETQEKK RLSRTNEELL WKLQTGDPTS PIKLSPTSPV 1350
YRGSSSGPSS PARVSTTPR 1369
Length:1,369
Mass (Da):150,195
Last modified:September 22, 2009 - v3
Checksum:i4BF7A754AB1ED7CF
GO
Isoform 2 (identifier: Q5JR59-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1021: Missing.
     1022-1039: AICGFDALAVATQHFFRK → MGHCCCKPYNCLQCLDKT

Note: No experimental confirmation available.

Show »
Length:348
Mass (Da):40,746
Checksum:iD352305A4FA0566B
GO
Isoform 3 (identifier: Q5JR59-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1111: Missing.

Show »
Length:258
Mass (Da):30,064
Checksum:i83363B0586426D1A
GO

Sequence cautioni

The sequence AAI50246.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA34494.2 differs from that shown. Reason: Erroneous initiation.
The sequence CAI39910.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI39912.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI40386.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI40565.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI40566.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI41204.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti955 – 9551P → H.
Corresponds to variant rs12874207 [ dbSNP | Ensembl ].
VAR_055941
Natural varianti1071 – 10711L → Q.
Corresponds to variant rs17073511 [ dbSNP | Ensembl ].
VAR_058831

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11111111Missing in isoform 3. VSP_023540Add
BLAST
Alternative sequencei1 – 10211021Missing in isoform 2. VSP_023541Add
BLAST
Alternative sequencei1022 – 103918AICGF…HFFRK → MGHCCCKPYNCLQCLDKT in isoform 2. VSP_023543Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti942 – 9421Q → P in BAA34494. 1 Publication
Sequence conflicti942 – 9421Q → P in AAI50246. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018317 mRNA. Translation: BAA34494.2. Different initiation.
AK293970 mRNA. Translation: BAG57342.1.
AL596114
, AL160255, AL596092, AL607144 Genomic DNA. Translation: CAI39910.1. Sequence problems.
AL596114, AL607144 Genomic DNA. Translation: CAI39912.1. Sequence problems.
AL596092
, AL160255, AL596114, AL607144 Genomic DNA. Translation: CAI40386.1. Sequence problems.
AL607144
, AL160255, AL596092, AL596114 Genomic DNA. Translation: CAI40565.1. Sequence problems.
AL607144, AL596114 Genomic DNA. Translation: CAI40566.1. Sequence problems.
AL160255
, AL596092, AL596114, AL607144 Genomic DNA. Translation: CAI41204.1. Sequence problems.
BC032481 mRNA. Translation: AAH32481.1.
BC119654 mRNA. Translation: AAI19655.1.
BC119655 mRNA. Translation: AAI19656.1.
BC129985 mRNA. Translation: AAI29986.1.
BC150245 mRNA. Translation: AAI50246.1. Different initiation.
CCDSiCCDS41874.1. [Q5JR59-3]
RefSeqiNP_001028774.2. NM_001033602.2.
NP_056048.1. NM_015233.5. [Q5JR59-3]
UniGeneiHs.22287.

Genome annotation databases

EnsembliENST00000380808; ENSP00000370186; ENSG00000132938. [Q5JR59-3]
ENST00000542829; ENSP00000445403; ENSG00000132938. [Q5JR59-4]
GeneIDi23281.
KEGGihsa:23281.
UCSCiuc001usm.4. human. [Q5JR59-3]
uc010aau.3. human. [Q5JR59-4]

Polymorphism databases

DMDMi259016371.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018317 mRNA. Translation: BAA34494.2 . Different initiation.
AK293970 mRNA. Translation: BAG57342.1 .
AL596114
, AL160255 , AL596092 , AL607144 Genomic DNA. Translation: CAI39910.1 . Sequence problems.
AL596114 , AL607144 Genomic DNA. Translation: CAI39912.1 . Sequence problems.
AL596092
, AL160255 , AL596114 , AL607144 Genomic DNA. Translation: CAI40386.1 . Sequence problems.
AL607144
, AL160255 , AL596092 , AL596114 Genomic DNA. Translation: CAI40565.1 . Sequence problems.
AL607144 , AL596114 Genomic DNA. Translation: CAI40566.1 . Sequence problems.
AL160255
, AL596092 , AL596114 , AL607144 Genomic DNA. Translation: CAI41204.1 . Sequence problems.
BC032481 mRNA. Translation: AAH32481.1 .
BC119654 mRNA. Translation: AAI19655.1 .
BC119655 mRNA. Translation: AAI19656.1 .
BC129985 mRNA. Translation: AAI29986.1 .
BC150245 mRNA. Translation: AAI50246.1 . Different initiation.
CCDSi CCDS41874.1. [Q5JR59-3 ]
RefSeqi NP_001028774.2. NM_001033602.2.
NP_056048.1. NM_015233.5. [Q5JR59-3 ]
UniGenei Hs.22287.

3D structure databases

ProteinModelPortali Q5JR59.
SMRi Q5JR59. Positions 1300-1334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116880. 8 interactions.
IntActi Q5JR59. 20 interactions.
MINTi MINT-1457050.
STRINGi 9606.ENSP00000255289.

PTM databases

PhosphoSitei Q5JR59.

Polymorphism databases

DMDMi 259016371.

Proteomic databases

MaxQBi Q5JR59.
PaxDbi Q5JR59.
PRIDEi Q5JR59.

Protocols and materials databases

DNASUi 23281.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380808 ; ENSP00000370186 ; ENSG00000132938 . [Q5JR59-3 ]
ENST00000542829 ; ENSP00000445403 ; ENSG00000132938 . [Q5JR59-4 ]
GeneIDi 23281.
KEGGi hsa:23281.
UCSCi uc001usm.4. human. [Q5JR59-3 ]
uc010aau.3. human. [Q5JR59-4 ]

Organism-specific databases

CTDi 23281.
GeneCardsi GC13P029599.
H-InvDB HIX0020942.
HGNCi HGNC:20595. MTUS2.
HPAi HPA031474.
HPA031475.
neXtProti NX_Q5JR59.
PharmGKBi PA165505194.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG119660.
InParanoidi Q5JR59.
PhylomeDBi Q5JR59.

Miscellaneous databases

ChiTaRSi MTUS2. human.
GenomeRNAii 23281.
NextBioi 45074.
PROi Q5JR59.

Gene expression databases

ArrayExpressi Q5JR59.
Bgeei Q5JR59.
CleanExi HS_KIAA0774.
Genevestigatori Q5JR59.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Cerebellum.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Pancreas.
  6. "CAZIP, a novel protein expressed in the developing heart and nervous system."
    Du Puy L., Beqqali A., Monshouwer-Kloots J., Haagsman H.P., Roelen B.A., Passier R.
    Dev. Dyn. 238:2903-2911(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "TIP150 interacts with and targets MCAK at the microtubule plus ends."
    Jiang K., Wang J., Liu J., Ward T., Wordeman L., Davidson A., Wang F., Yao X.
    EMBO Rep. 10:857-865(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KIF2C AND MAPRE1, HOMODIMERIZATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMTUS2_HUMAN
AccessioniPrimary (citable) accession number: Q5JR59
Secondary accession number(s): A7E292
, B4DF81, O94872, Q08E97, Q5JQR3, Q8N5E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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