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Protein

Microtubule-associated tumor suppressor candidate 2

Gene

MTUS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.1 Publication

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated tumor suppressor candidate 2
Alternative name(s):
Cardiac zipper protein
Microtubule plus-end tracking protein TIP150
Short name:
Tracking protein of 150 kDa
Gene namesi
Name:MTUS2
Synonyms:CAZIP, KIAA0774, TIP150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20595. MTUS2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • microtubule Source: UniProtKB-KW
  • nucleus Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165505194.

Polymorphism and mutation databases

BioMutaiMTUS2.
DMDMi259016371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13691369Microtubule-associated tumor suppressor candidate 2PRO_0000280111Add
BLAST

Proteomic databases

MaxQBiQ5JR59.
PaxDbiQ5JR59.
PRIDEiQ5JR59.

PTM databases

PhosphoSiteiQ5JR59.

Expressioni

Tissue specificityi

Detected in embryonic stem cells differentiating to cardiomyocytes.1 Publication

Gene expression databases

BgeeiQ5JR59.
CleanExiHS_KIAA0774.
ExpressionAtlasiQ5JR59. baseline and differential.
GenevisibleiQ5JR59. HS.

Organism-specific databases

HPAiHPA031474.
HPA031475.

Interactioni

Subunit structurei

Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K8Y53EBI-742948,EBI-10174635
A8KAD63EBI-742948,EBI-10174974
Q6ZVW33EBI-742948,EBI-10255586
Q9H6F03EBI-742948,EBI-10307481
AENQ8WTP83EBI-742948,EBI-8637627
AESQ081173EBI-742948,EBI-717810
AFF4Q9UHB73EBI-742948,EBI-395282
AFF4Q9UHB7-23EBI-742948,EBI-10261324
ALS2CR11Q53TS83EBI-742948,EBI-739879
AQP1P299723EBI-742948,EBI-745213
BMP7A8K5713EBI-742948,EBI-10174327
BYSLQ138955EBI-742948,EBI-358049
C14orf105Q17R993EBI-742948,EBI-10238351
C19orf66Q9NUL53EBI-742948,EBI-10313866
C1orf109Q9NX043EBI-742948,EBI-8643161
C1orf216Q8TAB54EBI-742948,EBI-747505
C20orf195Q9BVV23EBI-742948,EBI-744935
C21orf58Q0VAL73EBI-742948,EBI-10226774
CATIPQ7Z7H33EBI-742948,EBI-10258233
CATSPER1Q8NEC53EBI-742948,EBI-744545
CBX8Q9HC523EBI-742948,EBI-712912
CCDC116Q8IYX34EBI-742948,EBI-744311
CCDC146Q8IYE0-23EBI-742948,EBI-10247802
CCDC17Q96LX73EBI-742948,EBI-719840
CCDC60Q8IWA63EBI-742948,EBI-10262147
CCHCR1Q8TD31-33EBI-742948,EBI-10175300
CDC20BQ86Y333EBI-742948,EBI-10260504
CDC73Q6P1J95EBI-742948,EBI-930143
CDK18Q070023EBI-742948,EBI-746238
CDK5R1Q150783EBI-742948,EBI-746189
CDK5R1Q8N6193EBI-742948,EBI-10266998
CDK5R1Q8TAM43EBI-742948,EBI-10271838
CDKL3Q8IVW43EBI-742948,EBI-3919850
CEP57L1Q8IYX83EBI-742948,EBI-1104570
CEP57L1Q8IYX8-23EBI-742948,EBI-10181988
CEP95Q96GE43EBI-742948,EBI-372775
CERKQ8TCT03EBI-742948,EBI-10274247
COG2Q14746-23EBI-742948,EBI-10233912
CREB5Q02930-33EBI-742948,EBI-10192698
CRY2Q49AN03EBI-742948,EBI-2212355
CTSZQ9UBR23EBI-742948,EBI-8636823
CXCL11O146253EBI-742948,EBI-2871971
DCDC2BA2VCK23EBI-742948,EBI-10173222
DCTN4Q9UJW04EBI-742948,EBI-2134033
DLGAP5Q153983EBI-742948,EBI-748280
DMRT3Q9NQL93EBI-742948,EBI-9679045
DOCK2Q926083EBI-742948,EBI-448771
DTNBO609413EBI-742948,EBI-740402
FAM13CQ8NE313EBI-742948,EBI-751248
FAM161AQ3B8203EBI-742948,EBI-719941
FAM74A6Q5TZK33EBI-742948,EBI-10247271
FAM90A1Q86YD73EBI-742948,EBI-6658203
FBXL18Q96D163EBI-742948,EBI-744419
FBXO34Q9NWN33EBI-742948,EBI-719816
FCHSD2O948684EBI-742948,EBI-1215612
GAL3ST2Q9H3Q33EBI-742948,EBI-10306373
GTPBP10A4D1E93EBI-742948,EBI-5453796
HAUS1Q96CS23EBI-742948,EBI-2514791
HCKP086313EBI-742948,EBI-346340
HDAC4P565243EBI-742948,EBI-308629
HSF2Q03933-23EBI-742948,EBI-10223348
ITGB5L7RT223EBI-742948,EBI-10178729
KAT5Q929933EBI-742948,EBI-399080
KIF2CQ996614EBI-742948,EBI-1642317
LENG1Q96BZ83EBI-742948,EBI-726510
LIMS2Q7Z4I7-53EBI-742948,EBI-10257651
LMO2P257913EBI-742948,EBI-739696
LNX1Q8TBB13EBI-742948,EBI-739832
LRR1Q96L503EBI-742948,EBI-2510106
LYSMD1Q96S903EBI-742948,EBI-10293291
MAGEA8P433613EBI-742948,EBI-10182930
MAPRE1Q156917EBI-742948,EBI-1004115
MARK4Q6IPE93EBI-742948,EBI-10250211
MFAP1P550813EBI-742948,EBI-1048159
MTMR6Q9Y2173EBI-742948,EBI-766064
NDEL1Q9GZM83EBI-742948,EBI-928842
NDOR1Q9UHB43EBI-742948,EBI-10249760
NELFEP186153EBI-742948,EBI-348444
NUDT10Q8NFP73EBI-742948,EBI-726826
ODF1Q149903EBI-742948,EBI-10234557
PDE4DIPQ5VU433EBI-742948,EBI-1105124
PIN1Q135263EBI-742948,EBI-714158
PKP2Q999594EBI-742948,EBI-702235
PLSCR4Q9NRQ24EBI-742948,EBI-769257
POLDIP2Q9Y2S73EBI-742948,EBI-713000
POLDIP3Q8WUT13EBI-742948,EBI-10276663
PPHLN1Q8NEY83EBI-742948,EBI-474076
PPP1R18Q6NYC83EBI-742948,EBI-2557469
PRKAA1Q131313EBI-742948,EBI-1181405
PRPF31F1T0A53EBI-742948,EBI-10177194
PSMA1P257866EBI-742948,EBI-359352
PTPMT1Q8WUK03EBI-742948,EBI-7199479
RAB3IL1Q8TBN03EBI-742948,EBI-743796
RGS2P412203EBI-742948,EBI-712388
RHPN1Q8TCX53EBI-742948,EBI-746325
ROBO3Q96HH03EBI-742948,EBI-10288358
RPA1P276943EBI-742948,EBI-621389
RPL9P9P329693EBI-742948,EBI-358122
RTP5Q14D333EBI-742948,EBI-10217913
SCELO951713EBI-742948,EBI-7543896
SDCBPO005603EBI-742948,EBI-727004
SELMQ8WWX93EBI-742948,EBI-10277687
SETD5Q9C0A6-23EBI-742948,EBI-10303449
SH2D4AQ9H7883EBI-742948,EBI-747035
SH2D4AQ9H788-23EBI-742948,EBI-10308083
SH3RF2Q08AM83EBI-742948,EBI-10225873
SLC23A1Q9UHI73EBI-742948,EBI-1759386
SLC25A6P122364EBI-742948,EBI-356254
SLIRPQ9GZT33EBI-742948,EBI-1050793
SMARCE1Q969G33EBI-742948,EBI-455078
SNAI1O958633EBI-742948,EBI-1045459
SNRPAP090123EBI-742948,EBI-607085
SNRPB2P085793EBI-742948,EBI-1053651
SNW1Q135733EBI-742948,EBI-632715
SPATA8Q6RVD63EBI-742948,EBI-8635958
SPG7Q9UQ904EBI-742948,EBI-717201
STK16O757163EBI-742948,EBI-749295
SYT6Q5T7P8-23EBI-742948,EBI-10246152
TAF13Q155433EBI-742948,EBI-1026992
THAP7Q9BT493EBI-742948,EBI-741350
TP53RKQ96S443EBI-742948,EBI-739588
TRIM42A1L4B63EBI-742948,EBI-10172216
TSGA10IPQ3SY003EBI-742948,EBI-10241197
TSHZ3A1L0U73EBI-742948,EBI-10171826
TXN2Q997573EBI-742948,EBI-2932492
USP2O756043EBI-742948,EBI-743272
WACQ9BTA93EBI-742948,EBI-749118
WACQ9BTA9-23EBI-742948,EBI-10298216
WDYHV1Q96HA83EBI-742948,EBI-741158
ZC2HC1CQ53FD04EBI-742948,EBI-740767
ZFC3H1G3V1X13EBI-742948,EBI-6448783
ZFP2Q6ZN573EBI-742948,EBI-7236323
ZFYVE21Q9BQ243EBI-742948,EBI-2849569
ZMAT2Q96NC03EBI-742948,EBI-2682299
ZNF136P527374EBI-742948,EBI-749129
ZNF20P170243EBI-742948,EBI-717634
ZNF232Q9UNY53EBI-742948,EBI-749023
ZNF250P15622-33EBI-742948,EBI-10177272
ZNF3P170363EBI-742948,EBI-1640965
ZNF3Q86U763EBI-742948,EBI-10258769
ZNF329Q86UD43EBI-742948,EBI-7233259
ZNF337Q9Y3M93EBI-742948,EBI-714987
ZNF410Q86VK43EBI-742948,EBI-720304
ZNF415Q09FC83EBI-742948,EBI-10226171
ZNF417Q8TAU33EBI-742948,EBI-740727
ZNF426Q9BUY53EBI-742948,EBI-743265
ZNF439Q8NDP44EBI-742948,EBI-747580
ZNF440Q8IYI83EBI-742948,EBI-726439
ZNF490Q9ULM24EBI-742948,EBI-1105370
ZNF572A1L4E93EBI-742948,EBI-10172590
ZNF572Q7Z3I73EBI-742948,EBI-10257016
ZNF581Q9P0T43EBI-742948,EBI-745520
ZNF587Q96SQ53EBI-742948,EBI-6427977
ZNF599Q96NL33EBI-742948,EBI-8653994
ZNF607Q96SK33EBI-742948,EBI-747175
ZNF624Q9P2J83EBI-742948,EBI-9116427
ZNF670Q9BS343EBI-742948,EBI-745276
ZNF785A8K8V03EBI-742948,EBI-3925400
ZNF844Q08AG53EBI-742948,EBI-10225757
ZSCAN12O433093EBI-742948,EBI-1210440
ZSCAN26Q166703EBI-742948,EBI-3920053

Protein-protein interaction databases

BioGridi116880. 170 interactions.
IntActiQ5JR59. 163 interactions.
MINTiMINT-1457050.
STRINGi9606.ENSP00000392057.

Structurei

3D structure databases

ProteinModelPortaliQ5JR59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni641 – 980340Mediates interaction with MAPRE1Add
BLAST
Regioni801 – 1150350Localization to the growing distal tip of microtubulesAdd
BLAST
Regioni801 – 89090Sufficient for interaction with KIF2CAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili991 – 1335345Sequence AnalysisAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the MTUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG119660.
GeneTreeiENSGT00390000006245.
InParanoidiQ5JR59.
PhylomeDBiQ5JR59.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JR59-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVPVAPKKS CYTQLRDNRN AARNNNESIL SLGDTNANQI MLEVSSSHDE
60 70 80 90 100
SKTCDLGDEI GNTNSSEPEN RTHFHKEFHQ LQGFGKGSQA GSASLKDFRL
110 120 130 140 150
SSTIQRELNE EHTVERGTDS LQTTRSIQGP SLSSWRNVMS EASLDVLAKR
160 170 180 190 200
DAEIPRHVPK DKLAKTLDNE ELRRHSLERA SSSVAAVGSL TPQHPQPLSL
210 220 230 240 250
DSREARGQIP GGGEGPQKTL PDHAVPAAFP ATDSTSEGKS VRHPKPSTSE
260 270 280 290 300
SKQSTPSETQ TVGAHVLQVC SEHTSHSAHP EPALNLTLAS KEIPSKLEAQ
310 320 330 340 350
LGQGKGEAKL DLKYVPPRRV EQEGKAAQEG YLGCHKEENL SALEGRDPCG
360 370 380 390 400
EAHPEATDAL GHLLNSDLHH LGVGRGNCEE KRGVNPGEQD SLHTTPKQGS
410 420 430 440 450
ASLGGADNQP TGKISPCAGE KLGERTSSSF SPGDSHVAFI PNNLTDSKPL
460 470 480 490 500
DVIEEERRLG SGNKDSVMVL VFNPSVGENK TEVPEPLDPQ SGRSEARESK
510 520 530 540 550
EVTTSVAENR NLLENADKIE STSARADSVL NIPAPLHPET TVNMTYQPTT
560 570 580 590 600
PSSSFQDVSV FGMDAGSPLV VPPPTDSARL LNTSPKVPDK NTCPSGIPKP
610 620 630 640 650
VFTHSKDTPS SQEGMENYQV EKTEERTETK PIIMPKPKHV RPKIITYIRR
660 670 680 690 700
NPQALGQVDA SLVPVGLPYA PPTCTMPLPH EEKAAGGDLK PSANLYEKFK
710 720 730 740 750
PDLQKPRVFS SGLMVSGIKP PGHPFSQMSE KFLQEVTDHP GKEEFCSPPY
760 770 780 790 800
AHYEVPPTFY RSAMLLKPQL GLGAMSRLPS AKSRILIASQ RSSASAIHPP
810 820 830 840 850
GPITTATSLY SSDPSADLKK ASSSNAAKSN LPKSGLRPPG YSRLPAAKLA
860 870 880 890 900
AFGFVRSSSV SSVSSTQSGD SAQPEQGRPA TRSTFGNEEQ PVLKASLPSK
910 920 930 940 950
DTPKGAGRVA PPASSSVTAP RRSLLPAPKS TSTPAGTKKD AQKDQDTNKP
960 970 980 990 1000
AVSSPKRVAA STTKLHSPGY PKQRTAAARN GFPPKPDPQA REAERQLVLR
1010 1020 1030 1040 1050
LKERCEQQTR QLGVAQGELK RAICGFDALA VATQHFFRKN ESALVKEKEL
1060 1070 1080 1090 1100
SIELANIRDE VAFHTAKCEK LQKEKEELER RFEDEVKRLG WQQQAELQEL
1110 1120 1130 1140 1150
EERLQLQFEA EMARLQEEHG DQLLSIRCQH QEQVEDLTAS HDAALLEMEN
1160 1170 1180 1190 1200
NHTVAITILQ DDHDHKVQEL MSTHELEKKE LEENFEKLRL SLQDQVDTLT
1210 1220 1230 1240 1250
FQSQSLRDRA RRFEEALRKN TEEQLEIALA PYQHLEEDMK SLKQVLEMKN
1260 1270 1280 1290 1300
QQIHEQEKKI LELEKLAEKN IILEEKIQVL QQQNEDLKAR IDQNTVVTRQ
1310 1320 1330 1340 1350
LSEENANLQE YVEKETQEKK RLSRTNEELL WKLQTGDPTS PIKLSPTSPV
1360
YRGSSSGPSS PARVSTTPR
Length:1,369
Mass (Da):150,195
Last modified:September 22, 2009 - v3
Checksum:i4BF7A754AB1ED7CF
GO
Isoform 2 (identifier: Q5JR59-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1021: Missing.
     1022-1039: AICGFDALAVATQHFFRK → MGHCCCKPYNCLQCLDKT

Note: No experimental confirmation available.
Show »
Length:348
Mass (Da):40,746
Checksum:iD352305A4FA0566B
GO
Isoform 3 (identifier: Q5JR59-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1111: Missing.

Show »
Length:258
Mass (Da):30,064
Checksum:i83363B0586426D1A
GO

Sequence cautioni

The sequence AAI50246.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA34494.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI39910.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI39912.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI40386.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI40565.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI40566.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI41204.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti942 – 9421Q → P in BAA34494 (PubMed:9872452).Curated
Sequence conflicti942 – 9421Q → P in AAI50246 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti955 – 9551P → H.
Corresponds to variant rs12874207 [ dbSNP | Ensembl ].
VAR_055941
Natural varianti1071 – 10711L → Q.
Corresponds to variant rs17073511 [ dbSNP | Ensembl ].
VAR_058831

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11111111Missing in isoform 3. 2 PublicationsVSP_023540Add
BLAST
Alternative sequencei1 – 10211021Missing in isoform 2. 1 PublicationVSP_023541Add
BLAST
Alternative sequencei1022 – 103918AICGF…HFFRK → MGHCCCKPYNCLQCLDKT in isoform 2. 1 PublicationVSP_023543Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018317 mRNA. Translation: BAA34494.2. Different initiation.
AK293970 mRNA. Translation: BAG57342.1.
AL596114
, AL160255, AL596092, AL607144 Genomic DNA. Translation: CAI39910.1. Sequence problems.
AL596114, AL607144 Genomic DNA. Translation: CAI39912.1. Sequence problems.
AL596092
, AL160255, AL596114, AL607144 Genomic DNA. Translation: CAI40386.1. Sequence problems.
AL607144
, AL160255, AL596092, AL596114 Genomic DNA. Translation: CAI40565.1. Sequence problems.
AL607144, AL596114 Genomic DNA. Translation: CAI40566.1. Sequence problems.
AL160255
, AL596092, AL596114, AL607144 Genomic DNA. Translation: CAI41204.1. Sequence problems.
BC032481 mRNA. Translation: AAH32481.1.
BC119654 mRNA. Translation: AAI19655.1.
BC119655 mRNA. Translation: AAI19656.1.
BC129985 mRNA. Translation: AAI29986.1.
BC150245 mRNA. Translation: AAI50246.1. Different initiation.
CCDSiCCDS41874.1. [Q5JR59-3]
RefSeqiNP_001028774.2. NM_001033602.2.
NP_056048.1. NM_015233.5. [Q5JR59-3]
UniGeneiHs.22287.

Genome annotation databases

EnsembliENST00000380808; ENSP00000370186; ENSG00000132938. [Q5JR59-3]
ENST00000542829; ENSP00000445403; ENSG00000132938. [Q5JR59-4]
GeneIDi23281.
KEGGihsa:23281.
UCSCiuc001usm.4. human. [Q5JR59-3]
uc010aau.3. human. [Q5JR59-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018317 mRNA. Translation: BAA34494.2. Different initiation.
AK293970 mRNA. Translation: BAG57342.1.
AL596114
, AL160255, AL596092, AL607144 Genomic DNA. Translation: CAI39910.1. Sequence problems.
AL596114, AL607144 Genomic DNA. Translation: CAI39912.1. Sequence problems.
AL596092
, AL160255, AL596114, AL607144 Genomic DNA. Translation: CAI40386.1. Sequence problems.
AL607144
, AL160255, AL596092, AL596114 Genomic DNA. Translation: CAI40565.1. Sequence problems.
AL607144, AL596114 Genomic DNA. Translation: CAI40566.1. Sequence problems.
AL160255
, AL596092, AL596114, AL607144 Genomic DNA. Translation: CAI41204.1. Sequence problems.
BC032481 mRNA. Translation: AAH32481.1.
BC119654 mRNA. Translation: AAI19655.1.
BC119655 mRNA. Translation: AAI19656.1.
BC129985 mRNA. Translation: AAI29986.1.
BC150245 mRNA. Translation: AAI50246.1. Different initiation.
CCDSiCCDS41874.1. [Q5JR59-3]
RefSeqiNP_001028774.2. NM_001033602.2.
NP_056048.1. NM_015233.5. [Q5JR59-3]
UniGeneiHs.22287.

3D structure databases

ProteinModelPortaliQ5JR59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116880. 170 interactions.
IntActiQ5JR59. 163 interactions.
MINTiMINT-1457050.
STRINGi9606.ENSP00000392057.

PTM databases

PhosphoSiteiQ5JR59.

Polymorphism and mutation databases

BioMutaiMTUS2.
DMDMi259016371.

Proteomic databases

MaxQBiQ5JR59.
PaxDbiQ5JR59.
PRIDEiQ5JR59.

Protocols and materials databases

DNASUi23281.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380808; ENSP00000370186; ENSG00000132938. [Q5JR59-3]
ENST00000542829; ENSP00000445403; ENSG00000132938. [Q5JR59-4]
GeneIDi23281.
KEGGihsa:23281.
UCSCiuc001usm.4. human. [Q5JR59-3]
uc010aau.3. human. [Q5JR59-4]

Organism-specific databases

CTDi23281.
GeneCardsiGC13P029599.
H-InvDBHIX0020942.
HGNCiHGNC:20595. MTUS2.
HPAiHPA031474.
HPA031475.
neXtProtiNX_Q5JR59.
PharmGKBiPA165505194.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG119660.
GeneTreeiENSGT00390000006245.
InParanoidiQ5JR59.
PhylomeDBiQ5JR59.

Miscellaneous databases

ChiTaRSiMTUS2. human.
GenomeRNAii23281.
NextBioi45074.
PROiQ5JR59.

Gene expression databases

BgeeiQ5JR59.
CleanExiHS_KIAA0774.
ExpressionAtlasiQ5JR59. baseline and differential.
GenevisibleiQ5JR59. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Cerebellum.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Pancreas.
  6. "CAZIP, a novel protein expressed in the developing heart and nervous system."
    Du Puy L., Beqqali A., Monshouwer-Kloots J., Haagsman H.P., Roelen B.A., Passier R.
    Dev. Dyn. 238:2903-2911(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "TIP150 interacts with and targets MCAK at the microtubule plus ends."
    Jiang K., Wang J., Liu J., Ward T., Wordeman L., Davidson A., Wang F., Yao X.
    EMBO Rep. 10:857-865(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KIF2C AND MAPRE1, HOMODIMERIZATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMTUS2_HUMAN
AccessioniPrimary (citable) accession number: Q5JR59
Secondary accession number(s): A7E292
, B4DF81, O94872, Q08E97, Q5JQR3, Q8N5E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: September 22, 2009
Last modified: June 24, 2015
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.