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Q5JR59 (MTUS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Microtubule-associated tumor suppressor candidate 2
Alternative name(s):
Cardiac zipper protein
Microtubule plus-end tracking protein TIP150
Short name=Tracking protein of 150 kDa
Gene names
Name:MTUS2
Synonyms:CAZIP, KIAA0774, TIP150
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1369 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. Ref.7

Subunit structure

Homodimer. Interacts with KIF2C and MAPRE1; the interaction is direct and probably targets MTUS2 and KIF2C to microtubules. Ref.7

Subcellular location

Cytoplasmcytoskeleton. Note: Associated with the microtubule network at the growing distal tip (the plus-end) of microtubules. Ref.7

Tissue specificity

Detected in embryonic stem cells differentiating to cardiomyocytes. Ref.6

Sequence similarities

In the C-terminal section; belongs to the MTUS1 family.

Sequence caution

The sequence AAI50246.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA34494.2 differs from that shown. Reason: Erroneous initiation.

The sequence CAI39910.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI39912.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI40386.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI40565.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI40566.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI41204.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Binary interactions

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5JR59-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5JR59-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1021: Missing.
     1022-1039: AICGFDALAVATQHFFRK → MGHCCCKPYNCLQCLDKT
Note: No experimental confirmation available.
Isoform 3 (identifier: Q5JR59-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1111: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13691369Microtubule-associated tumor suppressor candidate 2
PRO_0000280111

Regions

Region641 – 980340Mediates interaction with MAPRE1
Region801 – 1150350Localization to the growing distal tip of microtubules
Region801 – 89090Sufficient for interaction with KIF2C
Coiled coil991 – 1335345 Potential

Natural variations

Alternative sequence1 – 11111111Missing in isoform 3.
VSP_023540
Alternative sequence1 – 10211021Missing in isoform 2.
VSP_023541
Alternative sequence1022 – 103918AICGF…HFFRK → MGHCCCKPYNCLQCLDKT in isoform 2.
VSP_023543
Natural variant9551P → H.
Corresponds to variant rs12874207 [ dbSNP | Ensembl ].
VAR_055941
Natural variant10711L → Q.
Corresponds to variant rs17073511 [ dbSNP | Ensembl ].
VAR_058831

Experimental info

Sequence conflict9421Q → P in BAA34494. Ref.1
Sequence conflict9421Q → P in AAI50246. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 22, 2009. Version 3.
Checksum: 4BF7A754AB1ED7CF

FASTA1,369150,195
        10         20         30         40         50         60 
MSVPVAPKKS CYTQLRDNRN AARNNNESIL SLGDTNANQI MLEVSSSHDE SKTCDLGDEI 

        70         80         90        100        110        120 
GNTNSSEPEN RTHFHKEFHQ LQGFGKGSQA GSASLKDFRL SSTIQRELNE EHTVERGTDS 

       130        140        150        160        170        180 
LQTTRSIQGP SLSSWRNVMS EASLDVLAKR DAEIPRHVPK DKLAKTLDNE ELRRHSLERA 

       190        200        210        220        230        240 
SSSVAAVGSL TPQHPQPLSL DSREARGQIP GGGEGPQKTL PDHAVPAAFP ATDSTSEGKS 

       250        260        270        280        290        300 
VRHPKPSTSE SKQSTPSETQ TVGAHVLQVC SEHTSHSAHP EPALNLTLAS KEIPSKLEAQ 

       310        320        330        340        350        360 
LGQGKGEAKL DLKYVPPRRV EQEGKAAQEG YLGCHKEENL SALEGRDPCG EAHPEATDAL 

       370        380        390        400        410        420 
GHLLNSDLHH LGVGRGNCEE KRGVNPGEQD SLHTTPKQGS ASLGGADNQP TGKISPCAGE 

       430        440        450        460        470        480 
KLGERTSSSF SPGDSHVAFI PNNLTDSKPL DVIEEERRLG SGNKDSVMVL VFNPSVGENK 

       490        500        510        520        530        540 
TEVPEPLDPQ SGRSEARESK EVTTSVAENR NLLENADKIE STSARADSVL NIPAPLHPET 

       550        560        570        580        590        600 
TVNMTYQPTT PSSSFQDVSV FGMDAGSPLV VPPPTDSARL LNTSPKVPDK NTCPSGIPKP 

       610        620        630        640        650        660 
VFTHSKDTPS SQEGMENYQV EKTEERTETK PIIMPKPKHV RPKIITYIRR NPQALGQVDA 

       670        680        690        700        710        720 
SLVPVGLPYA PPTCTMPLPH EEKAAGGDLK PSANLYEKFK PDLQKPRVFS SGLMVSGIKP 

       730        740        750        760        770        780 
PGHPFSQMSE KFLQEVTDHP GKEEFCSPPY AHYEVPPTFY RSAMLLKPQL GLGAMSRLPS 

       790        800        810        820        830        840 
AKSRILIASQ RSSASAIHPP GPITTATSLY SSDPSADLKK ASSSNAAKSN LPKSGLRPPG 

       850        860        870        880        890        900 
YSRLPAAKLA AFGFVRSSSV SSVSSTQSGD SAQPEQGRPA TRSTFGNEEQ PVLKASLPSK 

       910        920        930        940        950        960 
DTPKGAGRVA PPASSSVTAP RRSLLPAPKS TSTPAGTKKD AQKDQDTNKP AVSSPKRVAA 

       970        980        990       1000       1010       1020 
STTKLHSPGY PKQRTAAARN GFPPKPDPQA REAERQLVLR LKERCEQQTR QLGVAQGELK 

      1030       1040       1050       1060       1070       1080 
RAICGFDALA VATQHFFRKN ESALVKEKEL SIELANIRDE VAFHTAKCEK LQKEKEELER 

      1090       1100       1110       1120       1130       1140 
RFEDEVKRLG WQQQAELQEL EERLQLQFEA EMARLQEEHG DQLLSIRCQH QEQVEDLTAS 

      1150       1160       1170       1180       1190       1200 
HDAALLEMEN NHTVAITILQ DDHDHKVQEL MSTHELEKKE LEENFEKLRL SLQDQVDTLT 

      1210       1220       1230       1240       1250       1260 
FQSQSLRDRA RRFEEALRKN TEEQLEIALA PYQHLEEDMK SLKQVLEMKN QQIHEQEKKI 

      1270       1280       1290       1300       1310       1320 
LELEKLAEKN IILEEKIQVL QQQNEDLKAR IDQNTVVTRQ LSEENANLQE YVEKETQEKK 

      1330       1340       1350       1360 
RLSRTNEELL WKLQTGDPTS PIKLSPTSPV YRGSSSGPSS PARVSTTPR 

« Hide

Isoform 2 [UniParc].

Checksum: D352305A4FA0566B
Show »

FASTA34840,746
Isoform 3 [UniParc].

Checksum: 83363B0586426D1A
Show »

FASTA25830,064

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Cerebellum.
[4]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Pancreas.
[6]"CAZIP, a novel protein expressed in the developing heart and nervous system."
Du Puy L., Beqqali A., Monshouwer-Kloots J., Haagsman H.P., Roelen B.A., Passier R.
Dev. Dyn. 238:2903-2911(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"TIP150 interacts with and targets MCAK at the microtubule plus ends."
Jiang K., Wang J., Liu J., Ward T., Wordeman L., Davidson A., Wang F., Yao X.
EMBO Rep. 10:857-865(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH KIF2C AND MAPRE1, HOMODIMERIZATION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018317 mRNA. Translation: BAA34494.2. Different initiation.
AK293970 mRNA. Translation: BAG57342.1.
AL596114 expand/collapse EMBL AC list , AL160255, AL596092, AL607144 Genomic DNA. Translation: CAI39910.1. Sequence problems.
AL596114, AL607144 Genomic DNA. Translation: CAI39912.1. Sequence problems.
AL596092 expand/collapse EMBL AC list , AL160255, AL596114, AL607144 Genomic DNA. Translation: CAI40386.1. Sequence problems.
AL607144 expand/collapse EMBL AC list , AL160255, AL596092, AL596114 Genomic DNA. Translation: CAI40565.1. Sequence problems.
AL607144, AL596114 Genomic DNA. Translation: CAI40566.1. Sequence problems.
AL160255 expand/collapse EMBL AC list , AL596092, AL596114, AL607144 Genomic DNA. Translation: CAI41204.1. Sequence problems.
BC032481 mRNA. Translation: AAH32481.1.
BC119654 mRNA. Translation: AAI19655.1.
BC119655 mRNA. Translation: AAI19656.1.
BC129985 mRNA. Translation: AAI29986.1.
BC150245 mRNA. Translation: AAI50246.1. Different initiation.
CCDSCCDS41874.1. [Q5JR59-3]
RefSeqNP_001028774.2. NM_001033602.2.
NP_056048.1. NM_015233.5. [Q5JR59-3]
UniGeneHs.22287.

3D structure databases

ProteinModelPortalQ5JR59.
SMRQ5JR59. Positions 1300-1334.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116880. 8 interactions.
IntActQ5JR59. 20 interactions.
MINTMINT-1457050.
STRING9606.ENSP00000255289.

PTM databases

PhosphoSiteQ5JR59.

Polymorphism databases

DMDM259016371.

Proteomic databases

MaxQBQ5JR59.
PaxDbQ5JR59.
PRIDEQ5JR59.

Protocols and materials databases

DNASU23281.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380808; ENSP00000370186; ENSG00000132938. [Q5JR59-3]
ENST00000542829; ENSP00000445403; ENSG00000132938. [Q5JR59-4]
GeneID23281.
KEGGhsa:23281.
UCSCuc001usm.4. human. [Q5JR59-3]
uc010aau.3. human. [Q5JR59-4]

Organism-specific databases

CTD23281.
GeneCardsGC13P029599.
H-InvDBHIX0020942.
HGNCHGNC:20595. MTUS2.
HPAHPA031474.
HPA031475.
neXtProtNX_Q5JR59.
PharmGKBPA165505194.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG119660.
InParanoidQ5JR59.
PhylomeDBQ5JR59.

Gene expression databases

ArrayExpressQ5JR59.
BgeeQ5JR59.
CleanExHS_KIAA0774.
GenevestigatorQ5JR59.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSMTUS2. human.
GenomeRNAi23281.
NextBio45074.
PROQ5JR59.

Entry information

Entry nameMTUS2_HUMAN
AccessionPrimary (citable) accession number: Q5JR59
Secondary accession number(s): A7E292 expand/collapse secondary AC list , B4DF81, O94872, Q08E97, Q5JQR3, Q8N5E2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM