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Protein

Protein phosphatase 1J

Gene

PPM1J

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: Ensembl

GO - Biological processi

  1. protein dephosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1J (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform zeta
Short name:
PP2C-zeta
Gene namesi
Name:PPM1J
Synonyms:PPP2CZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20785. PPM1J.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Protein phosphatase 1JPRO_0000289058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5JR12.
PaxDbiQ5JR12.
PRIDEiQ5JR12.

PTM databases

DEPODiQ5JR12.
PhosphoSiteiQ5JR12.

Expressioni

Gene expression databases

BgeeiQ5JR12.
CleanExiHS_PPM1J.
ExpressionAtlasiQ5JR12. baseline and differential.
GenevestigatoriQ5JR12.

Organism-specific databases

HPAiHPA046045.

Interactioni

Subunit structurei

Interacts with UBE2I/UBC9.By similarity

Protein-protein interaction databases

BioGridi130612. 1 interaction.
STRINGi9606.ENSP00000308926.

Structurei

3D structure databases

ProteinModelPortaliQ5JR12.
SMRiQ5JR12. Positions 257-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 498365PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiNOG314780.
GeneTreeiENSGT00530000063231.
HOGENOMiHOG000251606.
HOVERGENiHBG105802.
InParanoidiQ5JR12.
KOiK17504.
OMAiDHNLKVC.
OrthoDBiEOG7F511J.
PhylomeDBiQ5JR12.
TreeFamiTF314700.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JR12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLNRVRSAVA HLVSSGGAPP PRPKSPDLPN AASAPPAAAP EAPRSPPAKA
60 70 80 90 100
GSGSATPAKA VEARASFSRP TFLQLSPGGL RRADDHAGRA VQSPPDTGRR
110 120 130 140 150
LPWSTGYAEV INAGKSRHNE DQACCEVVYV EGRRSVTGVP REPSRGQGLC
160 170 180 190 200
FYYWGLFDGH AGGGAAEMAS RLLHRHIREQ LKDLVEILQD PSPPPLCLPT
210 220 230 240 250
TPGTPDSSDP SHLLGPQSCW SSQKEVSHES LVVGAVENAF QLMDEQMARE
260 270 280 290 300
RRGHQVEGGC CALVVIYLLG KVYVANAGDS RAIIVRNGEI IPMSREFTPE
310 320 330 340 350
TERQRLQLLG FLKPELLGSE FTHLEFPRRV LPKELGQRML YRDQNMTGWA
360 370 380 390 400
YKKIELEDLR FPLVCGEGKK ARVMATIGVT RGLGDHSLKV CSSTLPIKPF
410 420 430 440 450
LSCFPEVRVY DLTQYEHCPD DVLVLGTDGL WDVTTDCEVA ATVDRVLSAY
460 470 480 490 500
EPNDHSRYTA LAQALVLGAR GTPRDRGWRL PNNKLGSGDD ISVFVIPLGG

PGSYS
Length:505
Mass (Da):54,834
Last modified:February 15, 2005 - v1
Checksum:i3A2329219D5823BF
GO
Isoform 2 (identifier: Q5JR12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.
     185-223: Missing.

Show »
Length:299
Mass (Da):33,464
Checksum:i89C79C8612037CF3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti213 – 2131L → F.
Corresponds to variant rs34611728 [ dbSNP | Ensembl ].
VAR_032566
Natural varianti236 – 2361V → I.4 Publications
Corresponds to variant rs10857971 [ dbSNP | Ensembl ].
VAR_032567

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 167167Missing in isoform 2. 1 PublicationVSP_025882Add
BLAST
Alternative sequencei185 – 22339Missing in isoform 2. 1 PublicationVSP_025883Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093270 mRNA. Translation: BAG52679.1.
AL133644 mRNA. Translation: CAB63764.1.
AL603832 Genomic DNA. Translation: CAI14062.1.
CH471122 Genomic DNA. Translation: EAW56543.1.
BC011803 mRNA. Translation: AAH11803.2.
BC073828 mRNA. Translation: AAH73828.1.
CCDSiCCDS855.2. [Q5JR12-1]
PIRiT43442.
RefSeqiNP_005158.5. NM_005167.5. [Q5JR12-1]
UniGeneiHs.655231.

Genome annotation databases

EnsembliENST00000309276; ENSP00000308926; ENSG00000155367. [Q5JR12-1]
ENST00000464951; ENSP00000475711; ENSG00000155367. [Q5JR12-2]
GeneIDi333926.
KEGGihsa:333926.
UCSCiuc001ecs.1. human. [Q5JR12-2]
uc001ect.1. human. [Q5JR12-1]

Polymorphism databases

DMDMi74741784.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093270 mRNA. Translation: BAG52679.1.
AL133644 mRNA. Translation: CAB63764.1.
AL603832 Genomic DNA. Translation: CAI14062.1.
CH471122 Genomic DNA. Translation: EAW56543.1.
BC011803 mRNA. Translation: AAH11803.2.
BC073828 mRNA. Translation: AAH73828.1.
CCDSiCCDS855.2. [Q5JR12-1]
PIRiT43442.
RefSeqiNP_005158.5. NM_005167.5. [Q5JR12-1]
UniGeneiHs.655231.

3D structure databases

ProteinModelPortaliQ5JR12.
SMRiQ5JR12. Positions 257-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130612. 1 interaction.
STRINGi9606.ENSP00000308926.

PTM databases

DEPODiQ5JR12.
PhosphoSiteiQ5JR12.

Polymorphism databases

DMDMi74741784.

Proteomic databases

MaxQBiQ5JR12.
PaxDbiQ5JR12.
PRIDEiQ5JR12.

Protocols and materials databases

DNASUi333926.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309276; ENSP00000308926; ENSG00000155367. [Q5JR12-1]
ENST00000464951; ENSP00000475711; ENSG00000155367. [Q5JR12-2]
GeneIDi333926.
KEGGihsa:333926.
UCSCiuc001ecs.1. human. [Q5JR12-2]
uc001ect.1. human. [Q5JR12-1]

Organism-specific databases

CTDi333926.
GeneCardsiGC01M113252.
HGNCiHGNC:20785. PPM1J.
HPAiHPA046045.
MIMi609957. gene.
neXtProtiNX_Q5JR12.
PharmGKBiPA142671150.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG314780.
GeneTreeiENSGT00530000063231.
HOGENOMiHOG000251606.
HOVERGENiHBG105802.
InParanoidiQ5JR12.
KOiK17504.
OMAiDHNLKVC.
OrthoDBiEOG7F511J.
PhylomeDBiQ5JR12.
TreeFamiTF314700.

Miscellaneous databases

GenomeRNAii333926.
NextBioi96732.
PROiQ5JR12.
SOURCEiSearch...

Gene expression databases

BgeeiQ5JR12.
CleanExiHS_PPM1J.
ExpressionAtlasiQ5JR12. baseline and differential.
GenevestigatoriQ5JR12.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-236.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-236.
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-236.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-236.
    Tissue: B-cell and Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiPPM1J_HUMAN
AccessioniPrimary (citable) accession number: Q5JR12
Secondary accession number(s): B3KSB7
, Q6DKJ7, Q96EZ7, Q9UF84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 15, 2005
Last modified: January 7, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.