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Q5JR12

- PPM1J_HUMAN

UniProt

Q5JR12 - PPM1J_HUMAN

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Protein

Protein phosphatase 1J

Gene

PPM1J

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: Ensembl

GO - Biological processi

  1. protein dephosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1J (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform zeta
Short name:
PP2C-zeta
Gene namesi
Name:PPM1J
Synonyms:PPP2CZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20785. PPM1J.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Protein phosphatase 1JPRO_0000289058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5JR12.
PaxDbiQ5JR12.
PRIDEiQ5JR12.

PTM databases

PhosphoSiteiQ5JR12.

Expressioni

Gene expression databases

BgeeiQ5JR12.
CleanExiHS_PPM1J.
ExpressionAtlasiQ5JR12. baseline and differential.
GenevestigatoriQ5JR12.

Organism-specific databases

HPAiHPA046045.

Interactioni

Subunit structurei

Interacts with UBE2I/UBC9.By similarity

Protein-protein interaction databases

BioGridi130612. 1 interaction.
STRINGi9606.ENSP00000308926.

Structurei

3D structure databases

ProteinModelPortaliQ5JR12.
SMRiQ5JR12. Positions 257-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 498365PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiNOG314780.
GeneTreeiENSGT00530000063231.
HOGENOMiHOG000251606.
HOVERGENiHBG105802.
InParanoidiQ5JR12.
KOiK17504.
OMAiDHNLKVC.
OrthoDBiEOG7F511J.
PhylomeDBiQ5JR12.
TreeFamiTF314700.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5JR12-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLNRVRSAVA HLVSSGGAPP PRPKSPDLPN AASAPPAAAP EAPRSPPAKA
60 70 80 90 100
GSGSATPAKA VEARASFSRP TFLQLSPGGL RRADDHAGRA VQSPPDTGRR
110 120 130 140 150
LPWSTGYAEV INAGKSRHNE DQACCEVVYV EGRRSVTGVP REPSRGQGLC
160 170 180 190 200
FYYWGLFDGH AGGGAAEMAS RLLHRHIREQ LKDLVEILQD PSPPPLCLPT
210 220 230 240 250
TPGTPDSSDP SHLLGPQSCW SSQKEVSHES LVVGAVENAF QLMDEQMARE
260 270 280 290 300
RRGHQVEGGC CALVVIYLLG KVYVANAGDS RAIIVRNGEI IPMSREFTPE
310 320 330 340 350
TERQRLQLLG FLKPELLGSE FTHLEFPRRV LPKELGQRML YRDQNMTGWA
360 370 380 390 400
YKKIELEDLR FPLVCGEGKK ARVMATIGVT RGLGDHSLKV CSSTLPIKPF
410 420 430 440 450
LSCFPEVRVY DLTQYEHCPD DVLVLGTDGL WDVTTDCEVA ATVDRVLSAY
460 470 480 490 500
EPNDHSRYTA LAQALVLGAR GTPRDRGWRL PNNKLGSGDD ISVFVIPLGG

PGSYS
Length:505
Mass (Da):54,834
Last modified:February 15, 2005 - v1
Checksum:i3A2329219D5823BF
GO
Isoform 2 (identifier: Q5JR12-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.
     185-223: Missing.

Show »
Length:299
Mass (Da):33,464
Checksum:i89C79C8612037CF3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti213 – 2131L → F.
Corresponds to variant rs34611728 [ dbSNP | Ensembl ].
VAR_032566
Natural varianti236 – 2361V → I.4 Publications
Corresponds to variant rs10857971 [ dbSNP | Ensembl ].
VAR_032567

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 167167Missing in isoform 2. 1 PublicationVSP_025882Add
BLAST
Alternative sequencei185 – 22339Missing in isoform 2. 1 PublicationVSP_025883Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093270 mRNA. Translation: BAG52679.1.
AL133644 mRNA. Translation: CAB63764.1.
AL603832 Genomic DNA. Translation: CAI14062.1.
CH471122 Genomic DNA. Translation: EAW56543.1.
BC011803 mRNA. Translation: AAH11803.2.
BC073828 mRNA. Translation: AAH73828.1.
CCDSiCCDS855.2. [Q5JR12-1]
PIRiT43442.
RefSeqiNP_005158.5. NM_005167.5. [Q5JR12-1]
UniGeneiHs.655231.

Genome annotation databases

EnsembliENST00000309276; ENSP00000308926; ENSG00000155367. [Q5JR12-1]
ENST00000464951; ENSP00000475711; ENSG00000155367. [Q5JR12-2]
GeneIDi333926.
KEGGihsa:333926.
UCSCiuc001ecs.1. human. [Q5JR12-2]
uc001ect.1. human. [Q5JR12-1]

Polymorphism databases

DMDMi74741784.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093270 mRNA. Translation: BAG52679.1 .
AL133644 mRNA. Translation: CAB63764.1 .
AL603832 Genomic DNA. Translation: CAI14062.1 .
CH471122 Genomic DNA. Translation: EAW56543.1 .
BC011803 mRNA. Translation: AAH11803.2 .
BC073828 mRNA. Translation: AAH73828.1 .
CCDSi CCDS855.2. [Q5JR12-1 ]
PIRi T43442.
RefSeqi NP_005158.5. NM_005167.5. [Q5JR12-1 ]
UniGenei Hs.655231.

3D structure databases

ProteinModelPortali Q5JR12.
SMRi Q5JR12. Positions 257-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130612. 1 interaction.
STRINGi 9606.ENSP00000308926.

PTM databases

PhosphoSitei Q5JR12.

Polymorphism databases

DMDMi 74741784.

Proteomic databases

MaxQBi Q5JR12.
PaxDbi Q5JR12.
PRIDEi Q5JR12.

Protocols and materials databases

DNASUi 333926.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309276 ; ENSP00000308926 ; ENSG00000155367 . [Q5JR12-1 ]
ENST00000464951 ; ENSP00000475711 ; ENSG00000155367 . [Q5JR12-2 ]
GeneIDi 333926.
KEGGi hsa:333926.
UCSCi uc001ecs.1. human. [Q5JR12-2 ]
uc001ect.1. human. [Q5JR12-1 ]

Organism-specific databases

CTDi 333926.
GeneCardsi GC01M113252.
HGNCi HGNC:20785. PPM1J.
HPAi HPA046045.
MIMi 609957. gene.
neXtProti NX_Q5JR12.
PharmGKBi PA142671150.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314780.
GeneTreei ENSGT00530000063231.
HOGENOMi HOG000251606.
HOVERGENi HBG105802.
InParanoidi Q5JR12.
KOi K17504.
OMAi DHNLKVC.
OrthoDBi EOG7F511J.
PhylomeDBi Q5JR12.
TreeFami TF314700.

Miscellaneous databases

GenomeRNAii 333926.
NextBioi 96732.
PROi Q5JR12.
SOURCEi Search...

Gene expression databases

Bgeei Q5JR12.
CleanExi HS_PPM1J.
ExpressionAtlasi Q5JR12. baseline and differential.
Genevestigatori Q5JR12.

Family and domain databases

Gene3Di 3.60.40.10. 3 hits.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 2 hits.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-236.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-236.
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-236.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-236.
    Tissue: B-cell and Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiPPM1J_HUMAN
AccessioniPrimary (citable) accession number: Q5JR12
Secondary accession number(s): B3KSB7
, Q6DKJ7, Q96EZ7, Q9UF84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3