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Protein

Olfactory receptor 2B11

Gene

OR2B11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2B11
Gene namesi
Name:OR2B11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31249. OR2B11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence analysisAdd
BLAST
Transmembranei30 – 5324Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini54 – 618CytoplasmicSequence analysis
Transmembranei62 – 8322Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini84 – 10421ExtracellularSequence analysisAdd
BLAST
Transmembranei105 – 12420Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14319CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16219Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19937ExtracellularSequence analysisAdd
BLAST
Transmembranei200 – 22324Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini224 – 24017CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26323Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini264 – 27613ExtracellularSequence analysisAdd
BLAST
Transmembranei277 – 29620Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini297 – 31721CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961529.

Polymorphism and mutation databases

BioMutaiOR2B11.
DMDMi74762190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Olfactory receptor 2B11PRO_0000150464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5JQS5.
PRIDEiQ5JQS5.

PTM databases

PhosphoSiteiQ5JQS5.

Expressioni

Gene expression databases

CleanExiHS_OR2B11.

Organism-specific databases

HPAiHPA047459.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000325682.

Structurei

3D structure databases

ProteinModelPortaliQ5JQS5.
SMRiQ5JQS5. Positions 40-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUR. Eukaryota.
ENOG41117FE. LUCA.
GeneTreeiENSGT00740000115013.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ5JQS5.
KOiK04257.
OMAiQYAVFHW.
OrthoDBiEOG751NFX.
PhylomeDBiQ5JQS5.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JQS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDNHSFLG DSPKAFILLG VSDRPWLELP LFVVLLLSYV LAMLGNVAII
60 70 80 90 100
LASRVDPQLH SPMYIFLSHL SFLDLCYTTT TVPQMLVNMG SSQKTISYGG
110 120 130 140 150
CTVQYAVFHW LGCTECIVLA AMALDRYVAI CKPLHYAVLM HRALCQQLVA
160 170 180 190 200
LAWLSGFGNS FVQVVLTVQL PFCGRQVLNN FFCEVPAVIK LSCADTAVND
210 220 230 240 250
TILAVLVAFF VLVPLALILL SYGFIARAVL RIQSSKGRHK AFGTCSSHLM
260 270 280 290 300
IVSLFYLPAI YMYLQPPSSY SQEQGKFISL FYSIITPTLN PFTYTLRNKD
310
MKGALRRLLA RIWRLCG
Length:317
Mass (Da):35,342
Last modified:February 15, 2005 - v1
Checksum:i468759E5D02127A6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301I → S.
Corresponds to variant rs11583410 [ dbSNP | Ensembl ].
VAR_062015
Natural varianti198 – 1981V → M.2 Publications
Corresponds to variant rs6695302 [ dbSNP | Ensembl ].
VAR_053132
Natural varianti223 – 2231G → D.
Corresponds to variant rs4925663 [ dbSNP | Ensembl ].
VAR_053133
Natural varianti293 – 2931T → I.
Corresponds to variant rs12065526 [ dbSNP | Ensembl ].
VAR_053134
Natural varianti300 – 3001D → G.
Corresponds to variant rs12070953 [ dbSNP | Ensembl ].
VAR_053135

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606804 Genomic DNA. Translation: CAI17145.1.
CH471148 Genomic DNA. Translation: EAW77188.1.
BC137181 mRNA. Translation: AAI37182.1.
BC137205 mRNA. Translation: AAI37206.1.
CCDSiCCDS31090.1.
RefSeqiNP_001004492.1. NM_001004492.1.
UniGeneiHs.446999.

Genome annotation databases

EnsembliENST00000318749; ENSP00000325682; ENSG00000177535.
GeneIDi127623.
KEGGihsa:127623.
UCSCiuc010pyx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606804 Genomic DNA. Translation: CAI17145.1.
CH471148 Genomic DNA. Translation: EAW77188.1.
BC137181 mRNA. Translation: AAI37182.1.
BC137205 mRNA. Translation: AAI37206.1.
CCDSiCCDS31090.1.
RefSeqiNP_001004492.1. NM_001004492.1.
UniGeneiHs.446999.

3D structure databases

ProteinModelPortaliQ5JQS5.
SMRiQ5JQS5. Positions 40-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000325682.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ5JQS5.

Polymorphism and mutation databases

BioMutaiOR2B11.
DMDMi74762190.

Proteomic databases

PaxDbiQ5JQS5.
PRIDEiQ5JQS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318749; ENSP00000325682; ENSG00000177535.
GeneIDi127623.
KEGGihsa:127623.
UCSCiuc010pyx.2. human.

Organism-specific databases

CTDi127623.
GeneCardsiOR2B11.
HGNCiHGNC:31249. OR2B11.
HPAiHPA047459.
neXtProtiNX_Q5JQS5.
PharmGKBiPA134961529.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVUR. Eukaryota.
ENOG41117FE. LUCA.
GeneTreeiENSGT00740000115013.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ5JQS5.
KOiK04257.
OMAiQYAVFHW.
OrthoDBiEOG751NFX.
PhylomeDBiQ5JQS5.
TreeFamiTF336512.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2B11.
GenomeRNAii127623.
NextBioi82147.
PROiQ5JQS5.

Gene expression databases

CleanExiHS_OR2B11.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-198.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-198.

Entry informationi

Entry nameiOR2BB_HUMAN
AccessioniPrimary (citable) accession number: Q5JQS5
Secondary accession number(s): B2RP03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: November 11, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.