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Protein

Olfactory receptor 2B11

Gene

OR2B11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2B11
Gene namesi
Name:OR2B11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000177535.7.
HGNCiHGNC:31249. OR2B11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 53Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini54 – 61CytoplasmicSequence analysis8
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 104ExtracellularSequence analysisAdd BLAST21
Transmembranei105 – 124Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 162Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini163 – 199ExtracellularSequence analysisAdd BLAST37
Transmembranei200 – 223Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini224 – 240CytoplasmicSequence analysisAdd BLAST17
Transmembranei241 – 263Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini264 – 276ExtracellularSequence analysisAdd BLAST13
Transmembranei277 – 296Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini297 – 317CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177535.
PharmGKBiPA134961529.

Polymorphism and mutation databases

BioMutaiOR2B11.
DMDMi74762190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504641 – 317Olfactory receptor 2B11Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5JQS5.
PeptideAtlasiQ5JQS5.
PRIDEiQ5JQS5.

PTM databases

iPTMnetiQ5JQS5.
PhosphoSitePlusiQ5JQS5.

Expressioni

Gene expression databases

BgeeiENSG00000177535.
CleanExiHS_OR2B11.
ExpressionAtlasiQ5JQS5. baseline and differential.

Organism-specific databases

HPAiHPA047459.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000325682.

Structurei

3D structure databases

ProteinModelPortaliQ5JQS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUR. Eukaryota.
ENOG41117FE. LUCA.
GeneTreeiENSGT00740000115013.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ5JQS5.
KOiK04257.
OMAiQYAVFHW.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ5JQS5.
TreeFamiTF336512.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5JQS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDNHSFLG DSPKAFILLG VSDRPWLELP LFVVLLLSYV LAMLGNVAII
60 70 80 90 100
LASRVDPQLH SPMYIFLSHL SFLDLCYTTT TVPQMLVNMG SSQKTISYGG
110 120 130 140 150
CTVQYAVFHW LGCTECIVLA AMALDRYVAI CKPLHYAVLM HRALCQQLVA
160 170 180 190 200
LAWLSGFGNS FVQVVLTVQL PFCGRQVLNN FFCEVPAVIK LSCADTAVND
210 220 230 240 250
TILAVLVAFF VLVPLALILL SYGFIARAVL RIQSSKGRHK AFGTCSSHLM
260 270 280 290 300
IVSLFYLPAI YMYLQPPSSY SQEQGKFISL FYSIITPTLN PFTYTLRNKD
310
MKGALRRLLA RIWRLCG
Length:317
Mass (Da):35,342
Last modified:February 15, 2005 - v1
Checksum:i468759E5D02127A6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062015130I → S. Corresponds to variant dbSNP:rs11583410Ensembl.1
Natural variantiVAR_053132198V → M2 PublicationsCorresponds to variant dbSNP:rs6695302Ensembl.1
Natural variantiVAR_053133223G → D. Corresponds to variant dbSNP:rs4925663Ensembl.1
Natural variantiVAR_053134293T → I. Corresponds to variant dbSNP:rs12065526Ensembl.1
Natural variantiVAR_053135300D → G. Corresponds to variant dbSNP:rs12070953Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606804 Genomic DNA. No translation available.
CH471148 Genomic DNA. Translation: EAW77188.1.
BC137181 mRNA. Translation: AAI37182.1.
BC137205 mRNA. Translation: AAI37206.1.
CCDSiCCDS31090.1.
RefSeqiNP_001004492.1. NM_001004492.1.
UniGeneiHs.446999.

Genome annotation databases

EnsembliENST00000318749; ENSP00000325682; ENSG00000177535.
ENST00000641149; ENSP00000492892; ENSG00000177535.
ENST00000641527; ENSP00000493421; ENSG00000177535.
GeneIDi127623.
KEGGihsa:127623.
UCSCiuc010pyx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2BB_HUMAN
AccessioniPrimary (citable) accession number: Q5JQS5
Secondary accession number(s): B2RP03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: November 22, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families