Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polyadenylate-binding protein 1-like 2

Gene

PABPC1L2A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

May be not functional as it lacks the poly(A)-binding protein C-terminal (PABC) domain implicated in the mRNA stability and translation regulation.

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 1-like 2
Alternative name(s):
RNA-binding motif protein 32
RNA-binding protein 32
Gene namesi
Name:PABPC1L2A
Synonyms:PABPC1L2, RBM32A
AND
Name:PABPC1L2B
Synonyms:PABPC1L2, RBM32B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000184388.5
HostDB:ENSG00000186288.5
HGNCiHGNC:27989 PABPC1L2A
HGNC:31852 PABPC1L2B
neXtProtiNX_Q5JQF8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184388
ENSG00000186288
PharmGKBiPA162398594

Polymorphism and mutation databases

BioMutaiPABPC1L2A
DMDMi74755614

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003045091 – 200Polyadenylate-binding protein 1-like 2Add BLAST200

Proteomic databases

EPDiQ5JQF8
PaxDbiQ5JQF8
PeptideAtlasiQ5JQF8
PRIDEiQ5JQF8

PTM databases

iPTMnetiQ5JQF8
PhosphoSitePlusiQ5JQF8

Expressioni

Gene expression databases

BgeeiENSG00000184388
CleanExiHS_PABPC1L2A
HS_PABPC1L2B
GenevisibleiQ5JQF8 HS

Organism-specific databases

HPAiHPA041573

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362621

Structurei

3D structure databases

ProteinModelPortaliQ5JQF8
SMRiQ5JQF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 80RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini90 – 166RRM 2PROSITE-ProRule annotationAdd BLAST77

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
InParanoidiQ5JQF8
KOiK13126
OrthoDBiEOG091G03ZE
PhylomeDBiQ5JQF8

Family and domain databases

Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequencei

Sequence statusi: Complete.

Q5JQF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLYVGDLH PEVTEAMLYE KFSPAGPILS IRICRDKITR RSLGYAYVNY
60 70 80 90 100
QQPVDAKRAL ETLNFDVIKG RPVRIMWSQR DPSLRKSGVG NVFIKNLGKT
110 120 130 140 150
IDNKALYNIF SAFGNILSCK VACDEKGPKG YGFVHFQKQE SAERAIDVMN
160 170 180 190 200
GMFLNYRKIF VGRFKSHKER EAERGAWARQ STSADVKDFE EDTDEEATLR
Length:200
Mass (Da):22,799
Last modified:February 15, 2005 - v1
Checksum:iBEF8BB66BE807DE7
GO

Sequence cautioni

The sequence AAH41956 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32R → S in AAH41956 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662864 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98671.1
BC041956 mRNA Translation: AAH41956.1 Different initiation.
BC136492 mRNA Translation: AAI36493.1
CCDSiCCDS35334.1
CCDS43972.1
RefSeqiNP_001012995.1, NM_001012977.2
NP_001035971.1, NM_001042506.1
UniGeneiHs.450320
Hs.567854

Genome annotation databases

EnsembliENST00000373519; ENSP00000362618; ENSG00000186288
ENST00000373521; ENSP00000362621; ENSG00000184388
GeneIDi340529
645974
KEGGihsa:340529
hsa:645974
UCSCiuc004ebf.4 human

Similar proteinsi

Entry informationi

Entry nameiPAP1M_HUMAN
AccessioniPrimary (citable) accession number: Q5JQF8
Secondary accession number(s): B2RMV9, Q8IVU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 15, 2005
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health