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Protein

Polyadenylate-binding protein 1-like 2

Gene

PABPC1L2A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 1-like 2
Alternative name(s):
RNA-binding motif protein 32
RNA-binding protein 32
Gene namesi
Name:PABPC1L2A
Synonyms:PABPC1L2, RBM32A
AND
Name:PABPC1L2B
Synonyms:PABPC1L2, RBM32B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:27989. PABPC1L2A.
HGNC:31852. PABPC1L2B.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398594.

Polymorphism and mutation databases

BioMutaiPABPC1L2A.
DMDMi74755614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Polyadenylate-binding protein 1-like 2PRO_0000304509Add
BLAST

Proteomic databases

EPDiQ5JQF8.
PaxDbiQ5JQF8.
PeptideAtlasiQ5JQF8.
PRIDEiQ5JQF8.

PTM databases

iPTMnetiQ5JQF8.
PhosphoSiteiQ5JQF8.

Expressioni

Gene expression databases

BgeeiQ5JQF8.
CleanExiHS_PABPC1L2A.
HS_PABPC1L2B.
GenevisibleiQ5JQF8. HS.

Organism-specific databases

HPAiHPA041573.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362621.

Structurei

3D structure databases

ProteinModelPortaliQ5JQF8.
SMRiQ5JQF8. Positions 1-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8079RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini90 – 16677RRM 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123. Eukaryota.
ENOG410XR5X. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000217922.
HOVERGENiHBG002295.
InParanoidiQ5JQF8.
KOiK13126.
OMAiFRTEDCA.
OrthoDBiEOG7RV9FP.
PhylomeDBiQ5JQF8.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JQF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLYVGDLH PEVTEAMLYE KFSPAGPILS IRICRDKITR RSLGYAYVNY
60 70 80 90 100
QQPVDAKRAL ETLNFDVIKG RPVRIMWSQR DPSLRKSGVG NVFIKNLGKT
110 120 130 140 150
IDNKALYNIF SAFGNILSCK VACDEKGPKG YGFVHFQKQE SAERAIDVMN
160 170 180 190 200
GMFLNYRKIF VGRFKSHKER EAERGAWARQ STSADVKDFE EDTDEEATLR
Length:200
Mass (Da):22,799
Last modified:February 15, 2005 - v1
Checksum:iBEF8BB66BE807DE7
GO

Sequence cautioni

The sequence AAH41956.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321R → S in AAH41956 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662864 Genomic DNA. Translation: CAI40930.1.
AL662864 Genomic DNA. Translation: CAI40931.1.
CH471104 Genomic DNA. Translation: EAW98671.1.
BC041956 mRNA. Translation: AAH41956.1. Different initiation.
BC136492 mRNA. Translation: AAI36493.1.
CCDSiCCDS35334.1.
CCDS43972.1.
RefSeqiNP_001012995.1. NM_001012977.2.
NP_001035971.1. NM_001042506.1.
UniGeneiHs.450320.
Hs.567854.

Genome annotation databases

EnsembliENST00000373519; ENSP00000362618; ENSG00000186288.
ENST00000373521; ENSP00000362621; ENSG00000184388.
GeneIDi340529.
645974.
KEGGihsa:340529.
hsa:645974.
UCSCiuc004ebf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662864 Genomic DNA. Translation: CAI40930.1.
AL662864 Genomic DNA. Translation: CAI40931.1.
CH471104 Genomic DNA. Translation: EAW98671.1.
BC041956 mRNA. Translation: AAH41956.1. Different initiation.
BC136492 mRNA. Translation: AAI36493.1.
CCDSiCCDS35334.1.
CCDS43972.1.
RefSeqiNP_001012995.1. NM_001012977.2.
NP_001035971.1. NM_001042506.1.
UniGeneiHs.450320.
Hs.567854.

3D structure databases

ProteinModelPortaliQ5JQF8.
SMRiQ5JQF8. Positions 1-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362621.

PTM databases

iPTMnetiQ5JQF8.
PhosphoSiteiQ5JQF8.

Polymorphism and mutation databases

BioMutaiPABPC1L2A.
DMDMi74755614.

Proteomic databases

EPDiQ5JQF8.
PaxDbiQ5JQF8.
PeptideAtlasiQ5JQF8.
PRIDEiQ5JQF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373519; ENSP00000362618; ENSG00000186288.
ENST00000373521; ENSP00000362621; ENSG00000184388.
GeneIDi340529.
645974.
KEGGihsa:340529.
hsa:645974.
UCSCiuc004ebf.4. human.

Organism-specific databases

CTDi340529.
645974.
GeneCardsiPABPC1L2A.
PABPC1L2B.
H-InvDBHIX0056425.
HGNCiHGNC:27989. PABPC1L2A.
HGNC:31852. PABPC1L2B.
HPAiHPA041573.
neXtProtiNX_Q5JQF8.
PharmGKBiPA162398594.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0123. Eukaryota.
ENOG410XR5X. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000217922.
HOVERGENiHBG002295.
InParanoidiQ5JQF8.
KOiK13126.
OMAiFRTEDCA.
OrthoDBiEOG7RV9FP.
PhylomeDBiQ5JQF8.

Miscellaneous databases

PROiQ5JQF8.

Gene expression databases

BgeeiQ5JQF8.
CleanExiHS_PABPC1L2A.
HS_PABPC1L2B.
GenevisibleiQ5JQF8. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPAP1M_HUMAN
AccessioniPrimary (citable) accession number: Q5JQF8
Secondary accession number(s): B2RMV9, Q8IVU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 15, 2005
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

May be not functional as it lacks the poly(A)-binding protein C-terminal (PABC) domain implicated in the mRNA stability and translation regulation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.