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Protein
Submitted name:

Vinculin

Gene

VCL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
VinculinImported
Gene namesi
Name:VCLImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:12665. VCL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000035403.

PTM / Processingi

Proteomic databases

MaxQBiQ5JQ13.
PaxDbiQ5JQ13.
PeptideAtlasiQ5JQ13.
PRIDEiQ5JQ13.

Expressioni

Gene expression databases

BgeeiENSG00000035403.
ExpressionAtlasiQ5JQ13. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000211998.

Structurei

3D structure databases

ProteinModelPortaliQ5JQ13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 59Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3681. Eukaryota.
ENOG410XSRU. LUCA.
GeneTreeiENSGT00550000074411.
HOGENOMiHOG000007828.
HOVERGENiHBG079758.

Family and domain databases

InterProiIPR006077. Vinculin/catenin.
IPR000633. Vinculin_CS.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 4 hits.
PfamiPF01044. Vinculin. 3 hits.
[Graphical view]
SUPFAMiSSF47220. SSF47220. 6 hits.
PROSITEiPS00664. VINCULIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5JQ13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GQMTDQVADL RARGQGSSPV AMQKAQQVSQ GLDVLTAKVE NAARKLEAMT
60 70 80 90 100
NSKQSIAKKI DAAQNWLADP NGGPEGEEQI RGALAEARKI AELCDDPKER
110 120 130 140 150
DDILRSLGEI SALTSKLADL RRQGKGDSPE ARALAKQVAT ALQNLQTKTN
160 170 180 190 200
RAVANSRPAK AAVHLEGKIE QAQRWIDNPT VDDRGVGQAA IRGLVAEGHR
210 220 230 240 250
LANVMMGPYR QDLLAKCDRV DQLTAQLADL AARGEGESPQ ARALASQLQD
260 270 280 290 300
SLKDLKARMQ EAMTQEVSDV FSDTTTPIKL LAVAATAPPD APNREEVFDE
310 320 330 340 350
RAANFENHSG KLGATAEKAA AVGTANKSTV EGIQASVKTA RELTPQVVSA
360 370 380 390 400
ARILLRNPGN QAAYEHFETM KNQWIDNVEK MTGLVDEAID TKSLLDASEE
410 420 430 440 450
AIKKDLDKCK VAMANIQPQM LVAGATSIAR RANRILLVAK REVENSEDPK
460 470 480 490 500
FREAVKAASD ELSKTISPMV MDAKAVAGNI SDPGLQKSFL DSGYRILGAV
510 520 530 540 550
AKVREAFQPQ EPDFPPPPPD LEQLRLTDEL APPKPPLPEG EVPPPRPPPP
560 570 580 590 600
EEKDEEFPEQ KAGEVINQPM MMAARQLHDE ARKWSSKPGI PAAEVGIGVV
610 620 630 640 650
AEADAADAAG FPVPPDMEDD YEPELLLMPS NQPVNQPILA AAQSLHREAT
660 670 680 690 700
KWSSKGNDII AAAKRMALLM AEMSRLVRGG SGTKRALIQC AKDIAKASDE
710 720 730 740 750
VTRLAKEVAK QCTDKRIRTN LLQVCERIPT ISTQLKILST VKATMLGRTN
760 770 780 790 800
ISDEESEQAT EMLVHNAQNL MQSVKETVRE AEAASIKIRT DAGFTLRWVR

KTPWYQ
Length:806
Mass (Da):87,444
Last modified:February 15, 2005 - v1
Checksum:iE713B2BF914B2023
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596247 Genomic DNA. No translation available.
AL731576 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000436396; ENSP00000415489; ENSG00000035403.
UCSCiuc057ueu.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596247 Genomic DNA. No translation available.
AL731576 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5JQ13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000211998.

Proteomic databases

MaxQBiQ5JQ13.
PaxDbiQ5JQ13.
PeptideAtlasiQ5JQ13.
PRIDEiQ5JQ13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436396; ENSP00000415489; ENSG00000035403.
UCSCiuc057ueu.1. human.

Organism-specific databases

HGNCiHGNC:12665. VCL.
OpenTargetsiENSG00000035403.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3681. Eukaryota.
ENOG410XSRU. LUCA.
GeneTreeiENSGT00550000074411.
HOGENOMiHOG000007828.
HOVERGENiHBG079758.

Miscellaneous databases

ChiTaRSiVCL. human.

Gene expression databases

BgeeiENSG00000035403.
ExpressionAtlasiQ5JQ13. baseline and differential.

Family and domain databases

InterProiIPR006077. Vinculin/catenin.
IPR000633. Vinculin_CS.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 4 hits.
PfamiPF01044. Vinculin. 3 hits.
[Graphical view]
SUPFAMiSSF47220. SSF47220. 6 hits.
PROSITEiPS00664. VINCULIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5JQ13_HUMAN
AccessioniPrimary (citable) accession number: Q5JQ13
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.