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Protein

EEF1A lysine methyltransferase 2

Gene

EEF1AKMT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.UniRule annotation1 Publication

GO - Molecular functioni

  • methyltransferase activity Source: UniProtKB
  • protein-lysine N-methyltransferase activity Source: UniProtKB

GO - Biological processi

  • peptidyl-lysine methylation Source: UniProtKB
  • protein methylation Source: Reactome

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-8876725. Protein methylation.

Names & Taxonomyi

Protein namesi
Recommended name:
EEF1A lysine methyltransferase 2UniRule annotationImported (EC:2.1.1.-UniRule annotation)
Alternative name(s):
Methyltransferase-like protein 10UniRule annotation
Protein-lysine N-methyltransferase METTL10UniRule annotation
Gene namesi
Name:EEF1AKMT2UniRule annotationImported
Synonyms:C10orf138, METTL10UniRule annotation
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:33787. EEF1AKMT2.

Subcellular locationi

  • Cytoplasm UniRule annotation1 Publication
  • Nucleus UniRule annotation1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi85 – 91DIGTGNG → AIATANA: Highly reduces methylation activity toward EEF1A1. 1 Publication7

Organism-specific databases

OpenTargetsiENSG00000203791.
PharmGKBiPA162395769.

Polymorphism and mutation databases

BioMutaiMETTL10.
DMDMi172044620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003258822 – 291EEF1A lysine methyltransferase 2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei21PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5JPI9.
MaxQBiQ5JPI9.
PaxDbiQ5JPI9.
PeptideAtlasiQ5JPI9.
PRIDEiQ5JPI9.

PTM databases

iPTMnetiQ5JPI9.
PhosphoSitePlusiQ5JPI9.

Expressioni

Gene expression databases

BgeeiENSG00000203791.
CleanExiHS_METTL10.
ExpressionAtlasiQ5JPI9. baseline and differential.
GenevisibleiQ5JPI9. HS.

Organism-specific databases

HPAiHPA050138.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357829.

Structurei

3D structure databases

ProteinModelPortaliQ5JPI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1271. Eukaryota.
ENOG4111PXE. LUCA.
GeneTreeiENSGT00390000013399.
HOGENOMiHOG000184298.
InParanoidiQ5JPI9.
OMAiNEFSEGW.
OrthoDBiEOG091G0T79.
PhylomeDBiQ5JPI9.
TreeFamiTF313057.

Family and domain databases

HAMAPiMF_03188. Methyltr_EFM4. 1 hit.
InterProiView protein in InterPro
IPR026635. Efm4.
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF13847. Methyltransf_31. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JPI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGADGGGG AAVAARSDKG SPGEDGFVPS ALGTREHWDA VYERELQTFR
60 70 80 90 100
EYGDTGEIWF GEESMNRLIR WMQKHKIPLD ASVLDIGTGN GVFLVELAKF
110 120 130 140 150
GFSNITGIDY SPSAIQLSGS IIEKEGLSNI KLKVEDFLNL STQLSGFHIC
160 170 180 190 200
IDKGTFDAIS LNPDNAIEKR KQYVKSLSRV LKVKGFFLIT SCNWTKEELL
210 220 230 240 250
NEFSEGWSTV AGFWLTAALT SWAQAIFSTS ASRVGGTTGT HHHAWIIFVF
260 270 280 290
LAETRFCHVV QAGLELLGSS DSPTWPPKVL GLYHARPSLA F
Length:291
Mass (Da):31,830
Last modified:March 18, 2008 - v2
Checksum:iE7A4486A4D1CCA50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8G → S in CAI46179 (PubMed:17974005).Curated1
Sequence conflicti97L → LL in CAI46179 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05029567R → Q. Corresponds to variant dbSNP:rs4347339Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832292 mRNA. Translation: CAI46179.1.
AC068896 Genomic DNA. No translation available.
CCDSiCCDS31307.1.
RefSeqiNP_001291396.1. NM_001304467.1.
NP_997719.2. NM_212554.3.
UniGeneiHs.720819.
Hs.741365.

Genome annotation databases

EnsembliENST00000368836; ENSP00000357829; ENSG00000203791.
GeneIDi399818.
KEGGihsa:399818.
UCSCiuc001lhy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEFMT2_HUMAN
AccessioniPrimary (citable) accession number: Q5JPI9
Secondary accession number(s): A8MPY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 5, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families