Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein-lysine N-methyltransferase METTL10

Gene

METTL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-lysine N-methyltransferase METTL10UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
Methyltransferase-like protein 10UniRule annotation
Gene namesi
Name:METTL10UniRule annotation
Synonyms:C10orf138
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:33787. METTL10.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162395769.

Polymorphism and mutation databases

BioMutaiMETTL10.
DMDMi172044620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 291290Protein-lysine N-methyltransferase METTL10PRO_0000325882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei21 – 211PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5JPI9.
MaxQBiQ5JPI9.
PaxDbiQ5JPI9.
PeptideAtlasiQ5JPI9.
PRIDEiQ5JPI9.

PTM databases

iPTMnetiQ5JPI9.
PhosphoSiteiQ5JPI9.

Expressioni

Gene expression databases

BgeeiENSG00000203791.
CleanExiHS_METTL10.
ExpressionAtlasiQ5JPI9. baseline and differential.
GenevisibleiQ5JPI9. HS.

Organism-specific databases

HPAiHPA050138.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357829.

Structurei

3D structure databases

ProteinModelPortaliQ5JPI9.
SMRiQ5JPI9. Positions 80-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1271. Eukaryota.
ENOG4111PXE. LUCA.
GeneTreeiENSGT00390000013399.
HOGENOMiHOG000184298.
InParanoidiQ5JPI9.
OMAiNEFSEGW.
OrthoDBiEOG091G0T79.
PhylomeDBiQ5JPI9.
TreeFamiTF313057.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03188. Methyltr_EFM4. 1 hit.
InterProiIPR026635. Efm4.
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR12843. PTHR12843. 1 hit.
PfamiPF13847. Methyltransf_31. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JPI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGADGGGG AAVAARSDKG SPGEDGFVPS ALGTREHWDA VYERELQTFR
60 70 80 90 100
EYGDTGEIWF GEESMNRLIR WMQKHKIPLD ASVLDIGTGN GVFLVELAKF
110 120 130 140 150
GFSNITGIDY SPSAIQLSGS IIEKEGLSNI KLKVEDFLNL STQLSGFHIC
160 170 180 190 200
IDKGTFDAIS LNPDNAIEKR KQYVKSLSRV LKVKGFFLIT SCNWTKEELL
210 220 230 240 250
NEFSEGWSTV AGFWLTAALT SWAQAIFSTS ASRVGGTTGT HHHAWIIFVF
260 270 280 290
LAETRFCHVV QAGLELLGSS DSPTWPPKVL GLYHARPSLA F
Length:291
Mass (Da):31,830
Last modified:March 18, 2008 - v2
Checksum:iE7A4486A4D1CCA50
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81G → S in CAI46179 (PubMed:17974005).Curated
Sequence conflicti97 – 971L → LL in CAI46179 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671R → Q.
Corresponds to variant rs4347339 [ dbSNP | Ensembl ].
VAR_050295

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832292 mRNA. Translation: CAI46179.1.
AC068896 Genomic DNA. No translation available.
CCDSiCCDS31307.1.
RefSeqiNP_001291396.1. NM_001304467.1.
NP_997719.2. NM_212554.3.
UniGeneiHs.720819.
Hs.741365.

Genome annotation databases

EnsembliENST00000368836; ENSP00000357829; ENSG00000203791.
GeneIDi399818.
KEGGihsa:399818.
UCSCiuc001lhy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832292 mRNA. Translation: CAI46179.1.
AC068896 Genomic DNA. No translation available.
CCDSiCCDS31307.1.
RefSeqiNP_001291396.1. NM_001304467.1.
NP_997719.2. NM_212554.3.
UniGeneiHs.720819.
Hs.741365.

3D structure databases

ProteinModelPortaliQ5JPI9.
SMRiQ5JPI9. Positions 80-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357829.

PTM databases

iPTMnetiQ5JPI9.
PhosphoSiteiQ5JPI9.

Polymorphism and mutation databases

BioMutaiMETTL10.
DMDMi172044620.

Proteomic databases

EPDiQ5JPI9.
MaxQBiQ5JPI9.
PaxDbiQ5JPI9.
PeptideAtlasiQ5JPI9.
PRIDEiQ5JPI9.

Protocols and materials databases

DNASUi399818.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368836; ENSP00000357829; ENSG00000203791.
GeneIDi399818.
KEGGihsa:399818.
UCSCiuc001lhy.2. human.

Organism-specific databases

CTDi399818.
GeneCardsiMETTL10.
H-InvDBHIX0009286.
HIX0022869.
HGNCiHGNC:33787. METTL10.
HPAiHPA050138.
neXtProtiNX_Q5JPI9.
PharmGKBiPA162395769.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1271. Eukaryota.
ENOG4111PXE. LUCA.
GeneTreeiENSGT00390000013399.
HOGENOMiHOG000184298.
InParanoidiQ5JPI9.
OMAiNEFSEGW.
OrthoDBiEOG091G0T79.
PhylomeDBiQ5JPI9.
TreeFamiTF313057.

Miscellaneous databases

GenomeRNAii399818.
PROiQ5JPI9.

Gene expression databases

BgeeiENSG00000203791.
CleanExiHS_METTL10.
ExpressionAtlasiQ5JPI9. baseline and differential.
GenevisibleiQ5JPI9. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03188. Methyltr_EFM4. 1 hit.
InterProiIPR026635. Efm4.
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR12843. PTHR12843. 1 hit.
PfamiPF13847. Methyltransf_31. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMET10_HUMAN
AccessioniPrimary (citable) accession number: Q5JPI9
Secondary accession number(s): A8MPY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 7, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.