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Protein

Uncharacterized protein C3orf38

Gene

C3orf38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in apoptosis regulation.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C3orf38
Gene namesi
Name:C3orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28384. C3orf38.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672399.

Polymorphism and mutation databases

BioMutaiC3orf38.
DMDMi74708031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Uncharacterized protein C3orf38PRO_0000244989Add
BLAST
Isoform 2 (identifier: Q5JPI3-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 2 (identifier: Q5JPI3-2)
Modified residuei2 – 21N-acetylserineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ5JPI3.
MaxQBiQ5JPI3.
PaxDbiQ5JPI3.
PeptideAtlasiQ5JPI3.
PRIDEiQ5JPI3.

PTM databases

iPTMnetiQ5JPI3.
PhosphoSiteiQ5JPI3.

Expressioni

Gene expression databases

BgeeiQ5JPI3.
CleanExiHS_C3orf38.
ExpressionAtlasiQ5JPI3. baseline and differential.
GenevisibleiQ5JPI3. HS.

Organism-specific databases

HPAiHPA034736.
HPA034737.

Interactioni

Protein-protein interaction databases

BioGridi130054. 3 interactions.
IntActiQ5JPI3. 1 interaction.
STRINGi9606.ENSP00000322469.

Structurei

3D structure databases

ProteinModelPortaliQ5JPI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKGU. Eukaryota.
ENOG4111AXV. LUCA.
GeneTreeiENSGT00390000000367.
HOGENOMiHOG000006998.
HOVERGENiHBG056177.
InParanoidiQ5JPI3.
OMAiMEGCRNL.
OrthoDBiEOG7WT41V.
PhylomeDBiQ5JPI3.
TreeFamiTF323327.

Family and domain databases

InterProiIPR032710. NTF2-like_dom.
IPR026698. UPF_C3orf38.
[Graphical view]
PANTHERiPTHR21084. PTHR21084. 1 hit.
PfamiPF15008. DUF4518. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JPI3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMSGLSFSE MEGCRNLLGL LDNDEIMALC DTVTNRLVQP QDRQDAVHAI
60 70 80 90 100
LAYSQSAEEL LRRRKVHREV IFKYLATQGI VIPPATEKHN LIQHAKDYWQ
110 120 130 140 150
KQPQLKLKET PEPVTKTEDI HLFQQQVKED KKAEKVDFRR LGEEFCHWFF
160 170 180 190 200
GLLNSQNPFL GPPQDEWGPQ HFWHDVKLRF YYNTSEQNVM DYHGAEIVSL
210 220 230 240 250
RLLSLVKEEF LFLSPNLDSH GLKCASSPHG LVMVGVAGTV HRGNTCLGIF
260 270 280 290 300
EQIFGLIRCP FVENTWKIKF INLKIMGESS LAPGTLPKPS VKFEQSDLEA
310 320
FYNVITVCGT NEVRHNVKQA SDSGTGDQV
Length:329
Mass (Da):37,541
Last modified:February 15, 2005 - v1
Checksum:i1D50C818B7F029ED
GO
Isoform 2 (identifier: Q5JPI3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Show »
Length:327
Mass (Da):37,281
Checksum:i539614E763F799B9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 22Missing in isoform 2. 2 PublicationsVSP_019621

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313547 mRNA. Translation: BAG36323.1.
AL832398 mRNA. Translation: CAI46184.1.
BC024188 mRNA. Translation: AAH24188.1.
CCDSiCCDS2921.2. [Q5JPI3-1]
RefSeqiNP_776185.2. NM_173824.3. [Q5JPI3-1]
UniGeneiHs.476944.
Hs.518099.

Genome annotation databases

EnsembliENST00000318887; ENSP00000322469; ENSG00000179021. [Q5JPI3-1]
GeneIDi285237.
KEGGihsa:285237.
UCSCiuc003dqw.4. human. [Q5JPI3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313547 mRNA. Translation: BAG36323.1.
AL832398 mRNA. Translation: CAI46184.1.
BC024188 mRNA. Translation: AAH24188.1.
CCDSiCCDS2921.2. [Q5JPI3-1]
RefSeqiNP_776185.2. NM_173824.3. [Q5JPI3-1]
UniGeneiHs.476944.
Hs.518099.

3D structure databases

ProteinModelPortaliQ5JPI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130054. 3 interactions.
IntActiQ5JPI3. 1 interaction.
STRINGi9606.ENSP00000322469.

PTM databases

iPTMnetiQ5JPI3.
PhosphoSiteiQ5JPI3.

Polymorphism and mutation databases

BioMutaiC3orf38.
DMDMi74708031.

Proteomic databases

EPDiQ5JPI3.
MaxQBiQ5JPI3.
PaxDbiQ5JPI3.
PeptideAtlasiQ5JPI3.
PRIDEiQ5JPI3.

Protocols and materials databases

DNASUi285237.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318887; ENSP00000322469; ENSG00000179021. [Q5JPI3-1]
GeneIDi285237.
KEGGihsa:285237.
UCSCiuc003dqw.4. human. [Q5JPI3-1]

Organism-specific databases

CTDi285237.
GeneCardsiC3orf38.
H-InvDBHIX0019911.
HGNCiHGNC:28384. C3orf38.
HPAiHPA034736.
HPA034737.
neXtProtiNX_Q5JPI3.
PharmGKBiPA142672399.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKGU. Eukaryota.
ENOG4111AXV. LUCA.
GeneTreeiENSGT00390000000367.
HOGENOMiHOG000006998.
HOVERGENiHBG056177.
InParanoidiQ5JPI3.
OMAiMEGCRNL.
OrthoDBiEOG7WT41V.
PhylomeDBiQ5JPI3.
TreeFamiTF323327.

Miscellaneous databases

GenomeRNAii285237.
PROiQ5JPI3.

Gene expression databases

BgeeiQ5JPI3.
CleanExiHS_C3orf38.
ExpressionAtlasiQ5JPI3. baseline and differential.
GenevisibleiQ5JPI3. HS.

Family and domain databases

InterProiIPR032710. NTF2-like_dom.
IPR026698. UPF_C3orf38.
[Graphical view]
PANTHERiPTHR21084. PTHR21084. 1 hit.
PfamiPF15008. DUF4518. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph node.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "Identification of novel regulators of apoptosis using a high-throughput cell-based screen."
    Park K.M., Kang E., Jeon Y.-J., Kim N., Kim N.-S., Yoo H.-S., Yeom Y.I., Kim S.J.
    Mol. Cells 23:170-174(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 (ISOFORM 2), CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCC038_HUMAN
AccessioniPrimary (citable) accession number: Q5JPI3
Secondary accession number(s): B2R8X6, Q8TC85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: February 15, 2005
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.