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Protein

Uncharacterized protein C3orf38

Gene

C3orf38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in apoptosis regulation.1 Publication

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C3orf38
Gene namesi
Name:C3orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28384. C3orf38.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179021.
PharmGKBiPA142672399.

Polymorphism and mutation databases

BioMutaiC3orf38.
DMDMi74708031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002449891 – 329Uncharacterized protein C3orf38Add BLAST329
Isoform 2 (identifier: Q5JPI3-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q5JPI3-2)
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ5JPI3.
MaxQBiQ5JPI3.
PaxDbiQ5JPI3.
PeptideAtlasiQ5JPI3.
PRIDEiQ5JPI3.

PTM databases

iPTMnetiQ5JPI3.
PhosphoSitePlusiQ5JPI3.

Expressioni

Gene expression databases

BgeeiENSG00000179021.
CleanExiHS_C3orf38.
ExpressionAtlasiQ5JPI3. baseline and differential.
GenevisibleiQ5JPI3. HS.

Organism-specific databases

HPAiHPA034736.
HPA034737.

Interactioni

Protein-protein interaction databases

BioGridi130054. 6 interactors.
IntActiQ5JPI3. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ5JPI3.
SMRiQ5JPI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKGU. Eukaryota.
ENOG4111AXV. LUCA.
GeneTreeiENSGT00390000000367.
HOGENOMiHOG000006998.
HOVERGENiHBG056177.
InParanoidiQ5JPI3.
OMAiFYYNTSE.
OrthoDBiEOG091G0JHV.
PhylomeDBiQ5JPI3.
TreeFamiTF323327.

Family and domain databases

InterProiView protein in InterPro
IPR032710. NTF2-like_dom.
IPR026698. UPF_C3orf38.
PANTHERiPTHR21084. PTHR21084. 1 hit.
PfamiView protein in Pfam
PF15008. DUF4518. 1 hit.
SUPFAMiSSF54427. SSF54427. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JPI3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMSGLSFSE MEGCRNLLGL LDNDEIMALC DTVTNRLVQP QDRQDAVHAI
60 70 80 90 100
LAYSQSAEEL LRRRKVHREV IFKYLATQGI VIPPATEKHN LIQHAKDYWQ
110 120 130 140 150
KQPQLKLKET PEPVTKTEDI HLFQQQVKED KKAEKVDFRR LGEEFCHWFF
160 170 180 190 200
GLLNSQNPFL GPPQDEWGPQ HFWHDVKLRF YYNTSEQNVM DYHGAEIVSL
210 220 230 240 250
RLLSLVKEEF LFLSPNLDSH GLKCASSPHG LVMVGVAGTV HRGNTCLGIF
260 270 280 290 300
EQIFGLIRCP FVENTWKIKF INLKIMGESS LAPGTLPKPS VKFEQSDLEA
310 320
FYNVITVCGT NEVRHNVKQA SDSGTGDQV
Length:329
Mass (Da):37,541
Last modified:February 15, 2005 - v1
Checksum:i1D50C818B7F029ED
GO
Isoform 2 (identifier: Q5JPI3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Show »
Length:327
Mass (Da):37,281
Checksum:i539614E763F799B9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0196211 – 2Missing in isoform 2. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313547 mRNA. Translation: BAG36323.1.
AL832398 mRNA. Translation: CAI46184.1.
BC024188 mRNA. Translation: AAH24188.1.
CCDSiCCDS2921.2. [Q5JPI3-1]
RefSeqiNP_776185.2. NM_173824.3. [Q5JPI3-1]
UniGeneiHs.476944.
Hs.518099.

Genome annotation databases

EnsembliENST00000318887; ENSP00000322469; ENSG00000179021. [Q5JPI3-1]
GeneIDi285237.
KEGGihsa:285237.
UCSCiuc003dqw.4. human. [Q5JPI3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCC038_HUMAN
AccessioniPrimary (citable) accession number: Q5JPI3
Secondary accession number(s): B2R8X6, Q8TC85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: February 15, 2005
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM