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Protein

Ankyrin repeat domain-containing protein 36C

Gene

ANKRD36C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ion channel inhibitor activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 36C
Alternative name(s):
Protein immuno-reactive with anti-PTH polyclonal antibodies
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:32946. ANKRD36C.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174501.

Polymorphism and mutation databases

DMDMi302393829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003345451 – 1778Ankyrin repeat domain-containing protein 36CAdd BLAST1778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei829PhosphoserineCombined sources1
Modified residuei897PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5JPF3.
MaxQBiQ5JPF3.
PaxDbiQ5JPF3.
PeptideAtlasiQ5JPF3.
PRIDEiQ5JPF3.

PTM databases

iPTMnetiQ5JPF3.
PhosphoSitePlusiQ5JPF3.

Expressioni

Gene expression databases

BgeeiENSG00000174501.
ExpressionAtlasiQ5JPF3. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ5JPF3. 2 interactors.
STRINGi9606.ENSP00000403302.

Structurei

3D structure databases

ProteinModelPortaliQ5JPF3.
SMRiQ5JPF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 93ANK 1Add BLAST30
Repeati97 – 126ANK 2Add BLAST30
Repeati130 – 159ANK 3Add BLAST30
Repeati163 – 192ANK 4Add BLAST30
Repeati196 – 225ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1157 – 1187Sequence analysisAdd BLAST31
Coiled coili1247 – 1333Sequence analysisAdd BLAST87
Coiled coili1362 – 1480Sequence analysisAdd BLAST119
Coiled coili1544 – 1768Sequence analysisAdd BLAST225

Sequence similaritiesi

Belongs to the ANKRD36 family.Curated
Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000185155.
HOVERGENiHBG108636.
InParanoidiQ5JPF3.
OMAiKGIHRAV.
OrthoDBiEOG091G01X9.
PhylomeDBiQ5JPF3.
TreeFamiTF333496.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JPF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDKEPKRWP TLRDRLCSDG FLFPQYPIKP YHLKGIHRAV FYRDLEELKF
60 70 80 90 100
VLLTRYDINK RDRKERTALH LACATGQPEM VHLLVSRRCE LNLCDREDRT
110 120 130 140 150
PLIKAVQLRQ EACATLLLQN GADPNITDVF GRTALHYAVY NEDTSMIEKL
160 170 180 190 200
LSYGANIEEC SEDEYPPLFL AVSQRKVKMV EFLLKKKANI NAVDYLGRSA
210 220 230 240 250
LIHAVTLGEK DIVILLLQHN IDVFSRDVYG KLAEDYASEA KNRVIFELIY
260 270 280 290 300
EYERKKHEEL SINSNPVSSQ KQPALKATSG KEDSISNIAT EIKDGQKSGT
310 320 330 340 350
VSSQKQPALK GTSDKNDSVS NTATEIKDEQ KSGTVSSQKQ PALKDTSDKN
360 370 380 390 400
DSVSNTATEI KDEQKSGTVL PAVEQCLNRS LYRPDAVAQP VTEDEFALES
410 420 430 440 450
EIISKLYIPK RKIISPRSIE DVLPPVEEAV DRCLYLLDRF AQAVTKDKFA
460 470 480 490 500
LESENISEPY FTNRRTISQQ SAEKLDAACG IDKTENGTLF EDQNVDKEGK
510 520 530 540 550
ALPATGQKAN VSPEQPPLFT HTVKDSDHIS TRFLGSMDSL TSSEESSERP
560 570 580 590 600
PLSTLTLKEA DPSSKAAMRR KDSPPPGKVS SQKQPAEKAT SDDKDSVSNI
610 620 630 640 650
ATEIKEGPIS GTVSSQKQPA EKATSDEKDS VSNIATEIKE GQQSGTVSPQ
660 670 680 690 700
KQSAWKVIFK KKVSLLNIAT RITGGGKSGT VSSQKQPPSK ATSDKTDSAL
710 720 730 740 750
NIATEIKDGL QCGTVSSQKQ PALKATTDEE DSVSNIATEI KDGEKSGTVS
760 770 780 790 800
SQKQPALKAT TDEEDSVSII ATEIKDGEKS GTVSSRKKPA LKATSDEKDS
810 820 830 840 850
FSNITREKKD GEISRTVTSE KPAGLKATSD EEDSVLNIAR GKEDGEKTRR
860 870 880 890 900
VSSRKKPALK ATSDEKDSFS NITREKKDGE TSRTVSSQKP PALKATSDEE
910 920 930 940 950
DSVLNIAREK KDGEKSRTVS SEKPSGLKAT SDEKDSVLNI ARGKKHGEKT
960 970 980 990 1000
RRVSSHKQPA LKATSDKENS VPNMATETKD EQISGTVSSQ KQPALKATSD
1010 1020 1030 1040 1050
KKDSVSNIPT EIKDGQQSGT VSSQKQLAWK ATSVKKDSVS NIATEIKDGQ
1060 1070 1080 1090 1100
IRGTVSSQRQ PALKATGDEK DSVSNIAREI KDGEKSGTVS PQKQSAQKVI
1110 1120 1130 1140 1150
FKKKVSLLNI ATRITGGWKS GTEYPENLPT LKATIENKNS VLNTATKMKD
1160 1170 1180 1190 1200
VQTSTPEQDL EMASEGEQKR LEEYENNQPQ VKNQIHSRDD LDDIIQSSQT
1210 1220 1230 1240 1250
VSEDGDSLCC NCKNVILLID QHEMKCKDCV HLLKIKKTFC LCKRLTELKD
1260 1270 1280 1290 1300
NHCEQLRVKI RKLKNKASVL QKRLSEKEEI KSQLKHETLE LEKELCSLRF
1310 1320 1330 1340 1350
AIQQEKKKRR NVEELHQKVR EKLRITEEQY RIEADVTKPI KPALKSAEVE
1360 1370 1380 1390 1400
LKTGGNNSNQ VSETDEKEDL LHENRLMQDE IARLRLEKDT IKNQNLEKKY
1410 1420 1430 1440 1450
LKDFEIVKRK HEDLQKALKR NEETLAETIA CYSGQLAALT DENTTLRSKL
1460 1470 1480 1490 1500
EKQRESGQRL ETEMQSYRCR LNAALCDHDQ SHSSKRDQEL AFQGTVDKCC
1510 1520 1530 1540 1550
HLQENLNSHV LILSLQLSKA ESKFRVLETE LHYTGEALKE KALVFEHVQS
1560 1570 1580 1590 1600
ELKQKQSQMK DIEKMYKSGY NTMEKCIEKQ ERFCQLKKQN MLLQQQLDDA
1610 1620 1630 1640 1650
RNKADNQEKA ILNIQARCDA RVENLQAECR KHRLLLEEDN KMLVNELNHS
1660 1670 1680 1690 1700
KEKKCQYEKE KAEREVAVRQ LQQKQDDVLN KRSATKALLD ASSRHCIYLE
1710 1720 1730 1740 1750
NGMQDSRKKL DQMRSQFQEI QDQLTATIRC TKEMEGDAQK LEVENVMMRK
1760 1770
IIKKQDEQIE RFEKILQHSS LMLQVFES
Length:1,778
Mass (Da):199,748
Last modified:August 10, 2010 - v3
Checksum:i2E89BDBDCC7EDE5D
GO
Isoform 2 (identifier: Q5JPF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-973: Missing.

Show »
Length:805
Mass (Da):92,832
Checksum:iEDB604722D351644
GO
Isoform 3 (identifier: Q5JPF3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-567: Missing.
     1181-1185: VKNQI → IVFTY
     1186-1778: Missing.

Show »
Length:618
Mass (Da):66,520
Checksum:i744CEC2DBEDF2D37
GO

Sequence cautioni

The sequence AAB02177 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAB02177 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAY24080 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH56324 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1027L → P in CAH56324 (PubMed:17974005).Curated1
Sequence conflicti1027L → P in CAI46156 (PubMed:17974005).Curated1
Sequence conflicti1027L → P in AK123626 (PubMed:14702039).Curated1
Sequence conflicti1027L → P in AAB02177 (PubMed:8608414).Curated1
Sequence conflicti1117G → S in CAH56324 (PubMed:17974005).Curated1
Sequence conflicti1117G → S in CAI46156 (PubMed:17974005).Curated1
Sequence conflicti1117G → S in AK123626 (PubMed:14702039).Curated1
Sequence conflicti1309R → K in CAH56324 (PubMed:17974005).Curated1
Sequence conflicti1315L → V in AK123626 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0336751 – 973Missing in isoform 2. 2 PublicationsAdd BLAST973
Alternative sequenceiVSP_0396721 – 567Missing in isoform 3. 1 PublicationAdd BLAST567
Alternative sequenceiVSP_0396731181 – 1185VKNQI → IVFTY in isoform 3. 1 Publication5
Alternative sequenceiVSP_0396741186 – 1778Missing in isoform 3. 1 PublicationAdd BLAST593

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832977 mRNA. Translation: CAH56324.1. Sequence problems.
AL832836 mRNA. Translation: CAI46156.1.
AC013272 Genomic DNA. No translation available.
AC073995 Genomic DNA. Translation: AAY24080.1. Sequence problems.
AK123626 mRNA. No translation available.
U28831 mRNA. Translation: AAB02177.1. Sequence problems.
UniGeneiHs.532921.
Hs.646318.

Genome annotation databases

EnsembliENST00000295246; ENSP00000295246; ENSG00000174501. [Q5JPF3-3]
ENST00000456556; ENSP00000403302; ENSG00000174501. [Q5JPF3-1]
UCSCiuc061ltz.1. human. [Q5JPF3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832977 mRNA. Translation: CAH56324.1. Sequence problems.
AL832836 mRNA. Translation: CAI46156.1.
AC013272 Genomic DNA. No translation available.
AC073995 Genomic DNA. Translation: AAY24080.1. Sequence problems.
AK123626 mRNA. No translation available.
U28831 mRNA. Translation: AAB02177.1. Sequence problems.
UniGeneiHs.532921.
Hs.646318.

3D structure databases

ProteinModelPortaliQ5JPF3.
SMRiQ5JPF3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5JPF3. 2 interactors.
STRINGi9606.ENSP00000403302.

PTM databases

iPTMnetiQ5JPF3.
PhosphoSitePlusiQ5JPF3.

Polymorphism and mutation databases

DMDMi302393829.

Proteomic databases

EPDiQ5JPF3.
MaxQBiQ5JPF3.
PaxDbiQ5JPF3.
PeptideAtlasiQ5JPF3.
PRIDEiQ5JPF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295246; ENSP00000295246; ENSG00000174501. [Q5JPF3-3]
ENST00000456556; ENSP00000403302; ENSG00000174501. [Q5JPF3-1]
UCSCiuc061ltz.1. human. [Q5JPF3-1]

Organism-specific databases

GeneCardsiANKRD36C.
H-InvDBHIX0002268.
HGNCiHGNC:32946. ANKRD36C.
neXtProtiNX_Q5JPF3.
OpenTargetsiENSG00000174501.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000185155.
HOVERGENiHBG108636.
InParanoidiQ5JPF3.
OMAiKGIHRAV.
OrthoDBiEOG091G01X9.
PhylomeDBiQ5JPF3.
TreeFamiTF333496.

Miscellaneous databases

PROiQ5JPF3.

Gene expression databases

BgeeiENSG00000174501.
ExpressionAtlasiQ5JPF3. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAN36C_HUMAN
AccessioniPrimary (citable) accession number: Q5JPF3
Secondary accession number(s): C9JZ08
, Q15694, Q53S06, Q658V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 10, 2010
Last modified: November 2, 2016
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.