Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nodal modulator 2

Gene

NOMO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN.By similarity

Caution

There are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1 (AC Q15155), NOMO2 and NOMO3 (AC P69849). All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members. The results reported in other entries may therefore apply for this protein.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Nodal modulator 2
Alternative name(s):
pM5 protein 2
Gene namesi
Name:NOMO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000185164.14
HGNCiHGNC:22652 NOMO2
MIMi609158 gene
neXtProtiNX_Q5JPE7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 1155LumenalSequence analysisAdd BLAST1124
Transmembranei1156 – 1176HelicalSequence analysisAdd BLAST21
Topological domaini1177 – 1267CytoplasmicSequence analysisAdd BLAST91

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958124

Polymorphism and mutation databases

BioMutaiNOMO2
DMDMi67460998

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000002182032 – 1267Nodal modulator 2Add BLAST1236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi618N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ5JPE7
MaxQBiQ5JPE7
PaxDbiQ5JPE7
PeptideAtlasiQ5JPE7
PRIDEiQ5JPE7

PTM databases

iPTMnetiQ5JPE7
PhosphoSitePlusiQ5JPE7
SwissPalmiQ5JPE7

Expressioni

Tissue specificityi

Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.1 Publication

Gene expression databases

BgeeiENSG00000185164
ExpressionAtlasiQ5JPE7 baseline and differential
GenevisibleiQ5JPE7 HS

Organism-specific databases

HPAiHPA046697
HPA061174

Interactioni

Subunit structurei

Forms a complex with NCLN and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome.

Protein-protein interaction databases

BioGridi129677, 9 interactors
IntActiQ5JPE7, 7 interactors
MINTiQ5JPE7
STRINGi9606.ENSP00000370883

Structurei

3D structure databases

ProteinModelPortaliQ5JPE7
SMRiQ5JPE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1948 Eukaryota
ENOG410XTI0 LUCA
GeneTreeiENSGT00390000000089
HOGENOMiHOG000230623
HOVERGENiHBG023764
InParanoidiQ5JPE7
OMAiGWSFEPE
OrthoDBiEOG091G0126
PhylomeDBiQ5JPE7
TreeFamiTF313696

Family and domain databases

InterProiView protein in InterPro
IPR013784 Carb-bd-like_fold
IPR008969 CarboxyPept-like_regulatory
SUPFAMiSSF49452 SSF49452, 3 hits
SSF49464 SSF49464, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JPE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLVGQGAGLL GPAVVTAAVV LLLSGVGPAH GSEDIVVGCG GFVKSDVEIN
60 70 80 90 100
YSLIEIKLYT KHGTLKYQTD CAPNNGYFMI PLYDKGDFIL KIEPPLGWSF
110 120 130 140 150
EPTTVELHVD GVSDICTKGG DINFVFTGFS VNGKVLSKGQ PLGPAGVQVS
160 170 180 190 200
LRNTGTEAKI QSTVTQPGGK FAFFKVLPGD YEILATHPTW ALKEASTTVR
210 220 230 240 250
VTNSNANAAS PLIVAGYNVS GSVRSDGEPM KGVKFLLFSS LVTKEDVLGC
260 270 280 290 300
NVSPVPGFQP QDESLVYLCY TVSREDGSFS FYSLPSGGYT VIPFYRGERI
310 320 330 340 350
TFDVAPSRLD FTVEHDSLKI EPVFHVMGFS VTGRVLNGPE GDGVPEAVVT
360 370 380 390 400
LNNQIKVKTK ADGSFRLENI TTGTYTIHAQ KEHLYFETVT IKIAPNTPQL
410 420 430 440 450
ADIVATGFSV CGRISIIRFP DTVKQMNKYK VVLSSQDKDK SLVTVETDAH
460 470 480 490 500
GSFCFKAKPG TYKVQVMVPE AETRAGLTLK PQTFPLTVTD RPVMDVAFVQ
510 520 530 540 550
FLASVSGKVS CLDTCGDLLV TLQSLSRQGE KRSLQLSGKV NAMTFTFDNV
560 570 580 590 600
LPGKYKISIM HEDWCWKNKS LEVEVLEDDV SAVEFRQTGY MLRCSLSHAI
610 620 630 640 650
TLEFYQDGNG RENVGIYNLS KGVNRFCLSK PGVYKVTPRS CHRFEQAFYT
660 670 680 690 700
YDTSSPSILT LTAIRHHVLG TITTDKMMDV TVTIKSSIDS EPALVLGPLK
710 720 730 740 750
SVQELRREQQ LAEIEARRQE REKNGNEEGE ERMTKPPVQE MVDELQGPFS
760 770 780 790 800
YDFSYWARSG EKITVTPSSK ELLFYPPSME AVVSGESCPG KLIEIHGKAG
810 820 830 840 850
LFLEGQIHPE LEGVEIVISE KGASSPLITV FTDDKGAYSV GPLHSDLEYT
860 870 880 890 900
VTSQKEGYVL TAVEGTIGDF KAYALAGVSF EIKAEDDQPL PGVLLSLSGG
910 920 930 940 950
LFRSNLLTQD NGILTFSNLS PGQYYFKPMM KEFRFEPSSQ MIEVQEGQNL
960 970 980 990 1000
KITITGYRTA YSCYGTVSSL NGEPEQGVAM EAVGQNDCSI YGEDTVTDEE
1010 1020 1030 1040 1050
GKFRLRGLLP GCVYHVQLKA EGNDHIERAL PHHRVIEVGN NDIDDVNIIV
1060 1070 1080 1090 1100
FRQINQFDLS GNVITSSEYL PTLWVKLYKS ENLDNPIQTV SLGQSLFFHF
1110 1120 1130 1140 1150
PPLLRDGENY VVLLDSTLPR SQYDYILPQV SFTAVGYHKH ITLIFNPTRK
1160 1170 1180 1190 1200
LPEQDIAQGS YIALPLTLLV LLAGYNHDKL IPLLLQLTSR LQGVGALGQA
1210 1220 1230 1240 1250
ASDNSGPEDA KRQAKKQKTR RTLRLQEEFQ LMWCLVPWRG TLGIHLFSSL
1260
PFASEILLET TATCIHY
Length:1,267
Mass (Da):139,439
Last modified:February 15, 2005 - v1
Checksum:i593D2AE67A46F5B0
GO
Isoform 2 (identifier: Q5JPE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1223-1267: Missing.

Note: No experimental confirmation available.
Show »
Length:1,222
Mass (Da):134,192
Checksum:iEB1925A40D85A8D1
GO
Isoform 3 (identifier: Q5JPE7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MLV → MAR
     4-170: Missing.

Note: No experimental confirmation available.
Show »
Length:1,100
Mass (Da):122,062
Checksum:i6D2CB089BE44496C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034139493V → M. Corresponds to variant dbSNP:rs1062413Ensembl.1
Natural variantiVAR_016104580V → M. Corresponds to variant dbSNP:rs15984Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0539281 – 3MLV → MAR in isoform 3. 1 Publication3
Alternative sequenceiVSP_0539294 – 170Missing in isoform 3. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_0138501223 – 1267Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832855 mRNA Translation: CAI46162.1
AC126755 Genomic DNA No translation available.
AC136618 Genomic DNA No translation available.
BC028389 mRNA Translation: AAH28389.1
BC041131 mRNA Translation: AAH41131.1
CCDSiCCDS10570.1 [Q5JPE7-2]
CCDS32394.1 [Q5JPE7-1]
RefSeqiNP_001004060.1, NM_001004060.1 [Q5JPE7-1]
NP_775885.1, NM_173614.2 [Q5JPE7-2]
UniGeneiHs.460141

Genome annotation databases

EnsembliENST00000330537; ENSP00000331851; ENSG00000185164 [Q5JPE7-2]
ENST00000381474; ENSP00000370883; ENSG00000185164 [Q5JPE7-1]
ENST00000543392; ENSP00000439970; ENSG00000185164 [Q5JPE7-3]
ENST00000621364; ENSP00000477502; ENSG00000185164 [Q5JPE7-1]
ENST00000622306; ENSP00000478653; ENSG00000185164 [Q5JPE7-2]
GeneIDi283820
KEGGihsa:283820
UCSCiuc032dtj.2 human [Q5JPE7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNOMO2_HUMAN
AccessioniPrimary (citable) accession number: Q5JPE7
Secondary accession number(s): Q4G177
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health