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Protein

Nodal modulator 2

Gene

NOMO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN.By similarity

GO - Molecular functioni

GO - Biological processi

  • protein destabilization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nodal modulator 2
Alternative name(s):
pM5 protein 2
Gene namesi
Name:NOMO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:22652. NOMO2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 11551124LumenalSequence analysisAdd
BLAST
Transmembranei1156 – 117621HelicalSequence analysisAdd
BLAST
Topological domaini1177 – 126791CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958124.

Polymorphism and mutation databases

BioMutaiNOMO2.
DMDMi67460998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 12671236Nodal modulator 2PRO_0000021820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence analysis
Glycosylationi618 – 6181N-linked (GlcNAc...)Sequence analysis
Modified residuei1205 – 12051PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ5JPE7.
MaxQBiQ5JPE7.
PaxDbiQ5JPE7.
PRIDEiQ5JPE7.

PTM databases

iPTMnetiQ5JPE7.
PhosphoSiteiQ5JPE7.
SwissPalmiQ5JPE7.

Expressioni

Tissue specificityi

Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.1 Publication

Gene expression databases

BgeeiQ5JPE7.
ExpressionAtlasiQ5JPE7. baseline and differential.
GenevisibleiQ5JPE7. HS.

Organism-specific databases

HPAiHPA046697.
HPA047245.
HPA061174.

Interactioni

Subunit structurei

Forms a complex with NCLN and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome.

Protein-protein interaction databases

BioGridi129677. 8 interactions.
IntActiQ5JPE7. 7 interactions.
STRINGi9606.ENSP00000370883.

Structurei

3D structure databases

ProteinModelPortaliQ5JPE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1948. Eukaryota.
ENOG410XTI0. LUCA.
GeneTreeiENSGT00390000000089.
HOGENOMiHOG000230623.
HOVERGENiHBG023764.
InParanoidiQ5JPE7.
OMAiHEEINTN.
OrthoDBiEOG77M8NC.
PhylomeDBiQ5JPE7.
TreeFamiTF313696.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1120. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JPE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLVGQGAGLL GPAVVTAAVV LLLSGVGPAH GSEDIVVGCG GFVKSDVEIN
60 70 80 90 100
YSLIEIKLYT KHGTLKYQTD CAPNNGYFMI PLYDKGDFIL KIEPPLGWSF
110 120 130 140 150
EPTTVELHVD GVSDICTKGG DINFVFTGFS VNGKVLSKGQ PLGPAGVQVS
160 170 180 190 200
LRNTGTEAKI QSTVTQPGGK FAFFKVLPGD YEILATHPTW ALKEASTTVR
210 220 230 240 250
VTNSNANAAS PLIVAGYNVS GSVRSDGEPM KGVKFLLFSS LVTKEDVLGC
260 270 280 290 300
NVSPVPGFQP QDESLVYLCY TVSREDGSFS FYSLPSGGYT VIPFYRGERI
310 320 330 340 350
TFDVAPSRLD FTVEHDSLKI EPVFHVMGFS VTGRVLNGPE GDGVPEAVVT
360 370 380 390 400
LNNQIKVKTK ADGSFRLENI TTGTYTIHAQ KEHLYFETVT IKIAPNTPQL
410 420 430 440 450
ADIVATGFSV CGRISIIRFP DTVKQMNKYK VVLSSQDKDK SLVTVETDAH
460 470 480 490 500
GSFCFKAKPG TYKVQVMVPE AETRAGLTLK PQTFPLTVTD RPVMDVAFVQ
510 520 530 540 550
FLASVSGKVS CLDTCGDLLV TLQSLSRQGE KRSLQLSGKV NAMTFTFDNV
560 570 580 590 600
LPGKYKISIM HEDWCWKNKS LEVEVLEDDV SAVEFRQTGY MLRCSLSHAI
610 620 630 640 650
TLEFYQDGNG RENVGIYNLS KGVNRFCLSK PGVYKVTPRS CHRFEQAFYT
660 670 680 690 700
YDTSSPSILT LTAIRHHVLG TITTDKMMDV TVTIKSSIDS EPALVLGPLK
710 720 730 740 750
SVQELRREQQ LAEIEARRQE REKNGNEEGE ERMTKPPVQE MVDELQGPFS
760 770 780 790 800
YDFSYWARSG EKITVTPSSK ELLFYPPSME AVVSGESCPG KLIEIHGKAG
810 820 830 840 850
LFLEGQIHPE LEGVEIVISE KGASSPLITV FTDDKGAYSV GPLHSDLEYT
860 870 880 890 900
VTSQKEGYVL TAVEGTIGDF KAYALAGVSF EIKAEDDQPL PGVLLSLSGG
910 920 930 940 950
LFRSNLLTQD NGILTFSNLS PGQYYFKPMM KEFRFEPSSQ MIEVQEGQNL
960 970 980 990 1000
KITITGYRTA YSCYGTVSSL NGEPEQGVAM EAVGQNDCSI YGEDTVTDEE
1010 1020 1030 1040 1050
GKFRLRGLLP GCVYHVQLKA EGNDHIERAL PHHRVIEVGN NDIDDVNIIV
1060 1070 1080 1090 1100
FRQINQFDLS GNVITSSEYL PTLWVKLYKS ENLDNPIQTV SLGQSLFFHF
1110 1120 1130 1140 1150
PPLLRDGENY VVLLDSTLPR SQYDYILPQV SFTAVGYHKH ITLIFNPTRK
1160 1170 1180 1190 1200
LPEQDIAQGS YIALPLTLLV LLAGYNHDKL IPLLLQLTSR LQGVGALGQA
1210 1220 1230 1240 1250
ASDNSGPEDA KRQAKKQKTR RTLRLQEEFQ LMWCLVPWRG TLGIHLFSSL
1260
PFASEILLET TATCIHY
Length:1,267
Mass (Da):139,439
Last modified:February 15, 2005 - v1
Checksum:i593D2AE67A46F5B0
GO
Isoform 2 (identifier: Q5JPE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1223-1267: Missing.

Note: No experimental confirmation available.
Show »
Length:1,222
Mass (Da):134,192
Checksum:iEB1925A40D85A8D1
GO
Isoform 3 (identifier: Q5JPE7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MLV → MAR
     4-170: Missing.

Note: No experimental confirmation available.
Show »
Length:1,100
Mass (Da):122,062
Checksum:i6D2CB089BE44496C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti490 – 4901D → N.
Corresponds to variant rs17435353 [ dbSNP | Ensembl ].
VAR_034138
Natural varianti493 – 4931V → M.
Corresponds to variant rs17425492 [ dbSNP | Ensembl ].
VAR_034139
Natural varianti580 – 5801V → M.
Corresponds to variant rs15984 [ dbSNP | Ensembl ].
VAR_016104
Natural varianti726 – 7261N → K.
Corresponds to variant rs370986 [ dbSNP | Ensembl ].
VAR_034140

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 33MLV → MAR in isoform 3. 1 PublicationVSP_053928
Alternative sequencei4 – 170167Missing in isoform 3. 1 PublicationVSP_053929Add
BLAST
Alternative sequencei1223 – 126745Missing in isoform 2. 1 PublicationVSP_013850Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832855 mRNA. Translation: CAI46162.1.
AC126755 Genomic DNA. No translation available.
AC136618 Genomic DNA. No translation available.
BC028389 mRNA. Translation: AAH28389.1.
BC041131 mRNA. Translation: AAH41131.1.
CCDSiCCDS10570.1. [Q5JPE7-2]
CCDS32394.1. [Q5JPE7-1]
RefSeqiNP_001004060.1. NM_001004060.1. [Q5JPE7-1]
NP_775885.1. NM_173614.2. [Q5JPE7-2]
UniGeneiHs.460141.

Genome annotation databases

EnsembliENST00000330537; ENSP00000331851; ENSG00000185164. [Q5JPE7-2]
ENST00000381474; ENSP00000370883; ENSG00000185164. [Q5JPE7-1]
ENST00000543392; ENSP00000439970; ENSG00000185164. [Q5JPE7-3]
ENST00000621364; ENSP00000477502; ENSG00000185164. [Q5JPE7-1]
ENST00000622306; ENSP00000478653; ENSG00000185164. [Q5JPE7-2]
GeneIDi283820.
KEGGihsa:283820.
UCSCiuc032dtj.2. human. [Q5JPE7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832855 mRNA. Translation: CAI46162.1.
AC126755 Genomic DNA. No translation available.
AC136618 Genomic DNA. No translation available.
BC028389 mRNA. Translation: AAH28389.1.
BC041131 mRNA. Translation: AAH41131.1.
CCDSiCCDS10570.1. [Q5JPE7-2]
CCDS32394.1. [Q5JPE7-1]
RefSeqiNP_001004060.1. NM_001004060.1. [Q5JPE7-1]
NP_775885.1. NM_173614.2. [Q5JPE7-2]
UniGeneiHs.460141.

3D structure databases

ProteinModelPortaliQ5JPE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129677. 8 interactions.
IntActiQ5JPE7. 7 interactions.
STRINGi9606.ENSP00000370883.

PTM databases

iPTMnetiQ5JPE7.
PhosphoSiteiQ5JPE7.
SwissPalmiQ5JPE7.

Polymorphism and mutation databases

BioMutaiNOMO2.
DMDMi67460998.

Proteomic databases

EPDiQ5JPE7.
MaxQBiQ5JPE7.
PaxDbiQ5JPE7.
PRIDEiQ5JPE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330537; ENSP00000331851; ENSG00000185164. [Q5JPE7-2]
ENST00000381474; ENSP00000370883; ENSG00000185164. [Q5JPE7-1]
ENST00000543392; ENSP00000439970; ENSG00000185164. [Q5JPE7-3]
ENST00000621364; ENSP00000477502; ENSG00000185164. [Q5JPE7-1]
ENST00000622306; ENSP00000478653; ENSG00000185164. [Q5JPE7-2]
GeneIDi283820.
KEGGihsa:283820.
UCSCiuc032dtj.2. human. [Q5JPE7-1]

Organism-specific databases

CTDi283820.
GeneCardsiNOMO2.
HGNCiHGNC:22652. NOMO2.
HPAiHPA046697.
HPA047245.
HPA061174.
MIMi609158. gene.
neXtProtiNX_Q5JPE7.
PharmGKBiPA134958124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1948. Eukaryota.
ENOG410XTI0. LUCA.
GeneTreeiENSGT00390000000089.
HOGENOMiHOG000230623.
HOVERGENiHBG023764.
InParanoidiQ5JPE7.
OMAiHEEINTN.
OrthoDBiEOG77M8NC.
PhylomeDBiQ5JPE7.
TreeFamiTF313696.

Miscellaneous databases

ChiTaRSiNOMO2. human.
GenomeRNAii283820.
PROiQ5JPE7.
SOURCEiSearch...

Gene expression databases

BgeeiQ5JPE7.
ExpressionAtlasiQ5JPE7. baseline and differential.
GenevisibleiQ5JPE7. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1120. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph node.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Leukocyte and Testis.
  4. "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists."
    Haffner C., Frauli M., Topp S., Irmler M., Hofmann K., Regula J.T., Bally-Cuif L., Haass C.
    EMBO J. 23:3041-3050(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NCLN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex."
    Haffner C., Dettmer U., Weiler T., Haass C.
    J. Biol. Chem. 282:10632-10638(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NCLN, SUBCELLULAR LOCATION.
  6. "Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex."
    Dettmer U., Kuhn P.H., Abou-Ajram C., Lichtenthaler S.F., Kruger M., Kremmer E., Haass C., Haffner C.
    J. Biol. Chem. 285:26174-26181(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NCLN AND TMEM147.

Entry informationi

Entry nameiNOMO2_HUMAN
AccessioniPrimary (citable) accession number: Q5JPE7
Secondary accession number(s): Q4G177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

There are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1 (AC Q15155), NOMO2 and NOMO3 (AC P69849). All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members. The results reported in other entries may therefore apply for this protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.