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Q5JPB2

- ZN831_HUMAN

UniProt

Q5JPB2 - ZN831_HUMAN

Protein

Zinc finger protein 831

Gene

ZNF831

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 4 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri144 – 16623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri172 – 19625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 831
    Gene namesi
    Name:ZNF831
    Synonyms:C20orf174
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16167. ZNF831.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410774.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16771677Zinc finger protein 831PRO_0000236041Add
    BLAST

    Proteomic databases

    PaxDbiQ5JPB2.
    PRIDEiQ5JPB2.

    PTM databases

    PhosphoSiteiQ5JPB2.

    Expressioni

    Gene expression databases

    BgeeiQ5JPB2.
    CleanExiHS_ZNF831.
    GenevestigatoriQ5JPB2.

    Organism-specific databases

    HPAiHPA016839.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000360069.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JPB2.
    SMRiQ5JPB2. Positions 142-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili391 – 42333Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 111108Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri144 – 16623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri172 – 19625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG331219.
    HOGENOMiHOG000231308.
    HOVERGENiHBG080221.
    InParanoidiQ5JPB2.
    OMAiSPGKVRN.
    OrthoDBiEOG769ZHP.
    PhylomeDBiQ5JPB2.
    TreeFamiTF338213.

    Family and domain databases

    Gene3Di3.30.160.60. 2 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 2 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5JPB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVPEPTCPA PPARDQPAPT PGPPGAPGGQ ASPHLTLGPV LLPPEQGLAP     50
    PTVFLKALPI PLYHTVPPGG LQPRAPLVTG SLDGGNVPFI LSPVLQPEGP 100
    GPTQVGKPAA PTLTVNIVGT LPVLSPGLGP TLGSPGKVRN AGKYLCPHCG 150
    RDCLKPSVLE KHIRSHTGER PFPCATCGIA FKTQSNLYKH RRTQTHLNNS 200
    RLSSESEGAG GGLLEEGDKA GEPPRPEGRG ESRCQGMHEG ASERPLSPGA 250
    HVPLLAKNLD VRTEAAPCPG SAFADREAPW DSAPMASPGL PAASTQPWRK 300
    LPEQKSPTAG KPCALQRQQA TAAEKPWDAK APEGRLRKCE STDSGYLSRS 350
    DSAEQPHAPC SPLHSLSEHS AESEGEGGPG PGPGVAGAEP GAREAGLELE 400
    KKRLEERIAQ LISHNQAVVD DAQLDNVRPR KTGLSKQGSI DLPTPYTYKD 450
    SFHFDIRALE PGRRRAPGPV RSTWTPPDKS RPLFFHSVPT QLSTTVECVP 500
    VTRSNSLPFV EGSRTWLEPR EPRDPWSRTQ KPLSPRPGPA RLGCRSGLSS 550
    TDVPSGHPRA LVRQAAVEDL PGTPIGDALV PAEDTDAKRT AAREAMAGKG 600
    RAGGRKCGQR RLKMFSQEKW QVYGDETFKR IYQKMKASPH GGKKAREVGM 650
    GSGAELGFPL QKEAAGSSGT VPTQDRRTPV HEDISAGATP EPWGNPPALE 700
    ASLVTEPTKH GETVARRGDS DRPRVEEAVS SPALGGRDSP CSGSRSPLVS 750
    PNGRLELGWQ MPPAPGPLKG GDVEAPRPVW PDPKLEGGAR GVGDVQETCL 800
    WAQTVLRWPS RGSGEDKLPS ERKKLKVEDL HSWKQPEPVS AETPGGPTQP 850
    ASLSSQKQDA DPGEVPGGSK ESARQVGEPL ESSGASLAAA SVALKRVGPR 900
    DKATPLHPAA PAPAEHPSLA TPPQAPRVLS ALADNAFSPK YLLRLPQAET 950
    PLPLPIPWGP RHSQDSLCSS GWPEERASFV GSGLGTPLSP SPASGPSPGE 1000
    ADSILEDPSC SRPQDGRKGA QLGGDKGDRM ATSRPAAREL PISAPGAPRE 1050
    ATSSPPTPTC EAHLVQDMEG DSHRIHRLCM GSTLARARLS GDVLNPWVPN 1100
    WELGEPPGNA PEDPSSGPLV GPDPCSPLQP GSFLTALTRP QGVPPGWPEL 1150
    ALSSHSGTSR SHSTRSPHST QNPFPSLKAE PRLTWCCLSR SVPLPAEQKA 1200
    KAASVYLAVH FPGSSLRDEG PNGPPGSNGG WTWTSPGEGG PAQMSKFSYP 1250
    TVPGVMPQHQ VSEPEWKKGL PWRAKMSRGN SKQRKLKINP KRYKGNFLQS 1300
    CVQLRASRLR TPTWVRRRSR HPPALEGLKP CRTPGQTSSE IAGLNLQEEP 1350
    SCATSESPPC CGKEEKKEGD CRQTLGTLSL GTSSRIVREM DKRTVKDISP 1400
    SAGEHGDCTT HSTAATSGLS LQSDTCLAVV NDVPLPPGKG LDLGLLETQL 1450
    LASQDSVSTD PKPYIFSDAQ RPSSFGSKGT FPHHDIATSV AAVCISLPVR 1500
    TDHIAQEIHS AESRDHSQTA GRTLTSSSPD SKVTEEGRAQ TLLPGRPSSG 1550
    QRISDSVPLE STEKTHLEIP ASGPSSASSH HKEGRHKTFF PSRGQYGCGE 1600
    MTVPCPSLGS DGRKRQVSGL ITRKDSVVPS KPEQPIEIPE APSKSLKKRS 1650
    LEGMRKQTRV EFSDTSSDDE DRLVIEI 1677
    Length:1,677
    Mass (Da):177,949
    Last modified:October 23, 2007 - v4
    Checksum:iD4D23943AAC3DA89
    GO

    Sequence cautioni

    The sequence CAI46154.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti845 – 8451G → R.
    Corresponds to variant rs181984 [ dbSNP | Ensembl ].
    VAR_026472
    Natural varianti1513 – 15131S → P.
    Corresponds to variant rs259956 [ dbSNP | Ensembl ].
    VAR_026473
    Natural varianti1615 – 16151R → H.1 Publication
    VAR_069367

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL121919 Genomic DNA. Translation: CAI21544.2.
    AL713683 mRNA. Translation: CAD28487.1.
    AL833682 mRNA. Translation: CAI46154.1. Different initiation.
    CCDSiCCDS42894.1.
    RefSeqiNP_848552.1. NM_178457.2.
    XP_005260329.1. XM_005260272.1.
    XP_005260330.1. XM_005260273.1.
    XP_005260331.1. XM_005260274.1.
    XP_006723761.1. XM_006723698.1.
    UniGeneiHs.473204.

    Genome annotation databases

    EnsembliENST00000371030; ENSP00000360069; ENSG00000124203.
    GeneIDi128611.
    KEGGihsa:128611.
    UCSCiuc002yan.3. human.

    Polymorphism databases

    DMDMi160370001.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL121919 Genomic DNA. Translation: CAI21544.2 .
    AL713683 mRNA. Translation: CAD28487.1 .
    AL833682 mRNA. Translation: CAI46154.1 . Different initiation.
    CCDSi CCDS42894.1.
    RefSeqi NP_848552.1. NM_178457.2.
    XP_005260329.1. XM_005260272.1.
    XP_005260330.1. XM_005260273.1.
    XP_005260331.1. XM_005260274.1.
    XP_006723761.1. XM_006723698.1.
    UniGenei Hs.473204.

    3D structure databases

    ProteinModelPortali Q5JPB2.
    SMRi Q5JPB2. Positions 142-190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000360069.

    PTM databases

    PhosphoSitei Q5JPB2.

    Polymorphism databases

    DMDMi 160370001.

    Proteomic databases

    PaxDbi Q5JPB2.
    PRIDEi Q5JPB2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371030 ; ENSP00000360069 ; ENSG00000124203 .
    GeneIDi 128611.
    KEGGi hsa:128611.
    UCSCi uc002yan.3. human.

    Organism-specific databases

    CTDi 128611.
    GeneCardsi GC20P057766.
    HGNCi HGNC:16167. ZNF831.
    HPAi HPA016839.
    neXtProti NX_Q5JPB2.
    PharmGKBi PA162410774.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331219.
    HOGENOMi HOG000231308.
    HOVERGENi HBG080221.
    InParanoidi Q5JPB2.
    OMAi SPGKVRN.
    OrthoDBi EOG769ZHP.
    PhylomeDBi Q5JPB2.
    TreeFami TF338213.

    Miscellaneous databases

    GenomeRNAii 128611.
    NextBioi 82396.
    PROi Q5JPB2.

    Gene expression databases

    Bgeei Q5JPB2.
    CleanExi HS_ZNF831.
    Genevestigatori Q5JPB2.

    Family and domain databases

    Gene3Di 3.30.160.60. 2 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 2 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-1677.
      Tissue: Lymph node.
    3. Cited for: VARIANT HIS-1615.

    Entry informationi

    Entry nameiZN831_HUMAN
    AccessioniPrimary (citable) accession number: Q5JPB2
    Secondary accession number(s): Q5TDR4, Q8TCP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 78 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3