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Q5JPB2 (ZN831_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 831
Gene names
Name:ZNF831
Synonyms:C20orf174
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1677 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 2 C2H2-type zinc fingers.

Sequence caution

The sequence CAI46154.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Repeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16771677Zinc finger protein 831
PRO_0000236041

Regions

Zinc finger144 – 16623C2H2-type 1
Zinc finger172 – 19625C2H2-type 2
Coiled coil391 – 42333 Potential
Compositional bias4 – 111108Pro-rich

Natural variations

Natural variant8451G → R.
Corresponds to variant rs181984 [ dbSNP | Ensembl ].
VAR_026472
Natural variant15131S → P.
Corresponds to variant rs259956 [ dbSNP | Ensembl ].
VAR_026473
Natural variant16151R → H. Ref.3
VAR_069367

Sequences

Sequence LengthMass (Da)Tools
Q5JPB2 [UniParc].

Last modified October 23, 2007. Version 4.
Checksum: D4D23943AAC3DA89

FASTA1,677177,949
        10         20         30         40         50         60 
MEVPEPTCPA PPARDQPAPT PGPPGAPGGQ ASPHLTLGPV LLPPEQGLAP PTVFLKALPI 

        70         80         90        100        110        120 
PLYHTVPPGG LQPRAPLVTG SLDGGNVPFI LSPVLQPEGP GPTQVGKPAA PTLTVNIVGT 

       130        140        150        160        170        180 
LPVLSPGLGP TLGSPGKVRN AGKYLCPHCG RDCLKPSVLE KHIRSHTGER PFPCATCGIA 

       190        200        210        220        230        240 
FKTQSNLYKH RRTQTHLNNS RLSSESEGAG GGLLEEGDKA GEPPRPEGRG ESRCQGMHEG 

       250        260        270        280        290        300 
ASERPLSPGA HVPLLAKNLD VRTEAAPCPG SAFADREAPW DSAPMASPGL PAASTQPWRK 

       310        320        330        340        350        360 
LPEQKSPTAG KPCALQRQQA TAAEKPWDAK APEGRLRKCE STDSGYLSRS DSAEQPHAPC 

       370        380        390        400        410        420 
SPLHSLSEHS AESEGEGGPG PGPGVAGAEP GAREAGLELE KKRLEERIAQ LISHNQAVVD 

       430        440        450        460        470        480 
DAQLDNVRPR KTGLSKQGSI DLPTPYTYKD SFHFDIRALE PGRRRAPGPV RSTWTPPDKS 

       490        500        510        520        530        540 
RPLFFHSVPT QLSTTVECVP VTRSNSLPFV EGSRTWLEPR EPRDPWSRTQ KPLSPRPGPA 

       550        560        570        580        590        600 
RLGCRSGLSS TDVPSGHPRA LVRQAAVEDL PGTPIGDALV PAEDTDAKRT AAREAMAGKG 

       610        620        630        640        650        660 
RAGGRKCGQR RLKMFSQEKW QVYGDETFKR IYQKMKASPH GGKKAREVGM GSGAELGFPL 

       670        680        690        700        710        720 
QKEAAGSSGT VPTQDRRTPV HEDISAGATP EPWGNPPALE ASLVTEPTKH GETVARRGDS 

       730        740        750        760        770        780 
DRPRVEEAVS SPALGGRDSP CSGSRSPLVS PNGRLELGWQ MPPAPGPLKG GDVEAPRPVW 

       790        800        810        820        830        840 
PDPKLEGGAR GVGDVQETCL WAQTVLRWPS RGSGEDKLPS ERKKLKVEDL HSWKQPEPVS 

       850        860        870        880        890        900 
AETPGGPTQP ASLSSQKQDA DPGEVPGGSK ESARQVGEPL ESSGASLAAA SVALKRVGPR 

       910        920        930        940        950        960 
DKATPLHPAA PAPAEHPSLA TPPQAPRVLS ALADNAFSPK YLLRLPQAET PLPLPIPWGP 

       970        980        990       1000       1010       1020 
RHSQDSLCSS GWPEERASFV GSGLGTPLSP SPASGPSPGE ADSILEDPSC SRPQDGRKGA 

      1030       1040       1050       1060       1070       1080 
QLGGDKGDRM ATSRPAAREL PISAPGAPRE ATSSPPTPTC EAHLVQDMEG DSHRIHRLCM 

      1090       1100       1110       1120       1130       1140 
GSTLARARLS GDVLNPWVPN WELGEPPGNA PEDPSSGPLV GPDPCSPLQP GSFLTALTRP 

      1150       1160       1170       1180       1190       1200 
QGVPPGWPEL ALSSHSGTSR SHSTRSPHST QNPFPSLKAE PRLTWCCLSR SVPLPAEQKA 

      1210       1220       1230       1240       1250       1260 
KAASVYLAVH FPGSSLRDEG PNGPPGSNGG WTWTSPGEGG PAQMSKFSYP TVPGVMPQHQ 

      1270       1280       1290       1300       1310       1320 
VSEPEWKKGL PWRAKMSRGN SKQRKLKINP KRYKGNFLQS CVQLRASRLR TPTWVRRRSR 

      1330       1340       1350       1360       1370       1380 
HPPALEGLKP CRTPGQTSSE IAGLNLQEEP SCATSESPPC CGKEEKKEGD CRQTLGTLSL 

      1390       1400       1410       1420       1430       1440 
GTSSRIVREM DKRTVKDISP SAGEHGDCTT HSTAATSGLS LQSDTCLAVV NDVPLPPGKG 

      1450       1460       1470       1480       1490       1500 
LDLGLLETQL LASQDSVSTD PKPYIFSDAQ RPSSFGSKGT FPHHDIATSV AAVCISLPVR 

      1510       1520       1530       1540       1550       1560 
TDHIAQEIHS AESRDHSQTA GRTLTSSSPD SKVTEEGRAQ TLLPGRPSSG QRISDSVPLE 

      1570       1580       1590       1600       1610       1620 
STEKTHLEIP ASGPSSASSH HKEGRHKTFF PSRGQYGCGE MTVPCPSLGS DGRKRQVSGL 

      1630       1640       1650       1660       1670 
ITRKDSVVPS KPEQPIEIPE APSKSLKKRS LEGMRKQTRV EFSDTSSDDE DRLVIEI 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-1677.
Tissue: Lymph node.
[3]"Diagnostic exome sequencing in persons with severe intellectual disability."
de Ligt J., Willemsen M.H., van Bon B.W., Kleefstra T., Yntema H.G., Kroes T., Vulto-van Silfhout A.T., Koolen D.A., de Vries P., Gilissen C., del Rosario M., Hoischen A., Scheffer H., de Vries B.B., Brunner H.G., Veltman J.A., Vissers L.E.
N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HIS-1615.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL121919 Genomic DNA. Translation: CAI21544.2.
AL713683 mRNA. Translation: CAD28487.1.
AL833682 mRNA. Translation: CAI46154.1. Different initiation.
RefSeqNP_848552.1. NM_178457.2.
XP_005260329.1. XM_005260272.1.
XP_005260330.1. XM_005260273.1.
XP_005260331.1. XM_005260274.1.
UniGeneHs.473204.

3D structure databases

ProteinModelPortalQ5JPB2.
SMRQ5JPB2. Positions 142-190.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000360069.

PTM databases

PhosphoSiteQ5JPB2.

Polymorphism databases

DMDM160370001.

Proteomic databases

PaxDbQ5JPB2.
PRIDEQ5JPB2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371030; ENSP00000360069; ENSG00000124203.
GeneID128611.
KEGGhsa:128611.
UCSCuc002yan.3. human.

Organism-specific databases

CTD128611.
GeneCardsGC20P057766.
HGNCHGNC:16167. ZNF831.
HPAHPA016839.
neXtProtNX_Q5JPB2.
PharmGKBPA162410774.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG331219.
HOGENOMHOG000231308.
HOVERGENHBG080221.
InParanoidQ5JPB2.
OMASPGKVRN.
OrthoDBEOG769ZHP.
PhylomeDBQ5JPB2.
TreeFamTF338213.

Gene expression databases

BgeeQ5JPB2.
CleanExHS_ZNF831.
GenevestigatorQ5JPB2.

Family and domain databases

Gene3D3.30.160.60. 2 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi128611.
NextBio82396.
PROQ5JPB2.

Entry information

Entry nameZN831_HUMAN
AccessionPrimary (citable) accession number: Q5JPB2
Secondary accession number(s): Q5TDR4, Q8TCP0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 23, 2007
Last modified: April 16, 2014
This is version 75 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM