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Protein

Zinc finger protein 831

Gene

ZNF831

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 166C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 196C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 831
Gene namesi
Name:ZNF831
Synonyms:C20orf174
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16167. ZNF831.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi128611.
OpenTargetsiENSG00000124203.
PharmGKBiPA162410774.

Polymorphism and mutation databases

DMDMi160370001.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002360411 – 1677Zinc finger protein 831Add BLAST1677

Proteomic databases

MaxQBiQ5JPB2.
PaxDbiQ5JPB2.
PeptideAtlasiQ5JPB2.
PRIDEiQ5JPB2.

PTM databases

iPTMnetiQ5JPB2.
PhosphoSitePlusiQ5JPB2.

Expressioni

Gene expression databases

BgeeiENSG00000124203.
CleanExiHS_ZNF831.
GenevisibleiQ5JPB2. HS.

Organism-specific databases

HPAiHPA016839.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360069.

Structurei

3D structure databases

ProteinModelPortaliQ5JPB2.
SMRiQ5JPB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili391 – 423Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 111Pro-richAdd BLAST108

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 166C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 196C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063161.
HOGENOMiHOG000231308.
HOVERGENiHBG080221.
InParanoidiQ5JPB2.
OMAiLRKCEST.
OrthoDBiEOG091G00NV.
PhylomeDBiQ5JPB2.
TreeFamiTF338213.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JPB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVPEPTCPA PPARDQPAPT PGPPGAPGGQ ASPHLTLGPV LLPPEQGLAP
60 70 80 90 100
PTVFLKALPI PLYHTVPPGG LQPRAPLVTG SLDGGNVPFI LSPVLQPEGP
110 120 130 140 150
GPTQVGKPAA PTLTVNIVGT LPVLSPGLGP TLGSPGKVRN AGKYLCPHCG
160 170 180 190 200
RDCLKPSVLE KHIRSHTGER PFPCATCGIA FKTQSNLYKH RRTQTHLNNS
210 220 230 240 250
RLSSESEGAG GGLLEEGDKA GEPPRPEGRG ESRCQGMHEG ASERPLSPGA
260 270 280 290 300
HVPLLAKNLD VRTEAAPCPG SAFADREAPW DSAPMASPGL PAASTQPWRK
310 320 330 340 350
LPEQKSPTAG KPCALQRQQA TAAEKPWDAK APEGRLRKCE STDSGYLSRS
360 370 380 390 400
DSAEQPHAPC SPLHSLSEHS AESEGEGGPG PGPGVAGAEP GAREAGLELE
410 420 430 440 450
KKRLEERIAQ LISHNQAVVD DAQLDNVRPR KTGLSKQGSI DLPTPYTYKD
460 470 480 490 500
SFHFDIRALE PGRRRAPGPV RSTWTPPDKS RPLFFHSVPT QLSTTVECVP
510 520 530 540 550
VTRSNSLPFV EGSRTWLEPR EPRDPWSRTQ KPLSPRPGPA RLGCRSGLSS
560 570 580 590 600
TDVPSGHPRA LVRQAAVEDL PGTPIGDALV PAEDTDAKRT AAREAMAGKG
610 620 630 640 650
RAGGRKCGQR RLKMFSQEKW QVYGDETFKR IYQKMKASPH GGKKAREVGM
660 670 680 690 700
GSGAELGFPL QKEAAGSSGT VPTQDRRTPV HEDISAGATP EPWGNPPALE
710 720 730 740 750
ASLVTEPTKH GETVARRGDS DRPRVEEAVS SPALGGRDSP CSGSRSPLVS
760 770 780 790 800
PNGRLELGWQ MPPAPGPLKG GDVEAPRPVW PDPKLEGGAR GVGDVQETCL
810 820 830 840 850
WAQTVLRWPS RGSGEDKLPS ERKKLKVEDL HSWKQPEPVS AETPGGPTQP
860 870 880 890 900
ASLSSQKQDA DPGEVPGGSK ESARQVGEPL ESSGASLAAA SVALKRVGPR
910 920 930 940 950
DKATPLHPAA PAPAEHPSLA TPPQAPRVLS ALADNAFSPK YLLRLPQAET
960 970 980 990 1000
PLPLPIPWGP RHSQDSLCSS GWPEERASFV GSGLGTPLSP SPASGPSPGE
1010 1020 1030 1040 1050
ADSILEDPSC SRPQDGRKGA QLGGDKGDRM ATSRPAAREL PISAPGAPRE
1060 1070 1080 1090 1100
ATSSPPTPTC EAHLVQDMEG DSHRIHRLCM GSTLARARLS GDVLNPWVPN
1110 1120 1130 1140 1150
WELGEPPGNA PEDPSSGPLV GPDPCSPLQP GSFLTALTRP QGVPPGWPEL
1160 1170 1180 1190 1200
ALSSHSGTSR SHSTRSPHST QNPFPSLKAE PRLTWCCLSR SVPLPAEQKA
1210 1220 1230 1240 1250
KAASVYLAVH FPGSSLRDEG PNGPPGSNGG WTWTSPGEGG PAQMSKFSYP
1260 1270 1280 1290 1300
TVPGVMPQHQ VSEPEWKKGL PWRAKMSRGN SKQRKLKINP KRYKGNFLQS
1310 1320 1330 1340 1350
CVQLRASRLR TPTWVRRRSR HPPALEGLKP CRTPGQTSSE IAGLNLQEEP
1360 1370 1380 1390 1400
SCATSESPPC CGKEEKKEGD CRQTLGTLSL GTSSRIVREM DKRTVKDISP
1410 1420 1430 1440 1450
SAGEHGDCTT HSTAATSGLS LQSDTCLAVV NDVPLPPGKG LDLGLLETQL
1460 1470 1480 1490 1500
LASQDSVSTD PKPYIFSDAQ RPSSFGSKGT FPHHDIATSV AAVCISLPVR
1510 1520 1530 1540 1550
TDHIAQEIHS AESRDHSQTA GRTLTSSSPD SKVTEEGRAQ TLLPGRPSSG
1560 1570 1580 1590 1600
QRISDSVPLE STEKTHLEIP ASGPSSASSH HKEGRHKTFF PSRGQYGCGE
1610 1620 1630 1640 1650
MTVPCPSLGS DGRKRQVSGL ITRKDSVVPS KPEQPIEIPE APSKSLKKRS
1660 1670
LEGMRKQTRV EFSDTSSDDE DRLVIEI
Length:1,677
Mass (Da):177,949
Last modified:October 23, 2007 - v4
Checksum:iD4D23943AAC3DA89
GO

Sequence cautioni

The sequence CAI46154 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026472845G → R.Corresponds to variant rs181984dbSNPEnsembl.1
Natural variantiVAR_0264731513S → P.Corresponds to variant rs259956dbSNPEnsembl.1
Natural variantiVAR_0693671615R → H.1 PublicationCorresponds to variant rs201549554dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121919 Genomic DNA. Translation: CAI21544.2.
AL713683 mRNA. Translation: CAD28487.1.
AL833682 mRNA. Translation: CAI46154.1. Different initiation.
CCDSiCCDS42894.1.
RefSeqiNP_848552.1. NM_178457.2.
XP_005260329.1. XM_005260272.3.
XP_005260330.1. XM_005260273.3.
XP_006723761.1. XM_006723698.3.
XP_011526836.1. XM_011528534.2.
XP_011526838.1. XM_011528536.2.
XP_011526839.1. XM_011528537.2.
XP_011526840.1. XM_011528538.2.
XP_016883131.1. XM_017027642.1.
XP_016883132.1. XM_017027643.1.
XP_016883133.1. XM_017027644.1.
UniGeneiHs.473204.

Genome annotation databases

EnsembliENST00000371030; ENSP00000360069; ENSG00000124203.
ENST00000637017; ENSP00000490240; ENSG00000124203.
GeneIDi128611.
KEGGihsa:128611.
UCSCiuc002yan.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121919 Genomic DNA. Translation: CAI21544.2.
AL713683 mRNA. Translation: CAD28487.1.
AL833682 mRNA. Translation: CAI46154.1. Different initiation.
CCDSiCCDS42894.1.
RefSeqiNP_848552.1. NM_178457.2.
XP_005260329.1. XM_005260272.3.
XP_005260330.1. XM_005260273.3.
XP_006723761.1. XM_006723698.3.
XP_011526836.1. XM_011528534.2.
XP_011526838.1. XM_011528536.2.
XP_011526839.1. XM_011528537.2.
XP_011526840.1. XM_011528538.2.
XP_016883131.1. XM_017027642.1.
XP_016883132.1. XM_017027643.1.
XP_016883133.1. XM_017027644.1.
UniGeneiHs.473204.

3D structure databases

ProteinModelPortaliQ5JPB2.
SMRiQ5JPB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360069.

PTM databases

iPTMnetiQ5JPB2.
PhosphoSitePlusiQ5JPB2.

Polymorphism and mutation databases

DMDMi160370001.

Proteomic databases

MaxQBiQ5JPB2.
PaxDbiQ5JPB2.
PeptideAtlasiQ5JPB2.
PRIDEiQ5JPB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371030; ENSP00000360069; ENSG00000124203.
ENST00000637017; ENSP00000490240; ENSG00000124203.
GeneIDi128611.
KEGGihsa:128611.
UCSCiuc002yan.4. human.

Organism-specific databases

CTDi128611.
DisGeNETi128611.
GeneCardsiZNF831.
HGNCiHGNC:16167. ZNF831.
HPAiHPA016839.
neXtProtiNX_Q5JPB2.
OpenTargetsiENSG00000124203.
PharmGKBiPA162410774.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063161.
HOGENOMiHOG000231308.
HOVERGENiHBG080221.
InParanoidiQ5JPB2.
OMAiLRKCEST.
OrthoDBiEOG091G00NV.
PhylomeDBiQ5JPB2.
TreeFamiTF338213.

Miscellaneous databases

GenomeRNAii128611.
PROiQ5JPB2.

Gene expression databases

BgeeiENSG00000124203.
CleanExiHS_ZNF831.
GenevisibleiQ5JPB2. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN831_HUMAN
AccessioniPrimary (citable) accession number: Q5JPB2
Secondary accession number(s): Q5TDR4, Q8TCP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 94 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.