Q5JPB2 (ZN831_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 831

Gene names

Name:	ZNF831
Synonyms:	C20orf174

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1677 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 2 C2H2-type zinc fingers.
Sequence caution	The sequence CAI46154.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1677	1677	Zinc finger protein 831		PRO_0000236041
Regions
	Zinc finger	144 – 166	23	C2H2-type 1
	Zinc finger	172 – 196	25	C2H2-type 2
	Coiled coil	391 – 423	33	Potential
	Compositional bias	4 – 111	108	Pro-rich
Natural variations
	Natural variant	845	1	G → R. Corresponds to variant rs181984 [ dbSNP | Ensembl ].		VAR_026472
	Natural variant	1513	1	S → P. Corresponds to variant rs259956 [ dbSNP | Ensembl ].		VAR_026473

Sequences

	Sequence		Length	Mass (Da)
	Q5JPB2 [UniParc]. Last modified October 23, 2007. Version 4. Checksum: D4D23943AAC3DA89	FASTA	1,677	177,949
	10 20 30 40 50 60 MEVPEPTCPA PPARDQPAPT PGPPGAPGGQ ASPHLTLGPV LLPPEQGLAP PTVFLKALPI 70 80 90 100 110 120 PLYHTVPPGG LQPRAPLVTG SLDGGNVPFI LSPVLQPEGP GPTQVGKPAA PTLTVNIVGT 130 140 150 160 170 180 LPVLSPGLGP TLGSPGKVRN AGKYLCPHCG RDCLKPSVLE KHIRSHTGER PFPCATCGIA 190 200 210 220 230 240 FKTQSNLYKH RRTQTHLNNS RLSSESEGAG GGLLEEGDKA GEPPRPEGRG ESRCQGMHEG 250 260 270 280 290 300 ASERPLSPGA HVPLLAKNLD VRTEAAPCPG SAFADREAPW DSAPMASPGL PAASTQPWRK 310 320 330 340 350 360 LPEQKSPTAG KPCALQRQQA TAAEKPWDAK APEGRLRKCE STDSGYLSRS DSAEQPHAPC 370 380 390 400 410 420 SPLHSLSEHS AESEGEGGPG PGPGVAGAEP GAREAGLELE KKRLEERIAQ LISHNQAVVD 430 440 450 460 470 480 DAQLDNVRPR KTGLSKQGSI DLPTPYTYKD SFHFDIRALE PGRRRAPGPV RSTWTPPDKS 490 500 510 520 530 540 RPLFFHSVPT QLSTTVECVP VTRSNSLPFV EGSRTWLEPR EPRDPWSRTQ KPLSPRPGPA 550 560 570 580 590 600 RLGCRSGLSS TDVPSGHPRA LVRQAAVEDL PGTPIGDALV PAEDTDAKRT AAREAMAGKG 610 620 630 640 650 660 RAGGRKCGQR RLKMFSQEKW QVYGDETFKR IYQKMKASPH GGKKAREVGM GSGAELGFPL 670 680 690 700 710 720 QKEAAGSSGT VPTQDRRTPV HEDISAGATP EPWGNPPALE ASLVTEPTKH GETVARRGDS 730 740 750 760 770 780 DRPRVEEAVS SPALGGRDSP CSGSRSPLVS PNGRLELGWQ MPPAPGPLKG GDVEAPRPVW 790 800 810 820 830 840 PDPKLEGGAR GVGDVQETCL WAQTVLRWPS RGSGEDKLPS ERKKLKVEDL HSWKQPEPVS 850 860 870 880 890 900 AETPGGPTQP ASLSSQKQDA DPGEVPGGSK ESARQVGEPL ESSGASLAAA SVALKRVGPR 910 920 930 940 950 960 DKATPLHPAA PAPAEHPSLA TPPQAPRVLS ALADNAFSPK YLLRLPQAET PLPLPIPWGP 970 980 990 1000 1010 1020 RHSQDSLCSS GWPEERASFV GSGLGTPLSP SPASGPSPGE ADSILEDPSC SRPQDGRKGA 1030 1040 1050 1060 1070 1080 QLGGDKGDRM ATSRPAAREL PISAPGAPRE ATSSPPTPTC EAHLVQDMEG DSHRIHRLCM 1090 1100 1110 1120 1130 1140 GSTLARARLS GDVLNPWVPN WELGEPPGNA PEDPSSGPLV GPDPCSPLQP GSFLTALTRP 1150 1160 1170 1180 1190 1200 QGVPPGWPEL ALSSHSGTSR SHSTRSPHST QNPFPSLKAE PRLTWCCLSR SVPLPAEQKA 1210 1220 1230 1240 1250 1260 KAASVYLAVH FPGSSLRDEG PNGPPGSNGG WTWTSPGEGG PAQMSKFSYP TVPGVMPQHQ 1270 1280 1290 1300 1310 1320 VSEPEWKKGL PWRAKMSRGN SKQRKLKINP KRYKGNFLQS CVQLRASRLR TPTWVRRRSR 1330 1340 1350 1360 1370 1380 HPPALEGLKP CRTPGQTSSE IAGLNLQEEP SCATSESPPC CGKEEKKEGD CRQTLGTLSL 1390 1400 1410 1420 1430 1440 GTSSRIVREM DKRTVKDISP SAGEHGDCTT HSTAATSGLS LQSDTCLAVV NDVPLPPGKG 1450 1460 1470 1480 1490 1500 LDLGLLETQL LASQDSVSTD PKPYIFSDAQ RPSSFGSKGT FPHHDIATSV AAVCISLPVR 1510 1520 1530 1540 1550 1560 TDHIAQEIHS AESRDHSQTA GRTLTSSSPD SKVTEEGRAQ TLLPGRPSSG QRISDSVPLE 1570 1580 1590 1600 1610 1620 STEKTHLEIP ASGPSSASSH HKEGRHKTFF PSRGQYGCGE MTVPCPSLGS DGRKRQVSGL 1630 1640 1650 1660 1670 ITRKDSVVPS KPEQPIEIPE APSKSLKKRS LEGMRKQTRV EFSDTSSDDE DRLVIEI

References

[1]

"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-1677. Tissue: Lymph node.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL121919 Genomic DNA. Translation: CAI21544.2. AL713683 mRNA. Translation: CAD28487.1. AL833682 mRNA. Translation: CAI46154.1. Different initiation.
IPI	IPI00791079.
RefSeq	NP_848552.1. NM_178457.2.
UniGene	Hs.473204.
3D structure databases
ProteinModelPortal	Q5JPB2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000360069.
PTM databases
PhosphoSite	Q5JPB2.
Polymorphism databases
DMDM	160370001.
Proteomic databases
PaxDb	Q5JPB2.
PRIDE	Q5JPB2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371030; ENSP00000360069; ENSG00000124203.
GeneID	128611.
KEGG	hsa:128611.
UCSC	uc002yan.3. human.
Organism-specific databases
CTD	128611.
GeneCards	GC20P057766.
HGNC	HGNC:16167. ZNF831.
HPA	HPA016839.
neXtProt	NX_Q5JPB2.
PharmGKB	PA162410774.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG331219.
HOGENOM	HOG000231308.
HOVERGEN	HBG080221.
InParanoid	Q5JPB2.
OMA	PGKVRNA.
OrthoDB	EOG42NHZH.
Gene expression databases
Bgee	Q5JPB2.
CleanEx	HS_ZNF831.
Genevestigator	Q5JPB2.
GermOnline	ENSG00000124203. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 2 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 2 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	128611.
NextBio	82396.

Entry information

Entry name

ZN831_HUMAN

Accession

Primary (citable) accession number: Q5JPB2
Secondary accession number(s): Q5TDR4, Q8TCP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 67 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.