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Protein
Submitted name:

C2

Gene

C2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei507Charge relay systemUniRule annotation1
Active sitei561Charge relay systemUniRule annotation1
Active sitei679Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
C2Imported
Submitted name:
Complement component 2, isoform CRA_bImported
Gene namesi
Name:C2Imported
ORF Names:hCG_43694Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000166278.14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25637

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501458677421 – 752Sequence analysisAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi117 ↔ 144PROSITE-ProRule annotation
Disulfide bondi177 ↔ 204PROSITE-ProRule annotation
Disulfide bondi463 ↔ 581Combined sources
Disulfide bondi492 ↔ 508Combined sources
Disulfide bondi584 ↔ 600Combined sources
Disulfide bondi638 ↔ 665Combined sources
Disulfide bondi675 ↔ 705Combined sources

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000166278

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ODQX-ray2.30A244-752[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 86SushiInterPro annotationAdd BLAST65
Domaini87 – 146SushiInterPro annotationAdd BLAST60
Domaini149 – 206SushiInterPro annotationAdd BLAST58
Domaini254 – 452VWFAInterPro annotationAdd BLAST199
Domaini464 – 744Peptidase S1InterPro annotationAdd BLAST281

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOVERGENiHBG002567
KOiK01332
OMAiRNVSEFY
OrthoDBiEOG09370DBA

Family and domain databases

CDDicd00033 CCP, 3 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR011360 Compl_C2_B
IPR037568 Complement_C2
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR19325:SF387 PTHR19325:SF387, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 2 hits
PF00089 Trypsin, 1 hit
PF00092 VWA, 1 hit
PIRSFiPIRSF001154 Compl_C2_B, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00032 CCP, 3 hits
SM00020 Tryp_SPc, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF53300 SSF53300, 1 hit
SSF57535 SSF57535, 3 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 3 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JP69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS
60 70 80 90 100
CPQGLYPSPA SRLCKSSGQW QTPGATRSLS KAVCKPVRCP APVSFENGIY
110 120 130 140 150
TPRLGSYPVG GNVSFECEDG FILRGSPVRQ CRPNGMWDGE TAVCDNGAGH
160 170 180 190 200
CPNPGISLGA VRTGFRFGHG DKVRYRCSSN LVLTGSSERE CQGNGVWSGT
210 220 230 240 250
EPICRQPYSY DFPEDVAPAL GTSFSHMLGA TNPTQKTKES LGRKIQIQRS
260 270 280 290 300
GHLNLYLLLD CSQSVSENDF LIFKESASLM VDRIFSFEIN VSVAIITFAS
310 320 330 340 350
EPKVLMSVLN DNSRDMTEVI SSLENANYKD HENGTGTNTY AALNSVYLMM
360 370 380 390 400
NNQMRLLGME TMAWQEIRHA IILLTDGKSN MGGSPKTAVD HIREILNINQ
410 420 430 440 450
KRNDYLDIYA IGVGKLDVDW RELNELGSKK DGERHAFILQ DTKALHQVFE
460 470 480 490 500
HMLDVSKLTD TICGVGNMSA NASDQERTPW HVTIKPKSQE TCRGALISDQ
510 520 530 540 550
WVLTAAHCFR DGNDHSLWRV NVGDPKSQWG KEFLIEKAVI SPGFDVFAKK
560 570 580 590 600
NQGILEFYGD DIALLKLAQK VKMSTHARPI CLPCTMEANL ALRRPQGSTC
610 620 630 640 650
RDHENELLNK QSVPAHFVAL NGSKLNINLK MGVEWTSCAE VVSQEKTMFP
660 670 680 690 700
NLTDVREVVT DQFLCSGTQE DESPCKGESG GAVFLERRFR FFQVGLVSWG
710 720 730 740 750
LYNPCLGSAD KNSRKRAPRS KVPPPRDFHI NLFRMQPWLR QHLGDVLNFL

PL
Length:752
Mass (Da):83,268
Last modified:May 10, 2005 - v1
Checksum:i5A96A13E700CF444
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY500771 Genomic DNA Translation: AQY77241.1
KY500774 Genomic DNA Translation: AQY77244.1
KY500776 Genomic DNA Translation: AQY77246.1
AK312581 mRNA Translation: BAG35475.1
CH471081 Genomic DNA Translation: EAX03549.1
RefSeqiNP_000054.2, NM_000063.5
UniGeneiHs.408903

Genome annotation databases

GeneIDi717
KEGGihsa:717
UCSCiuc003nyf.5 human

Similar proteinsi

Entry informationi

Entry nameiQ5JP69_HUMAN
AccessioniPrimary (citable) accession number: Q5JP69
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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