Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tubulin beta chain

Gene

TUBB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta chainUniRule annotation
Gene namesi
Name:TUBBImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20778. TUBB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MicrotubuleUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

EPDiQ5JP53.
MaxQBiQ5JP53.
PeptideAtlasiQ5JP53.
PRIDEiQ5JP53.

Expressioni

Gene expression databases

BgeeiENSG00000183311.

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotationSAAS annotation

Protein-protein interaction databases

MINTiMINT-2984859.
STRINGi9606.ENSP00000339001.

Structurei

3D structure databases

SMRiQ5JP53. Positions 2-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 226198TubulinInterPro annotationAdd
BLAST
Domaini228 – 365138Tubulin_CInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili390 – 41728Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1375. Eukaryota.
COG5023. LUCA.
GeneTreeiENSGT00760000119061.
HOGENOMiHOG000165710.
HOVERGENiHBG000089.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JP53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFWEVISDEH GIDPTGTYHG DSDLQLDRIS VYYNEATGGK YVPRAILVDL
60 70 80 90 100
EPGTMDSVRS GPFGQIFRPD NFVFGQSGAG NNWAKGHYTE GAELVDSVLD
110 120 130 140 150
VVRKEAESCD CLQGFQLTHS LGGGTGSGMG TLLISKIREE YPDRIMNTFS
160 170 180 190 200
VVPSPKVSDT VVEPYNATLS VHQLVENTDE TYCIDNEALY DICFRTLKLT
210 220 230 240 250
TPTYGDLNHL VSATMSGVTT CLRFPGQLNA DLRKLAVNMV PFPRLHFFMP
260 270 280 290 300
GFAPLTSRGS QQYRALTVPE LTQQVFDAKN MMAACDPRHG RYLTVAAVFR
310 320 330 340 350
GRMSMKEVDE QMLNVQNKNS SYFVEWIPNN VKTAVCDIPP RGLKMAVTFI
360 370 380 390 400
GNSTAIQELF KRISEQFTAM FRRKAFLHWY TGEGMDEMEF TEAESNMNDL
410 420
VSEYQQYQDA TAEEEEDFGE EAEEEA
Length:426
Mass (Da):47,767
Last modified:February 15, 2005 - v1
Checksum:iD134159AB81CE51F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662797 Genomic DNA. No translation available.
AL662848 Genomic DNA. No translation available.
AL845353 Genomic DNA. No translation available.
BX248307 Genomic DNA. No translation available.
BX927283 Genomic DNA. No translation available.
CR759873 Genomic DNA. No translation available.
CR788240 Genomic DNA. No translation available.
CR936878 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000396389; ENSP00000379672; ENSG00000196230.
ENST00000400534; ENSP00000383378; ENSG00000183311.
ENST00000412136; ENSP00000400108; ENSG00000229684.
ENST00000419551; ENSP00000401546; ENSG00000224156.
ENST00000420400; ENSP00000409249; ENSG00000227739.
ENST00000424734; ENSP00000413589; ENSG00000232421.
ENST00000425136; ENSP00000403868; ENSG00000235067.
ENST00000426754; ENSP00000399280; ENSG00000232575.
UCSCiuc063mug.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662797 Genomic DNA. No translation available.
AL662848 Genomic DNA. No translation available.
AL845353 Genomic DNA. No translation available.
BX248307 Genomic DNA. No translation available.
BX927283 Genomic DNA. No translation available.
CR759873 Genomic DNA. No translation available.
CR788240 Genomic DNA. No translation available.
CR936878 Genomic DNA. No translation available.

3D structure databases

SMRiQ5JP53. Positions 2-409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-2984859.
STRINGi9606.ENSP00000339001.

Proteomic databases

EPDiQ5JP53.
MaxQBiQ5JP53.
PeptideAtlasiQ5JP53.
PRIDEiQ5JP53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396389; ENSP00000379672; ENSG00000196230.
ENST00000400534; ENSP00000383378; ENSG00000183311.
ENST00000412136; ENSP00000400108; ENSG00000229684.
ENST00000419551; ENSP00000401546; ENSG00000224156.
ENST00000420400; ENSP00000409249; ENSG00000227739.
ENST00000424734; ENSP00000413589; ENSG00000232421.
ENST00000425136; ENSP00000403868; ENSG00000235067.
ENST00000426754; ENSP00000399280; ENSG00000232575.
UCSCiuc063mug.1. human.

Organism-specific databases

HGNCiHGNC:20778. TUBB.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1375. Eukaryota.
COG5023. LUCA.
GeneTreeiENSGT00760000119061.
HOGENOMiHOG000165710.
HOVERGENiHBG000089.

Miscellaneous databases

ChiTaRSiTUBB. human.

Gene expression databases

BgeeiENSG00000183311.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5JP53_HUMAN
AccessioniPrimary (citable) accession number: Q5JP53
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.