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Protein

Tubulin beta chain

Gene

TUBB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta chainUniRule annotation
Gene namesi
Name:TUBBImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000196230.12
HGNCiHGNC:20778 TUBB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MicrotubuleUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196230

Expressioni

Gene expression databases

BgeeiENSG00000196230

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 226TubulinInterPro annotationAdd BLAST198
Domaini228 – 365Tubulin_CInterPro annotationAdd BLAST138

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili390 – 417Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00760000119061
HOGENOMiHOG000165710
HOVERGENiHBG000089

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002453 Beta_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PTHR11588:SF256 PTHR11588:SF256, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01163 BETATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JP53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFWEVISDEH GIDPTGTYHG DSDLQLDRIS VYYNEATGGK YVPRAILVDL
60 70 80 90 100
EPGTMDSVRS GPFGQIFRPD NFVFGQSGAG NNWAKGHYTE GAELVDSVLD
110 120 130 140 150
VVRKEAESCD CLQGFQLTHS LGGGTGSGMG TLLISKIREE YPDRIMNTFS
160 170 180 190 200
VVPSPKVSDT VVEPYNATLS VHQLVENTDE TYCIDNEALY DICFRTLKLT
210 220 230 240 250
TPTYGDLNHL VSATMSGVTT CLRFPGQLNA DLRKLAVNMV PFPRLHFFMP
260 270 280 290 300
GFAPLTSRGS QQYRALTVPE LTQQVFDAKN MMAACDPRHG RYLTVAAVFR
310 320 330 340 350
GRMSMKEVDE QMLNVQNKNS SYFVEWIPNN VKTAVCDIPP RGLKMAVTFI
360 370 380 390 400
GNSTAIQELF KRISEQFTAM FRRKAFLHWY TGEGMDEMEF TEAESNMNDL
410 420
VSEYQQYQDA TAEEEEDFGE EAEEEA
Length:426
Mass (Da):47,767
Last modified:February 15, 2005 - v1
Checksum:iD134159AB81CE51F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662797 Genomic DNA No translation available.
AL662848 Genomic DNA No translation available.
AL845353 Genomic DNA No translation available.
BX248307 Genomic DNA No translation available.
BX927283 Genomic DNA No translation available.
CR759873 Genomic DNA No translation available.
CR788240 Genomic DNA No translation available.
CR936878 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000396389; ENSP00000379672; ENSG00000196230
ENST00000400534; ENSP00000383378; ENSG00000183311
ENST00000412136; ENSP00000400108; ENSG00000229684
ENST00000419551; ENSP00000401546; ENSG00000224156
ENST00000420400; ENSP00000409249; ENSG00000227739
ENST00000424734; ENSP00000413589; ENSG00000232421
ENST00000425136; ENSP00000403868; ENSG00000235067
ENST00000426754; ENSP00000399280; ENSG00000232575
UCSCiuc063mug.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5JP53_HUMAN
AccessioniPrimary (citable) accession number: Q5JP53
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health