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Q5JP05 (Q5JP05_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

cGMP-dependent protein kinase 1 Ensembl ENSP00000363086
Gene names
Name:PRKG1 Ensembl ENSP00000363086
OrganismHomo sapiens (Human) [Reference proteome] Ensembl ENSP00000363086
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. SAAS SAAS000961

Sequence similarities

Contains AGC-kinase C-terminal domain. SAAS SAAS000961

Sequences

Sequence LengthMass (Da)Tools
Q5JP05 [UniParc].

Last modified June 26, 2013. Version 2.
Checksum: 9792149F93773D55

FASTA38944,185
        10         20         30         40         50         60 
MEKQNMFLHG SYILREDVRT ANVIAAEAVT CLVIDRDSFK HLIGGLDDVS NKAYEDAEAK 

        70         80         90        100        110        120 
AKYEAEAAFF ANLKLSDFNI IDTLGVGGFG RVELVQLKSE ESKTFAMKIL KKRHIVDTRQ 

       130        140        150        160        170        180 
QEHIRSEKQI MQGAHSDFIV RLYRTFKDSK YLYMLMEACL GGELWTILRD RGSFEDSTTR 

       190        200        210        220        230        240 
FYTACVVEAF AYLHSKGIIY RDLKPENLIL DHRGYAKLVD FGFAKKIGFG KKTWTFCGTP 

       250        260        270        280        290        300 
EYVAPEIILN KGHDISADYW SLGILMYELL TGSPPFSGPD PMKTYNIILR GIDMIEFPKK 

       310        320        330        340        350        360 
IAKNAANLIK KLCRDNPSER LGNLKNGVKD IQKHKWFEGF NWEGLRKGTL TPPIIPSVAS 

       370        380 
PTDTSNFDSF PEDNDEPPPD DNSGWDIDF 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Testis EMBL BAG52715.1.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]Ensembl
Submitted (MAY-2013) to UniProtKB
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC009986 Genomic DNA. No translation available.
AC022025 Genomic DNA. No translation available.
AC022537 Genomic DNA. No translation available.
AC026228 Genomic DNA. No translation available.
AC027118 Genomic DNA. No translation available.
AC068062 Genomic DNA. No translation available.
AC069079 Genomic DNA. No translation available.
AC073584 Genomic DNA. No translation available.
AL157399 Genomic DNA. No translation available.
AL391378 Genomic DNA. No translation available.
AL596105 Genomic DNA. No translation available.
AL607031 Genomic DNA. No translation available.
AL731537 Genomic DNA. No translation available.
AL928686 Genomic DNA. No translation available.
AK093436 mRNA. Translation: BAG52715.1.
UniGeneHs.407535.

3D structure databases

ProteinModelPortalQ5JP05.
SMRQ5JP05. Positions 16-373.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBB3KSF3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373975; ENSP00000363086; ENSG00000185532.
UCSCuc009xow.2. human.

Organism-specific databases

HGNCHGNC:9414. PRKG1.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG108317.

Enzyme and pathway databases

SignaLinkB3KSF3.
Q5JP05.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR000961. AGC-kinase_C.
IPR002374. cGMP_dep_kinase.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR00104. CGMPKINASE.
SMARTSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPRKG1. human.
NextBio35469703.

Entry information

Entry nameQ5JP05_HUMAN
AccessionPrimary (citable) accession number: Q5JP05
Secondary accession number(s): B3KSF3
Entry history
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: June 26, 2013
Last modified: June 11, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.