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Protein

Zinc finger protein 311

Gene

ZNF311

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri247 – 26923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri303 – 32523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri331 – 35323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri359 – 38123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 40923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri415 – 43723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 52123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 54923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri583 – 60523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri611 – 63424C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 311
Alternative name(s):
Zinc finger protein zfp-31
Gene namesi
Name:ZNF311
Synonyms:ZFP31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13847. ZNF311.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134865305.

Polymorphism and mutation databases

BioMutaiZNF311.
DMDMi143758539.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 666666Zinc finger protein 311PRO_0000280404Add
BLAST

Proteomic databases

EPDiQ5JNZ3.
PaxDbiQ5JNZ3.
PRIDEiQ5JNZ3.

PTM databases

iPTMnetiQ5JNZ3.
PhosphoSiteiQ5JNZ3.

Expressioni

Gene expression databases

BgeeiQ5JNZ3.
CleanExiHS_ZNF311.
GenevisibleiQ5JNZ3. HS.

Organism-specific databases

HPAiHPA050541.

Interactioni

Protein-protein interaction databases

BioGridi129424. 4 interactions.
IntActiQ5JNZ3. 1 interaction.
STRINGi9606.ENSP00000366384.

Structurei

3D structure databases

ProteinModelPortaliQ5JNZ3.
SMRiQ5JNZ3. Positions 58-105, 244-631.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 13572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri247 – 26923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri303 – 32523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri331 – 35323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri359 – 38123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 40923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri415 – 43723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 52123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 54923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri583 – 60523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri611 – 63424C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130008.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5JNZ3.
KOiK09228.
OMAiCRRRAHE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5JNZ3.
TreeFamiTF341635.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JNZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEVVLLDES SGPPSQLLWT RQDTQLPQES ALLPAPYPAF TKDGSQGNLP
60 70 80 90 100
QADITLMSQA QESVTFEDVA VNFTNREWQC LTYAQRHLYK DVMLENYGNM
110 120 130 140 150
VSLGFPFPKP PLISHLEREV DPCVQDPQDR ESLSCSYPVS ADKMWPENEK
160 170 180 190 200
ASSQQEIFEN GEAYWMKFNS LLKVDSRDPK VREVCVQDVK LENQWETSIR
210 220 230 240 250
EKLREEKEGS EEVTCKKGKN QKVLSKNLNP NSKHSQCNKV LIAQKLHECA
260 270 280 290 300
RCGKNFSWHS DLILHEQIHS GEKPHVCNEC GKAFKTRNQL SMHRIIHTGE
310 320 330 340 350
KPFNCTQCGK AFNSRSALCR HKKTHSGEKP HECRDCGKAF KTRNRLCMHQ
360 370 380 390 400
LIHTGEKPYK CNCCGKAFQF KHSLTIHGRI HTGEKPYECE ECGKAFSGSS
410 420 430 440 450
DLTKHIRIHT GERPYECSKC GRAFSRSSDL SKHKRIHTRE KHYGCPQCGK
460 470 480 490 500
DFSIKAELTK HRRIHTEEKR YRCEECGKAF RHNCKRRAHE REHTGEKPYQ
510 520 530 540 550
CRDCGKTFQD KHCLTIHQRI HTGEKPYKCL ECGKAFSGKS NLTNHRRIHT
560 570 580 590 600
GEKPHKCEVC GMAFHHSSVL RQHKRIHTGE KPYTCSECGT SFRQGSALIG
610 620 630 640 650
HKRVHTGEKP YECEECGKAF RVSSNLTGHK KRKHQVWSTH ELDGSRKSLS
660
PVTVSQTSVV SILTSA
Length:666
Mass (Da):76,322
Last modified:February 20, 2007 - v2
Checksum:i24407CFED3DE28E6
GO

Sequence cautioni

The sequence AAB16812.1 differs from that shown. Reason: Frameshift at positions 396 and 408. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti486 – 4861R → C.
Corresponds to variant rs9295783 [ dbSNP | Ensembl ].
VAR_031136
Natural varianti511 – 5111K → Q.1 Publication
Corresponds to variant rs6456880 [ dbSNP | Ensembl ].
VAR_031137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662791 Genomic DNA. Translation: CAI18241.2.
AL662865 Genomic DNA. Translation: CAI41641.2.
AL929561 Genomic DNA. Translation: CAI41765.2.
BX293545 Genomic DNA. Translation: CAM25873.1.
CR759957 Genomic DNA. Translation: CAQ07347.1.
BX927167 Genomic DNA. Translation: CAQ07641.1.
CR759835 Genomic DNA. Translation: CAQ08423.1.
BC136745 mRNA. Translation: AAI36746.1.
U71600 mRNA. Translation: AAB16812.1. Frameshift.
CCDSiCCDS34357.1.
RefSeqiNP_001010877.2. NM_001010877.3.
NP_001305463.1. NM_001318534.1.
XP_011545942.1. XM_011547640.1.
XP_011546171.1. XM_011547869.1.
XP_011546528.1. XM_011548226.1.
UniGeneiHs.148218.

Genome annotation databases

EnsembliENST00000377179; ENSP00000366384; ENSG00000197935.
ENST00000383655; ENSP00000373151; ENSG00000169260.
ENST00000426120; ENSP00000398983; ENSG00000225351.
ENST00000429714; ENSP00000399157; ENSG00000235178.
ENST00000436574; ENSP00000405154; ENSG00000235589.
ENST00000452316; ENSP00000415772; ENSG00000223687.
ENST00000458265; ENSP00000398440; ENSG00000233831.
GeneIDi282890.
KEGGihsa:282890.
UCSCiuc003nlu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662791 Genomic DNA. Translation: CAI18241.2.
AL662865 Genomic DNA. Translation: CAI41641.2.
AL929561 Genomic DNA. Translation: CAI41765.2.
BX293545 Genomic DNA. Translation: CAM25873.1.
CR759957 Genomic DNA. Translation: CAQ07347.1.
BX927167 Genomic DNA. Translation: CAQ07641.1.
CR759835 Genomic DNA. Translation: CAQ08423.1.
BC136745 mRNA. Translation: AAI36746.1.
U71600 mRNA. Translation: AAB16812.1. Frameshift.
CCDSiCCDS34357.1.
RefSeqiNP_001010877.2. NM_001010877.3.
NP_001305463.1. NM_001318534.1.
XP_011545942.1. XM_011547640.1.
XP_011546171.1. XM_011547869.1.
XP_011546528.1. XM_011548226.1.
UniGeneiHs.148218.

3D structure databases

ProteinModelPortaliQ5JNZ3.
SMRiQ5JNZ3. Positions 58-105, 244-631.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129424. 4 interactions.
IntActiQ5JNZ3. 1 interaction.
STRINGi9606.ENSP00000366384.

PTM databases

iPTMnetiQ5JNZ3.
PhosphoSiteiQ5JNZ3.

Polymorphism and mutation databases

BioMutaiZNF311.
DMDMi143758539.

Proteomic databases

EPDiQ5JNZ3.
PaxDbiQ5JNZ3.
PRIDEiQ5JNZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377179; ENSP00000366384; ENSG00000197935.
ENST00000383655; ENSP00000373151; ENSG00000169260.
ENST00000426120; ENSP00000398983; ENSG00000225351.
ENST00000429714; ENSP00000399157; ENSG00000235178.
ENST00000436574; ENSP00000405154; ENSG00000235589.
ENST00000452316; ENSP00000415772; ENSG00000223687.
ENST00000458265; ENSP00000398440; ENSG00000233831.
GeneIDi282890.
KEGGihsa:282890.
UCSCiuc003nlu.3. human.

Organism-specific databases

CTDi282890.
GeneCardsiZNF311.
HGNCiHGNC:13847. ZNF311.
HPAiHPA050541.
neXtProtiNX_Q5JNZ3.
PharmGKBiPA134865305.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130008.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5JNZ3.
KOiK09228.
OMAiCRRRAHE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5JNZ3.
TreeFamiTF341635.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii282890.
PROiQ5JNZ3.

Gene expression databases

BgeeiQ5JNZ3.
CleanExiHS_ZNF311.
GenevisibleiQ5JNZ3. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-511.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Computer sequence analysis of human highly conserved zinc finger modules."
    Petroni D., Bartolini E., Chiaramonte R., Ottolenghi S., Comi P.
    DNA Seq. 9:163-169(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 328-547.

Entry informationi

Entry nameiZN311_HUMAN
AccessioniPrimary (citable) accession number: Q5JNZ3
Secondary accession number(s): A2BFK5, B0S7Y4, Q92971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 20, 2007
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.