Reviewed, UniProtKB/Swiss-Prot Q5JK68 (CDKC2_ORYSJ)

Names and origin

Protein names

Recommended name:
    Cyclin-dependent kinase C-2
      Short name=CDKC;2
    EC=2.7.11.22
    EC=2.7.11.23

Gene names

Name:	CDKC-2
Synonyms:	CDKC1
Ordered Locus Names:	Os01g0958000, LOC_Os01g72790
ORF Names:	OJ1294_F06.25

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Induction	Down-regulated by cytokinin. Ref.5
Sequence similarities	Belongs to the Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence CAD54641.1 differs from that shown. Reason: Frameshift at position 309. The sequence CAD92448.1 differs from that shown. Reason: Frameshift at position 309.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activity Inferred from electronic annotation. Source: EC cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	Cyclin-dependent kinase C-2		PRO_0000296101
Regions
	Domain	25 – 325	301	Protein kinase
	Nucleotide binding	31 – 39	9	ATP By similarity
Sites
	Active site	164	1	Proton acceptor By similarity
	Binding site	54	1	ATP By similarity
Amino acid modifications
	Modified residue	35	1	Phosphothreonine By similarity
	Modified residue	36	1	Phosphotyrosine By similarity
	Modified residue	191	1	Phosphoserine By similarity
	Modified residue	198	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5JK68-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 77BFC08EF38E1D96	FASTA	513	56,826
	10 20 30 40 50 60 MAVAAPGQLN LDESPSWGSR SVDCFEKLEQ IGEGTYGQVY MAKETETNEI VALKKIRMDN 70 80 90 100 110 120 EREGFPITAI REIKILKKLH HQNVIQLKEI VTSPGPERDE QGKPIEGNKY KGSIYMVFEY 130 140 150 160 170 180 MDHDLTGLAD RPGMRFTVPQ IKCYMRQLLT GLHYCHVNQV LHRDIKGSNL LIDNEGNLKL 190 200 210 220 230 240 ADFGLARSFS SDHNGNLTNR VITLWYRPPE LLLGSTRYGP AVDMWSVGCI FAELLNGKPI 250 260 270 280 290 300 LTGKNEPEQL SKIFELCGTP DELIWPGVTK MPWYNNFKPQ RPMKRRVKES FKHFDQHALD 310 320 330 340 350 360 LLEKMLTLDP SQRISAKDAL DAEYFWTDPL PCDPKSLPKY EASHEFQTKK KRQQQRQAEE 370 380 390 400 410 420 AAKRQKLQHP PPHSRLPPIQ NPGQPHQIRP GQPMHNAPPV AAGPSHHYAK PRGPGGPNRY 430 440 450 460 470 480 PQGGNQGGYN PNRGGQGGGY GSGPYPQQGR GPPPYPGGGM GGAGGPRGGG GSGYGVGGPN 490 500 510 YQQGGPYGAS GPGRGPNYNQ GGSRNQQQYG NWQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel developmentally regulated C type cyclin-dependent kinase in rice plants." Huang Y.W., Huang H.J. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genome sequence and structure of rice chromosome 1." Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T. Nature 420:312-316(2002) [PubMed: 12447438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[4]	"Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana." The rice annotation project (RAP) Genome Res. 17:175-183(2007) [PubMed: 17210932] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[5]	"Genome-wide identification and expression analysis of rice cell cycle genes." Guo J., Song J., Wang F., Zhang X.S. Plant Mol. Biol. 64:349-360(2007) [PubMed: 17443292] [Abstract] Cited for: INDUCTION, GENE FAMILY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ512410 mRNA. Translation: CAD54641.1. Frameshift. AJ564977 mRNA. Translation: CAD92448.1. Frameshift. AP004326 Genomic DNA. Translation: BAD88154.1. AP008207 Genomic DNA. Translation: BAF07364.1.
RefSeq	NP_001045450.1.
UniGene	Os.14473
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4325386.
GenomeReviews	Gene locus CDKC-2 in contig AP008207_GR.
KEGG	osa:4325386.
Organism-specific databases
Gramene	Q5JK68.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDKC2_ORYSJ

Accession

Primary (citable) accession number: Q5JK68
Secondary accession number(s): Q5K4U5, Q7Y0V2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	February 15, 2005
Last modified:	September 22, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)