Q5JJ82 (MFNA_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-tyrosine decarboxylase
Short name=TDC
EC=4.1.1.25

Gene names

Name:	mfnA
Ordered Locus Names:	TK1814

Organism

Pyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1)) [Reference proteome] [HAMAP]

Taxonomic identifier

69014 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus › Thermococcus kodakarensis

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine By similarity. HAMAP-Rule MF_01610
Catalytic activity	L-tyrosine = tyramine + CO2. HAMAP-Rule MF_01610
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_01610
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01610
Sequence similarities	Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tyrosine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP tyrosine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	L-tyrosine decarboxylase HAMAP-Rule MF_01610		PRO_0000147031
Amino acid modifications
	Modified residue	231	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5JJ82 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 3F4F757953FA9C33	FASTA	384	42,545
	10 20 30 40 50 60 MFPERGASEE EVLRELEEKT REDLTFDSGK ILGSMCTYPH PFAVKVVMKY IDRNLGDPGL 70 80 90 100 110 120 HIGSQKIEKE AVDMLANLLG LEKGYGHIVS GGTEANILAV RAMRNLAGIE KPELILPESA 130 140 150 160 170 180 HFSFIKAAEM LGVKLVWAEL NDDYTVNVKD VEKKITDRTI GIVGIAGTTG LGVVDDIPAL 190 200 210 220 230 240 SDLALDYGLP LHVDAAFGGF VIPFAKALGY EIPDFDFRLK GVKSITIDPH KMGMVPIPAG 250 260 270 280 290 300 GIIFREKKFL DSISVLAPYL AGGKIWQATI TGTRPGANAL AVWAMIKHLG FDGYKEVVKE 310 320 330 340 350 360 KMELARWFAS ELKKIPGIYL IREPVLNIVS FGSEKLEELE KELKARGWGV SAHRGYIRIV 370 380 VMPHVKREHL EEFLRDLREI AKRL

References

[1]

"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006878 Genomic DNA. Translation: BAD86003.1.
RefSeq	YP_184227.1. NC_006624.1.
3D structure databases
ProteinModelPortal	Q5JJ82.
ModBase	Search...
Protein-protein interaction databases
STRING	69014.TK1814.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD86003; BAD86003; TK1814.
GeneID	3234484.
KEGG	tko:TK1814.
Phylogenomic databases
eggNOG	COG0076.
HOGENOM	HOG000246269.
KO	K01592.
OMA	DLTFDSG.
ProtClustDB	PRK13520.
Enzyme and pathway databases
BioCyc	TKOD69014:GH72-1851-MONOMER.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
HAMAP	MF_01610. Tyr_decarbox.
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR021115. Pyridoxal-P_BS. IPR020931. Tyr_deCO2ase. [Graphical view]
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR03812. tyr_de_CO2_Arch. 1 hit.
PROSITE	PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MFNA_PYRKO

Accession

Primary (citable) accession number: Q5JJ82

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	February 15, 2005
Last modified:	May 29, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program