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Protein

4-phosphopantoate--beta-alanine ligase

Gene

TK1686

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. Cannot use (R)-pantoate as substrate and thus does not display pantothenate synthetase (PS) activity.1 Publication

Catalytic activityi

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15971
TKOD69014:G1G2A-1689-MONOMER
BRENDAi6.3.2.26 5246
6.3.2.36 5246

Names & Taxonomyi

Protein namesi
Recommended name:
4-phosphopantoate--beta-alanine ligase (EC:6.3.2.36)
Alternative name(s):
Phosphopantothenate synthetase
Short name:
PPS
Gene namesi
Ordered Locus Names:TK1686
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Only viable in the presence of CoA or 4'-phosphopantothenate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004092601 – 2614-phosphopantoate--beta-alanine ligaseAdd BLAST261

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi69014.TK1686

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 25Combined sources15
Helixi31 – 47Combined sources17
Helixi53 – 68Combined sources16
Beta strandi73 – 76Combined sources4
Helixi78 – 83Combined sources6
Helixi85 – 95Combined sources11
Beta strandi98 – 101Combined sources4
Helixi108 – 119Combined sources12
Beta strandi137 – 139Combined sources3
Helixi141 – 143Combined sources3
Turni148 – 150Combined sources3
Helixi151 – 153Combined sources3
Beta strandi155 – 158Combined sources4
Helixi164 – 172Combined sources9
Beta strandi176 – 180Combined sources5
Helixi187 – 191Combined sources5
Beta strandi192 – 196Combined sources5
Helixi200 – 213Combined sources14
Turni214 – 216Combined sources3
Helixi219 – 227Combined sources9
Helixi231 – 252Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WDKX-ray2.30A/B/C/D1-261[»]
3WDLX-ray2.40A/B/C/D1-261[»]
3WDMX-ray2.00A/B/C/D1-261[»]
SMRiQ5JIZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04262 Archaea
COG1701 LUCA
HOGENOMiHOG000230027
InParanoidiQ5JIZ8
KOiK09722
OMAiPKSHPRY
OrthoDBiPOG093Z08SC

Family and domain databases

Gene3Di3.40.50.12640, 1 hit
InterProiView protein in InterPro
IPR002855 PPS/PS
IPR038138 PPS/PS_sf
PANTHERiPTHR40695 PTHR40695, 1 hit
PfamiView protein in Pfam
PF02006 PPS_PS, 1 hit
PIRSFiPIRSF004853 UCP004853, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016827 DUF137, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JIZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNIPKSHPR YWSLYYREKI IEGMEKGMTA KAGLIAHGRG EAFDYLIGER
60 70 80 90 100
TIEPAERAMR AAVAKFLLAE HPVISVNGNV AALVPKETIE LAKALNAKLE
110 120 130 140 150
INLFYRTEER VRTIAEELRK YDPEIEILGI NPTKRIPGLE HERGKVDENG
160 170 180 190 200
IWKADVVLVP LEDGDRTEAL VRMGKFVVTV DLNPLSRSAR MADITIVDNI
210 220 230 240 250
VRAYPRMVEL AREMKDYSRE ELLKIVGEYD NGKTLSDVLL HIRDRLTRLA
260
EEGIWRRKEL E
Length:261
Mass (Da):29,845
Last modified:February 15, 2005 - v1
Checksum:iD36C99384454D82E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD85875.1
RefSeqiWP_011250637.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD85875; BAD85875; TK1686
GeneIDi3235144
KEGGitko:TK1686
PATRICifig|69014.16.peg.1643

Similar proteinsi

Entry informationi

Entry nameiPPS_THEKO
AccessioniPrimary (citable) accession number: Q5JIZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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