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Protein

Probable hydrogenase nickel incorporation protein HypA

Gene

hypA

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in a hydrogenase nickel cofactor insertion step.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2NickelUniRule annotation1
Metal bindingi73NickelUniRule annotation1
Metal bindingi76NickelUniRule annotation1
Metal bindingi110NickelUniRule annotation1
Metal bindingi113NickelUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Nickel

Names & Taxonomyi

Protein namesi
Recommended name:
Probable hydrogenase nickel incorporation protein HypAUniRule annotation
Gene namesi
Name:hypAUniRule annotation
Ordered Locus Names:TK2008
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001290851 – 139Probable hydrogenase nickel incorporation protein HypAAdd BLAST139

Interactioni

Protein-protein interaction databases

STRINGi69014.TK2008.

Structurei

Secondary structure

1139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 20Combined sources18
Beta strandi24 – 34Combined sources11
Helixi35 – 37Combined sources3
Helixi41 – 52Combined sources12
Turni56 – 59Combined sources4
Beta strandi61 – 67Combined sources7
Beta strandi70 – 73Combined sources4
Turni74 – 76Combined sources3
Beta strandi79 – 81Combined sources3
Helixi82 – 84Combined sources3
Helixi86 – 88Combined sources3
Helixi91 – 99Combined sources9
Helixi101 – 103Combined sources3
Helixi104 – 107Combined sources4
Turni111 – 113Combined sources3
Beta strandi118 – 122Combined sources5
Beta strandi125 – 134Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A43X-ray2.30A/B1-139[»]
3A44X-ray3.31A/B/C/D1-139[»]
5AUNX-ray1.63A1-139[»]
5AUOX-ray1.80A1-139[»]
5AUPX-ray3.10A/H1-139[»]
SMRiQ5JIH3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5JIH3.

Family & Domainsi

Sequence similaritiesi

Belongs to the HypA/HybF family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04426. Archaea.
COG0375. LUCA.
HOGENOMiHOG000291316.
InParanoidiQ5JIH3.
KOiK04651.
OMAiHEWALAD.

Family and domain databases

HAMAPiMF_00213. HypA. 1 hit.
InterProiIPR000688. Hydgase_Ni_incorp_HypA/HybF.
IPR020538. Hydgase_Ni_incorp_HypA/HybF_CS.
[Graphical view]
PfamiPF01155. HypA. 1 hit.
[Graphical view]
PIRSFiPIRSF004761. Hydrgn_mat_HypA. 1 hit.
PROSITEiPS01249. HYPA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JIH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEWALADAI VRTVLDYAQR EGASRVKAVR VVLGELQDVA EDIVKFAMEQ
60 70 80 90 100
LFAGTIAEGA EIEFVEEEAV FKCRNCNYEW KLKEVKDKFD ERIKEDIHFI
110 120 130
PEVVHAFLAC PKCGSHDFEV VKGRGVYVAG IKIEKEGGS
Length:139
Mass (Da):15,689
Last modified:February 15, 2005 - v1
Checksum:i2D8CC76DE5D9C55B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD86197.1.
RefSeqiWP_011250958.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD86197; BAD86197; TK2008.
GeneIDi3234885.
KEGGitko:TK2008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD86197.1.
RefSeqiWP_011250958.1. NC_006624.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A43X-ray2.30A/B1-139[»]
3A44X-ray3.31A/B/C/D1-139[»]
5AUNX-ray1.63A1-139[»]
5AUOX-ray1.80A1-139[»]
5AUPX-ray3.10A/H1-139[»]
SMRiQ5JIH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi69014.TK2008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD86197; BAD86197; TK2008.
GeneIDi3234885.
KEGGitko:TK2008.

Phylogenomic databases

eggNOGiarCOG04426. Archaea.
COG0375. LUCA.
HOGENOMiHOG000291316.
InParanoidiQ5JIH3.
KOiK04651.
OMAiHEWALAD.

Miscellaneous databases

EvolutionaryTraceiQ5JIH3.

Family and domain databases

HAMAPiMF_00213. HypA. 1 hit.
InterProiIPR000688. Hydgase_Ni_incorp_HypA/HybF.
IPR020538. Hydgase_Ni_incorp_HypA/HybF_CS.
[Graphical view]
PfamiPF01155. HypA. 1 hit.
[Graphical view]
PIRSFiPIRSF004761. Hydrgn_mat_HypA. 1 hit.
PROSITEiPS01249. HYPA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYPA_THEKO
AccessioniPrimary (citable) accession number: Q5JIH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.