Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hydrogenase maturation factor HypA

Gene

hypA

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1Nickel; via amino nitrogenCombined sources1 Publication1
Metal bindingi2Nickel; via pros nitrogenCombined sources1 Publication1
Metal bindingi73ZincUniRule annotationCombined sources2 Publications1
Metal bindingi76ZincUniRule annotationCombined sources2 Publications1
Metal bindingi98Nickel; via tele nitrogenCombined sources1 Publication1
Metal bindingi110ZincUniRule annotationCombined sources2 Publications1
Metal bindingi113ZincUniRule annotationCombined sources2 Publications1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Nickel, Zinc

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-2023-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase maturation factor HypACurated
Gene namesi
Name:hypA1 Publication
Ordered Locus Names:TK2008
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001290851 – 139Hydrogenase maturation factor HypAAdd BLAST139

Interactioni

Subunit structurei

Monomer and homodimer. Could also form hexamers (PubMed:19769985). Forms a complex with HypB (PubMed:26056269).2 Publications

Protein-protein interaction databases

STRINGi69014.TK2008

Structurei

Secondary structure

1139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 20Combined sources18
Beta strandi24 – 34Combined sources11
Helixi35 – 37Combined sources3
Helixi41 – 52Combined sources12
Turni56 – 59Combined sources4
Beta strandi61 – 67Combined sources7
Beta strandi70 – 73Combined sources4
Turni74 – 76Combined sources3
Beta strandi79 – 81Combined sources3
Helixi82 – 84Combined sources3
Helixi86 – 88Combined sources3
Helixi91 – 99Combined sources9
Helixi101 – 103Combined sources3
Helixi104 – 107Combined sources4
Turni111 – 113Combined sources3
Beta strandi118 – 122Combined sources5
Beta strandi125 – 134Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A43X-ray2.30A/B1-139[»]
3A44X-ray3.31A/B/C/D1-139[»]
5AUNX-ray1.63A1-139[»]
5AUOX-ray1.80A1-139[»]
5AUPX-ray3.10A/H1-139[»]
SMRiQ5JIH3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5JIH3

Family & Domainsi

Sequence similaritiesi

Belongs to the HypA/HybF family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04426 Archaea
COG0375 LUCA
HOGENOMiHOG000291316
InParanoidiQ5JIH3
KOiK04651
OMAiHEWALAD
OrthoDBiPOG093Z0MH7

Family and domain databases

HAMAPiMF_00213 HypA_HybF, 1 hit
InterProiView protein in InterPro
IPR000688 Hydgase_Ni_incorp_HypA/HybF
IPR020538 Hydgase_Ni_incorp_HypA/HybF_CS
PANTHERiPTHR34535 PTHR34535, 1 hit
PfamiView protein in Pfam
PF01155 HypA, 1 hit
PIRSFiPIRSF004761 Hydrgn_mat_HypA, 1 hit
PROSITEiView protein in PROSITE
PS01249 HYPA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JIH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHEWALADAI VRTVLDYAQR EGASRVKAVR VVLGELQDVA EDIVKFAMEQ
60 70 80 90 100
LFAGTIAEGA EIEFVEEEAV FKCRNCNYEW KLKEVKDKFD ERIKEDIHFI
110 120 130
PEVVHAFLAC PKCGSHDFEV VKGRGVYVAG IKIEKEGGS
Length:139
Mass (Da):15,689
Last modified:February 15, 2005 - v1
Checksum:i2D8CC76DE5D9C55B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD86197.1
RefSeqiWP_011250958.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD86197; BAD86197; TK2008
GeneIDi3234885
KEGGitko:TK2008
PATRICifig|69014.16.peg.1961

Similar proteinsi

Entry informationi

Entry nameiHYPA_THEKO
AccessioniPrimary (citable) accession number: Q5JIH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health