ID   Q5JI10_THEKO            Unreviewed;       621 AA.
AC   Q5JI10;
DT   15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   RecName: Full=aldehyde ferredoxin oxidoreductase {ECO:0000256|ARBA:ARBA00012818};
DE            EC=1.2.7.5 {ECO:0000256|ARBA:ARBA00012818};
GN   OrderedLocusNames=TK0844 {ECO:0000313|EMBL:BAD85033.1};
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014 {ECO:0000313|EMBL:BAD85033.1, ECO:0000313|Proteomes:UP000000536};
RN   [1] {ECO:0000313|EMBL:BAD85033.1, ECO:0000313|Proteomes:UP000000536}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1
RC   {ECO:0000313|Proteomes:UP000000536};
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a
CC         carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:16421, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.2.7.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001714};
CC   -!- COFACTOR:
CC       Name=W-bis(molybdopterin guanine dinucleotide); Xref=ChEBI:CHEBI:60537;
CC         Evidence={ECO:0000256|ARBA:ARBA00001930};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the AOR/FOR family.
CC       {ECO:0000256|ARBA:ARBA00011032}.
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DR   EMBL; AP006878; BAD85033.1; -; Genomic_DNA.
DR   RefSeq; WP_011249795.1; NC_006624.1.
DR   AlphaFoldDB; Q5JI10; -.
DR   STRING; 69014.TK0844; -.
DR   EnsemblBacteria; BAD85033; BAD85033; TK0844.
DR   GeneID; 78447359; -.
DR   KEGG; tko:TK0844; -.
DR   PATRIC; fig|69014.16.peg.824; -.
DR   eggNOG; arCOG00709; Archaea.
DR   HOGENOM; CLU_020364_1_0_2; -.
DR   InParanoid; Q5JI10; -.
DR   OrthoDB; 30771at2157; -.
DR   PhylomeDB; Q5JI10; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0033726; F:aldehyde ferredoxin oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.569.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 2; 1.
DR   Gene3D; 1.10.599.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 3; 1.
DR   Gene3D; 3.60.9.10; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
DR   InterPro; IPR013984; Ald_Fedxn_OxRdtase_dom2.
DR   InterPro; IPR013985; Ald_Fedxn_OxRdtase_dom3.
DR   InterPro; IPR013983; Ald_Fedxn_OxRdtase_N.
DR   InterPro; IPR036503; Ald_Fedxn_OxRdtase_N_sf.
DR   InterPro; IPR001203; OxRdtase_Ald_Fedxn_C.
DR   InterPro; IPR036021; Tungsten_al_ferr_oxy-like_C.
DR   PANTHER; PTHR30038; ALDEHYDE FERREDOXIN OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR30038:SF0; TUNGSTEN-CONTAINING ALDEHYDE FERREDOXIN OXIDOREDUCTASE; 1.
DR   Pfam; PF01314; AFOR_C; 1.
DR   Pfam; PF02730; AFOR_N; 1.
DR   SMART; SM00790; AFOR_N; 1.
DR   SUPFAM; SSF48310; Aldehyde ferredoxin oxidoreductase, C-terminal domains; 1.
DR   SUPFAM; SSF56228; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000536};
KW   Tungsten {ECO:0000256|ARBA:ARBA00023245}.
FT   DOMAIN          4..204
FT                   /note="Aldehyde ferredoxin oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00790"
SQ   SEQUENCE   621 AA;  69177 MW;  21F24DDC52E04350 CRC64;
     MYGYQNKIAR VNLTTGKVTY EELPDEVIRK FIGGKGLGYY IIYREVPPGT DPLSPANKFV
     FAAGGLTGLV PGSSKVIAIS KSPETRLISD SSGGDAFGPK LRGHFDALII EGKSEEPVYL
     YIHDGKVEIK DASHLWGKGN YEVAKELWKE YPTASMAMVG PAGERLSRIA DIIYDTERAS
     GRGGLGAVLG SKRVKAVVVE PGEKPKVAEP EEFQRLWQEY YNEFATNPKY EHTRTYGTTD
     ALRSAASLGM SPAYNFSRPY IPDELASKLG GDEVKKYEVE PEWFVHGKSC PIKCARYVEV
     EYKGKKIRVK PEYESIAMLG AATGVFDFPA VAYFIHLVND YGMDSIATGA TIGWLFEMVE
     RGLISEDEIG FPVKGFGDAE AEERLIKLMA ERKGIGAILA DGVKRACERL GRGCEFAVHV
     KGMESPAWDP RGRRTYGLSY ATADVGASHL RGWPRPHQLP NQGPAKELVP SLIEGRDESY
     ITDMLGTCKF VPYKMEDLAK LYSVATGEEW TVEELRKRAW GVESIARIHD ALDWVTPPLD
     DTIPPRWWEP EPDGPAKGNA AFIDYNDFLE ARREFYRLRG WHEELGVPLP ETMEKLGLPE
     FKEDAARAID VVKKRMEFSG Q
//