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Q5JHT4

- RIBL_THEKO

UniProt

Q5JHT4 - RIBL_THEKO

Protein

FAD synthase

Gene

ribL

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.UniRule annotation

    Catalytic activityi

    ATP + FMN = diphosphate + FAD.UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 162ATPUniRule annotation
    Nucleotide bindingi20 – 234ATPUniRule annotation
    Nucleotide bindingi99 – 1024ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. FMN adenylyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. FAD biosynthetic process Source: UniProtKB-HAMAP
    2. FMN metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTKOD69014:GH72-2326-MONOMER.
    UniPathwayiUPA00277; UER00407.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FAD synthaseUniRule annotation (EC:2.7.7.2UniRule annotation)
    Alternative name(s):
    FMN adenylyltransferaseUniRule annotation
    Flavin adenine dinucleotide synthaseUniRule annotation
    Gene namesi
    Name:ribLUniRule annotation
    Ordered Locus Names:TK2274
    OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
    Taxonomic identifieri69014 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000000536: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 149149FAD synthasePRO_0000406282Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi69014.TK2274.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JHT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the archaeal FAD synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0615.
    HOGENOMiHOG000284153.
    KOiK14656.
    OMAiPGTIDME.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_02115. FAD_synth_arch.
    InterProiIPR004821. Cyt_trans-like.
    IPR024902. FAD_synth_RibL.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01467. CTP_transf_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5JHT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEKRKKIRV LVGGVFDILH VGHIHFLKQA KELGDELVVI VAHDETVRMQ    50
    KRREPINPAE DRAELLRAIR YVDEVYIGTP GTIDMELVKR IDPDVIAIGP 100
    DQFFNCEKLK EELRKHGINA EVIRIPYLYK SDRAKTSKII QRIVETFCE 149
    Length:149
    Mass (Da):17,304
    Last modified:February 15, 2005 - v1
    Checksum:i5D0C81C1322844C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD86463.1.
    RefSeqiYP_184687.1. NC_006624.1.

    Genome annotation databases

    EnsemblBacteriaiBAD86463; BAD86463; TK2274.
    GeneIDi3234716.
    KEGGitko:TK2274.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD86463.1 .
    RefSeqi YP_184687.1. NC_006624.1.

    3D structure databases

    ProteinModelPortali Q5JHT4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 69014.TK2274.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD86463 ; BAD86463 ; TK2274 .
    GeneIDi 3234716.
    KEGGi tko:TK2274.

    Phylogenomic databases

    eggNOGi COG0615.
    HOGENOMi HOG000284153.
    KOi K14656.
    OMAi PGTIDME.

    Enzyme and pathway databases

    UniPathwayi UPA00277 ; UER00407 .
    BioCyci TKOD69014:GH72-2326-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_02115. FAD_synth_arch.
    InterProi IPR004821. Cyt_trans-like.
    IPR024902. FAD_synth_RibL.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01467. CTP_transf_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
      Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
      Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-918 / JCM 12380 / KOD1.

    Entry informationi

    Entry nameiRIBL_THEKO
    AccessioniPrimary (citable) accession number: Q5JHT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3