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Q5JH71

- GLMS_THEKO

UniProt

Q5JH71 - GLMS_THEKO

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei597 – 5971For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciTKOD69014:GH72-822-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:TK0809
    OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
    Taxonomic identifieri69014 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000000536: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 602601Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135432Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi69014.TK0809.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5JH71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini280 – 420141SIS 1UniRule annotationAdd
    BLAST
    Domaini453 – 592140SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258898.
    KOiK00820.
    OMAiPVTRRFM.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5JH71-1 [UniParc]FASTAAdd to Basket

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    MCGIIGYIGD RKACEVIVKG LKRLEYRGYD SAGVVTGNGE TLDVRKGAGR    50
    IDKLTEKLGF LEMEGNRGIG HTRWATHGVP NDINAHPQKD CTGKIVLVHN 100
    GIIENFAELK EELLKKGHVF RSDTDTEVIA HLIEEELKGS ENFEEALRKA 150
    LNKLRGSFAL AIVYADEPDK LYVVRNESPL VLGIGEGEMF AASDVPAFLE 200
    YTNKVIFLDD GEYAILTKDS YVVKRIDTGE VVEKPVHEIS WTLEMAEKAG 250
    YPHFMLKEIY EQPRAIKDAI HGNREIIRSV AEEIANYDKI IFVAMGTSYH 300
    AALVGKSLFQ RLAKKVPIVE EASEFRYEFE DLIDDKTLVI AITQSGETAD 350
    TLAAMKLAKK NGAKVLAVVN VVGSMATRIA DLTLYTHAGP EIGVAATKTY 400
    TTQLTVLTML AIELAKVLGT ASEDYLEKLE DELMKVPELV ELALKHDEAL 450
    RELAETLKDK RDFFYIGRGI SVPTALEGAL KLKEISYIHA EGLSAGELKH 500
    GPLALLEDGV PVVAINPSGK VFDKMVSNIE EAKARGAMII SLSDREELSR 550
    VSDVLVKMPE VDELLSPIVY VVPLQLLAYH LAVLRGNDPD KPRNLAKSVT 600
    VE 602
    Length:602
    Mass (Da):66,353
    Last modified:January 23, 2007 - v3
    Checksum:i40A7AA289CDA96B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD84998.1.
    RefSeqiYP_183222.1. NC_006624.1.

    Genome annotation databases

    EnsemblBacteriaiBAD84998; BAD84998; TK0809.
    GeneIDi3234017.
    KEGGitko:TK0809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006878 Genomic DNA. Translation: BAD84998.1 .
    RefSeqi YP_183222.1. NC_006624.1.

    3D structure databases

    ProteinModelPortali Q5JH71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 69014.TK0809.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD84998 ; BAD84998 ; TK0809 .
    GeneIDi 3234017.
    KEGGi tko:TK0809.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258898.
    KOi K00820.
    OMAi PVTRRFM.

    Enzyme and pathway databases

    BioCyci TKOD69014:GH72-822-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
      Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
      Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-918 / JCM 12380 / KOD1.

    Entry informationi

    Entry nameiGLMS_THEKO
    AccessioniPrimary (citable) accession number: Q5JH71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3