Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei597For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:TK0809
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001354322 – 602Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST601

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi69014.TK0809.

Structurei

3D structure databases

ProteinModelPortaliQ5JH71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 219Glutamine amidotransferase type-2UniRule annotationAdd BLAST218
Domaini280 – 420SIS 1UniRule annotationAdd BLAST141
Domaini453 – 592SIS 2UniRule annotationAdd BLAST140

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiarCOG00057. Archaea.
COG0449. LUCA.
HOGENOMiHOG000258898.
InParanoidiQ5JH71.
KOiK00820.
OMAiGEFFCAS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JH71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIIGYIGD RKACEVIVKG LKRLEYRGYD SAGVVTGNGE TLDVRKGAGR
60 70 80 90 100
IDKLTEKLGF LEMEGNRGIG HTRWATHGVP NDINAHPQKD CTGKIVLVHN
110 120 130 140 150
GIIENFAELK EELLKKGHVF RSDTDTEVIA HLIEEELKGS ENFEEALRKA
160 170 180 190 200
LNKLRGSFAL AIVYADEPDK LYVVRNESPL VLGIGEGEMF AASDVPAFLE
210 220 230 240 250
YTNKVIFLDD GEYAILTKDS YVVKRIDTGE VVEKPVHEIS WTLEMAEKAG
260 270 280 290 300
YPHFMLKEIY EQPRAIKDAI HGNREIIRSV AEEIANYDKI IFVAMGTSYH
310 320 330 340 350
AALVGKSLFQ RLAKKVPIVE EASEFRYEFE DLIDDKTLVI AITQSGETAD
360 370 380 390 400
TLAAMKLAKK NGAKVLAVVN VVGSMATRIA DLTLYTHAGP EIGVAATKTY
410 420 430 440 450
TTQLTVLTML AIELAKVLGT ASEDYLEKLE DELMKVPELV ELALKHDEAL
460 470 480 490 500
RELAETLKDK RDFFYIGRGI SVPTALEGAL KLKEISYIHA EGLSAGELKH
510 520 530 540 550
GPLALLEDGV PVVAINPSGK VFDKMVSNIE EAKARGAMII SLSDREELSR
560 570 580 590 600
VSDVLVKMPE VDELLSPIVY VVPLQLLAYH LAVLRGNDPD KPRNLAKSVT

VE
Length:602
Mass (Da):66,353
Last modified:January 23, 2007 - v3
Checksum:i40A7AA289CDA96B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84998.1.
RefSeqiWP_011249760.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84998; BAD84998; TK0809.
GeneIDi3234017.
KEGGitko:TK0809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD84998.1.
RefSeqiWP_011249760.1. NC_006624.1.

3D structure databases

ProteinModelPortaliQ5JH71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi69014.TK0809.

Protein family/group databases

MEROPSiC44.971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD84998; BAD84998; TK0809.
GeneIDi3234017.
KEGGitko:TK0809.

Phylogenomic databases

eggNOGiarCOG00057. Archaea.
COG0449. LUCA.
HOGENOMiHOG000258898.
InParanoidiQ5JH71.
KOiK00820.
OMAiGEFFCAS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLMS_THEKO
AccessioniPrimary (citable) accession number: Q5JH71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.