SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5JH71

- GLMS_THEKO

UniProt

Q5JH71 - GLMS_THEKO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, TK0809
Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei597 – 5971For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciTKOD69014:GH72-822-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:TK0809
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 602601Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135432Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi69014.TK0809.

Structurei

3D structure databases

ProteinModelPortaliQ5JH71.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2
Add
BLAST
Domaini280 – 420141SIS 1
Add
BLAST
Domaini453 – 592140SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiPVTRRFM.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JH71-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIIGYIGD RKACEVIVKG LKRLEYRGYD SAGVVTGNGE TLDVRKGAGR    50
IDKLTEKLGF LEMEGNRGIG HTRWATHGVP NDINAHPQKD CTGKIVLVHN 100
GIIENFAELK EELLKKGHVF RSDTDTEVIA HLIEEELKGS ENFEEALRKA 150
LNKLRGSFAL AIVYADEPDK LYVVRNESPL VLGIGEGEMF AASDVPAFLE 200
YTNKVIFLDD GEYAILTKDS YVVKRIDTGE VVEKPVHEIS WTLEMAEKAG 250
YPHFMLKEIY EQPRAIKDAI HGNREIIRSV AEEIANYDKI IFVAMGTSYH 300
AALVGKSLFQ RLAKKVPIVE EASEFRYEFE DLIDDKTLVI AITQSGETAD 350
TLAAMKLAKK NGAKVLAVVN VVGSMATRIA DLTLYTHAGP EIGVAATKTY 400
TTQLTVLTML AIELAKVLGT ASEDYLEKLE DELMKVPELV ELALKHDEAL 450
RELAETLKDK RDFFYIGRGI SVPTALEGAL KLKEISYIHA EGLSAGELKH 500
GPLALLEDGV PVVAINPSGK VFDKMVSNIE EAKARGAMII SLSDREELSR 550
VSDVLVKMPE VDELLSPIVY VVPLQLLAYH LAVLRGNDPD KPRNLAKSVT 600
VE 602
Length:602
Mass (Da):66,353
Last modified:January 23, 2007 - v3
Checksum:i40A7AA289CDA96B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006878 Genomic DNA. Translation: BAD84998.1.
RefSeqiYP_183222.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD84998; BAD84998; TK0809.
GeneIDi3234017.
KEGGitko:TK0809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006878 Genomic DNA. Translation: BAD84998.1 .
RefSeqi YP_183222.1. NC_006624.1.

3D structure databases

ProteinModelPortali Q5JH71.
ModBasei Search...

Protein-protein interaction databases

STRINGi 69014.TK0809.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD84998 ; BAD84998 ; TK0809 .
GeneIDi 3234017.
KEGGi tko:TK0809.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi PVTRRFM.

Enzyme and pathway databases

BioCyci TKOD69014:GH72-822-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiGLMS_THEKO
AccessioniPrimary (citable) accession number: Q5JH71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi