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Q5JH53 (KHSE_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:TK1444
OrganismPyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1))
Taxonomic identifier69014 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384

Subcellular location

Cytoplasm Potential HAMAP MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Homoserine kinase HAMAP MF_00384
PRO_0000156648

Regions

Nucleotide binding81 – 9111ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q5JH53 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: DA10531B5C8A0B96

FASTA29231,146
        10         20         30         40         50         60 
MRIRVPATIA NFGPGFDVFG VGIGEPYDEL KFVESDEWEI EVEGYDVPTD GRNVAVVAAR 

        70         80         90        100        110        120 
ALATLVGEEL YLRMKLRKEI RPRSGLGSSG ASSLAGALAA ARVLGIEDDG LIIKAALAGE 

       130        140        150        160        170        180 
EAASGSAHGD NVVPAYYGDF TIIESLNPLR VHRIPVDFPL VVVLPQIEVP TREARRILPE 

       190        200        210        220        230        240 
RVPMGDAVRN VALAGALVKA LTSGDVQTVG RLLEDRIALP YRLRLMPWFA RVWKAALDAG 

       250        260        270        280        290 
AYGAFVSGSG PAIFALGEDL HAIGKAIAEA FLEIGVDAEV YITRAGVGAF WL

« Hide

References

[1]"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
Genome Res. 15:352-363(2005) [PubMed: 15710748] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006878 Genomic DNA. Translation: BAD85633.1.
RefSeqYP_183857.1. NC_006624.1.

3D structure databases

ProteinModelPortalQ5JH53.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000008402; EBPYRP00000008183; EBPYRG00000008401.
GeneID3233676.
GenomeReviewsGene locus TK1444 in contig AP006878_GR.
KEGGtko:TK1444.
NMPDRfig|69014.3.peg.1315.

Phylogenomic databases

eggNOGarNOG05905.
GeneTreeEBGT00050000022725.
HOGENOMHBG646290.
OMANNALMST.
PhylomeDBQ5JH53.
ProtClustDBPRK01212.

Enzyme and pathway databases

BioCycTKOD69014:TK1444-MONOMER.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_PYRKO
AccessionPrimary (citable) accession number: Q5JH53
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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