Q5JH51 (METE_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable methylcobalamin:homocysteine methyltransferase
EC=2.1.1.-

Alternative name(s):
Methionine synthase

Gene names

Name:	metE
Ordered Locus Names:	TK1446

Organism

Pyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1)) [Reference proteome] [HAMAP]

Taxonomic identifier

69014 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus › Thermococcus kodakarensis

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a methyl group from methylcobalamin and methylcobinamide to homocysteine resulting in methionine formation By similarity. HAMAP-Rule MF_00288
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00288
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway. HAMAP-Rule MF_00288
Sequence similarities	Belongs to the vitamin-B12 independent methionine synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	methionine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Probable methylcobalamin:homocysteine methyltransferase HAMAP-Rule MF_00288		PRO_0000098690
Sites
	Metal binding	210	1	Zinc By similarity
	Metal binding	212	1	Zinc By similarity
	Metal binding	294	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5JH51 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 37A65C2BC9440915	FASTA	336	39,054
	10 20 30 40 50 60 MELPILPTSI IGSYPKPRWL LRMYNLRELG RLPEEDFREA VRDASVAVLR EHERAGIDIP 70 80 90 100 110 120 WDGEMGRSEM TEYFTAKIAG FKFYGPIRVW GNAYFNKAAA VSKLEYREPL VLDEFRWVKE 130 140 150 160 170 180 NTTREIIKVP ITGPYTIAEW SFNEYYSSKE ELAFDLAKIL NKEFKLLEKE GATFIQIDEP 190 200 210 220 230 240 AMLNHPDEVS IAVEAINRAV KGVKVKFGLH VCYSNYYLLA DYFDDIKVSQ FALEAANRNF 250 260 270 280 290 300 RDLDYLKKLT HQELGFGVVD VHNPRVESPE EVAKAIRKVM EYIEPERLYI NPDCGLKLLD 310 320 330 RRIAYQKLVN MVKGVEIVRR ELAREGKTSI PFRREV

References

[1]

"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006878 Genomic DNA. Translation: BAD85635.1.
RefSeq	YP_183859.1. NC_006624.1.
3D structure databases
ProteinModelPortal	Q5JH51.
ModBase	Search...
Protein-protein interaction databases
STRING	69014.TK1446.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD85635; BAD85635; TK1446.
GeneID	3235806.
KEGG	tko:TK1446.
Phylogenomic databases
eggNOG	COG0620.
HOGENOM	HOG000140559.
KO	K00549.
OMA	VEMGIRK.
ProtClustDB	PRK04326.
Enzyme and pathway databases
BioCyc	TKOD69014:GH72-1471-MONOMER.
UniPathway	UPA00051.
Family and domain databases
HAMAP	MF_00288. MetE.
InterPro	IPR022921. MetE_arc. IPR002629. Methionine_synth. [Graphical view]
Pfam	PF01717. Meth_synt_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

METE_PYRKO

Accession

Primary (citable) accession number: Q5JH51

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	February 15, 2005
Last modified:	May 29, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program