Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-1375-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:TK1379
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001670301 – 502Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ5JGX6

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

IntActiQ5JGX6, 1 interactor
MINTiQ5JGX6
STRINGi69014.TK1379

Structurei

3D structure databases

ProteinModelPortaliQ5JGX6
SMRiQ5JGX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00076 Archaea
COG1003 LUCA
HOGENOMiHOG000239368
InParanoidiQ5JGX6
KOiK00283
OMAiMHINLHK
OrthoDBiPOG093Z01WJ

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JGX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHQAKWDEP TIFELSRPGR IGYTLPKPIE DVDVDIPEKL RRKSPLNLPE
60 70 80 90 100
LSEPEVVKHY TRLSEMNYGV DSGIYPLGSC TMKYNPKINE EIASHPGVAY
110 120 130 140 150
VHPYQDEGTV QGALKIMWEL EQWLKEITGM DRFTLQPAAG ANGEFTGVSI
160 170 180 190 200
IRAYHIDRGE TQRTEMLVPD SAHGTNPASA AMAGFKVIEI PSNENGTVDL
210 220 230 240 250
EALENAVSER TAGLMLTNPN TLGIFEDEIL EIAKIVHKAG GLLYYDGANL
260 270 280 290 300
NAVLGKIRPG DMGFDVVHLN LHKTFSTPHG GGGPGSGPVG VKDFLKDYLP
310 320 330 340 350
VPLVSYDAEN DRYYLDYNVP RSIGKVKELY GNFAVIVRAL TYLKIMGREG
360 370 380 390 400
LKEVSEVAVL NANYLTQKLK GTRGYELPGK ELRKHETVFS AEPMKKETGV
410 420 430 440 450
KALDVAKRLL DFCMHAPTIY FPLIVHEALM IEPTETVSKE ELDAYVEALK
460 470 480 490 500
RISEEAYSNP EVVTSAPHNT AVRRVDDVLA AKKPVITWRM YRELKERGEI

DY
Length:502
Mass (Da):55,991
Last modified:February 15, 2005 - v1
Checksum:iAFE4AC2931468554
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD85568.1
RefSeqiWP_011250330.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD85568; BAD85568; TK1379
GeneIDi3235783
KEGGitko:TK1379
PATRICifig|69014.16.peg.1341

Similar proteinsi

Entry informationi

Entry nameiGCSPB_THEKO
AccessioniPrimary (citable) accession number: Q5JGX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health