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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-1376-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:TK1380
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669871 – 451Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST451

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi69014.TK1380

Structurei

3D structure databases

ProteinModelPortaliQ5JGX5
SMRiQ5JGX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00077 Archaea
COG0403 LUCA
HOGENOMiHOG000132025
InParanoidiQ5JGX5
KOiK00282
OMAiMYDGASA
OrthoDBiPOG093Z02N9

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JGX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKHYIPNSA HKDEMLKEIG FSSIEDLFSD VPKGMVKEFN LPEGKSEYEV
60 70 80 90 100
FTELNETLSK NKTVLEMPSF LGAGTYFHYV PAHVKYLIER SEFLTAYTPY
110 120 130 140 150
QPEISQGMLQ ALFEYQSLIA ELVGLPIVNS SMYDWGTAMA EAALMSARVT
160 170 180 190 200
KRNKFVVPKH LSPEKKLVLK TYTAGPGLET VEVPWDERGQ MDIEKLKEAV
210 220 230 240 250
EGAAGVYIEM PNFFGLLEEN IREIGEIAHD AGALFVVGVD PTILGIVEAP
260 270 280 290 300
GELGADIVVG EAAYFGNPMN FGGPRAGIFA VRNDRKLIRQ MPGRIIGMTK
310 320 330 340 350
DADGKRAFVM TLQTREQHIR RAKATSNICS NEALVAVAAA IHLATLGPKG
360 370 380 390 400
VRELGEVILK NTAYLKKRLA EVGEIVFDGV NFKDVPVRFE VPYSVIHERL
410 420 430 440 450
LERNIHGGYY IGKHFQELGE TALFAATETT RKEWVDGLVD ALREIIGEAE

L
Length:451
Mass (Da):50,014
Last modified:February 15, 2005 - v1
Checksum:i9A29DDFFC0F7BE19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD85569.1
RefSeqiWP_011250331.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD85569; BAD85569; TK1380
GeneIDi3235784
KEGGitko:TK1380
PATRICifig|69014.16.peg.1342

Similar proteinsi

Entry informationi

Entry nameiGCSPA_THEKO
AccessioniPrimary (citable) accession number: Q5JGX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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