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Q5JGP4 (CDR_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coenzyme A disulfide reductase
Short name=CoA-disulfide reductase
Short name=CoADR
EC=1.8.1.14
Gene names
Ordered Locus Names:TK1299
OrganismPyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1))
Taxonomic identifier69014 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 CoA + NAD(P)+ = CoA-disulfide + NAD(P)H.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Coenzyme A disulfide reductase
PRO_0000184700

Regions

Nucleotide binding10 – 3526FAD By similarity
Nucleotide binding151 – 16616NADP By similarity
Nucleotide binding270 – 28011FAD By similarity

Sites

Active site451Nucleophile By similarity
Active site451Redox-active By similarity
Binding site171Substrate By similarity
Binding site211Substrate By similarity
Binding site241Substrate By similarity
Binding site411Substrate By similarity
Binding site721Substrate By similarity
Binding site4221FAD; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5JGP4 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: A51CC778EA62E476

FASTA44248,610
        10         20         30         40         50         60 
MERKTVVVIG GGAAGMSTAS RVKRLKPEWD VKVFEATEWV SHAPCGIPYV VEGISPKEKL 

        70         80         90        100        110        120 
MHYPPEVFIK KRGIDLHLKA EVIEVEQGRV RVREEDGEKT YEWDYLVFAN GASPQVPAIE 

       130        140        150        160        170        180 
GIDLPGVFTA DLPPDAVAIT EYLEKNPVEN VVVIGTGYIA IEMAEAFVER GKNVTLIGRS 

       190        200        210        220        230        240 
ERVLRKTFDK EITDIVEEKL RNHLNLRLEE VTLRIEGKER VERVVTDAGE YPADLVIVAT 

       250        260        270        280        290        300 
GIKPNTELAR GLGVRIGETG AIWTNDRMQT SVENVYAAGD VAETKHLITG RRVWMPLAPA 

       310        320        330        340        350        360 
GNKMGYVAGS NIAGKEIHFP GVLGTSITKF LDLEIGKTGL TEAEAMKEGY DVRTAFIKAG 

       370        380        390        400        410        420 
TRPHYYPGSK TIWLKGVVDN ETNRLLGVQA VGGDILPRID TAAAMITAGF TTKDVFFTDL 

       430        440 
AYAPPFAPVW DPLIVLARVL KF

« Hide

References

[1]"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
Genome Res. 15:352-363(2005) [PubMed: 15710748] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006878 Genomic DNA. Translation: BAD85488.1.
RefSeqYP_183712.1. NC_006624.1.

3D structure databases

ProteinModelPortalQ5JGP4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000007693; EBPYRP00000007474; EBPYRG00000007692.
GeneID3235301.
GenomeReviewsGene locus TK1299 in contig AP006878_GR.
KEGGtko:TK1299.
NMPDRfig|69014.3.peg.905.

Phylogenomic databases

eggNOGarNOG04436.
GeneTreeEBGT00050000022426.
HOGENOMHBG535576.
OMADLHLKAE.
PhylomeDBQ5JGP4.
ProtClustDBCLSK541377.

Enzyme and pathway databases

BioCycTKOD69014:TK1299-MONOMER.

Family and domain databases

InterProIPR017758. CoA_disulphide_reductase.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
Gene3DG3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
KOK00359.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
TIGRFAMsTIGR03385. CoA_CoA_reduc. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCDR_PYRKO
AccessionPrimary (citable) accession number: Q5JGP4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: February 15, 2005
Last modified: December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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