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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTKOD69014:G1G2A-1225-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:TK1235
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001516541 – 642Arginine--tRNA ligaseAdd BLAST642

Proteomic databases

PRIDEiQ5JGH7

Interactioni

Protein-protein interaction databases

STRINGi69014.TK1235

Structurei

3D structure databases

ProteinModelPortaliQ5JGH7
SMRiQ5JGH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 143"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00487 Archaea
COG0018 LUCA
HOGENOMiHOG000247213
InParanoidiQ5JGH7
KOiK01887
OMAiNKPLHLG
OrthoDBiPOG093Z013U

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 2 hits
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JGH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYKEVQERV RLALRQALDE MLHEAGKEWD GEITFDDTPS IELGDFGTAV
60 70 80 90 100
SFQLARVFRK APKFIAEELV GRVKEKLPEE IRDVKAVNGY INFYLDYEFF
110 120 130 140 150
GKALVREILE KGEKYGESEL GSGKKVIVEH TSVNPTKPLH MGHARNAVLG
160 170 180 190 200
DTMARIMRKL GYTVEVQNYI DDLGVQFAQV LWGYLNLKEE FERIEAELRE
210 220 230 240 250
KGLKEDFIDH VMGLLYVEVN KKLEENPEVD KEVRELMKKL EEGDNEIAEV
260 270 280 290 300
GRKLAERVVR AQMLTTYRMG ITYDLLSWES DIMKSGIFGE AYGLIEKNEN
310 320 330 340 350
FFWATEGKYK GAFVMDLRKL FPDMKNPFLV LRRSDGTATY TGKDIAYHLW
360 370 380 390 400
KFGKVKADML YKLWDRVEDH ETWTTAPDGK EMPGKFGRAD IVINVIGAEQ
410 420 430 440 450
KHPQMAIKYA LQLLGFEDAA ENFHHLAYEH VVRPEGSFSG RKGTWVGFTV
460 470 480 490 500
DEVLNEAVQR ARELVEQKNP NLSDEEKDEI AEAVGVGAVR YNLVKYSPDK
510 520 530 540 550
VITFRWEDVL NFEGDSAPYL QYAHARCASI LRKAEESGVE TDWNALLEKA
560 570 580 590 600
DFSKLTNREK ELIKFLAKFP EVLESAGRDV KPHLVPAYLN ELASLFNRFY
610 620 630 640
MDHPVLKAEE GIREERLLLV LAVKQVLRNG LDVLGIKAPE RM
Length:642
Mass (Da):73,657
Last modified:February 15, 2005 - v1
Checksum:iFDE442F1E63B933A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA Translation: BAD85424.1
RefSeqiWP_011250186.1, NC_006624.1

Genome annotation databases

EnsemblBacteriaiBAD85424; BAD85424; TK1235
GeneIDi3234303
KEGGitko:TK1235
PATRICifig|69014.16.peg.1209

Similar proteinsi

Entry informationi

Entry nameiSYR_THEKO
AccessioniPrimary (citable) accession number: Q5JGH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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