Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5JGH7 (SYR_THEKO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:TK1235
OrganismThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) [Reference proteome] [HAMAP]
Taxonomic identifier69014 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151654

Regions

Motif133 – 14311"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q5JGH7 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: FDE442F1E63B933A

FASTA64273,657
        10         20         30         40         50         60 
MVYKEVQERV RLALRQALDE MLHEAGKEWD GEITFDDTPS IELGDFGTAV SFQLARVFRK 

        70         80         90        100        110        120 
APKFIAEELV GRVKEKLPEE IRDVKAVNGY INFYLDYEFF GKALVREILE KGEKYGESEL 

       130        140        150        160        170        180 
GSGKKVIVEH TSVNPTKPLH MGHARNAVLG DTMARIMRKL GYTVEVQNYI DDLGVQFAQV 

       190        200        210        220        230        240 
LWGYLNLKEE FERIEAELRE KGLKEDFIDH VMGLLYVEVN KKLEENPEVD KEVRELMKKL 

       250        260        270        280        290        300 
EEGDNEIAEV GRKLAERVVR AQMLTTYRMG ITYDLLSWES DIMKSGIFGE AYGLIEKNEN 

       310        320        330        340        350        360 
FFWATEGKYK GAFVMDLRKL FPDMKNPFLV LRRSDGTATY TGKDIAYHLW KFGKVKADML 

       370        380        390        400        410        420 
YKLWDRVEDH ETWTTAPDGK EMPGKFGRAD IVINVIGAEQ KHPQMAIKYA LQLLGFEDAA 

       430        440        450        460        470        480 
ENFHHLAYEH VVRPEGSFSG RKGTWVGFTV DEVLNEAVQR ARELVEQKNP NLSDEEKDEI 

       490        500        510        520        530        540 
AEAVGVGAVR YNLVKYSPDK VITFRWEDVL NFEGDSAPYL QYAHARCASI LRKAEESGVE 

       550        560        570        580        590        600 
TDWNALLEKA DFSKLTNREK ELIKFLAKFP EVLESAGRDV KPHLVPAYLN ELASLFNRFY 

       610        620        630        640 
MDHPVLKAEE GIREERLLLV LAVKQVLRNG LDVLGIKAPE RM 

« Hide

References

[1]"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006878 Genomic DNA. Translation: BAD85424.1.
RefSeqYP_183648.1. NC_006624.1.

3D structure databases

ProteinModelPortalQ5JGH7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING69014.TK1235.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD85424; BAD85424; TK1235.
GeneID3234303.
KEGGtko:TK1235.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMANPNGPLH.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycTKOD69014:GH72-1251-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_THEKO
AccessionPrimary (citable) accession number: Q5JGH7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries