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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Gene

uppS

Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431UniRule annotation
Metal bindingi43 – 431MagnesiumUniRule annotation
Binding sitei48 – 481SubstrateUniRule annotation
Binding sitei60 – 601SubstrateUniRule annotation
Active sitei91 – 911Proton acceptorUniRule annotation
Binding sitei92 – 921SubstrateUniRule annotation
Binding sitei94 – 941SubstrateUniRule annotation
Binding sitei213 – 2131SubstrateUniRule annotation
Metal bindingi232 – 2321MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciTKOD69014:GH72-1188-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)UniRule annotation (EC:2.5.1.89UniRule annotation)
Alternative name(s):
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:TK1173
OrganismiThermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000000536 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)PRO_0000123740Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi69014.TK1173.

Structurei

3D structure databases

ProteinModelPortaliQ5JGE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni44 – 474Substrate bindingUniRule annotation
Regioni88 – 903Substrate bindingUniRule annotation
Regioni219 – 2213Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
HOGENOMiHOG000006056.
InParanoidiQ5JGE1.
KOiK15888.
OMAiWNRPKLE.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5JGE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYRLVSHIP HILFKPVYDA YESYLLEKVK SGNIPKHVAI IMDGNRRWAR
60 70 80 90 100
KLEKPPWYGH LFGSKKLEEI LEWCRELNIR TLTVYAFSTE NFKRSKEEVE
110 120 130 140 150
ALMNLFEEKF KELVQDERVH RYGIRVNVLG RKDMLPENVR KAAEEAERAT
160 170 180 190 200
RKYSNYNLNI ALAYGGRSEI ADAVREIVRD VLEGKIKPED IDEEAIKRYL
210 220 230 240 250
YYPNMPDPDI VIRTGGEVRI SNFLLYQIAY SELFFVDVYF PEFRKIDFLR
260
IIREFQKRQR RFGR
Length:264
Mass (Da):31,552
Last modified:February 15, 2005 - v1
Checksum:i52A215866298217E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD85362.1.
RefSeqiWP_011250124.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD85362; BAD85362; TK1173.
GeneIDi3235773.
KEGGitko:TK1173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006878 Genomic DNA. Translation: BAD85362.1.
RefSeqiWP_011250124.1. NC_006624.1.

3D structure databases

ProteinModelPortaliQ5JGE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi69014.TK1173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD85362; BAD85362; TK1173.
GeneIDi3235773.
KEGGitko:TK1173.

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
HOGENOMiHOG000006056.
InParanoidiQ5JGE1.
KOiK15888.
OMAiWNRPKLE.

Enzyme and pathway databases

BioCyciTKOD69014:GH72-1188-MONOMER.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiUPPS_THEKO
AccessioniPrimary (citable) accession number: Q5JGE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.